Category: 91-00-9

An article Microwave-assisted synthesis of alpha-aminophosphonates with sterically demanding alpha-aryl substituents WOS:000519425200001 published article about KABACHNIK-FIELDS REACTION; DOT-H DISTANCES; DERIVATIVES; SOLVENT; BONDS; ACIDS; DFT in [Hudson, Harry R.] London Metropolitan Univ, Fac Life Sci & Comp, London, England; [Tajti, Adam; Balint, Erika; Czugler, Matyas; Keglevich, Gyorgy] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1521 Budapest, Hungary; [Karaghiosoff, Konstantin] Ludwig Maximilians Univ Munchen, Dept Chem, Munich, Germany in 2020.0, Cited 38.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Formula: C13H13N

A series of N-benzhydryl protected alpha-aminophosphonates with alpha-phenyl, alpha-(1-naphtyl), alpha-(9-anthryl) or alpha-(1-pyrenyl) substituents was synthesized by the Kabachnik-Fields condensation of diphenylmethylamine (benzhydrylamine), the corresponding aryl aldehyde and a dialkyl phosphite under MW irradiation. X-ray studies performed at low temperatures for a few of these alpha-aminophosphonates confirmed the presence of unusually short intramolecular C-alpha-H delta+ center dot center dot center dot H delta+-C-peri contacts. [GRAPHICS] .

About Diphenylmethanamine, If you have any questions, you can contact Hudson, HR; Tajti, A; Balint, E; Czugler, M; Karaghiosoff, K; Keglevich, G or concate me.. Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Karasik, AA; Strelnik, ID; Musina, EI; Dayanova, IR; Elistratova, JG; Mustafina, AR; Sinyashin, OG in [Karasik, Andrey A.; Strelnik, Igor D.; Musina, Elvira I.; Dayanova, Irina R.; Elistratova, Julia G.; Mustafina, Asiya R.; Sinyashin, Oleg G.] RAS, FRC Kazan Sci Ctr, Arbuzov Inst Organ & Phys Chem, Kazan, Russia published Luminescent complexes of 1,5-diaza-3,7-diphosphacyclooctanes with coinage metals in 2019.0, Cited 23.0. Quality Control of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Cyclic aminomethylphosphines in general and 1,5-diaza-3,7-dihposphacyclooctanes in particular are widely used for the design of d(10)-metal complexes with catalytic or luminescent properties. 1,5-Diaza-3,7-diphosphacyclooctanes are chelating ligands towards Ni subgroup metals and chelating or bridging ligands towards copper subgroup metals. These ligands can be utilized for the design of polynuclear complexes with stimuli-responsive luminescence. Nowadays several complexes based on 1,5-diaza-3,7-diphosphacyclooctanes demonstrating stimuli-response of emission towards organic substrates or temperature are known. Some of the gold(I) complexes are able to sensitize the luminescent anionic rhenium cluster. Copper(I) complexes display rather strong luminescence with quantum yields 20-40%. [GRAPHICS] .

About Diphenylmethanamine, If you have any questions, you can contact Karasik, AA; Strelnik, ID; Musina, EI; Dayanova, IR; Elistratova, JG; Mustafina, AR; Sinyashin, OG or concate me.. Quality Control of Diphenylmethanamine

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recommanded Product: 91-00-9. Jaganmohan, C; Kumar, KPV; Venkateshwarlu, R; Mohanty, S; Kumar, J; Rao, BV; Raghunadh, A; Tadiparthi, K in [Jaganmohan, Chikkanti; Kumar, Vinay K. P.; Venkateshwarlu, R.; Mohanty, Sandeep; Kumar, Jaydeep; Raghunadh, Akula] Dr Reddys Labs Ltd, Hyderabad 500049, India; [Jaganmohan, Chikkanti; Rao, Venkateswara B.] Andhra Univ, Dept Organ Chem & FDW, Visakhapatnam, Andhra Pradesh, India; [Tadiparthi, Krishnaji] CHRIST Deemed Be Univ, Dept Chem, Hosur Rd, Bangalore 560029, Karnataka, India published A novel approach for the synthesis of functionalized hydroxylamino derivative of dihydroquinazolinones in 2020.0, Cited 41.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A new metal-free and modular approach for the synthesis of various functionalized dihydroquinazolinones has been developed from isatoic anhydride, amines, 4-chloro-N-hydroxybenzimidoylchloride to yield up to 71%. The reaction has been screened in various bases, solvents at different temperatures. The substrate scope of the reaction has been studied with various amines and the possible reaction mechanism for this reaction has also been proposed.

About Diphenylmethanamine, If you have any questions, you can contact Jaganmohan, C; Kumar, KPV; Venkateshwarlu, R; Mohanty, S; Kumar, J; Rao, BV; Raghunadh, A; Tadiparthi, K or concate me.. Recommanded Product: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Formula: C13H13N. Recently I am researching about MECHANICALLY INTERLOCKED MOLECULES; ASYMMETRIC CATALYSIS; PEPTIDE-SYNTHESIS; MACHINES; COOPERATION; CATENANES; ALDEHYDES; SWITCHES; PYRIDYL, Saw an article supported by the Engineering and Physical Sciences Research Council (EPSRC)UK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [EP/P027067/1]; EU (European Research Council (ERC))European Research Council (ERC) [786630, 642083]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Dommaschk, M; Echavarren, J; Leigh, DA; Marcos, V; Singleton, TA. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

We report on a switchable rotaxane molecular shuttle that features a pseudo-meso 2,5-disubstituted pyrrolidine catalytic unit on the axle whose local symmetry is broken according to the position of a threaded benzylic amide macrocycle. The macrocycle can be selectively switched (with light in one direction; with catalytic acid in the other) with high fidelity between binding sites located to either side of the pyrrolidine unit. The position of the macrocycle dictates the facial bias of the rotaxane-catalyzed conjugate addition of aldehydes to vinyl sulfones. The pseudo-meso non-interlocked thread does not afford significant selectivity as a catalyst (2-14 % ee), whereas the rotaxane affords selectivities of up to 40 % ee with switching of the position of the macrocycle changing the handedness of the product formed (up to 60 % Delta ee).

About Diphenylmethanamine, If you have any questions, you can contact Dommaschk, M; Echavarren, J; Leigh, DA; Marcos, V; Singleton, TA or concate me.. Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Position of lipidation influences anticancer activity of Smac analogs WOS:000468145300016 published article about APOPTOSIS PROTEINS IAPS; HUMAN SERUM-ALBUMIN; X-LINKED INHIBITOR; STRUCTURAL BASIS; CELL-DEATH; REVERSIBLE LIPIDIZATION; CASPASE INHIBITION; POTENT ANTAGONISTS; TUMOR-REGRESSION; BIR DOMAINS in [Micewicz, Ewa D.; Nguyen, Christine; McBrid, William H.] Univ Calif Los Angeles, Dept Radiat Oncol, 10833 Le Conte Ave, Los Angeles, CA 90095 USA; [Micewicz, Alina] Univ Calif Los Angeles, David Geffen Sch Med, Volunteering Program, 10833 Le Conte Ave, Los Angeles, CA 90095 USA; [Waring, Alan J.] Harbor UCLA Med Ctr, Dept Med, Los Angeles Biomed Res Inst, 1000 West Carson St, Torrance, CA 90502 USA; [Ruchala, Piotr] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, 760 Westwood Plaza, Los Angeles, CA 90024 USA; [Ruchala, Piotr] Jane & Terry Semel Inst Neurosci & Human Behav, Pasarow Mass Spectrometry Lab, 760 Westwood Plaza, Los Angeles, CA 90024 USA in 2019.0, Cited 79.0. Safety of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A small group of lipid-conjugated Smac mimetics was synthesized to probe the influence of the position of lipidation on overall anti-cancer activity. Specifically, new compounds were modified with lipid(s) in position 3 and C-terminus. Previously described position 2 lipidated analog M11 was also synthesized. The resulting mini library of Smacs lipidated in positions 2, 3 and C-terminus was screened extensively in vitro against a total number of 50 diverse cancer cell lines revealing that both the position of lipidation as well as the type of lipid, influence their anti-cancer activity and cancer type specificity. Moreover, when used in combination therapy with inhibitor of menin-MLL1 protein interactions, position 2 modified analog SM2 showed strong synergistic anti-cancer properties. The most promising lipid-conjugated analogs SM2 and SM6, showed favorable pharmacokinetics and in vivo activity while administered subcutaneously in the preclinical mouse model. Collectively, our findings suggest that lipid modification of Smacs may be a viable approach in the development of anti-cancer therapeutic leads.

About Diphenylmethanamine, If you have any questions, you can contact Micewicz, ED; Nguyen, C; Micewicz, A; Waring, AJ; McBrid, WH; Ruchala, P or concate me.. Safety of Diphenylmethanamine

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Meng, GY; Guo, TJ; Ma, TC; Zhang, J; Shen, YC; Sharpless, KB; Dong, JJ in [Meng, Genyi; Guo, Taijie; Ma, Tiancheng; Zhang, Jiong; Shen, Yucheng; Sharpless, Karl Barry; Dong, Jiajia] Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem,Chinese Acad Sci, Shanghai, Peoples R China published Modular click chemistry libraries for functional screens using a diazotizing reagent in 2019, Cited 33. COA of Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Click chemistry is a concept in which modular synthesis is used to rapidly find new molecules with desirable properties(1). Copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) triazole annulation and sulfur(VI) fluoride exchange (SuFEx) catalysis are widely regarded as click reactions(2-4), providing rapid access to their products in yields approaching 100% while being largely orthogonal to other reactions. However, in the case of CuAAC reactions, the availability of azide reagents is limited owing to their potential toxicity and the risk of explosion involved in their preparation. Here we report another reaction to add to the click reaction family: the formation of azides from primary amines, one of the most abundant functional groups(5). The reaction uses just one equivalent of a simple diazotizing species, fluorosulfuryl azide(6-11) (FSO2N3), and enables the preparation of over 1,200 azides on 96-well plates in a safe and practical manner. This reliable transformation is a powerful tool for the CuAAC triazole annulation, the most widely used click reaction at present. This method greatly expands the number of accessible azides and 1,2,3-triazoles and, given the ubiquity of the CuAAC reaction, it should find application in organic synthesis, medicinal chemistry, chemical biology and materials science.

COA of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Meng, GY; Guo, TJ; Ma, TC; Zhang, J; Shen, YC; Sharpless, KB; Dong, JJ or concate me.

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

COA of Formula: C13H13N. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli published in 2019.0, Reprint Addresses LaVoie, EJ (corresponding author), Rutgers State Univ, Ernest Mario Sch Pharm, 160 Frelinghuysen Rd, Piscataway, NJ 08854 USA.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine.

Several studies that have identified agents that potentiate the antimicrobial activity of antibiotics, but there are limited insights into their structure-activity relationships (SAR). The SAR associated with select N-alkylaryl amide derivatives of ornithine was performed to establish those structural features that were associated with potentiation of the antimicrobial activity of clarithromycin against E. coli ATCC 25922. The data indicate that the N-propyl derivative was slightly more active in reducing the effective MIC of clarithromycin against E. coli ATCC 25922. In addition, the S-enantiomer of compound 9 was somewhat more potent than the R-enantiomer in potentiating clarithromycin activity. No significant enhancement in potentiation activity was observed with the conversion of these secondary amides to their N-methyl tertiary amides. Formation of the N-methyl or N,N-dimethyl derivatives of the primary amine of 9 was associated with the loss of potentiation activity. Conversion of this primary amine to a guanidine was also not associated with an increase in potentiation activity. Among the isomeric diamino pentamides, 15 potentiated the antibacterial activity of clarithromycin to the greatest extent In addition to these amide derivatives, the desoxy derivatives 16 and 18 were the more potent potentiators within this triamine series. The relative location of the primary amines, as indicated by the relative differences in the potentiation observed with 16 compared to 14, appears to be a critical factor in determining potentiation activity. Cell-based membrane permeabilization and efflux inhibition studies in E. coli ATCC 25922 suggest that the potentiation of clarithromycin activity by 16 reflects its ability to inhibit efflux pump activity and to a lesser extent its actions as a permeabilizer of the outer leaflet of the outer cell membrane. (C) 2019 Elsevier Masson SAS. All rights reserved.

COA of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Blankson, G; Parhi, AK; Kaul, M; Pilch, DS; LaVoie, EJ or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

COA of Formula: C13H13N. In 2019.0 ORG LETT published article about DIRECT AMIDE FORMATION; MECHANISTIC INSIGHTS; BOND FORMATION; BORONIC ACIDS; CONDENSATION; ALPHA; CYCLOADDITIONS; ACTIVATION; CHEMISTRY; AMINES in [Shimada, Naoyuki] Kitasato Univ, Dept Pharmaceut Sci, Lab Organ Chem Drug Dev, Tokyo 1088641, Japan; Kitasato Univ, Dept Pharmaceut Sci, Med Res Labs, Tokyo 1088641, Japan in 2019.0, Cited 72.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

The direct catalytic dehydrative amidation of beta-hydroxycarboxylic acids with amines is described. A biphenyl-based diboronic acid anhydride with a B-O-B skeleton is shown to be an exceptionally effective catalyst for the reaction, providing beta-hydroxycarboxylic amides in high to excellent yields with a low catalyst loading (minimum of 0.01 mol %, TON up to 7,500). This hydroxy-directed amidation shows excellent chemoselectivity and is applicable to gram-scale drug synthesis.

About Diphenylmethanamine, If you have any questions, you can contact Shimada, N; Hirata, M; Koshizuka, M; Ohse, N; Kaito, R; Makino, K or concate me.. COA of Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Product Details of 91-00-9. In 2020.0 ORG LETT published article about EFFICIENT; ARYLATION; AMIDES in [Gao, Zhenhua; Li, Junchen; Shi, Enxue] State Key Lab NBC Protect Civilian, Beijing 102205, Peoples R China; [Li, Bowen; Aliyu, Muinat; Li, Tiejun; Dong, Wei; Tang, Wenjun] Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China; [Li, Bowen; Tang, Wenjun] Univ Chinese Acad Sci, Sch Chem & Mat Sci, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China in 2020.0, Cited 34.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A general synthesis of chiral alpha,alpha-diaryl carboxamides is developed by enantioselective cross-coupling between 2-bromo-2-aryl carboxamides and arylboronic acids, leading to a series of chiral alpha,alpha-diaryl carboxamides with various electronic properties and functionalities in moderate to excellent enantioselectivities and yields. The employment of a sterically bulky chiral P,P=O ligand L2 is critical for the reactivity and selectivity. This protocol is applied to an efficient asymmetric synthesis of a key intermediate of dopamine receptor agonist SKF 38393.

Product Details of 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Li, BW; Aliyu, M; Gao, ZH; Li, TJ; Dong, W; Li, JC; Shi, EX; Tang, WJ or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Computed Properties of C13H13N. In 2020.0 BIOL PHARM BULL published article about POTENT; MICROSOMES; BENZOFURAN; DIMERS in [Yamaguchi, Yuki; Nishizono, Naozumi; Oda, Kazuaki] Hlth Sci Univ Hokkaido, Sch Pharmaceut Sci, Ishikari, Hokkaido 0610293, Japan in 2020.0, Cited 27.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Aromatase inhibitors are effective for the treatment of diseases such as breast cancer, which has led to an increase in their demand. However, only a limited number of aromatase inhibitor drugs are currently being marketed. In addition, considering the important aspect of drug resistance, the development of newer drug types is required. We have been developing inhibitors with backbone structures that differ from existing aromatase inhibitors. In this regard, we previously reported that diethylaminocoumarin dimers and thiazolyl coumarin derivatives possess strong aromatase inhibiting capabilities. In this study, we further examined the structure activity relationships of coumarin derivatives synthesized from thiazolyl coumarin derivatives and their aromatase inhibiting capabilities. Consequently, amide coumarin N-benzhydry1-7-(diethylamino)2-oxo-2H-chromene-3-carboxamide (IC50 values 4.5 mu M) is inhibitor of aromatase. This inhibitor was found to be comparable aromatase inhibitory activity to the 1st generation aromatase inhibitor aminoglutethimide (3.2 mu M). Substitution of the amide group on the amide coumarin derivative affects the aromatase inhibiting activity. Our findings suggest that the structure of each substituent changes the orientation of the compound in the active site of aromatase, thus creating a difference in their activities.

Computed Properties of C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Yamaguchi, Y; Nishizono, N; Oda, K or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics