Category: 91-00-9

An article Modular click chemistry libraries for functional screens using a diazotizing reagent WOS:000488832500035 published article about DIAZO TRANSFER; IMIDAZOLE-1-SULFONYL AZIDE; DIAZOTRANSFER; CYCLOADDITION; ALKYNES; AMINES; SUFEX; SAFE in [Meng, Genyi; Guo, Taijie; Ma, Tiancheng; Zhang, Jiong; Shen, Yucheng; Sharpless, Karl Barry; Dong, Jiajia] Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem,Chinese Acad Sci, Shanghai, Peoples R China in 2019, Cited 33. Product Details of 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Click chemistry is a concept in which modular synthesis is used to rapidly find new molecules with desirable properties(1). Copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) triazole annulation and sulfur(VI) fluoride exchange (SuFEx) catalysis are widely regarded as click reactions(2-4), providing rapid access to their products in yields approaching 100% while being largely orthogonal to other reactions. However, in the case of CuAAC reactions, the availability of azide reagents is limited owing to their potential toxicity and the risk of explosion involved in their preparation. Here we report another reaction to add to the click reaction family: the formation of azides from primary amines, one of the most abundant functional groups(5). The reaction uses just one equivalent of a simple diazotizing species, fluorosulfuryl azide(6-11) (FSO2N3), and enables the preparation of over 1,200 azides on 96-well plates in a safe and practical manner. This reliable transformation is a powerful tool for the CuAAC triazole annulation, the most widely used click reaction at present. This method greatly expands the number of accessible azides and 1,2,3-triazoles and, given the ubiquity of the CuAAC reaction, it should find application in organic synthesis, medicinal chemistry, chemical biology and materials science.

About Diphenylmethanamine, If you have any questions, you can contact Meng, GY; Guo, TJ; Ma, TC; Zhang, J; Shen, YC; Sharpless, KB; Dong, JJ or concate me.. Product Details of 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Mercea, DM; Howlett, MG; Piascik, AD; Scott, DJ; Steven, A; Ashley, AE; Fuchter, MJ in [Mercea, Dan M.; Howlett, Michael G.; Piascik, Adam D.; Scott, Daniel J.; Ashley, Andrew E.; Fuchter, Matthew J.] Imperial Coll London, Mol Sci Res Hub, Dept Chem, White City Campus,Wood Lane, London W12 0BZ, England; [Steven, Alan] AstraZeneca PT&D, Charter Way, Macclesfield SK10 2NA, Cheshire, England published Enantioselective reduction of N-alkyl ketimines with frustrated Lewis pair catalysis using chiral borenium ions in 2019.0, Cited 54.0. HPLC of Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Enantioselective reduction of ketimines was demonstrated using chiral N-heterocyclic carbene (NHC)-stabilised borenium ions in frustrated Lewis pair catalysis. High levels of enantioselectivity were achieved for substrates featuring secondary N-alkyl substituents. Comparative reactivity and mechanistic studies identify key determinants required to achieve useful enantioselectivity and represent a step forward in the further development of enantioselective FLP methodologies.

HPLC of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Mercea, DM; Howlett, MG; Piascik, AD; Scott, DJ; Steven, A; Ashley, AE; Fuchter, MJ or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Synthesis of deuterium-labeled DL-threo-thiamphenicol WOS:000528146700001 published article about STEREOSELECTIVE-SYNTHESIS; (-)-CHLORAMPHENICOL in [Zhang, Meihui; Zhang, Lizhi; Xu, Liying; Dong, Jinhua] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, 85 Hongliu Rd, Benxi 117004, Liaoning, Peoples R China; [Wang, Wei; Yan, Tingchang] Shandong Huijing Biopharmaceut Technol Co Ltd, Zibo 255000, Shandong, Peoples R China in 2020.0, Cited 12.0. SDS of cas: 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A convenient and inexpensive approach for the synthesis of deuterium-labeled thiamphenicol was described. DL-threo-Thiamphenicol-methyl-d(3) was prepared with high chemical purity and isotopic enrichment via a six-step process starting from 4-bromobenzaldehyde and DMSO-d(6) by employing microwave-assisted copper-mediated methylthiolation and modified Wulff’s asymmetric aziridination.

SDS of cas: 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Zhang, MH; Zhang, LZ; Wang, W; Yan, TC; Xu, LY; Dong, JH or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Chithanna, S; Vyasamudri, S; Yang, DY in AMER CHEMICAL SOC published article about SOLID-PHASE SYNTHESIS; DDE; STRATEGY; ACIDS; FMOC; BOC in [Chithanna, Sivanna; Vyasamudri, Sameer; Yang, Ding-Yah] Tunghai Univ, Dept Chem, Taichung 40704, Taiwan in 2020.0, Cited 42.0. Quality Control of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A simple protocol for the protection of amines was realized through a base-catalyzed one-pot reaction of dimedone, beta-nitroalkene, and amine. Employing this strategy, a variety of amines/amino acids were protected in excellent yields. These acid/base stable protected amines can be deprotected by either ethylene diamine or hydrazine hydrate under mild conditions. The practical application of this orthogonal protecting group was demonstrated by the synthesis of cyclic peptide melanotan II via SPPS.

Quality Control of Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Chithanna, S; Vyasamudri, S; Yang, DY or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recommanded Product: Diphenylmethanamine. In 2021.0 CHEMMEDCHEM published article about CORONAVIRUS PAPAIN-LIKE; RESPIRATORY SYNDROME CORONAVIRUS; PNEUMONIA in [Welker, Armin; Sotriffer, Christoph] Justus Maximilians Univ Wurzburg, Inst Pharm & Food Chem, D-97074 Wurzburg, Germany; [Kersten, Christian; Zimmer, Collin; Mueller, Patrick; Zimmermann, Robert; Hammerschmidt, Stefan; Maus, Hannah; Schirmeister, Tanja] Johannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci, Staudingerweg 5, D-55128 Mainz, Germany; [Mueller, Christin; Madhugiri, Ramakanth; Ziebuhr, John] Justus Liebig Univ Giessen, Inst Med Virol, Schubertstr 81, D-35392 Giessen, Germany in 2021.0, Cited 29.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Inhibition of coronavirus (CoV)-encoded papain-like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure-activity relationships (SAR) of the noncovalent active-site directed inhibitor (R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl) benzamide (2 b), which is known to bind into the S3 and S4 pockets of the SARS-CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PL(pro)inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS-CoV-2 replication in cell culture suggesting that, due to the high structural similarities of the target proteases, inhibitors identified against SARS-CoV PL(pro)are valuable starting points for the development of new pan-coronaviral inhibitors.

Recommanded Product: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Welker, A; Kersten, C; Muller, C; Madhugiri, R; Zimmer, C; Muller, P; Zimmermann, R; Hammerschmidt, S; Maus, H; Ziebuhr, J; Sotriffer, C; Schirmeister, T or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Uniform Cu/chitosan beads as a green and reusable catalyst for facile synthesis of imines via oxidative coupling reaction WOS:000540547000064 published article about HETEROGENEOUS CATALYST; METAL-FREE; FUNCTIONALIZED-CHITOSAN; EFFICIENT CATALYST; AEROBIC OXIDATION; COPPER CATALYST; PRIMARY AMINES; BENZYLAMINES; COMPLEXES; AMBIENT in [Chutimasakul, Threeraphat; Nakhonpanom, Pakamon Na; Tirdtrakool, Warinda; Intanin, Apichai; Bunchuay, Thanthapatra; Chantiwas, Rattikan; Tantirungrotechai, Jonggol] Mahidol Univ, Fac Sci, Ctr Excellence Innovat Chem, Dept Chem, Bangkok 10400, Thailand in 2020.0, Cited 52.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Computed Properties of C13H13N

A nonprecious metal and biopolymer-based catalyst, Cu/chitosan beads, has been successfully prepared by using a software-controlled flow system. Uniform, spherical Cu/chitosan beads can be obtained with diameters in millimeter-scale and narrow size distribution (0.78 +/- 0.04 mm). The size and morphology of the Cu/chitosan beads are reproducible due to high precision of the flow rate. In addition, the application of the Cu/chitosan beads as a green and reusable catalyst has been demonstrated using a convenient and efficient protocol for the direct synthesis of imines via the oxidative self- and cross-coupling of amines (24 examples) with moderate to excellent yields. Importantly, the beads are stable and could be reused more than ten times without loss of the catalytic performance. Furthermore, because of the bead morphology, the Cu/chitosan catalyst has greatly simplified recycling and workup procedures.

About Diphenylmethanamine, If you have any questions, you can contact Chutimasakul, T; Nakhonpanom, PN; Tirdtrakool, W; Intanin, A; Bunchuay, T; Chantiwas, R; Tantirungrotechai, J or concate me.. Computed Properties of C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Tong, S; Wang, MX in [Tong, Shuo; Wang, Mei-Xiang] Tsinghua Univ, Dept Chem, MOE Key Lab Bioorgan Phosphorous Chem & Chem Biol, Beijing 100084, Peoples R China published Catalytic Enantioselective Synthesis of 4-Amino-1,2,3,4-tetrahydropyridine Derivatives from Intramolecular Nucleophilic Addition Reaction of Tertiary Enamides in 2019.0, Cited 54.0. Category: amides-buliding-blocks. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a substrate engineering strategy to significantly improve the enantioselectivity of asymmetric catalysis

Category: amides-buliding-blocks. About Diphenylmethanamine, If you have any questions, you can contact Tong, S; Wang, MX or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification published in 2020.0. HPLC of Formula: C13H13N, Reprint Addresses Cink, RD (corresponding author), AbbVie Inc, Proc Res & Dev, N Chicago, IL 60064 USA.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Glecaprevir was identified as a potent hepatitis C virus (HCV) protease inhibitor, and a large-scale synthesis was required to support the late-stage clinical trials and subsequent commercial launch. The large-scale synthetic route to glecaprevir required the development of completely new synthetic approaches to the two key structural features: the 18-membered macrocycle 3 and the difluoromethyl-substituted cyclopropyl amino acid 4. In this first manuscript, we describe the route development for the macrocycle 3; the second manuscript will describe the development of a new synthetic route to the difluoromethyl-substituted cyclopropyl amino acid 4 and the final assembly of glecaprevir. The large-scale synthetic route to the macrocycle employed a unique intramolecular etherification reaction as the key step in the macrocycle synthesis, avoiding the scalability limitations of the ring-closing metathesis (RCM) reaction of the enabling route. The large-scale synthetic route to the macrocycle was successfully used to produce the amount of glecaprevir required to support the late-stage clinical development.

About Diphenylmethanamine, If you have any questions, you can contact Kallemeyn, JM; Engstrom, KM; Pelc, MJ; Lukin, KA; Morrill, WH; Wei, HJ; Towne, TB; Henle, J; Nere, NK; Welch, DS; Shekhar, S; Ravn, MM; Zhao, G; Fickes, MG; Ding, C; Vinci, JC; Marren, J; Cink, RD or concate me.. HPLC of Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Switchable synthesis of cyclic carbamates by carbon dioxide fixation at atmospheric pressure published in 2021.0. Formula: C13H13N, Reprint Addresses Toda, Y; Suga, H (corresponding author), Shinshu Univ, Fac Engn, Dept Mat Chem, 4-17-1 Wakasato, Nagano 3808553, Japan.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

The base-promoted switchable synthesis of five- and six-membered cyclic carbamates using atmospheric pressure carbon dioxide as the C1 source was developed. The chemoselectivity of products was simply controlled by changing bases and solvents. The reaction proceeds effectively under mild conditions, affording valuable cyclic carbamates. Experimental results and DFT studies revealed the reaction mechanism.

Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Toda, Y; Shishido, M; Aoki, T; Sukegawa, K; Suga, H or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Computed Properties of C13H13N. In 2020 J ORG CHEM published article about N-ACYLIMINIUM IONS; OXIDATIVE DECARBOXYLATION; RADICAL CHEMISTRY; ARYL; DERIVATIVES; ALDEHYDES; ALCOHOLS; KETONES; MILD; HYDROGENATION in [Khan, Shah Nawaz; Zaman, Muhammad Kashif; Li, Ruining; Sun, Zhankui] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China; [Sun, Zhankui] Chinese Acad Sci, Huzhou Res & Industrializat Ctr Technol, Huzhou 313000, Peoples R China in 2020, Cited 49. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A general and practical method for decarboxylative hydroxylation of carboxylic acids was developed through visible light-induced photocatalysis using molecular oxygen as the green oxidant. The addition of NaBH4 to in situ reduce the unstable peroxyl radical intermediate much broadened the substrate scope. Different sp a carbon-bearing carboxylic acids were successfully employed as substrates, including phenylacetic acid-type substrates, as well as aliphatic carboxylic acids. This transformation worked smoothly on primary, secondary, and tertiary carboxylic acids.

Computed Properties of C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Khan, SN; Zaman, MK; Li, RN; Sun, ZK or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics