Category: 91-00-9

HPLC of Formula: C13H13N. Recently I am researching about E3 UBIQUITIN LIGASE; 2 SH2 DOMAIN; SIGNAL TRANSDUCER; PEPTIDOMIMETIC INHIBITORS; SMALL MOLECULES; DESIGN; DEGRADATION; ACTIVATOR; OPTIMIZATION; VALIDATION, Saw an article supported by the Oncopia Therapeutics Inc.; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [P30 CA046592]; (Rogel Cancer Center) Core grant from the National Cancer Institute (NCI), NIH; DOE Office of ScienceUnited States Department of Energy (DOE) [DE-AC02-06CH11357]; Michigan Technology Tri-Corridor [085P1000817]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhou, HB; Bai, LC; Xu, RQ; Zhao, YJ; Chen, JY; McEachern, D; Chinnaswamy, K; Wen, B; Dai, LP; Kumar, P; Yang, CY; Liu, ZM; Wang, M; Liu, L; Meagher, JL; Yi, H; Sun, DX; Stuckey, JA; Wang, SM. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor and an attractive therapeutic target for cancer and other human diseases. Despite 20 years of persistent research efforts, targeting STAT3 has been very challenging. We report herein the structure-based discovery of potent small-molecule STAT3 degraders based upon the proteolysis targeting chimera (PROTAC) concept. We first designed SI-109 as a potent, small-molecule inhibitor of the STAT3 SH2 domain. Employing ligands for cereblon/cullin 4A E3 ligase and SI-109, we obtained a series of potent PROTAC STAT3 degraders, exemplified by SD-36. SD-36 induces rapid STAT3 degradation at low nanomolar concentrations in cells and fails to degrade other STAT proteins. SD-36 achieves nanomolar cell growth inhibitory activity in leukemia and lymphoma cell lines with high levels of phosphorylated STAT3. A single dose of SD-36 results in complete STAT3 protein degradation in xenograft tumor tissue and normal mouse tissues. SD-36 achieves complete and long-lasting tumor regression in the Molm-16 xenograft tumor model at well-tolerated dose-schedules. SD-36 is a potent, selective, and efficacious STAT3 degrader.

About Diphenylmethanamine, If you have any questions, you can contact Zhou, HB; Bai, LC; Xu, RQ; Zhao, YJ; Chen, JY; McEachern, D; Chinnaswamy, K; Wen, B; Dai, LP; Kumar, P; Yang, CY; Liu, ZM; Wang, M; Liu, L; Meagher, JL; Yi, H; Sun, DX; Stuckey, JA; Wang, SM or concate me.. HPLC of Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2021.0 ORG LETT published article about UGI-AZIDE; IODINE(III) REAGENTS; ORGANIC CATALYSIS; PROTOCOL; GENERALITY; STRATEGIES; AMINATION; AMINES; SCOPE; IBX in [Schofield, Kevin; Foley, Christopher; Hulme, Christopher] Univ Arizona, Coll Sci, Dept Chem & Biochem, Tucson, AZ 85721 USA; [Hulme, Christopher] Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA in 2021.0, Cited 35.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Recommanded Product: 91-00-9

A 5-endo trig oxidative radical cyclization of benzylamine-derived Ugi three-component reaction products rapidly affords imidazolidinones with three diversity elements. This adaptation of our previously described multicomponent reactionoxidation methodology further showcases manipulation of the diversity elements in multicomponent reaction products via oxidative radical cyclizations, which generates highly decorated privileged heterocycles.

Recommanded Product: 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Schofield, K; Foley, C; Hulme, C or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Wang, L; Wang, XW; Hou, HB; Zhu, GQ; Han, ZY; Yang, WY; Chen, X; Wang, QG in ROYAL SOC CHEMISTRY published article about 3,4-SELECTIVE LIVING POLYMERIZATION; 1,3-BUTADIENE POLYMERIZATION; METAL; IRON(III); 3,4-POLYMERIZATION; REGIOSELECTIVITY; 1,3-DIENES; BUTADIENE; LIGANDS; SYSTEMS in [Wang, Liang; Wang, Xiaowu; Hou, Hongbin; Zhu, Guangqian; Han, Zhenyu; Yang, Weiying; Chen, Xiao; Wang, Qinggang] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biobased Mat, Qingdao 266101, Peoples R China; [Zhu, Guangqian; Han, Zhenyu; Yang, Weiying] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China in 2020.0, Cited 51.0. Name: Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A series of chloride-bridged unsymmetrical mixed Fe(ii)-HS/Fe(ii)-LS binuclear structures has been prepared and characterized. Upon activation with MAO, highly efficient catalytic polymerization of isoprene was achieved, delivering an ultra-high molecular weight (catalyst loading = 2.5 ppm,M-n= 1.8 x 10(6)g mol(-1),M-w/M-n= 1.4).

About Diphenylmethanamine, If you have any questions, you can contact Wang, L; Wang, XW; Hou, HB; Zhu, GQ; Han, ZY; Yang, WY; Chen, X; Wang, QG or concate me.. Name: Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Metal-Free Transamidation of Primary Amides using Trimethylsilyl Chloride WOS:000487092300006 published article about CATALYZED TRANSAMIDATION; EFFICIENT CATALYST; CARBOXYLIC-ACIDS; SECONDARY AMIDES; CARBOXAMIDES; AMINES; SOLVENT; UREAS; COMPLEX in [Yu, Subeen; Lee, Sunwoo] Chonnam Natl Univ, Dept Chem, Gwangju 61186, South Korea; [Song, Kwang Ho] Korea Univ, Dept Chem & Biol Engn, Seoul 02841, South Korea in 2019.0, Cited 66.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. SDS of cas: 91-00-9

A metal-free transamidation of primary amides was developed. Trimethylsilyl chloride (TMSCl) acted as the activator in transamidation. In the presence of TMSCl, primary amides reacted with primary amines to yield transamidated secondary amides in NMP solvent. The transamidation of benzamide with secondary amines for the formation of tertiary amides succeeds in an NMP/CHCl3 solvent mixture.

About Diphenylmethanamine, If you have any questions, you can contact Yu, S; Song, KH; Lee, S or concate me.. SDS of cas: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Evaluation of Synthesized Ester or Amide Coumarin Derivatives on Aromatase Inhibitory Activity WOS:000567184000005 published article about POTENT; MICROSOMES; BENZOFURAN; DIMERS in [Yamaguchi, Yuki; Nishizono, Naozumi; Oda, Kazuaki] Hlth Sci Univ Hokkaido, Sch Pharmaceut Sci, Ishikari, Hokkaido 0610293, Japan in 2020.0, Cited 27.0. Recommanded Product: 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Aromatase inhibitors are effective for the treatment of diseases such as breast cancer, which has led to an increase in their demand. However, only a limited number of aromatase inhibitor drugs are currently being marketed. In addition, considering the important aspect of drug resistance, the development of newer drug types is required. We have been developing inhibitors with backbone structures that differ from existing aromatase inhibitors. In this regard, we previously reported that diethylaminocoumarin dimers and thiazolyl coumarin derivatives possess strong aromatase inhibiting capabilities. In this study, we further examined the structure activity relationships of coumarin derivatives synthesized from thiazolyl coumarin derivatives and their aromatase inhibiting capabilities. Consequently, amide coumarin N-benzhydry1-7-(diethylamino)2-oxo-2H-chromene-3-carboxamide (IC50 values 4.5 mu M) is inhibitor of aromatase. This inhibitor was found to be comparable aromatase inhibitory activity to the 1st generation aromatase inhibitor aminoglutethimide (3.2 mu M). Substitution of the amide group on the amide coumarin derivative affects the aromatase inhibiting activity. Our findings suggest that the structure of each substituent changes the orientation of the compound in the active site of aromatase, thus creating a difference in their activities.

Recommanded Product: 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Yamaguchi, Y; Nishizono, N; Oda, K or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Product Details of 91-00-9. Recently I am researching about FORMYLMETHYL-SUBSTITUTED ENAMIDES; HIGHLY EFFICIENT; BRONSTED ACID; DIASTEREOSELECTIVE SYNTHESIS; BETA-HYDROXY; CYCLOADDITION; BIOTRANSFORMATIONS; PIPERIDINES; CYCLIZATION; PYRIDINES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21320102002, 91427301]. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Tong, S; Wang, MX. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a substrate engineering strategy to significantly improve the enantioselectivity of asymmetric catalysis

About Diphenylmethanamine, If you have any questions, you can contact Tong, S; Wang, MX or concate me.. Product Details of 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Das, S; Kumar, R; Devadkar, A; Panda, TK in WILEY-V C H VERLAG GMBH published article about RING-OPENING POLYMERIZATION; ONE-POT SYNTHESIS; STEREOSELECTIVE HYDROSILYLATION; DIASTEREOSELECTIVE SYNTHESIS; CARBONYL-COMPOUNDS; METAL-COMPLEXES; ENANTIOSELECTIVE ADDITION; 3-COMPONENT CONDENSATION; TRIMETHYLSILYL CYANIDE; COORDINATION CHEMISTRY in [Das, Suman; Kumar, Ravi; Devadkar, Ajitrao; Panda, Tarun K.] Indian Inst Technol Hyderabad, Dept Chem, Sangareddy 502285, Telangana, India in 2020.0, Cited 127.0. Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

We report the synthesis of alpha-aminonitriles by one-pot coupling reaction of aldehyde, amines and trimethylsilyl cyanide (TMSCN) using beta-ketoiminato zinc complexes as a pre-catalyst in very good yield under mild reaction condition. Homoleptic zinc complex [{kappa(2)-(2,4,6-Me3C6H2NC(Me)=CHC(Me)=O)}(2)Zn] (1 a) was synthesized by the treatment of protic ligand [(2,4,6-Me3C6H2NHC(Me)=CHC(Me)=O)] ((LH)-H-1) with potassium hydride and anhydrous zinc diiodide in 2 : 2 : 1 molar ratio in THF. Analogous reactions using [(2,6-(Pr2C6H3NHC)-Pr-i(Me)=CHC(Me)=O)] ((LH)-H-2) and [(Ph2CHNHC(Me)=CHC(Me)=O)] ((LH)-H-3) as protic ligands, dinuclear zinc complexes [{kappa(3)-(2,6-(Pr2C6H3NC)-Pr-i(Me)=CHC(Me)=O)}ZnI](2)(1 b) and [Zn(Ph2CHNHC-(Me)=CHC(Me)=O)ZnI2] (1 c) were obtained in good yield. Molecular structures of ligandsL(1)H,(LH)-H-3, and zinc complexes1 a,1 b, and1 cwere established by single-crystal x-ray diffraction analysis. Dinuclear zinc complexes1 b, and1 cexhibited high transformation, greater selectivity and broad substrate scope for the synthesis of alpha-aminonitrile under mild condition. A most plausible mechanism for synthesis alpha-aminonitrile is proposed based on several controlled reactions.

Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Das, S; Kumar, R; Devadkar, A; Panda, TK or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Water-mediated C-H activation of arenes with secure carbene precursors: the reaction and its application published in 2019. COA of Formula: C13H13N, Reprint Addresses Wang, QT; Wu, Y (corresponding author), Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Sichuan Engn Lab Plant Sourced Drug, Educ Minist,West China Sch Pharm, Chengdu 610041, Sichuan, Peoples R China.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

A water-mediated C-H activation using sulfoxonium ylides is reported, providing a general, green and step-economic approach to construct a C-C bond and varieties of useful N-heterocycle scaffolds. Notably, the water-mediated activation, in contrast to that in organic solvents, shows great potential in pharmaceutical, biochemistry and chemical industries.

COA of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Nie, RF; Lai, RZ; Lv, SY; Xu, YY; Guo, L; Wang, QT; Wu, Y or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Name: Diphenylmethanamine. Recently I am researching about CATALYZED TRANSFER HYDROGENATION; STEREOSELECTIVE TRANSFER SEMIHYDROGENATION; HIGHLY-ACTIVE HYDROGENATION; ORGANIC FRAMEWORK NODES; SITE COBALT CATALYSTS; BORANE-AMINE ADDUCTS; SELECTIVE HYDROGENATION; CONJUGATE REDUCTION; AMMONIA-BORANE; ASYMMETRIC HYDROGENATION, Saw an article supported by the Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2016YFE0132600]; Henan Center for Outstanding Overseas Scientists [GZS2020001]; National Innovation and Entrepreneurship Training Program for College students [201910459064]; Zhengzhou University. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Wang, Y; Cao, XY; Zhao, LY; Pi, C; Ji, JF; Cui, XL; Wu, YJ. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

A generalized, simple and efficient transfer hydrogenation of unsaturated bonds has been developed using HBP in and various proton reagents as hydrogen sources. The substrates, including alkenes, alkynes, aromatic heterocycles, aldehydes, ketones, imines, azo, nitro, epoxy and nitrile compounds, are all applied to this catalytic system. Various groups, which cannot survive under the Pd/C/H-2 combination, are tolerated. The activity of the reactants was studied and the trends are as follows:styrene>diphenylmethanimine>benzaldehyde>azobenzene>nitrobenzene>quinoline>acetophenone>benzonitrile. Substrates bearing two or more different unsaturated bonds were also investigated and transfer hydrogenation occurred with excellent chemoselectivity. Nano-palladium catalystin situgenerated from Pd(OAc)(2) and HBP in extremely improved the TH efficiency. Furthermore, chemoselective anti-Markovnikov hydrodeuteration of terminal aromatic olefins was achieved using D2O and HBP in via in situ HD generation and discrimination.

Name: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Wang, Y; Cao, XY; Zhao, LY; Pi, C; Ji, JF; Cui, XL; Wu, YJ or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocks. Naqvi, S; Kumar, M; Kumar, R in [Naqvi, Samya; Kumar, Rachana] CSIR Natl Phys Lab, Adv Mat & Devices Metrol Div, Photovolta Metrol Grp, Dr KS Krishnan Marg, New Delhi 110012, India; [Kumar, Mahesh] CSIR Natl Phys Lab, Adv Mat & Devices Metrol Div, Photon Mat Metrol Grp, Dr KS Krishnan Marg, New Delhi 110012, India published Facile Synthesis and Evaluation of Electron Transport and Photophysical Properties of Photoluminescent PDI Derivatives in 2019.0, Cited 83.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Perylenediimides (PDIs) have emerged as potential materials for optoelectronic applications. In the current work, four PDI derivatives, substituted at imide nitrogen with 2,6-diisopropyl phenyl, 2-nitrophenyl, diphenylmethylene, and pentafluorophenyl groups, have been synthesized from perylene 3,4,9,10-tetracarboxylic dianhydride using a facile imidization synthesis process. PDI derivatives have been spectroscopically characterized for their structure and optical properties. Temperature-variable absorption and emission spectroscopy study confirmed the H-aggregation property. H-aggregation along with strong emission suggests the slipped pi-pi stacking of PDI molecules. Electrochemical analysis was performed for their redox behavior and calculation of lowest unoccupied molecular orbital and highest occupied molecular orbital energy levels. Scanning electron microscopy showed the formation of ordered structures. The PDI derivatives showed excellent electron conductivity without doping and 5-10x higher electron mobility than that of state-of-the-art fullerene acceptor phenyl-C-61 -butyric acid methyl ester (PC61BM). Finally, the charge generation and charge transfer phenomenon was studied by transient absorption spectroscopy (TAS). TAS showed ultrafast charge transfer from the poly(3-hexyl)thiophene (P3HT) donor polymer to PDI and formation of long-lived charge-separated states similar to fullerene derivative PC61 BM/P3HT blends. Such PDI derivatives with excellent solubility and photophysical and electronic properties are potential n-type materials to be used in organic electronic devices.

Category: amides-buliding-blocks. About Diphenylmethanamine, If you have any questions, you can contact Naqvi, S; Kumar, M; Kumar, R or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics