Category: 91-00-9

An article Synthesis of deuterium-labeled DL-threo-thiamphenicol WOS:000528146700001 published article about STEREOSELECTIVE-SYNTHESIS; (-)-CHLORAMPHENICOL in [Zhang, Meihui; Zhang, Lizhi; Xu, Liying; Dong, Jinhua] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, 85 Hongliu Rd, Benxi 117004, Liaoning, Peoples R China; [Wang, Wei; Yan, Tingchang] Shandong Huijing Biopharmaceut Technol Co Ltd, Zibo 255000, Shandong, Peoples R China in 2020.0, Cited 12.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Computed Properties of C13H13N

A convenient and inexpensive approach for the synthesis of deuterium-labeled thiamphenicol was described. DL-threo-Thiamphenicol-methyl-d(3) was prepared with high chemical purity and isotopic enrichment via a six-step process starting from 4-bromobenzaldehyde and DMSO-d(6) by employing microwave-assisted copper-mediated methylthiolation and modified Wulff’s asymmetric aziridination.

Computed Properties of C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Zhang, MH; Zhang, LZ; Wang, W; Yan, TC; Xu, LY; Dong, JH or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Highly enantioselective carbene insertion into N-H bonds of aliphatic amines WOS:000498849000040 published article about THERMOCHEMICAL KINETICS; EQUILIBRIUM ACIDITIES; DENSITY FUNCTIONALS; CONJUGATE ADDITION; MICHAEL ADDITION; DIAZO-COMPOUNDS; BASIS-SETS; CATALYSIS; CARBON; ORGANOCATALYSTS in [Zhu, Shou-Fei; Zhou, Qi-Lin] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China; Nankai Univ, Coll Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China in 2019, Cited 67. Application In Synthesis of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Aliphatic amines strongly coordinate, and therefore easily inhibit, the activity of transition-metal catalysts, posing a marked challenge to nitrogen-hydrogen (N-H) insertion reactions. Here, we report highly enantioselective carbene insertion into N-H bonds of aliphatic amines using two catalysts in tandem: an achiral copper complex and chiral amino-thiourea. Coordination by a homoscorpionate ligand protects the copper center that activates the carbene precursor. The chiral amino-thiourea catalyst then promotes enantioselective proton transfer to generate the stereocenter of the insertion product. This reaction couples a wide variety of diazo esters and amines to produce chiral alpha-alkyl alpha-amino acid derivatives.

About Diphenylmethanamine, If you have any questions, you can contact Li, ML; Yu, JH; Li, YH; Zhu, SF; Zhou, QL or concate me.. Application In Synthesis of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification published in 2020.0. HPLC of Formula: C13H13N, Reprint Addresses Cink, RD (corresponding author), AbbVie Inc, Proc Res & Dev, N Chicago, IL 60064 USA.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Glecaprevir was identified as a potent hepatitis C virus (HCV) protease inhibitor, and a large-scale synthesis was required to support the late-stage clinical trials and subsequent commercial launch. The large-scale synthetic route to glecaprevir required the development of completely new synthetic approaches to the two key structural features: the 18-membered macrocycle 3 and the difluoromethyl-substituted cyclopropyl amino acid 4. In this first manuscript, we describe the route development for the macrocycle 3; the second manuscript will describe the development of a new synthetic route to the difluoromethyl-substituted cyclopropyl amino acid 4 and the final assembly of glecaprevir. The large-scale synthetic route to the macrocycle employed a unique intramolecular etherification reaction as the key step in the macrocycle synthesis, avoiding the scalability limitations of the ring-closing metathesis (RCM) reaction of the enabling route. The large-scale synthetic route to the macrocycle was successfully used to produce the amount of glecaprevir required to support the late-stage clinical development.

About Diphenylmethanamine, If you have any questions, you can contact Kallemeyn, JM; Engstrom, KM; Pelc, MJ; Lukin, KA; Morrill, WH; Wei, HJ; Towne, TB; Henle, J; Nere, NK; Welch, DS; Shekhar, S; Ravn, MM; Zhao, G; Fickes, MG; Ding, C; Vinci, JC; Marren, J; Cink, RD or concate me.. HPLC of Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2021.0 DALTON T published article about HOMOGENEOUS CATALYSIS; AEROBIC OXIDATION; CONVENIENT METHOD; FORMIC-ACID; HYDROGENATION; MILD; REAGENTS; OXYGEN; CO2 in [Dan, Demin; Yu, Han; Han, Sheng] Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China; [Chen, Fubo] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Stomatol, Shanghai 200072, Peoples R China; [Zhao, Whenshu] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200000, Peoples R China; [Yu, Han; Wei, Yongge] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100081, Peoples R China; [Wei, Yongge] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China in 2021.0, Cited 52.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Recommanded Product: 91-00-9

A simple and efficient protocol for the formylation of amines with formic acid, catalyzed by a polyoxometalate-based chromium catalyst, is described. Notably, this method shows excellent activity and chemo-selectivity for the formylation of primary amines; diamines have also been successfully employed. Importantly, the chromium catalyst is potentially non-toxic, environmentally benign and safer than the widely used high valence chromium catalysts such as CrO3 and K2Cr2O7. The catalyst can be recycled several times with a negligible impact on activity. Finally, a plausible mechanism is provided based on the observation of intermediate and control experiments.

About Diphenylmethanamine, If you have any questions, you can contact Dan, DM; Chen, FB; Zhao, WS; Yu, H; Han, S; Wei, YG or concate me.. Recommanded Product: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Enhanced arecoline derivatives as muscarinic acetylcholine receptor M1 ligands for potential application as PET radiotracers WOS:000573916100028 published article about HUMAN BRAIN; ARECAIDINE; AGONIST; LOGP; OPPORTUNITIES; GUVACINE; SUBTYPES in [Ozenil, Marius; Pacher, Katharina; Balber, Theresa; Vraka, Chrysoula; Mitterhauser, Markus; Wadsak, Wolfgang; Hacker, Marcus; Pichler, Verena] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, Div Nucl Med, Vienna, Austria; [Balber, Theresa; Mitterhauser, Markus] Ludwig Boltzmann Inst Appl Diagnost, Vienna, Austria; [Roller, Alexander] Univ Vienna, Fac Chem, Xray Struct Anal Ctr, Vienna, Austria; [Holzer, Wolfgang; Spreitzer, Helmut] Univ Vienna, Fac Life Sci, Dept Pharmaceut Chem, Vienna, Austria; [Wadsak, Wolfgang] CBmed GmbH, Ctr Biomarker Res Med, Graz, Austria in 2020.0, Cited 50.0. Product Details of 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Supported by their involvement in many neurodegenerative disorders, muscarinic acetylcholine receptors ( mAChRs) are an interesting target for PET imaging. Nevertheless, no radiotracer is established in clinical routine. Within this work we aim to develop novel PET tracers based on the structure of arecoline. Fifteen novel arecoline derivatives were synthesized, characterized and tested for their affinity to the mAChRs M1-M5 and the conceivable off-target acetylcholinesterase. Five arecoline derivatives and arecoline were labeled with carbon-11 in good yields. Arecaidine diphenylmethyl ester (3b), arecaidine bis(4-fluorophenyl)methyl ester (3c) and arecaidine (4-bromophenyl)(4-fluorophenyl)methyl ester (3e) showed a tremendous gain in mAChR affinity compared to arecoline and a pronounced subtype selectivity for M1. Metabolic stability and serum protein binding of [C-11] 3b and [C-11] 3c were in line with properties of established brain tracers. Nonspecific binding of [C-11]3c was prevalent in kinetic and endpoint experiment on living cells as well as in autoradiography on native mouse brain sections, which motivates us to decrease the lipophilicity of this substance class prior to in vivo experiments. (C) 2020 The Author(s). Published by Elsevier Masson SAS.

Product Details of 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Ozenil, M; Pacher, K; Balber, T; Vraka, C; Roller, A; Holzer, W; Spreitzer, H; Mitterhauser, M; Wadsak, W; Hacker, M; Pichler, V or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Pro-Phe Derivatives as Organocatalysts in Asymmetric Aldol Reaction published in 2021. Product Details of 91-00-9, Reprint Addresses Yolacan, C (corresponding author), Yildiz Tech Univ, Dept Chem, Davutpasa Campus, TR-34010 Istanbul, Turkey.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

