Category: amides-buliding-blocks

Related Products of 16695-22-0, A common heterocyclic compound, 16695-22-0, name is (Tosylazanediyl)bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate), molecular formula is C25H29NO8S3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 50 ml three-neck bottle are sequentially added myricitrin in (509 mg, 1 . 6mmol), DMF (15 ml), K2CO3(276 mg, 2 . 0mmol), heating to 110 C, and then is slowly dripped N, N-bis [2 – (P-sulfonyloxy) ethyl]-P-toluene sulfonamide (454 mg, 0 . 8mmol) solution of DMF (15 ml), constant temperature 110 C reaction 3-5h (TLC tracking of the reaction, developing agent is petroleum ether (PE): ethyl acetate (EA): formic acid (HCOOH) =10:10:1, v/v), the reaction solution is poured into the acetic acid ethyl ester (30-60mL) in, filtered, concentrated under reduced pressure to get the crude product, the crude product by silica gel chromatography purification column or half preparation HPLC method, drying, HTEMY obtained compound (402 mg). The preparation method of this invention has the synthetic steps are simple, low cost, mild condition, and the like.

The synthetic route of 16695-22-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ningbo Institute of Technology, Zhejiang University; Gao, Kun; Wu, Yuechan; Chen, Jia; (9 pag.)(2016);,
Amide – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 121492-06-6, name: N-Boc-(2-Aminoethyl)-N-methylamine

EXAMPLE H-l 4 Example H-14 N-ethyl-N-(2-((4-(2-hvdroxypropan-2-yl)pyrinudin-2-yl)(methyl)aniino)ethyl)-2- isopropoxynicotinamide Step 1 : tert-butyl (2-(((benzyloxy)carbonyl)amino)ethyl)(methyl)carbamate (H-7) To a solution of tert-butyl (2-aminoethyl) (methyl)carbamate (5.0 g, 28.7 mmol) in THF (100 mL) was added NaHC03 (12.1 g, 143.5 mmol) at 0 C. The resulting mixture was stirred at the same temperature for 15 min. Cbz-Cl (5.9 g, 34.4 mmol) was added dropwise. The mixture was stirred at RT overnight, then filtered and the filtrate was concentrated in vacuo. The residue was purified by combiflash (10% EtOAc in petroleum ether) to give the title compound H-7. LRMS m/z (M+H) 309.1found, 309.4 required.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Boc-(2-Aminoethyl)-N-methylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KIM, Ronald; KUDUK, Scott, D.; LIVERTON, Nigel; ZHUO, Gang; (116 pag.)WO2016/100161; (2016); A1;,
Amide – Wikipedia,
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Some common heterocyclic compound, 1092522-02-5, name is tert-Butyl (4-aminophenyl)(methyl)carbamate, molecular formula is C12H18N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C12H18N2O2

General procedure: HBTU (1.82g, 3.59mmol), DIPEA (0.84mL, 4.80mmol) and monomethyl suberate (0.93mL, 5.28mmol) were added to a solution of 34 (1.0g, 4.80mmol) in DMF (10mL) and the mixture was stirred for 12hat rt. Then the reaction was quenched with H2O and extracted using EtOAc, dried over MgSO4 and passed through a filter column to give corresponding ester which was dissolved in the minimum amount of dioxane. H2O with pH adjusted to 3 using 3N HCl was added and the reaction mixture was stirred at reflux overnight to yield the corresponding free amine. The reaction was basified and extracted using EtOAc, then dried, concentrated and passed through a filter column to give the free amine. To a solution of this free amine (1.0g, 3.59mmol) in DMF (10mL) was added HBTU (1.36g, 3.59mmol), DIPEA (0.66mL, 3.59mmol) and 1,4-dibenzyloxy-5-isopropyl benzoic acid (0.76g, 4.31mmol) and the solution was stirred for 12hat 80C. The reaction mixture was quenched with H2O and extracted with EtOAc (25mL¡Á3). The combined organic layer was collected, dried over anhydrous MgSO4 and concentrated under reduced pressure to give a light yellow residue, which was purified by silica gel chromatography (EtOAc:n-hexane=1: 1) to give 42 as a colorless liquid in 65% yield (overall from 34)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1092522-02-5, its application will become more common.

Reference:
Article; Mehndiratta, Samir; Lin, Mei-Hsiang; Wu, Yi-Wen; Chen, Chun-Han; Wu, Tung-Yun; Chuang, Kuo-Hsiang; Chao, Min-Wu; Chen, Yi-Ying; Pan, Shiow-Lin; Chen, Mei-Chuan; Liou, Jing-Ping; European Journal of Medicinal Chemistry; vol. 185; (2020);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 21744-84-3,Some common heterocyclic compound, 21744-84-3, name is 4-Methyl-2H-1,4-Benzoxazin-3-one, molecular formula is C9H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a cooled solution of 2H-1,4-benzoxazin-3(4H)-one (11.93 g, 80 mmol) in N,N-dimethylformamide (120 ml) was added sodium hydride (60% dispersion in mineral oil, 3.2 g, 80 mmol) in portions between 0 C. and 5 C. (1 h).The mixture was stirred 1 h at 0 C. To the cooled mixture was added ethyl iodide (13.7 g, 88 mmol) dropwise. The ice bath was removed and the mixture was stirred at r.t. for 17 h. The mixture was poured on water and extracted twice with AcOEt. The organic layers were washed with brine and water, dried (MgSO4) and concentrated. The crude product was purified by column chromatography (silica gel, heptane/AcOEt 9:1) to give the title compound (13.3 g) as colorless oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Methyl-2H-1,4-Benzoxazin-3-one, its application will become more common.

Reference:
Patent; Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius; US2010/249124; (2010); A1;,
Amide – Wikipedia,
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Application of 97-35-8,Some common heterocyclic compound, 97-35-8, name is 3-Amino-N,N-diethyl-4-methoxybenzenesulfonamide, molecular formula is C11H18N2O3S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 Production of 3-amino-N,N-diethyl-4-hydroxybenzenesulfonamide 3-Amino-N,N-diethyl-4-methoxybenzenesulfonamide (5 g) was dissolved in methylene chloride (150 mL). Under ice-cooling, boron tribromide (1.0 M methylene chloride solution, 38.7 mL) was added dropwise, and the mixture was stirred overnight at room temperature. Water (150 mL) was added dropwise to the reaction mixture under ice-cooling, and the aqueous layer was washed with chloroform. The obtained aqueous layer was weak acidified with 4N aqueous sodium hydroxide under ice-cooling. The precipitated solid was collected by filtration to give the title compound (4.0344 g) as a pale-beige solid.

The synthetic route of 97-35-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Japan Tobacco Inc.; US2008/64871; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 138-41-0, name is Carzenide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 138-41-0, Application In Synthesis of Carzenide

Tolylsulfonamide 10 (1.00mM) was first converted to 4-aminosulfonyl benzoic acid by refluxing its aqueous suspension with KMnO4 (3.00mM) to generate the corresponding carboxylic acid followed by refluxing its methanolic solution firstly in acidic condition and then in excess of hydrazine hydrate.37 Yield 74%, lit. mp: 230-232C, Obs. mp: 228-230C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Carzenide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sitaram; Celik, Gulsah; Khloya, Poonam; Vullo, Daniela; Supuran, Claudiu T.; Sharma, Pawan K.; Bioorganic and Medicinal Chemistry; vol. 22; 6; (2014); p. 1873 – 1882;,
Amide – Wikipedia,
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Reference of 54616-47-6, A common heterocyclic compound, 54616-47-6, name is 2-Bromo-N,N-dimethylbenzamide, molecular formula is C9H10BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of 1 (0.23 g, 1.0 mmol) in THF (6 mL) at -78C was added n-BuLi (1.6 M in hexane; 1.0 mmol) dropwise. After 15 min, PhNCS(0.14 g, 1.0 mmol) was added and stirring was continued for an additional 5 min before addition of saturated aqueous NH4Cl (15 mL). The mixture was extracted with AcOEt (3 ¡Á 10 mL), and the combined extracts were washed with brine (10 mL), dried (Na2SO4) and concentrated by evaporation

The synthetic route of 54616-47-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kobayashi, Kazuhiro; Shigemura, Yuuho; Fujiwara, Daiki; Heterocycles; vol. 94; 6; (2017); p. 1152 – 1158;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 35303-76-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35303-76-5 as follows.

4-(2-aminoethyl)benzenesulfonamide (0.86 mmol) was added to a THF solution (20 ml) of 1- (3-isocyanatopropyl) -4-methoxybenzene Gt; min. & Lt; / RTI & gt; The reaction mixture was stirred at 40-45¡ã C for 24 hours. The next day, TLC was used to confirm the termination of the reaction. The solvent was distilled off and ammonium chloride (100 ml), 1N HCl solution (50 ml) and ethyl acetate (100 ml) were added to the remaining residue. The organic layer was washed with brine and dried over sodium sulfate. The solvent was distilled off and the residue was adsorbed onto silica gel using methylene chloride. The title compound was then separated and purified by column chromatography using ethyl acetate and hexane

According to the analysis of related databases, 35303-76-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHUNGNAM NATIONAL UNIVERSITY INDUSTRY & ACADEMIC COOPERATION (IAC); JUNG, SANG HUN; WOO, SUN HEE; KIM, SANG KYUM; JEON, EUN SEOK; LEE, YOU JUNG; MANICKAM, MANOJ; JALANI HITESHKUMAR, HITESHKUMAR; SHARMA, NITI; (234 pag.)KR2015/111825; (2015); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 120157-97-3, name is N-Boc-2-(4-Bromophenyl)ethylamine, molecular formula is C13H18BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: amides-buliding-blocks

(0937) [00331] Into a 100-mL round-bottom flask, purged and maintained under an inert atmosphere of nitrogen, was added fe/t~buty (4~bromophenethyl)carbarnate (4.00 g, 13.3 mmol) dissolved in anhydrous toluene (50-mL). To the resulting solution was added benzyl piperazine-1- carboxylate (3.53 g, 16.0 mmol), Pd(OAc)2 (0.300 g, 1.34 mmol), XPhos (1.28 g, 2.69 mmol), and CS2CO3 (13.1 g, 40.0 mmol). The reaction mixture was stirred overnight at 105 C in an oil bath and then cooled to RT and quenched with H2O (200 mL). The resulting mixture was extracted with ethyl acetate (2 x 50 mL). The combined organic layers were washed with brine (1 x 200 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The resulting crude product was purified by FCC eluting with ethyl acetate/petroleum ether (PE/EA=3: 1) to afford benzyl 4-(4-(2-((feri-butoxycarbonyl)amino)ethyl)phenyl) piperazine-1- carboxylate as a yellow solid (5 g, 85%), LCMS (ESI, m/z): 440 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 120157-97-3, its application will become more common.

Reference:
Patent; FORMA THERAPEUTICS, INC.; GUERIN, David Joseph; BAIR, Kenneth W.; CARAVELLA, Justin A.; IOANNIDIS, Stephanos; LANCIA JR., David R.; LI, Hongbin; MISCHKE, Steven; NG, Pui Yee; RICHARD, David; SCHILLER, Shawn E. R.; SHELEKHIN, Tatiana; WANG, Zhongguo; (365 pag.)WO2017/139778; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

These common heterocyclic compound, 366-49-4, name is 2-Acetamido-4-fluorotoluene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-Acetamido-4-fluorotoluene

To a stirred solution of DMF (3 mL) at 00C was added phosphorus oxychloride (12 mL, 126 mmol) over 30 minutes, keeping the internal temperature below 7C. N-(5- Fluoro-2-methylphenyl)acetamide (2 g, 12 mmol) was added to the solution and heated to 85C overnight. The reaction was cooled to room temperature and added dropwise to water (50 mL). The precipitate was collected by filtration, washed with water and dried in the vacuum oven to give the title compound (274 mg, 10%) as a yellow solid. 5H (CDCl3) 10.58 (s, IH), 9.01 (s, IH), 7.60-7.70 (m, IH), 7.15-7.25 (m, IH), 2.75 (s, 3H).

The synthetic route of 2-Acetamido-4-fluorotoluene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UCB PHARMA S.A.; WO2009/81105; (2009); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics