Category: 91-00-9

An article A Novel Prodrug of a nNOS Inhibitor with Improved Pharmacokinetic Potential WOS:000579806900001 published article about NITRIC-OXIDE SYNTHASE; SELECTIVE-INHIBITION; DERIVATIVES; AGENT; IDENTIFICATION; ACETAMIDINES; AMIDOXIME; COMPONENT; THERAPY; AMIDINE in [Maccallini, Cristina; Marinelli, Lisa; Cacciatore, Ivana; Fantacuzzi, Marialuigia; Di Stefano, Antonio; Amoroso, Rosa] Univ G dAnnunzio, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy; [Indorf, Patrick; Clement, Bernd] Univ Kiel, Inst Pharmaceut, Gutenbergstr 76, D-24118 Kiel, Germany in 2020.0, Cited 48.0. Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Under different pathological conditions, aberrant induction of neuronal nitric oxide synthase (nNOS) generates overproduction of NO that can cause irreversible cell damage. The aim of this study was to develop an amidoxime prodrug of a potent nNOS inhibitor, the benzhydryl acetamidine. We synthesized the benzhydryl acetamidoxime, which was evaluatedin vitroto ascertain the potential NOS inhibitory activity, as well as conducting bioconversion into the parent acetamidine. The prodrug was also profiled forin vitrophysicochemical properties, by determining the lipophilicity, passive permeation through the human gastrointestinal tract and across the blood-brain barrier by PAMPA, and chemical, enzymatic, and plasma stability. The obtained data demonstrate that the amidoxime prodrug shows an improved pharmacokinetic profile with respect to the acetamidine nNOS inhibitor, thus suggesting that it could be a promising lead compound to treat all those pathological conditions in which nNOS activity is dysregulated.

About Diphenylmethanamine, If you have any questions, you can contact Maccallini, C; Marinelli, L; Indorf, P; Cacciatore, I; Fantacuzzi, M; Clement, B; Di Stefano, A; Amoroso, R or concate me.. Formula: C13H13N

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Computed Properties of C13H13N. I found the field of Chemistry very interesting. Saw the article Reactions between 5-Nitroso-1,3-diphenyltetrazolium Salts and Electron-Rich Arenes, Amines, Thiophenol, Sulfoxides, and Thioanisole published in 2019.0, Reprint Addresses Hirashita, T (corresponding author), Nagoya Inst Technol, Grad Sch Engn, Life Sci & Appl Chem, Showa Ku, Gokiso Cho, Nagoya, Aichi 4668555, Japan.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine.

A series of reactions between 5-nitroso-1,3-diphenyltetrazolium tetrafluoroborate and methoxybenzenes, amines, thiols, sulfoxides, and sulfides, most of which are generally accepted as being inert to nitroso groups, is reported here. The tetrazolium-activated nitroso functionality is capable of oxidizing the aforementioned substrates to give the corresponding oxidized products, and the nitroso tetrazolium itself is transformed into the corresponding amide or hydroxyamide, depending on the nature of the reaction partners. In the case of thioanisole, an addition product was obtained.

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Category: amides-buliding-blocks. Chen, X; Yang, X; Mao, F; Wei, JL; Xu, YX; Li, BL; Zhu, J; Ni, SS; Jia, LJ; Li, J in [Chen, Xin; Mao, Fei; Wei, Jinlian; Xu, Yixiang; Li, Baoli; Zhu, Jin; Li, Jian] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, 130 Mei Long Rd, Shanghai 200237, Peoples R China; [Yang, Xi; Ni, Shuaishuai; Jia, Lijun] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Canc Inst, Shanghai 200032, Peoples R China; [Li, Jian] Dali Univ, Coll Pharm & Chem, 5 Xue Ren Rd, Dali 671000, Yunnan, Peoples R China; [Li, Jian] East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, 130 Mei Long Rd, Shanghai 200237, Peoples R China published Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth in vitro and in vivo in 2021.0, Cited 41.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Ubiquitin-like protein neddylation is overactivated in various human cancers and correlates with disease progression, and targeting this pathway represents a valuable therapeutic strategy. Our previous work disclosed an antihypertensive agent, candesartan cilexetic (CDC), serves as a novel neddylation inhibitor for suppressing tumor growth by targeting Nedd8-activating enzyme (NAE). In this study, 42 benzimidazole derivatives were designed and synthesized based on lead compound CDC to improve the neddylation inhibition and anticancer efficacy. Optimal benzimidazole-derived 35 displayed superior neddylation inhibition in enzyme assay compared to CDC (IC50 = 5.51 mu M vs 16.43 mu M), along with promising target inhibitory activity and killing selectivity in cancer cell. The results of cellular mechanism research combined with tumor growth suppression in human lung cancer cell A549 in vivo, accompanied with docking model, revealed that 35 has the potential to be developed as a promising neddylation inhibitor for anticancer therapy. (C) 2020 Elsevier Masson SAS. All rights reserved.

Category: amides-buliding-blocks. About Diphenylmethanamine, If you have any questions, you can contact Chen, X; Yang, X; Mao, F; Wei, JL; Xu, YX; Li, BL; Zhu, J; Ni, SS; Jia, LJ; Li, J or concate me.

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Category: amides-buliding-blocks. Recently I am researching about CARBONYL-COMPOUNDS; DEOXYGENATION; ALCOHOLS; HYDROGENOLYSIS; 1,2-DIOLS; AMINES; HYDROSILYLATION; ACTIVATION; CONVERSION; MECHANISM, Saw an article supported by the Alexander von Humboldt FoundationAlexander von Humboldt Foundation. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Fang, HQ; Oestreich, M. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

The strong boron Lewis acid tris(pentafluorophenyl)borane B(C6F5)(3) is known to catalyze the dehydrogenative coupling of certain amines and hydrosilanes at elevated temperatures. At higher temperature, the dehydrogenation pathway competes with cleavage of the C-N bond and defunctionalization is obtained. This can be turned into a useful methodology for the transition-metal-free reductive deamination of a broad range of amines as well as heterocumulenes such as an isocyanate and an isothiocyanate.

About Diphenylmethanamine, If you have any questions, you can contact Fang, HQ; Oestreich, M or concate me.. Category: amides-buliding-blocks

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Formula: C13H13N. Biosca, M; Salto, J; Magre, M; Norrby, PO; Pamies, O; Dieguez, M in [Biosca, Maria; Salto, Joan; Magre, Marc; Pamies, Oscar; Dieguez, Montserrat] Univ Rovira & Virgili, Dept Quim Fis & Inorgan, C Marcel Li Domingo 1, E-43007 Tarragona, Spain; [Norrby, Per-Ola] AstraZeneca Gothenburg, R&D BioPharmaceut, Pharmaceut Sci, Data Sci & Modelling, Pepparedsleden 1, S-43150 Molndal, Sweden; [Norrby, Per-Ola] Univ Gothenburg, Dept Chem & Mol Biol, Kemigarden 4, S-41296 Gothenburg, Sweden published An Improved Class of Phosphite-Oxazoline Ligands for Pd-Catalyzed Allylic Substitution Reactions in 2019.0, Cited 129.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A method for generation of Pd/phosphite-oxazoline catalysts containing an alkyl backbone chain has been successfully applied to Pd-catalyzed allylic substitution reactions. By carefully selecting the substituents at both the alkyl backbone chain and the oxazoline of the ligand, as well as the configuration of the biaryl phosphite group, high activities (TOF > 8000 mol substrate X (mol Pd X h)(-1)) and excellent enantioselectivities (ee’s up to 99%) have been achieved for many hindered and unhindered substrates with a wide range of C-, O-, and N-nucleophiles (73 substitution products in total). Moreover, DFT and NMR studies of the key Pd-allyl complexes allowed us to better understand the origin of the excellent enantioselectivities observed experimentally. The useful application of the Pd/phosphite-oxazoline catalysts was demonstrated by the syntheses of many chiral carbobicycles, with multiples stereocenters, by simple sequential reactions involving Pd-allylic substitution and either 1,6-enyne cyclization or Pauson-Khand enyne cyclization.

Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Biosca, M; Salto, J; Magre, M; Norrby, PO; Pamies, O; Dieguez, M or concate me.

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Application In Synthesis of Diphenylmethanamine. In 2019.0 ADV SYNTH CATAL published article about CATALYZED CARBONYLATION; REDUCTION; GUANIDINES; CHEMISTRY; FIXATION; DIOXIDE; UREAS in [Noh, Hyeong-Wan; Lee, Seulchan; Jang, Hye-Young] Ajou Univ, Dept Energy Syst Res, Suwon 16499, South Korea; [An, Youngjoon; Jung, Jaehoon] Univ Ulsan, Dept Chem, Ulsan 44610, South Korea; [Son, Seung Uk] Sungkyunkwan Univ, Dept Chem, Suwon 16419, South Korea in 2019.0, Cited 56.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

The capture and utilization of CO by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) were performed in the absence of transition-metal complexes. The reaction of TBD with CO afforded TBD-CO adducts, which were converted to formylated TBD (TBD-CHO). TBD-CO adducts may include an interaction of CO with positively charged species based on NMR and IR analysis. In the presence of amines, CO was transferred from TBD-CO to amines, producing formylated amines with good yields. The reaction mechanism involving TBD-CO adducts is presented based on theoretical calculations.

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Quality Control of Diphenylmethanamine. Authors Chen, DH; Sun, WT; Zhu, CJ; Lu, GS; Wu, DP; Wang, AE; Huang, PQ in WILEY-V C H VERLAG GMBH published article about in [Chen, Dong-Huang; Sun, Wei-Ting; Zhu, Cheng-Jie; Lu, Guang-Sheng; Wu, Dong-Ping; Wang, Ai-E; Huang, Pei-Qiang] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; [Chen, Dong-Huang; Sun, Wei-Ting; Zhu, Cheng-Jie; Lu, Guang-Sheng; Wu, Dong-Ping; Wang, Ai-E; Huang, Pei-Qiang] Xiamen Univ, Fujian Prov Key Lab Chem Biol, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; [Wang, Ai-E; Huang, Pei-Qiang] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China in 2021.0, Cited 89.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The combination of transition-metal catalysis and organocatalysis increasingly offers chemists opportunities to realize diverse unprecedented chemical transformations. By combining iridium with chiral thiourea catalysis, direct enantioselective reductive cyanation and phosphonylation of secondary amides have been accomplished for the first time for the synthesis of enantioenriched chiral alpha-aminonitriles and alpha-aminophosphonates. The protocol is highly efficient and enantioselective, providing a novel route to the synthesis of optically active alpha-functionalized amines from the simple, readily available feedstocks. In addition, the reactions are scalable and the thiourea catalyst can be recycled and reused.

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Quality Control of Diphenylmethanamine. Dommaschk, M; Echavarren, J; Leigh, DA; Marcos, V; Singleton, TA in [Dommaschk, Marcel; Echavarren, Javier; Leigh, David A.; Marcos, Vanesa; Singleton, Thomas A.] Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs, England published Dynamic Control of Chiral Space Through Local Symmetry Breaking in a Rotaxane Organocatalyst in 2019.0, Cited 87.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

We report on a switchable rotaxane molecular shuttle that features a pseudo-meso 2,5-disubstituted pyrrolidine catalytic unit on the axle whose local symmetry is broken according to the position of a threaded benzylic amide macrocycle. The macrocycle can be selectively switched (with light in one direction; with catalytic acid in the other) with high fidelity between binding sites located to either side of the pyrrolidine unit. The position of the macrocycle dictates the facial bias of the rotaxane-catalyzed conjugate addition of aldehydes to vinyl sulfones. The pseudo-meso non-interlocked thread does not afford significant selectivity as a catalyst (2-14 % ee), whereas the rotaxane affords selectivities of up to 40 % ee with switching of the position of the macrocycle changing the handedness of the product formed (up to 60 % Delta ee).

Quality Control of Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Dommaschk, M; Echavarren, J; Leigh, DA; Marcos, V; Singleton, TA or concate me.

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Name: Diphenylmethanamine. Recently I am researching about N-C CLEAVAGE; METAL-FREE TRANSAMIDATION; PRIMARY CARBOXAMIDES; SECONDARY AMIDES; CARBOXYLIC-ACIDS; AMIDATION; ESTERIFICATION; CARBONYLATION; AMINES; ESTERS, Saw an article supported by the National Research Foundation of Korea (NRF) – Korea government [NRF-2012M3A7B4049655, 2020R1A2C2013420]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Yang, D; Shin, T; Kim, H; Lee, S. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

The transamidation of tertiary amides was achievedvianickel catalysis in combination with briphos ligands.N-Methyl-N-phenylbenzamide derivatives reacted with primary amines in the presence of NiCl2/briphos L4 to provide the transamidated products in moderate to good yields. Primary aromatic amines delivered higher product yields than aliphatic amines.

Name: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Yang, D; Shin, T; Kim, H; Lee, S or concate me.

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Khan, SN; Zaman, MK; Li, RN; Sun, ZK in [Khan, Shah Nawaz; Zaman, Muhammad Kashif; Li, Ruining; Sun, Zhankui] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China; [Sun, Zhankui] Chinese Acad Sci, Huzhou Res & Industrializat Ctr Technol, Huzhou 313000, Peoples R China published A General Method for Photocatalytic Decarboxylative Hydroxylation of Carboxylic Acids in 2020, Cited 49. Recommanded Product: 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A general and practical method for decarboxylative hydroxylation of carboxylic acids was developed through visible light-induced photocatalysis using molecular oxygen as the green oxidant. The addition of NaBH4 to in situ reduce the unstable peroxyl radical intermediate much broadened the substrate scope. Different sp a carbon-bearing carboxylic acids were successfully employed as substrates, including phenylacetic acid-type substrates, as well as aliphatic carboxylic acids. This transformation worked smoothly on primary, secondary, and tertiary carboxylic acids.

Recommanded Product: 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Khan, SN; Zaman, MK; Li, RN; Sun, ZK or concate me.

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