The aldol reaction which is the most important one among the C-C bond forming reactions, is widely used by synthetic organic chemists to obtain beta-hydroxycarbonyl compounds which are important starting components for biologically active compounds in optically pure form. In this research, five Pro-Phe derivatives were synthesized by simple amidation reactions and characterized by their spectral data. Their catalytic activities in asymmetric aldol reaction were investigated. The catalytic activity studies were performed with aliphatic ketones and various aromatic aldehydes. Especially, (S)methyl 3-mercapto-2-(S)-3-phenyl-2-((S)-pyrrolidine-2-carboxamido)propanamido)propanoate showed good catalytic activities in water at 0 degrees C in the presence of p-nitrobenzoic acid cocatalyst. The enantioselectivities were up to 90.4%, the diastereomeric ratios were up to 97/3 and yields were 99%. The results showed that these organocatalysts were promising organocatalysts for aldol reaction. Besides, this catalyst showed its best catalytic activities in water which is also an important contribution to green chemistry requirements.

About Diphenylmethanamine, If you have any questions, you can contact Karaoglu, M; Aydogan, F; Yolacan, C or concate me.. SDS of cas: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Li, BW; Aliyu, M; Gao, ZH; Li, TJ; Dong, W; Li, JC; Shi, EX; Tang, WJ in [Gao, Zhenhua; Li, Junchen; Shi, Enxue] State Key Lab NBC Protect Civilian, Beijing 102205, Peoples R China; [Li, Bowen; Aliyu, Muinat; Li, Tiejun; Dong, Wei; Tang, Wenjun] Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China; [Li, Bowen; Tang, Wenjun] Univ Chinese Acad Sci, Sch Chem & Mat Sci, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China published General Synthesis of Chiral alpha,alpha-Diaryl Carboxamides by Enantioselective Palladium-Catalyzed Cross-Coupling in 2020.0, Cited 34.0. Product Details of 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A general synthesis of chiral alpha,alpha-diaryl carboxamides is developed by enantioselective cross-coupling between 2-bromo-2-aryl carboxamides and arylboronic acids, leading to a series of chiral alpha,alpha-diaryl carboxamides with various electronic properties and functionalities in moderate to excellent enantioselectivities and yields. The employment of a sterically bulky chiral P,P=O ligand L2 is critical for the reactivity and selectivity. This protocol is applied to an efficient asymmetric synthesis of a key intermediate of dopamine receptor agonist SKF 38393.

Product Details of 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Li, BW; Aliyu, M; Gao, ZH; Li, TJ; Dong, W; Li, JC; Shi, EX; Tang, WJ or concate me.

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about MOLECULAR-ORBITAL METHODS; FORCE-FIELD PARAMETERS; ASYMMETRIC-SYNTHESIS; KINETIC RESOLUTION; ENANTIOSELECTIVE ALLYLATION; CYCLOBUTANE BACKBONE; MODULAR LIGANDS; BASIS-SETS; AB-INITIO; ALKYLATION, Saw an article supported by the Spanish Ministry of Economy and Competitiveness [CTQ2016-74878-P]; European Regional Development Fund (AEI/FEDER, UE); Catalan Government [2017SGR1472]; ICREA Foundation (ICREA Academia award). Recommanded Product: Diphenylmethanamine. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Biosca, M; Salto, J; Magre, M; Norrby, PO; Pamies, O; Dieguez, M. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

A method for generation of Pd/phosphite-oxazoline catalysts containing an alkyl backbone chain has been successfully applied to Pd-catalyzed allylic substitution reactions. By carefully selecting the substituents at both the alkyl backbone chain and the oxazoline of the ligand, as well as the configuration of the biaryl phosphite group, high activities (TOF > 8000 mol substrate X (mol Pd X h)(-1)) and excellent enantioselectivities (ee’s up to 99%) have been achieved for many hindered and unhindered substrates with a wide range of C-, O-, and N-nucleophiles (73 substitution products in total). Moreover, DFT and NMR studies of the key Pd-allyl complexes allowed us to better understand the origin of the excellent enantioselectivities observed experimentally. The useful application of the Pd/phosphite-oxazoline catalysts was demonstrated by the syntheses of many chiral carbobicycles, with multiples stereocenters, by simple sequential reactions involving Pd-allylic substitution and either 1,6-enyne cyclization or Pauson-Khand enyne cyclization.

Recommanded Product: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Biosca, M; Salto, J; Magre, M; Norrby, PO; Pamies, O; Dieguez, M or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Product Details of 91-00-9. In 2019.0 ACS MED CHEM LETT published article about NEUTROPHIL EXTRACELLULAR TRAPS; PROGRAMMED CELL-DEATH in [Dodo, Kosuke; Shimizu, Tadashi; Nakao, Shuhei; Terayama, Naoki; Sodeoka, Mikiko] RIKEN Cluster Pioneering Res, Synthet Organ Chem Lab, 2-1 Hirosawa, Wako, Saitama 3510198, Japan; [Dodo, Kosuke; Sodeoka, Mikiko] JST, ERATO, Sodeoka Live Cell Chem Project, 2-1 Hirosawa, Wako, Saitama 3510198, Japan; [Dodo, Kosuke; Shimizu, Tadashi; Takahashi, Masahiro; Sodeoka, Mikiko] Tohoku Univ, IMRAM, Aoba Ku, 2-1-1 Katahira, Sendai, Miyagi 9808577, Japan; [Kuboki, Erika; Magarisawa, Megumi; Tokuhiro, Takuto; Yotsumoto, Satoshi; Asano, Kenichi; Tanaka, Masato] Tokyo Univ Pharm & Life Sci, Sch Life Sci, Lab Immune Regulat, HAC, 1432-1 Horinouchi, Tokyo 1920392, Japan; [Imamura, Ryu; Suda, Takashi] Kanazawa Univ, Canc Res Inst, Div Immunol & Mol Biol, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan; [Shimizu, Tadashi] Hyogo Univ Hlth Sci, Adv Med Res Ctr, 1-3-6 Minatojima, Kobe, Hyogo 6508530, Japan in 2019.0, Cited 31.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

The indolylmaleimide (IM) derivative IM-17 shows inhibitory activity against oxidative-stress-induced necrotic cell death and cardioprotective activity in rat ischemia-reperfusion injury models. In order to develop a more potent derivative, we conducted a detailed structure-activity relationship study of IM derivatives and identified IM 93 as the most potent derivative with good water solubility. IM-93 inhibited ferroptosis and NETosis, but not necroptosis or pyroptosis. In contrast, ferrostatin-1 (Fer-1), a ferroptosis inhibitor, did not inhibit NETosis, although the accompanying lipid peroxidation was partially inhibited by Fer-1, as well as by IM-93. Thus, IM derivatives have a unique activity profile and appear to be promising candidates for in vivo application.

Product Details of 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Dodo, K; Kuboki, E; Shimizu, T; Imamura, R; Magarisawa, M; Takahashi, M; Tokuhiro, T; Yotsumoto, S; Asano, K; Nakao, S; Terayama, N; Suda, T; Tanaka, M; Sodeoka, M or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2020.0 POLYMER published article about SOLID-STATE SYNTHESIS; TEMPERATURE SENSOR; CATALYZED POLYCONDENSATION; CONJUGATED POLYMER; POLY(3,4-ETHYLENEDIOXYTHIOPHENE); POLY(IMINOARYLENE)S; POLYTHIOPHENE; CELLS in [Peng, Kai; Luo, Qi; Zhang, Yichi; Xia, Jiangbin] Wuhan Univ, Coll Chem & Mol Sci, Hubei Key Lab Organ & Polymer Optoelect Mat, Wuhan 430072, Peoples R China; [Xia, Jiangbin] Wuhan Univ, Coll Chem & Mol Sci, Minist Educ, Engn Res Ctr Organosilicon Cpds & Mat, Wuhan 430072, Peoples R China in 2020.0, Cited 42.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Category: amides-buliding-blocks

C-Br/N-H bulk polycondensation is firstly proposed and corresponding poly(3,4-dinitm-thiophen-2-yl aryl-amine)s derivatives have been successfully obtained with quantitative yield. Typical crystal analysis reveals that its effective reaction points distance (RPD, distance between Br and H atom) is 5.083 angstrom, which is 66.7% longer than the sum of van der Waals radius (r(w)) of bromine and hydrogen atoms (3.05 angstrom). Carbazole-based monomer was explored as a thermalsensor with excellent relative sensitivity (S-a) of 0.45% K-1.

Category: amides-buliding-blocks. About Diphenylmethanamine, If you have any questions, you can contact Peng, K; Luo, Q; Zhang, YC; Xia, JB or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics