Category: amides-buliding-blocks

Wu, Y.-Q. published the artcileCyanogen halides, cyanates and their sulfur, selenium, and tellurium analogues, sulfinyl and sulfonyl cyanides, cyanamides, and phosphaalkynes, Related Products of amides-buliding-blocks, the publication is Science of Synthesis (2005), 17-63, database is CAplus.

A review of the preparation of cyanogen halides and cyanates as well as their application to organic synthesis. Sulfur, selenium, and tellurium analogs, sulfinyl and sulfonyl cyanides, cyanamides, and phosphaalkynes are included.

Science of Synthesis published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C9H9F5Si, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Birkofer, Leonhard published the artcileRegularities in the hydrogenative fission of N-benzyl compounds, Recommanded Product: N,N-Dibenzylcyanamide, the publication is Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen (1942), 429-41, database is CAplus.

Because of the value of the preparative method of the catalytic removal of the N-CH₂Ph group, a study has been made of the influence of the residue on the N atom upon catalytic debenzylation. All hydrogenations were carried out at room temperature and atm. pressure in EtOH or AcOH, using PdO or PtO₂ as catalyst. PhCH₂NH₂, (PhCH₂)₂NH and PhCH₂NHMe are unchanged in the presence of PdO. (PhCH₂)₃N in AcOH (PdO) or its HCl salt in H₂O (PdO) gives 97% of (PhCH₂)₂NH.HCl; the amine is not reduced by Na and EtOH. Methylcetylbenzylamine in AcOH (PdO) gives 92% of cetylmethylamine-HCl and lauryldibenzylamine gives laurylmethylamine. Dodecyldibenzylamine in AcOH (PtO₂) gives 84% of dodecylhexahydrobenzylamine-HCl, m. 218°. (PhCH₂)₂NNH₂ in absolute EtOH (PdO) yields 88% of PhCH₂NHNH₂; tetrabenzyltetrazene [(PhCH₂)₂NN:]₂ gives (PhCH₂)₂NH. (PhCH₂)₃MeNOH with PdO in EtOH readily yields PhCH₂NHMe (flavianate, m. 190°; picrolonate, m. 210°), whereas (PhCH₂)₃MeNI is not reduced. PhCH₂NPhMe₂Cl gives 90% of cyclohexyldimethylamine. 2-Benzyldihydroisoindole in EtOH (PdO) yields 75% of 1,3-dihydroisoindole, b₃ 100°. 1,4-Dibenzylpiperazine in AcOH (PdO) gives 92% of piperazine diacetate, m. 234°. α-Monobenzylaminotetrazole gives aminotetrazole. PhCH₂NH₂ (1 mol.) in AcOEt is treated with a concentrated aqueous solution of 4 mols. of KCN and then dropwise with 1.1 mols. of Br in AcOEt at 5-10°, and the AcOEt solution shaken with 30% NaOH; the alkali removes the benzylcyanamide, which is polymerized to tribenzylisomelamine (1,3,5-tribenzyl-2,4,6-triimino-1,3,5-triazine) (I), m. 129-30°; short heating with HCl gives NH₃; with H and PdO in EtOH this yields melamine. The elimination of PhCH₂ from 2-imino-1-benzyl-1,2-dihydropyridine is slow and incomplete and is accompanied by nuclear hydrogenation, the products being 2-amino-3,4,5,6-tetrahydropyridine and 2-imino-1-benzylpiperidine (picrate, m. 106°). 2-Benzylaminopyridine does not lose PhCH₂ but is hydrogenated to 2-benzylamino-3,4,5,6-tetrahydropyridine, m. 40-1° (picrate, yellow, m. 131°; picrolonate, yellow, m. 199°). Aromatic rings, CO₂H and CN groups activate the compounds so that PhCH₂ is removed from a sec-N atom. PhNHCH₂Ph in EtOH (PdO) gives 97.5% of PhNH₂ and PhMe, whereas PtO₂ gives mainly cyclohexylhexahydrobenzylamine and small amounts of cyclohexylamine and hexahydrotoluene. PhN(CH₂Ph)₂ with PdO in EtOH gives 89% of PhNH₂ and PhMe. 2-(Dibenzylamino)naphthalene in AcOH (PdO) gives 88% of 2-C₁₀H₇NH₂ and PhMe. ClCH₂CO₂H (9 g.) and 40 g. (PhCH₂)₂NH in 20 cc. dioxane, heated 5 h. at 120°, give 82% of N,N-dibenzylglycocoll, m. 200°; Me ester, m. 41°; hydrogenation in AcOH (PdO) or in EtOH (PdO) gives NH₂CO₂H (95%) or its Me ester (96%). (PhCH₂)₂NCN yields NCNH₂ or I because of polymerization of PhCH₂NHCN if hydrogenation is interrupted before it is complete. (CONHCH₂Ph)₂ and N,N-dibenzylurethane, b₂ 169°, b₄ 181° (82% yield), are stable toward H.

Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Recommanded Product: N,N-Dibenzylcyanamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Gelfand, Erwin W. published the artcileImportance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma, Recommanded Product: [(2-Hexylcyclopentylidene)amino]thiourea, the publication is Seminars in Immunology (2017), 44-51, database is CAplus and MEDLINE.

For several decades, the leukotriene pathways have been implicated as playing a central role in the pathophysiol. of asthma. The presence and elevation of numerous metabolites in the blood, sputum, and bronchoalveolar lavage fluid from asthmatics or exptl. animals adds support to this notion. However, targeting of the leukotriene pathways has had, in general, limited success. The single exception in asthma therapy has been targeting of the cysteinyl leukotriene receptor 1, which clin. has proven effective but only in certain clin. situations. Interference with 5-lipoxygenase has had limited success, in part due to adverse drug effects. The importance of the LTB4-BLT1 pathway in asthma pathogenesis has extensive exptl. support and findings, albeit limited, from clin. samples. The LTB4-BLT1 pathway was shown to be important as a neutrophil chemoattractant. Despite observations made more than two decades ago, the LTB4-BLT1 pathway has only recently been shown to exhibit important activities on subsets of T lymphocytes, both as a chemoattractant and on lymphocyte activation, as well as on dendritic cells, the major antigen presenting cell in the lung. The role of BLT2 in asthma remains unclear. Targeting of components of the LTB4-BLT1 pathway offers innovative therapeutic opportunities especially in patients with asthma that remain uncontrolled despite intensive corticosteroid treatment.

Seminars in Immunology published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Recommanded Product: [(2-Hexylcyclopentylidene)amino]thiourea.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Graham, Laurine L. published the artcileChemical shift assignments in N,N-disubstituted trifluoroacetamides, Computed Properties of 360-92-9, the publication is Organic Magnetic Resonance (1972), 4(2), 335-42, database is CAplus.

Due to hindered rotation about the central C-N bond in N,N-disubstituted trifluoroacetamides, CF3CONR1R2, two resonance peaks are usually observed for each proton in R1 and R2. Chem. shift assignments are made for the following amides: R1 = R2 = Me; R1 = R2 = Et; R1 = Me, R2 = Me2CH; R1 = Me, R2 = Bu; R1 = Me, R2 = cyclohexyl; R1 = R2 = Me2CH; R1 = Me2CH, R2 = cyclohexyl. Amides, where R1 = R2 = Me2CH and R1 = Me2CH, R2 = cyclohexyl, show an inversion of the relative chem. shift for both the methine and methyl protons of the 2-propyl group as compared with the amide where R1 = Me, R2 = Me2CH. For non-fluorinated amides, aromatic solvents shift the trans alkyl peaks to higher field faster than those cis (to the carbonyl oxygen atom); however, this generalization does not apply to all trifluoroacetamide proton peaks.

Organic Magnetic Resonance published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Computed Properties of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Gryszkiewicz-Trochimowski, E. published the artcileAmides of carboxylic acids of the heterocyclic series, Application of N,N-Diethylisonicotinamide, the publication is Roczniki Chemii (1931), 193-202;201-2 in French, database is CAplus.

In analogy with the N-diethylamide of 3-pyridinecarboxylic acid coramine, 3 new diethylamides were prepared, viz., of 2-pyridinecarboxylic, of 4-pyridinecarboxylic and of tetramethylpyrrolinecarboxylic acid, resp., and their chem. and physiol. properties were investigated. Picolinyl chloride (I) is prepared according to Meyer, Monatsh. 22, 112(1901), from the acid (II) and SOCl₂. N-Diethylamide of II, prepared from pulverized (I) and dry Et₂NH, almost odorless oil of bitter taste, neutral, m. 26-8°, b₃ 122.5-3°, corrected, d₄^16.2 1.0603, n_α^16.2 1.5209, n_D^16.2 1.5254, n_β^16.2 1.5348. Coramine, m. 21-3°, b₃ 128.5-9°, corrected, n_α16.2 1.5235, n_D^16.2 1.5279, n_β^16.2 1.5391. N-Diethylamide of 4-pyridinecarboxylic acid (isonicotinic acid), prepared similarly to II, is a neutral, viscous oil, m. 22-4°, b₃ 123-3.5°, corrected, d₄^16.2 1.0630, n_α^16.2 1.5225, n_D^16.2 1.5269, n_β^16.2 1.5380. N-Diethylamide of 2,2′,5,5′-tetramethylpyrrolinecarboxylic acid (III), prepared by interaction of dibromotriacetoneamine-HBr (prepared according to Pauly, Ber. 31, 672), and 33% aqueous Et₂NH, m. 33-4°, b₉ 129.5-30°. It tastes bitter and reacts strongly alk. The 3 diethylamides differ in their physiol. action. The 2-isomer has an action on the heart similar to that of coramine, but does not affect the nervous system. The physiol. action of III is entirely different from that of coramine.

Roczniki Chemii published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Application of N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Haggam, Reda A. published the artcileMicrowave-assisted synthesis of double-headed derivatives of 1,2-bis(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)ethan-1-ol and study of their biological activity, SDS of cas: 79-07-2, the publication is Research on Chemical Intermediates (2021), 47(9), 3733-3749, database is CAplus.

Rapid and efficient synthesis of a series of some novel derivatives of 1,2-bis(4-amino-5-mercapto-1,2,4-triazol-3-yl)ethan-1-ol (I), prepared from thiocarbohydrazide and dl-malic acid under microwave (MW) irradiation, is described. Reactions of I with several alkylating agents, such as epichlorohydrin, 3-chloro-1-propanol, (2-acetoxyethoxy)methyl bromide, propargyl bromide, chloroacetamide, etc., as well as cyclization reactions with α-bromoacetophenone, benzoyl isothiocyanate, chloroacetyl chloride, succinic anhydride, etc. were studied. Higher yields and shorter reaction times were observed under microwave irradiation conditions in comparison to conventional heating procedures. The structures of the obtained products were established based on their ¹H/¹³C NMR, IR, elemental anal. and correlation experiments The synthesized compounds were screened for their antifungal activities. The minimal inhibitory concentration (MIC) of the screened compounds showed significant activity of several compounds against Gram (+ve) and Gram (-ve) bacteria and antifungal activity compared to the standard drugs.

Research on Chemical Intermediates published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, SDS of cas: 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hoerlein, Ulrich published the artcileNonsymmetric N-substituted bispidine (3,7-diazabicyclo[3.3.1]nonane. I, Formula: C5H8N2O, the publication is European Journal of Medicinal Chemistry (1977), 12(4), 301-5, database is CAplus.

Bispidine derivatives I [R = R1 = Me, RR1 = (CH2)5, R2 = Me, Et, CH2Ph, R3 = H; RR1 = (CH2)4, R2 = Me, Et, R3 = H] were prepared by condensing RR1C:C(CN)CO2Et with R2NHCOCH2CN, hydrolyzing II, and reducing diimides with LiAlH4. I [R3 = acyl, 4-FC6H4CO(CH2)3, 8-chloro-10,11-dihydrobenzo[b,f]thiepin-10-yl] were prepared by substitution of I (R3 = H). I [RR1 = (CH2)5, (CH2)4, R2 = Me, R3 = COCH2Ph] had analgesic activities of the same magnitude as morphine. Some other I exhibited various pharmacol. activity, but only to a degree.

European Journal of Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ivanciuc, Ovidiu published the artcileSupport vector machines prediction of the mechanism of toxic action from hydrophobicity and experimental toxicity against Pimephales promelas and Tetrahymena pyriformis, Application of 2,4-Dichlorobenzamide, the publication is Internet Electronic Journal of Molecular Design (2004), 3(12), 802-821, database is CAplus.

Motivation: The prediction of the mechanism of action (MOA) using structural descriptors has major applications in selecting the appropriate quant. structure-activity relationships (QSAR) model, to identify chems. with similar toxicity mechanism, and in extrapolating toxic effects between different species and exposure regimes. Method: The SVM (support vector machines) algorithm was recently proposed as an efficient and flexible classification method for various bioinformatics and cheminformatics applications. In this study we have investigated the application of SVM for the classification of 337 organic compounds from eight MOA classes (nonpolar narcosis, polar narcosis, ester narcosis, amine narcosis, weak acid respiratory uncoupling, electrophilicity, proelectrophilicity, and nucleophilicity). The MOA classification was based on three indexes, namely: log K_ow, the octanol-water partition coefficient; log 1/IGC₅₀, the 50% inhibitory growth concentration against Tetrahymena pyriformis; log 1/LC₅₀, the 50% lethal concentration against Pimephales promelas. The prediction power of each SVM model was evaluated with a leave – 5/% – out cross – validation procedure. Results: In order to find classification models with good predictive power, we have investigated a large number of SVM models obtained with the dot, polynomial, radial basis function, neural, and anova kernels. The MOA classification performances of SVM models depend strongly on the kernel type and various parameters that control the kernel shape. The discrimination between nonpolar narcotic compounds and the other chems. can be obtained with radial and anova SVM models, with a prediction accuracy of 0.80. The separation of less reactive compounds (polar, ester, and amine narcotics) from more reactive compounds (electrophiles, proelectrophiles, and nucleophiles) is obtained with a slightly higher error (prediction accuracy 0.71, obtained with radial SVM models). Conclusions: SVM models that use as input parameters hydrophobicity and exptl. toxicity against Pimephales promelas and Tetrahymena pyriformis represent an effective MOA classification method for a large diversity of organic compounds This approach can be used to predict the aquatic toxicity mechanism and to select the appropriate QSAR model for new chem. compounds

Internet Electronic Journal of Molecular Design published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Application of 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Jart, A. published the artcileInfrared spectra of carboxylic acid derivatives. IV. Amides and hydrazides, HPLC of Formula: 2447-79-2, the publication is Acta Polytech. Scand., Chem. Met. Ser. (1965), 55 pp., database is CAplus.

cf. CA 63, 14654f. The ir spectra of 91 carboxylic acid amides, 6 thioamides, and 11 sulfonamides, as well as 30 carboxylic acid monohydrazides, and 3 sym. dihydrazides are given. The spectra were recorded by means of a Perkin-Elmer grating spectrophotometer, model 421, within the range 550-4000 cm.^-1 by using the KBr disk technique. Some of the amides and hydrazides prepared have not been described previously in the literature. M.ps. are given for all the compounds considered.

Acta Polytech. Scand., Chem. Met. Ser. published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, HPLC of Formula: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Jart, Aage published the artcileInfrared spectra of carboxylic acid derivatives. VI. Equivalent weight determination. Quantitative aspects of the pressed halide disk technique, Computed Properties of 2447-79-2, the publication is Acta Polytechnica Scandinavica, Chemistry Including Metallurgy Series (1974), 118 pp., database is CAplus.

Ir spectroscopic quant. equivalent weight measurements were made using the C:O band and other absorptions exhibited by the KBr pellets of amides and esters as well on the bands exhibited by the KBr pellets of S-benzylthiouronium salts. The sp. absorptions and intensity variations of 19 p-thiocyanatoanilides, 12 p-thiocyanatophenacyl esters, 12 p-thiocyanato-S-benzylthiouronium salts and 21 p-cyano-S-benzylthiouronium salts were examined The p-cyano-S-benzylthiouronium salts were models for the study of internal standards, the relation between band intensity and the nature of the matrix, and to the interchange between the sample and the KBr, RbBr, CsBr, or TlBr matrixes. A quant. method for the determination of the equivalent weight of carboxylic acids in KBr based on lyophilization with HBr (extinction coefficient measured at 2233 cm-1) was also developed.

Acta Polytechnica Scandinavica, Chemistry Including Metallurgy Series published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Computed Properties of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics