Category: 91-00-9

I found the field of Chemistry very interesting. Saw the article Scalable electrochemical oxidant-and metal-free dehydrogenative coupling of S-H/N-H published in 2019. SDS of cas: 91-00-9, Reprint Addresses Li, H; Yuan, BX (corresponding author), Zhengzhou Univ, Dept Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

A practical and scalable electrochemical oxidation of S-H and N-H was developed. This oxidant-and catalyst-free electrochemical process enables S-N bond formation with inexpensive nickel electrodes in an undivided cell. This procedure exhibits broad substrate scopes and good functional-group compatibility. A 50 g scale oxidative coupling augurs well for industrial applications.

About Diphenylmethanamine, If you have any questions, you can contact Tang, SY; Liu, Y; Li, LJ; Ren, XH; Li, J; Yang, GY; Li, H; Yuan, BX or concate me.. SDS of cas: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocks. Recently I am researching about UGI-AZIDE; IODINE(III) REAGENTS; ORGANIC CATALYSIS; PROTOCOL; GENERALITY; STRATEGIES; AMINATION; AMINES; SCOPE; IBX, Saw an article supported by the [T32 GM008804]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Schofield, K; Foley, C; Hulme, C. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

A 5-endo trig oxidative radical cyclization of benzylamine-derived Ugi three-component reaction products rapidly affords imidazolidinones with three diversity elements. This adaptation of our previously described multicomponent reactionoxidation methodology further showcases manipulation of the diversity elements in multicomponent reaction products via oxidative radical cyclizations, which generates highly decorated privileged heterocycles.

Category: amides-buliding-blocks. About Diphenylmethanamine, If you have any questions, you can contact Schofield, K; Foley, C; Hulme, C or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recommanded Product: 91-00-9. In 2019.0 ASIAN J ORG CHEM published article about CATALYZED TRANSAMIDATION; EFFICIENT CATALYST; CARBOXYLIC-ACIDS; SECONDARY AMIDES; CARBOXAMIDES; AMINES; SOLVENT; UREAS; COMPLEX in [Yu, Subeen; Lee, Sunwoo] Chonnam Natl Univ, Dept Chem, Gwangju 61186, South Korea; [Song, Kwang Ho] Korea Univ, Dept Chem & Biol Engn, Seoul 02841, South Korea in 2019.0, Cited 66.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A metal-free transamidation of primary amides was developed. Trimethylsilyl chloride (TMSCl) acted as the activator in transamidation. In the presence of TMSCl, primary amides reacted with primary amines to yield transamidated secondary amides in NMP solvent. The transamidation of benzamide with secondary amines for the formation of tertiary amides succeeds in an NMP/CHCl3 solvent mixture.

Recommanded Product: 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Yu, S; Song, KH; Lee, S or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Safety of Diphenylmethanamine. Recently I am researching about RING-OPENING POLYMERIZATION; ONE-POT SYNTHESIS; STEREOSELECTIVE HYDROSILYLATION; DIASTEREOSELECTIVE SYNTHESIS; CARBONYL-COMPOUNDS; METAL-COMPLEXES; ENANTIOSELECTIVE ADDITION; 3-COMPONENT CONDENSATION; TRIMETHYLSILYL CYANIDE; COORDINATION CHEMISTRY, Saw an article supported by the Science and Engineering Research Board (SERB), Government of India [EMR/2016/005150]; MHRD; CSIRCouncil of Scientific & Industrial Research (CSIR) – India [09/1001(0048)/2019-EMR-I]; UGC, IndiaUniversity Grants Commission, India; Osaka University, Japan. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Das, S; Kumar, R; Devadkar, A; Panda, TK. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

We report the synthesis of alpha-aminonitriles by one-pot coupling reaction of aldehyde, amines and trimethylsilyl cyanide (TMSCN) using beta-ketoiminato zinc complexes as a pre-catalyst in very good yield under mild reaction condition. Homoleptic zinc complex [{kappa(2)-(2,4,6-Me3C6H2NC(Me)=CHC(Me)=O)}(2)Zn] (1 a) was synthesized by the treatment of protic ligand [(2,4,6-Me3C6H2NHC(Me)=CHC(Me)=O)] ((LH)-H-1) with potassium hydride and anhydrous zinc diiodide in 2 : 2 : 1 molar ratio in THF. Analogous reactions using [(2,6-(Pr2C6H3NHC)-Pr-i(Me)=CHC(Me)=O)] ((LH)-H-2) and [(Ph2CHNHC(Me)=CHC(Me)=O)] ((LH)-H-3) as protic ligands, dinuclear zinc complexes [{kappa(3)-(2,6-(Pr2C6H3NC)-Pr-i(Me)=CHC(Me)=O)}ZnI](2)(1 b) and [Zn(Ph2CHNHC-(Me)=CHC(Me)=O)ZnI2] (1 c) were obtained in good yield. Molecular structures of ligandsL(1)H,(LH)-H-3, and zinc complexes1 a,1 b, and1 cwere established by single-crystal x-ray diffraction analysis. Dinuclear zinc complexes1 b, and1 cexhibited high transformation, greater selectivity and broad substrate scope for the synthesis of alpha-aminonitrile under mild condition. A most plausible mechanism for synthesis alpha-aminonitrile is proposed based on several controlled reactions.

About Diphenylmethanamine, If you have any questions, you can contact Das, S; Kumar, R; Devadkar, A; Panda, TK or concate me.. Safety of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Improving C=N Bond Reductions with (Cyclopentadienone)iron Complexes: Scope and Limitations WOS:000457450900005 published article about CHIRAL BRONSTED ACID; CATALYSIS ENANTIOSELECTIVE HYDROGENATION; COOPERATIVE TRANSITION-METAL; OPPENAUER-TYPE OXIDATION; IRON COMPLEXES; TRICARBONYL COMPLEXES; EFFICIENT; ALCOHOLS; KETONES; IMINES in [Cettolin, Mattia; Bai, Xishan; Lubken, Dennis; Gatti, Marco; Pignataro, Luca; Gennari, Cesare] Univ Milan, Dipartimento Chim, Via C Golgi 19, I-20133 Milan, Italy; [Facchini, Sofia Vailati; Piarulli, Umberto] Univ Insubria, Dipartimento Sci & Alta Tecnol, Via Valleggio 11, I-22100 Como, Italy in 2019.0, Cited 71.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Name: Diphenylmethanamine

Herein, we broaden the application scope of (cyclopentadienone)iron complexes 1 in C=N bond reduction. The catalytic scope of pre-catalyst 1b, which is more active than the Knolker complex (1a) and other members of its family, has been expanded to the catalytic transfer hydrogenation (CTH) of a wider range of aldimines and ketimines, either pre-isolated or generated in situ. The kinetics of 1b-promoted CTH of ketimine S1 were assessed, showing a pseudo-first order profile, with TOF = 6.07 h(-1) at 50 % conversion. Moreover, the chiral complex 1c and its analog 1d were employed in the enantioselective reduction of ketimines and reductive amination of ketones, giving fair to good yields and moderate enantioselectivity.

Name: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Cettolin, M; Bai, XS; Lubken, D; Gatti, M; Facchini, SV; Piarulli, U; Pignataro, L; Gennari, C or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Product Details of 91-00-9. Authors Harrison, D; Boutard, N; Brzozka, K; Bugaj, M; Chmielewski, S; Cierpich, A; Doedens, JR; Fabritius, CHRY; Gabel, CA; Galezowski, M; Kowalczyk, P; Levenets, O; Mroczkowska, M; Palica, K; Porter, RA; Schultz, D; Sowinska, M; Topolnicki, G; Urbanski, P; Woyciechowski, J; Watt, AP in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Harrison, David; Watt, Alan P.] NodThera Ltd, Suite 8,Chesterford Res Pk, Saffron Walden CB10 1XL, Essex, England; [Doedens, John R.; Gabel, Christopher A.] NodThera Inc, 454 N 34th St, Seattle, WA 98103 USA; [Boutard, Nicolas; Brzozka, Krzysztof; Bugaj, Marta; Chmielewski, Stefan; Cierpich, Anna; Fabritius, Charles-Henry R. Y.; Galezowski, Michal; Kowalczyk, Piotr; Levenets, Oleksandr; Mroczkowska, Magdalena; Palica, Katarzyna; Schultz, David; Sowinska, Marta; Topolnicki, Grzegorz; Urbanski, Piotr; Woyciechowski, Jakub] Ryvu Therapeut, Selvita SA, Pk Life Sci,Ul Bobrssynskiego 14, PL-30348 Krakow, Poland; [Porter, Roderick A.] Rod Porter Consultancy, 89 Back St, Baldock SG7 5PG, Herts, England in 2020.0, Cited 25.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The NLRP3 inflammasome is a component of the innate immune system involved in the production of proinflammatory cytokines. Aberrant activation by a wide range of exogenous and endogenous signals can lead to chronic, low-grade inflammation. It has attracted a great deal of interest as a drug target due to the association with diseases of large unmet medical need such as Alzheimer’s disease, Parkinson’s disease, arthritis, and cancer. To date, no drugs specifically targeting inhibition of the NLRP3 inflammasome have been approved. In this work, we used the known NLRP3 inflammasome inhibitor CP-456,773 (aka CRID3 or MCC 950) as our starting point and undertook a Structure-Activity Relationship (SAR) analysis and subsequent scaffold-hopping exercise. This resulted in the rational design of a series of novel ester-substituted urea compounds that are highly potent and selective NLRP3 inflammasome inhibitors, as exemplified by compounds 44 and 45. It is hypothesized that the ester moiety acts as a highly permeable delivery vehicle and is subsequently hydrolyzed to the carboxylic acid active species by carboxylesterase enzymes. These molecules are greatly differentiated from the state-of-the-art and offer potential in the treatment of NLRP3-driven diseases, particularly where tissue penetration is required.

Product Details of 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Harrison, D; Boutard, N; Brzozka, K; Bugaj, M; Chmielewski, S; Cierpich, A; Doedens, JR; Fabritius, CHRY; Gabel, CA; Galezowski, M; Kowalczyk, P; Levenets, O; Mroczkowska, M; Palica, K; Porter, RA; Schultz, D; Sowinska, M; Topolnicki, G; Urbanski, P; Woyciechowski, J; Watt, AP or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Vanadium- and Chromium-Catalyzed Dehydrogenative Synthesis of Imines from Alcohols and Amines WOS:000651063700017 published article about ONE-POT SYNTHESIS; CONJUGATED DIENES; HYDROGENATION; COMPLEXES; ELIMINATION; ALKYLATION; PORPHYRIN; LIGAND; SITE in [Miao, Yulong; Samuelsen, Simone, V; Madsen, Robert] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark in 2021.0, Cited 48.0. Safety of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Vanadium(IV) tetraphenylporphyrin dichloride and chromium(III) tetraphenylporphyrin chloride have been developed as catalysts for the acceptorless dehydrogenation of alcohols. The catalysts have been applied to the direct synthesis of imines in overall good yields from a variety of alcohols and amines. The transformations are proposed to proceed by metal-ligand bifunctional pathways with an outer-sphere transfer of two hydrogen atoms from the alcohol to the metal porphyrin complexes. The results show that vanadium and chromium catalysts can also be employed for the dehydrogenation of alcohols with the release of hydrogen gas, and they may represent valuable alternatives to other catalysts based on Earth-abundant metals.

About Diphenylmethanamine, If you have any questions, you can contact Miao, YL; Samuelsen, SV; Madsen, R or concate me.. Safety of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2019.0 SYNLETT published article about FORMYLMETHYL-SUBSTITUTED ENAMIDES; HIGHLY EFFICIENT; BRONSTED ACID; DIASTEREOSELECTIVE SYNTHESIS; BETA-HYDROXY; CYCLOADDITION; BIOTRANSFORMATIONS; PIPERIDINES; CYCLIZATION; PYRIDINES in [Tong, Shuo; Wang, Mei-Xiang] Tsinghua Univ, Dept Chem, MOE Key Lab Bioorgan Phosphorous Chem & Chem Biol, Beijing 100084, Peoples R China in 2019.0, Cited 54.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. COA of Formula: C13H13N

A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a substrate engineering strategy to significantly improve the enantioselectivity of asymmetric catalysis

About Diphenylmethanamine, If you have any questions, you can contact Tong, S; Wang, MX or concate me.. COA of Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Deal;Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2 published in 2021.0. Quality Control of Diphenylmethanamine, Reprint Addresses Schirmeister, T (corresponding author), Johannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci, Staudingerweg 5, D-55128 Mainz, Germany.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Inhibition of coronavirus (CoV)-encoded papain-like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure-activity relationships (SAR) of the noncovalent active-site directed inhibitor (R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl) benzamide (2 b), which is known to bind into the S3 and S4 pockets of the SARS-CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PL(pro)inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS-CoV-2 replication in cell culture suggesting that, due to the high structural similarities of the target proteases, inhibitors identified against SARS-CoV PL(pro)are valuable starting points for the development of new pan-coronaviral inhibitors.

Quality Control of Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Welker, A; Kersten, C; Muller, C; Madhugiri, R; Zimmer, C; Muller, P; Zimmermann, R; Hammerschmidt, S; Maus, H; Ziebuhr, J; Sotriffer, C; Schirmeister, T or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2019.0 ASIAN J ORG CHEM published article about CATALYZED TRANSAMIDATION; EFFICIENT CATALYST; CARBOXYLIC-ACIDS; SECONDARY AMIDES; CARBOXAMIDES; AMINES; SOLVENT; UREAS; COMPLEX in [Yu, Subeen; Lee, Sunwoo] Chonnam Natl Univ, Dept Chem, Gwangju 61186, South Korea; [Song, Kwang Ho] Korea Univ, Dept Chem & Biol Engn, Seoul 02841, South Korea in 2019.0, Cited 66.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Recommanded Product: Diphenylmethanamine

A metal-free transamidation of primary amides was developed. Trimethylsilyl chloride (TMSCl) acted as the activator in transamidation. In the presence of TMSCl, primary amides reacted with primary amines to yield transamidated secondary amides in NMP solvent. The transamidation of benzamide with secondary amines for the formation of tertiary amides succeeds in an NMP/CHCl3 solvent mixture.

About Diphenylmethanamine, If you have any questions, you can contact Yu, S; Song, KH; Lee, S or concate me.. Recommanded Product: Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics