Category: amides-buliding-blocks

Spagnolo, Piero published the artcileOne-pot preparation of isomeric acetyl- and 2,2,2-trifluoroacetylazidothiophenes by selective bifunctionalization of dibromothiophenes via halogen-lithio exchange, COA of Formula: C6H10F3NO, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1996), 963-964, database is CAplus.

A series of isomeric acetyl- (I, R = H) and 2,2,2-trifluoroacetylazidothiophenes (I, R = F) are prepared from 2,3-, 3,4-, and 2,5-dibromothiophenes via a one-pot procedure entailing stepwise halogen-lithium exchange and successive reaction of the resulting thienyllithium derivatives with tosyl azide and either N,N-dimethylacetamide or N,N-diethyl-2,2,2-trifluoroacetamide.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C7H6BF3O2S, COA of Formula: C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Lu, Xiao-Wei published the artcileModulating the hybridization property of PNA with a peptoid-like side chain, Quality Control of 186046-83-3, the publication is Organic Letters (2009), 11(11), 2329-2332, database is CAplus and MEDLINE.

Modification on the γ-N of the PNA backbone yielded a PNA analog with a peptoid-like side chain. We found that the length of the side chain was important in influencing the hybridization affinity of the modified PNA.

Organic Letters published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Quality Control of 186046-83-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yilmaz, Sakir published the artcileBentonite grafted with poly(N-acryloylglycineamide) brush: A novel clay-polymer brush hybrid material for the effective removal of Hg(II) and As(V) from aqueous environments, Name: N-(2-Amino-2-oxoethyl)acrylamide, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2021), 125979, database is CAplus.

The present work was conducted to indicate bentonite grafted with poly(N-acryloylglycineamide) (PNAGA@BNT) could be applied as a novel clay-polymer brush hybrid material for the removal of Hg(II) and As(V) from aqueous environments. The PNAGA@BNT synthesized via the surface initiated reversible addition fragmentation chain transfer (SI-RAFT) polymerization method was characterized by BET anal., Fourier transform IR spectrometry (FTIR), X-ray diffraction (XRD), XPS, SEM (SEM) and water contact angle measurements. Hg(II)% and As(V)% removal onto PNAGA@BNT was carried out with response surface methodol. (RSM). The effects of the operating parameters, like pH, heavy metal ion concentration (Co), PNAGA@BNT amount, and mixing time were evaluated by central composite design (CCD). The optimum Hg(II) adsorption conditions from the CCD were found to be 6.54, 24.46 mg/L, 23.98 mg, and 106.83 min for pH, Co, PNAGA@BNT dosage, and mixing time, resp. On the other hand, the optimum points obtained for As(V) adsorption from CCD were 4.36, 7.30 mg/L, 25.75 mg, and 83.37 min for pH, Co, PNAGA@BNT dosage, and mixing time, in their given order. At the optimal points obtained for Hg(II) and As(V) adsorption, the maximum Hg(II)% and As(V)% removal efficiencies were 98.58% and 90.95%, resp. The kinetic models with best fit were the pseudo-second-order kinetic model for Hg(II) and As(V) and Weber-Morris intraparticle diffusion was the dominant mechanism for As(V) and Hg(II). Among the isotherms, the equilibrium data best fit the Langmuir and Freundlich models for Hg(II), and the Dubinin-Radushkevich (D-R) and Freundlich models for As(V). Moreover, thermodn. studies suggested the adsorption process was exothermic and spontaneous.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 2479-62-1. 2479-62-1 belongs to amides-buliding-blocks, auxiliary class Monomers,Acrylamide Monomers, name is N-(2-Amino-2-oxoethyl)acrylamide, and the molecular formula is C24H29N5O3, Name: N-(2-Amino-2-oxoethyl)acrylamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liu, Qianqian published the artcileSH2 Domain-Containing Phosphatase 2 Inhibition Attenuates Osteoarthritis by Maintaining Homeostasis of Cartilage Metabolism via the Docking Protein 1/Uridine Phosphorylase 1/Uridine Cascade, Product Details of C17H14F3N3O2S, the publication is Arthritis & Rheumatology (2022), 74(3), 462-474, database is CAplus and MEDLINE.

Protein tyrosine kinases regulate osteoarthritis (OA) progression by activating a series of signal transduction pathways. However, the roles of protein tyrosine phosphatases (PTPs) in OA remain obscure. This study was undertaken to identify specific PTPs involved in OA and investigate their underlying mechanisms. The expression of 107 PTP genes in human OA cartilage was analyzed based on a single-cell sequencing data set. The enzyme activity of the PTP SH2 domain-containing phosphatase 2 (SHP-2) was detected in primary chondrocytes after interleukin-1β (IL-1β) treatment and in human OA cartilage. Mice subjected to destabilization of the medial meniscus (DMM) and IL-1β-stimulated mouse primary chondrocytes were treated with an SHP-2 inhibitor or celecoxib (a drug used for the clin. treatment of OA). The function of SHP-2 in OA pathogenesis was further verified in Aggrecan-CreERT;SHP2flox/flox mice. The downstream protein expression profile and dephosphorylated substrate of SHP-2 were examined by tandem mass tag labeling-based global proteomic anal. and stable isotope labeling with amino acids in cell culture-labeled tyrosine phosphoproteomic anal., resp. SHP-2 enzyme activity significantly increased in human OA samples with serious articular cartilage injury and in IL-1β-stimulated mouse chondrocytes. Pharmacol. inhibition or genetic deletion of SHP-2 ameliorated OA progression. SHP-2 inhibitors dramatically reduced the expression of cartilage degradation-related genes and simultaneously promoted the expression of cartilage synthesis-related genes. Mechanistically, SHP-2 inhibition suppressed the dephosphorylation of docking protein 1 and subsequently reduced the expression of uridine phosphorylase 1 and increased the uridine level, thereby contributing to the homeostasis of cartilage metabolism Conclusion : SHP-2 is a novel accelerator of the imbalance in cartilage homeostasis. Specific inhibition of SHP-2 may ameliorate OA by maintaining the anabolic-catabolic balance.

Arthritis & Rheumatology published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, Product Details of C17H14F3N3O2S.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Fellah, Noalle published the artcileHighly Polymorphous Nicotinamide and Isonicotinamide: Solution versus Melt Crystallization, Name: Isonicotinamide, the publication is Crystal Growth & Design (2021), 21(8), 4713-4724, database is CAplus.

The crystallization of nicotinamide (NA) and its constitutional isomer, isonicotinamide (INA), is compared. NA formed eight polymorphs from the melt and two from solution, whereas INA formed two polymorphs from the melt and six from solution This anal. was provoked by the observation that NA is highly polymorphic from the melt, while the closely related INA is highly polymorphous from solution A combination of hot stage polarized light microscopy, powder X-ray diffraction, and Raman spectroscopy revealed that the polymorph selectivities are not related to supramol. self-association in the growth media. The larger estimated free energy gap separating NA polymorphs, compared with that of the INA polymorphs, is consistent with the smaller number of NA polymorphs generated from solution Phenomenol. analyses of crystallization kinetics suggest that cross nucleation is the most likely reason more polymorphs of NA than INA crystallize from the melt.

Crystal Growth & Design published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Name: Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wu, Yueming published the artcileLithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides, Application of H-Lys(Boc)-OH, the publication is Nature Communications (2018), 9(1), 5297, database is CAplus and MEDLINE.

Polypeptides have broad applications and can be prepared via ring-opening polymerization of α-amino acid N-carboxyanhydrides (NCAs). Conventional initiators, such as primary amines, give slow NCA polymerization, which requires multiple days to reach completion and can result in substantial side reactions, especially for very reactive NCAs. Moreover, current NCA polymerizations are very sensitive to moisture and must typically be conducted in a glove box. Here we show that lithium hexamethyldisilazide (LiHMDS) initiates an extremely rapid NCA polymerization process that is completed within minutes or hours and can be conducted in an open vessel. Polypeptides with variable chain length (DP = 20-1294) and narrow mol. weight distribution (Mw/Mn = 1.08-1.28) were readily prepared with this approach. Mechanistic studies support an anionic ring opening polymerization mechanism. This living NCA polymerization method allowed rapid synthesis of polypeptide libraries for high-throughput functional screening.

Nature Communications published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C10H18O, Application of H-Lys(Boc)-OH.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bonaga, Llorente V. R. published the artcileCobalt-mediated cyclotrimerization of bis-alkynes and cyanamides, Application of N,N-Dibenzylcyanamide, the publication is Chemical Communications (Cambridge, United Kingdom) (2004), 2394-2395, database is CAplus and MEDLINE.

CpCo(CO)₂-mediated cyclotrimerization of bis-alkynes and cyanamides provides multi-substituted (amino)pyridines, including macrocyclic products, in 50% yield. For example, the dicarbonyl(η⁵-cyclopentadienyl)cobaltate(1-)-catalyzed cyclotrimerization of di(2-propynyl)propanedioic acid di-Me ester (I) with 1-pyrrolidinecarbonitrile (II) gave (pyrrolidinyl)cyclopenta[c]pyridine-6,6-dicarboxylic acid (III).

Chemical Communications (Cambridge, United Kingdom) published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Application of N,N-Dibenzylcyanamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Jin, Guohua published the artcileCelecoxib Reverse Invasion and Metastasis of Gastric Cancer through Lnc_AC006548.28-miR-223-LAMC2 Pathway., Quality Control of 169590-42-5, the publication is Computational intelligence and neuroscience (2022), 6140727, database is MEDLINE.

Celecoxib, a specific cyclooxygenase-2 (COX-2) inhibitor, is a traditional nonsteroidal antipyretic analgesic and anti-inflammatory drug commonly used in clinic, which has inhibitory effect on colorectal cancer, gastric cancer, and other malignant tumors. This study showed that Celecoxib could significantly reverse the invasion and metastasis of gastric cancer and improved the pathological changes due to GC. We collected the clinical specimens to analyze the correlation between the expression of Lnc_AC006548.28, miR-223, and LAMC2. In the mouse model, Celecoxib can slowdown the growth of GC tumor and the occurrence of this effect may depend on Lnc_AC006548.28-miR-223-LAMC2 pathway, in vitro transfection, RT-PCR, western blot, CCK8, small chamber assay, flow cytometry, and immunohistochemistry to retest the protective effect of celecoxib. Our results showed that Celecoxib could reverse invasion and metastasis of gastric cancer through Lnc_AC006548.28-miR-223-LAMC2 pathway.

Computational intelligence and neuroscience published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, Quality Control of 169590-42-5.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liu, Zhendong published the artcileThe regulating effect of Tibet Opuntia ficus-indica (Linn.) Mill. polysaccharides on the intestinal flora of cyclophosphamide-induced immunocompromised mice, Product Details of C17H14F3N3O2S, the publication is International Journal of Biological Macromolecules (2022), 570-579, database is CAplus and MEDLINE.

The stem of Opuntia species, a traditional medicinal plant, is widely used as food and functional raw material because of its rich polysaccharide content. There have been many studies on the immune function of polysaccharides from Opuntia stem, but only few have examined this function with respect to intestinal microbes. In this study, the effects of different concentrations of Opuntia stem polysaccharides on the immunity and intestinal microflora of cyclophosphamide (CTX)-induced immunocompromised mice were explored. The results showed that Tibet Opuntia ficus-indica (Linn.) Mill. polysaccharides (ODPs) could effectively increase the white blood cells (WBC) count index of mice and improve their thymus and spleen indexes, while effectively promoting the secretion of IL-4, IL-1β, TNF-α and IFN-γ, with these effects being dependent on the concentration of crude polysaccharides. The intake of ODPs significantly regulated the relative abundance of Lactobacillus, Bacteroides and Akkermansia, and the new dominant intestinal bacterial species were Deferribacteres, Actinomycetes, Firmicutes, Tenericutes, Actinomycetes and Pasteurella. In addition, the ODPs could effectively enhance the metabolic level of lysine synthesis and decomposition, regulate the gene expression level after immune disorders, and enhance the overall health of the immunodeficient mice.

International Journal of Biological Macromolecules published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, Product Details of C17H14F3N3O2S.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wei, Jie published the artcileThe COX-2-PGE2 pathway promotes tumor evasion in colorectal adenomas, Quality Control of 169590-42-5, the publication is Cancer Prevention Research (2022), 15(5), 285-296, database is CAplus and MEDLINE.

The mechanisms underlying the regulation of a checkpoint receptor, PD-1, in tumor-infiltrating immune cells during the development of colorectal cancer are not fully understood. Here we demonstrate that COX-2-derived PGE2, an inflammatory mediator and tumor promoter, induces PD-1 expression by enhancing NFκB’s binding to the PD-1 promoter via an EP4-PI3K-Akt signaling pathway in both CD8+ T cells and macrophages. Moreover, PGE2 suppresses CD8+ T-cell proliferation and cytotoxicity against tumor cells and impairs macrophage phagocytosis of cancer cells via an EP4-PI3K-Akt-NFκB-PD-1 signaling pathway. In contrast, inhibiting the COX-2-PGE2-EP4 pathway increases intestinal CD8+ T-cell activation and proliferation and enhances intestinal macrophage phagocytosis of carcinoma cells accompanied by reduction of PD-1 expression in intestinal CD8+ T cells and macrophages in ApcMin/+ mice. PD-1 expression correlates well with COX-2 levels in human colorectal cancer specimens. Both elevated PD-1 and COX-2 are associated with poorer overall survival in patients with colorectal cancer. Our results uncover a novel role of PGE2 in tumor immune evasion. They may provide the rationale for developing new therapeutic approaches to subvert this process by targeting immune checkpoint pathways using EP4 antagonists. In addition, our findings reveal a novel mechanism explaining how NSAIDs reduce colorectal cancer risk by suppressing tumor immune evasion.

Cancer Prevention Research published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C28H29NO4, Quality Control of 169590-42-5.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics