Category: 91-00-9

Recently I am researching about HUMAN BRAIN; ARECAIDINE; AGONIST; LOGP; OPPORTUNITIES; GUVACINE; SUBTYPES, Saw an article supported by the Medical University of Vienna; University of Vienna. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Ozenil, M; Pacher, K; Balber, T; Vraka, C; Roller, A; Holzer, W; Spreitzer, H; Mitterhauser, M; Wadsak, W; Hacker, M; Pichler, V. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Category: amides-buliding-blocks

Supported by their involvement in many neurodegenerative disorders, muscarinic acetylcholine receptors ( mAChRs) are an interesting target for PET imaging. Nevertheless, no radiotracer is established in clinical routine. Within this work we aim to develop novel PET tracers based on the structure of arecoline. Fifteen novel arecoline derivatives were synthesized, characterized and tested for their affinity to the mAChRs M1-M5 and the conceivable off-target acetylcholinesterase. Five arecoline derivatives and arecoline were labeled with carbon-11 in good yields. Arecaidine diphenylmethyl ester (3b), arecaidine bis(4-fluorophenyl)methyl ester (3c) and arecaidine (4-bromophenyl)(4-fluorophenyl)methyl ester (3e) showed a tremendous gain in mAChR affinity compared to arecoline and a pronounced subtype selectivity for M1. Metabolic stability and serum protein binding of [C-11] 3b and [C-11] 3c were in line with properties of established brain tracers. Nonspecific binding of [C-11]3c was prevalent in kinetic and endpoint experiment on living cells as well as in autoradiography on native mouse brain sections, which motivates us to decrease the lipophilicity of this substance class prior to in vivo experiments. (C) 2020 The Author(s). Published by Elsevier Masson SAS.

Category: amides-buliding-blocks. About Diphenylmethanamine, If you have any questions, you can contact Ozenil, M; Pacher, K; Balber, T; Vraka, C; Roller, A; Holzer, W; Spreitzer, H; Mitterhauser, M; Wadsak, W; Hacker, M; Pichler, V or concate me.

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An article Asymmetric Hydrogenation of Dibenzo[c,e]azepine Derivatives with Chiral Cationic Ruthenium Diamine Catalysts WOS:000476957200035 published article about HIGHLY ENANTIOSELECTIVE HYDROGENATION; REDUCTIVE AMINATION; CYCLIC AMINES; IMINES; BENZODIAZEPINONES; KETONES; ACCESS; ROUTE; SCOPE in [Chen, Fei; Fan, Qing-Hua] Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China; Univ Chinese Acad Sci, Beijing 100190, Peoples R China in 2019.0, Cited 59.0. COA of Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

An efficient Ru-catalyzed asymmetric hydrogenation of dibenzo[c,e]azepines is reported. A series of seven-membered cyclic amines were obtained with moderate to excellent enantioselectivity. The catalyst counteranion played an important role in achieving high-level chiral induction. Moreover, a one-pot synthesis of chiral 6,7-dihydro-5H-dibenz[c,e]azepines via two-step reductive amination was also developed.

COA of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Zhang, SS; Chen, F; He, YM; Fan, QH or concate me.

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An article Catalytic Enantioselective Synthesis of 4-Amino-1,2,3,4-tetrahydropyridine Derivatives from Intramolecular Nucleophilic Addition Reaction of Tertiary Enamides WOS:000459590400024 published article about FORMYLMETHYL-SUBSTITUTED ENAMIDES; HIGHLY EFFICIENT; BRONSTED ACID; DIASTEREOSELECTIVE SYNTHESIS; BETA-HYDROXY; CYCLOADDITION; BIOTRANSFORMATIONS; PIPERIDINES; CYCLIZATION; PYRIDINES in [Tong, Shuo; Wang, Mei-Xiang] Tsinghua Univ, Dept Chem, MOE Key Lab Bioorgan Phosphorous Chem & Chem Biol, Beijing 100084, Peoples R China in 2019.0, Cited 54.0. HPLC of Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a substrate engineering strategy to significantly improve the enantioselectivity of asymmetric catalysis

HPLC of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Tong, S; Wang, MX or concate me.

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Application In Synthesis of Diphenylmethanamine. Mercea, DM; Howlett, MG; Piascik, AD; Scott, DJ; Steven, A; Ashley, AE; Fuchter, MJ in [Mercea, Dan M.; Howlett, Michael G.; Piascik, Adam D.; Scott, Daniel J.; Ashley, Andrew E.; Fuchter, Matthew J.] Imperial Coll London, Mol Sci Res Hub, Dept Chem, White City Campus,Wood Lane, London W12 0BZ, England; [Steven, Alan] AstraZeneca PT&D, Charter Way, Macclesfield SK10 2NA, Cheshire, England published Enantioselective reduction of N-alkyl ketimines with frustrated Lewis pair catalysis using chiral borenium ions in 2019.0, Cited 54.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Enantioselective reduction of ketimines was demonstrated using chiral N-heterocyclic carbene (NHC)-stabilised borenium ions in frustrated Lewis pair catalysis. High levels of enantioselectivity were achieved for substrates featuring secondary N-alkyl substituents. Comparative reactivity and mechanistic studies identify key determinants required to achieve useful enantioselectivity and represent a step forward in the further development of enantioselective FLP methodologies.

About Diphenylmethanamine, If you have any questions, you can contact Mercea, DM; Howlett, MG; Piascik, AD; Scott, DJ; Steven, A; Ashley, AE; Fuchter, MJ or concate me.. Application In Synthesis of Diphenylmethanamine

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Li, J; Xing, JD; Shi, YB in [Li, J.; Xing, J. D.; Shi, Y. B.] Taiyuan Univ Technol, Sch Biomed Engn, Taiyuan 030000, Peoples R China published Selective Hydrogen Transfer in N-(Diphenylmethyl)-1-phenylethan-1-imine in 2021.0, Cited 25.0. HPLC of Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Proton transfer processes mediate many organic reactions. How to realize stereochemical control of this process has always been a challenging topic in the field of asymmetric catalysis. In this study, N-(diphenylmethyl)-1-phenylethan-1-imine (Schiff base derived from 2,2-diphenylethan-1-amine and acetophenone) was used as substrate, and different near neutral solvents and various chiral metal complex catalysts were used to carry out photoinduced C=N double bond transfer in the substrate under irradiation with a mercury ultraviolet lamp. The double bond transfer in the substrate molecule was highly selective. Solvents containing strong electronegative atoms like oxygen and chlorine, such as alcohols, aldehydes, and carbon tetrachloride, were more effective than other solvents under high light intensity. The 1,3-proton transfer process involves photoexcitation of the Schiff base and coordination of the latter to the central metal atom of the chiral catalyst, so that the substrate molecule is placed in a stable chiral environment to form a transition state. The strongly electronegative atom of the near-neutral solvent attracts the active a-hydrogen from the excited Schiff base molecule to form a negatively charged delocalized p-bond structure. The subsequent proton addition yields more stable molecular structure to complete the selective proton transfer process. Among the examined chiral catalysts, divalent tin porphyrin was the most effective, and the product yield and enantiomeric excess were 98% and 91.49%, respectively. The described photoinduced C=N double bond transfer in N-(diphenylmethyl)-1-phenylethan-1-imine is characterized by mild conditions (room temperature), high stereoselectivity, and simple operation.

About Diphenylmethanamine, If you have any questions, you can contact Li, J; Xing, JD; Shi, YB or concate me.. HPLC of Formula: C13H13N

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Chen, X; Yang, X; Mao, F; Wei, JL; Xu, YX; Li, BL; Zhu, J; Ni, SS; Jia, LJ; Li, J in [Chen, Xin; Mao, Fei; Wei, Jinlian; Xu, Yixiang; Li, Baoli; Zhu, Jin; Li, Jian] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, 130 Mei Long Rd, Shanghai 200237, Peoples R China; [Yang, Xi; Ni, Shuaishuai; Jia, Lijun] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Canc Inst, Shanghai 200032, Peoples R China; [Li, Jian] Dali Univ, Coll Pharm & Chem, 5 Xue Ren Rd, Dali 671000, Yunnan, Peoples R China; [Li, Jian] East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, 130 Mei Long Rd, Shanghai 200237, Peoples R China published Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth in vitro and in vivo in 2021.0, Cited 41.0. Computed Properties of C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Ubiquitin-like protein neddylation is overactivated in various human cancers and correlates with disease progression, and targeting this pathway represents a valuable therapeutic strategy. Our previous work disclosed an antihypertensive agent, candesartan cilexetic (CDC), serves as a novel neddylation inhibitor for suppressing tumor growth by targeting Nedd8-activating enzyme (NAE). In this study, 42 benzimidazole derivatives were designed and synthesized based on lead compound CDC to improve the neddylation inhibition and anticancer efficacy. Optimal benzimidazole-derived 35 displayed superior neddylation inhibition in enzyme assay compared to CDC (IC50 = 5.51 mu M vs 16.43 mu M), along with promising target inhibitory activity and killing selectivity in cancer cell. The results of cellular mechanism research combined with tumor growth suppression in human lung cancer cell A549 in vivo, accompanied with docking model, revealed that 35 has the potential to be developed as a promising neddylation inhibitor for anticancer therapy. (C) 2020 Elsevier Masson SAS. All rights reserved.

Computed Properties of C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Chen, X; Yang, X; Mao, F; Wei, JL; Xu, YX; Li, BL; Zhu, J; Ni, SS; Jia, LJ; Li, J or concate me.

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COA of Formula: C13H13N. Authors Chang, YJ; Cao, M; Chan, JZ; Zhao, CY; Wang, YK; Yang, R; Wasa, M in AMER CHEMICAL SOC published article about in [Chang, Yejin; Cao, Min; Chan, Jessica Z.; Zhao, Cunyuan; Wang, Yuankai; Yang, Rose; Wasa, Masayuki] Boston Coll, Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02467 USA in 2021.0, Cited 123.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

We disclose a catalytic method for beta-C(sp(3))-H functionalization of N-alkylamines for the synthesis of enantiomerically enriched beta-substituted amines, entities prevalent in pharmaceutical compounds and used to generate different families of chiral catalysts. We demonstrate that a catalyst system comprising of seemingly competitive Lewis acids, B(C6F5)(3), and a chiral Mg- or Sc-based complex, promotes the highly enantioselective union of N-alkylamines and alpha,beta-unsaturated compounds. An array of delta-amino carbonyl compounds was synthesized under redox-neutral conditions by enantioselective reaction of a N-alkylamine-derived enamine and an electrophile activated by the chiral Lewis acid co-catalyst. The utility of the approach is highlighted by late-stage beta-C-H functionalization of bioactive amines. Investigations in regard to the mechanistic nuances of the catalytic processes are described.

COA of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Chang, YJ; Cao, M; Chan, JZ; Zhao, CY; Wang, YK; Yang, R; Wasa, M or concate me.

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Wu, ZK; Zhai, YY; Zhao, WS; Wei, ZY; Yu, H; Han, S; Wei, YG in [Wu, Zhikang; Zhai, Yongyan; Wei, Zheyu; Yu, Han; Han, Sheng] Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China; [Zhao, Wenshu] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai, Peoples R China; [Yu, Han; Wei, Yongge] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China; [Wei, Yongge] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China published An efficient way for the N-formylation of amines by inorganic-ligand supported iron catalysis in 2020, Cited 62. Category: amides-buliding-blocks. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

The first example of an inorganic-ligand supported iron(iii) catalysed coupling of formic acid and amines to form formamides is reported. The pure inorganic catalyst (NH4)(3)[FeMo6O18(OH)(6)] (1), which consists of a central Fe-III single-atomic core supported within a cycle-shaped inorganic ligand consisting of six (MoO6)-O-VI octahedra, shows excellent activity and selectivity, and avoids the use of complicated/commercially unavailable organic ligands. Various primary amines and secondary amines have been successfully transformed into the corresponding formamides under mild conditions, and the formylation of primary diamines has also been achieved for the first time. The Fe catalyst 1 can be reused several times without appreciable loss of activity.

Category: amides-buliding-blocks. About Diphenylmethanamine, If you have any questions, you can contact Wu, ZK; Zhai, YY; Zhao, WS; Wei, ZY; Yu, H; Han, S; Wei, YG or concate me.

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Product Details of 91-00-9. Ghosh, S; Purkait, A; Jana, CK in [Ghosh, Santanu; Purkait, Anisha; Jana, Chandan K.] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India published Environmentally benign decarboxylative N-, O-, and S-acetylations and acylations in 2020.0, Cited 76.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

An operationally simple and general method for acetylation and acylation of a wide variety of substrates (amines, alcohols, phenols, thiols, and hydrazones) has been reported. Meldrum’s acid and its derivatives have been used as an air-stable, non-volatile, cost-effective, and easy to handle acetylating/acylating agent. Easily separable byproducts (CO2 and acetone) allowed the isolation of analytically pure acetylated products without the requirement of work-up and any chromatography.

Product Details of 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Ghosh, S; Purkait, A; Jana, CK or concate me.

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I found the field of Chemistry very interesting. Saw the article Selective Synthesis of Secondary Amines from Nitriles by a User-Friendly Cobalt Catalyst published in 2019.0. Safety of Diphenylmethanamine, Reprint Addresses Punji, B (corresponding author), NCL, CSIR, Div Chem Engn, Organometall Synth & Catalysis Grp, Pune 411008, Maharashtra, India.; Punji, B (corresponding author), NCL, CSIR, Acad Sci & Innovat Res AcSIR, Pune 411008, Maharashtra, India.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Selective hydrogenation/reductive amination of nitriles to secondary amines catalyzed by an inexpensive and user-friendly cobalt complex, (Xantphos)CoCl2, is reported. The use of (Xantphos)CoCl2 and ammonia borane (NH3-BH3) combination affords the selective reduction of nitriles to symmetrical secondary amines, whereas the employment of (Xantphos)CoCl2 and dimethylamine borane (Me2NH-BH3) along with external amines produce unsymmetrical secondary amines and tertiary amines. The general applicability of this methodology is demonstrated by the synthesis of 43 symmetrical and unsymmetrical secondary and tertiary amines bearing diverse functionalities.

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