Application of 75178-90-4

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl (5-hydroxypentyl)carbamate, its application will become more common.

Reference of 75178-90-4,Some common heterocyclic compound, 75178-90-4, name is tert-Butyl (5-hydroxypentyl)carbamate, molecular formula is C10H21NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred mixture of tert-butyl 5-hydroxypentylcarbamate (2)(9.8 g, 48.2 mmol) and triethyl amine (13.44 mL, 96.0 mmol) in DCM (85 mL) at-10 oC was added methanesulfonyl chloride (4.5 mL, 57.9 mmol) in adropwise fashion and the resulting solution was stirred at the same temperaturefor 3h. The reaction was quenched with the addition of water (5 mL). Theorganic phase was washed with water, brine, dried over MgSO4,filtered and evaporated under reduced pressure to afford the title compound asyellow oil (13.16g, 97%). The product was directly taken to next step withoutany further purification. 1H NMR(CDCl3) d 4.22 (t, 2H, J = 6.42 Hz), 3.09 (m, 2H), 1.82 (m, 4H), 1.56-1.40(m, 11H). 13C NMR (75 MHz, CDCl3) d 155.8, 79.3, 70.0,41.8, 37.9, 29.8, 28.3, 22.5. IR: 2981, 1707, 1516, 1354, 1171 cm-1. MS m/z (ESI) 304.26 (M +Na+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl (5-hydroxypentyl)carbamate, its application will become more common.

Reference:
Article; Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 9; (2013); p. 2808 – 2811;,
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The important role of 154350-29-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Cyclopropanesulfonamide, its application will become more common.

Application of 154350-29-5,Some common heterocyclic compound, 154350-29-5, name is Cyclopropanesulfonamide, molecular formula is C3H7NO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of (22E)-3-oxo-4,6,22-cholatrien-24-oic acid (2.00 g, 5.43 mmol) in CH2CI2(40 mL) was added EDCI (1.69 g, 10.9 mmol) and DMAP (1.33 g, 10.9 mmol).Cyclopropane sulfonamide (1.97 g, 16.3 mmol) was added and the reaction was stirred at room temperature for 22 h. Water (25 mL) was added and the layers were separated. The aqueous layer was extracted with CH2CI2 (2 x 25 mL) and the combined organics were washed with 2 M aq HCI (20 mL), 10percent aq. NaCI (10 mL), dried over sodium sulfate andconcentrated under reduced pressure. The residue was purified by column chromatography on silica gel (0-10percent acetone in toluene) to give the desired product (1.68 g, 66percent) asan off-white solid. OH (400 MHz, CDCI3); 8.90 (1H, s, NH), 6.95 (1H, dd, J15.5,9.0, 023-OH), 6.11 (2H, brs, 06-OH and 07-OH), 5.86 (1H, dd, J15.5, 0.5, 022-OH), 5.68 (1H, s, 04-OH), 3.00 (1H, dddd, J 12.8, 9.5, 8.1, 4.8, SO2OH), 2.64 (1H, ddd, J 18.1, 14.4,5.4, O2OHaHb), 2.51-2.41 (1H, m, 02-OHaHb), 2.40-2.28 (1H, m), 2.25-2.15 (1H, m), 2.09-1.96 (2H, m), 1.85-1.64 (3H, m), 1.63-1.52 (1H, m), 1.51-1.17 (9H, m), 1.17-1.07 (5H, m),1.12 (3H, s, 019-OH3), 0.80 (3H, s, 018-OH3); 00 (100 MHz, 0D013); 200.0, 164.2, 164.1,155.5, 141.3, 127.9, 123.6, 119.4,54.7, 53.2, 50.6, 43.8, 39.8, 39.3, 37.8, 36.1, 33.9, 33.9,31.5, 28.1, 23.7, 20.6, 19.1, 16.3, 12.2, 6.3, 6.3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Cyclopropanesulfonamide, its application will become more common.

Reference:
Patent; NZP UK LIMITED; WEYMOUTH-WILSON, Alexander Charles; KOMSTA, Zofia; WALLIS, Laura; EVANS, Timothy; (139 pag.)WO2017/199036; (2017); A1;,
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Introduction of a new synthetic route about 117009-97-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Benzyl 1,4-diazepane-1-carboxylate, its application will become more common.

Application of 117009-97-9,Some common heterocyclic compound, 117009-97-9, name is Benzyl 1,4-diazepane-1-carboxylate, molecular formula is C13H18N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound BB-18-3 (1.8g crude) was dissolved in dilute hydrochloric acid (6M, 40mL) was stirred until uniform, slowly under nitrogenwas added dropwise sodium nitrite solution (2N, 17mL), then stirred at room temperature for 1 hour, 50mL of water was added, extracted with ethyl acetate(60mL ¡Á 3).The combined organic phases with saturated brine (20 mL), dried over anhydrous sodium sulfate, the solvent was removed under reduced pressure to give the titlecompound BB-18-4 (2g crude) was used directly in the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Benzyl 1,4-diazepane-1-carboxylate, its application will become more common.

Reference:
Patent; Changzhou Yin Sheng Pharmaceutical Co., Ltd.; Sichuan University; Zhang, Yang; Fu, Zhifei; Li, Jian; Chen, Shuhui; Wei, Yuquan; Tao, Xin; (65 pag.)CN105732602; (2016); A;,
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Extended knowledge of 640-61-9

The chemical industry reduces the impact on the environment during synthesis N,4-Dimethylbenzenesulfonamide. I believe this compound will play a more active role in future production and life.

Electric Literature of 640-61-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 640-61-9, name is N,4-Dimethylbenzenesulfonamide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a resealable Schlenk tube was added Fe3O4SiO2-P-AuOTf (66 mg, 0.025 mmol). The reaction tubewas evacuated and back-filled with argon and this evacuation/back-fillprocedure was repeated one additional time. Alkynylcyclopropane(0.5 mmol), sulfonamide (0.6 mmol) and DCE (5 mL) were then addedunder a stream of argon. The reaction tube was quickly sealed and thecontents were stirred while heating in an oil bath at 100 C for 24 h. After thereaction mixture was cooled to room temperature, the supported goldcatalyst was magnetically separated and the reaction mixture wasconcentrated under vacuum and then purified by flash chromatography(petroleum ether/ethyl acetate = 7:1) to afford the corresponding product.The recovered gold catalyst was washed with DCE (2 2 mL), air-dried andused directly for the next run.

The chemical industry reduces the impact on the environment during synthesis N,4-Dimethylbenzenesulfonamide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Yi, Feiyan; Huang, Bin; Nie, Quan; Cai, Mingzhong; Tetrahedron Letters; vol. 57; 39; (2016); p. 4405 – 4410;,
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The important role of 13304-62-6

According to the analysis of related databases, 13304-62-6, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13304-62-6, name is N-Benzylacrylamide, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 13304-62-6

A mixture of 11-iodo-7,12-dihydropyrido[2?,3?:2,3]azepino[4,5-b]indol-6(5H)-one (11 b, 200mg, 0.530mmol), N-benzylacrylamide (95mg, 0.59mmol), triethylamine (101mg, 1.00mmol, 0.14mL), and Pd(OAc)2 (7mg, 0.03mmol) in DMF (3 mL) was heated for 40 min to 100 C in a sealed microwave reaction vial by means of a mono mode microwave device (100 W, 150 PSI, CEM Discover, CEM GmbH, Kamp-Lintfort, Germany). After cooling to room temperature the mixture was filtered through a charcoal frit. Upon addition of ethyl acetate (220 mL) to the filtrate a precipitate formed, which was filtered off and was washed on the frit with n-hexane (320 mL). In the combined washing layers more precipitate formed, which was also filtered off. The combined precipitates were crystallized from ethanol to yield a brown solid (49.0 mg, 22.7%); dec. starting at 226 C; IR (KBr): 3423 (NH), 2918 (CH aliphat.), 1655 (C=O), 1441, 1350 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 11.95 (s, 1H), 10.38 (s, 1H), 8.64 (t, 1H, 3JH,H = 6.0 Hz), 8.44 (dd, 1H, 3JH,H = 4.7 Hz, 4JH,H = 1.7 Hz), 8.36 (dd, 1H, 3JH,H = 7.9Hz, 4JH,H = 1.8 Hz), 8.23 (d, 1H, 3JH,H = 15.5 Hz), 7.95 (s, 1H), 7.75 (dd, 1H, 3JH,H= 7.8 Hz, 4JH,H = 0.9 Hz), 7.59 – 7.45 (m, 1H), 7.44 – 7.30 (m, 4H), 7.32 – 7.20 (m, 1H), 7.22 – 7.09 (m, 1H), 6.86 (d, 1H, 3JH,H = 15.6 Hz), 4.46 (d, 2H, 3JH,H = 5.9Hz), 3.63 (s, 2H); 13C NMR (100.6 MHz, DMSO-d6): delta = 171.4, 165.2, 162.3, 147.7, 139.4, 136.6, 131.2, 127.4, 117.6, 108.4 (quat C); 147.6, 136.3, 134.5, 128.3 (2C), 127.4 (2C), 126.8, 122.1, 119.5, 119.5, 119.3, 119.0 (tert C); 42.3, 35.7 (sec C); C25H20N4O2 (408.45); MS (EI): m/z = 408 ([M]+, 95), 301 (52), 274 ([C17H12N3O]+, 21), 259 (100); HRMS (EI): m/z ([M]+) calcd. 408.15808, found 408.15883; HPLC: 96.8% at 254 nm, 97.1% at 280 nm, tN = 6.4 min, tM = 1.09 min (ACN/H2O; 40:60), max = 269, 338 nm.

According to the analysis of related databases, 13304-62-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Maiwald, Franziska; Benitez, Diego; Charquero, Diego; Dar, Mahin Abad; Erdmann, Hanna; Preu, Lutz; Koch, Oliver; Hoelscher, Christoph; Loaec, Nadege; Meijer, Laurent; Comini, Marcelo A.; Kunick, Conrad; European Journal of Medicinal Chemistry; vol. 83; (2014); p. 274 – 283;,
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Sources of common compounds: 207405-68-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 207405-68-3, its application will become more common.

Some common heterocyclic compound, 207405-68-3, name is tert-Butyl endo-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate, molecular formula is C12H22N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C12H22N2O2

step 2-A mixture of 68b (2 mmol) and 80 (2 mmol) in n-BuOH was heated in a sealed tube at 160 C. for 6 h. When no starting material was detected by TLC, the reaction was cooled to RT and concentrated in vacuo. The crude product 82a was used in the next step without further purification

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 207405-68-3, its application will become more common.

Reference:
Patent; Roche Palo Alto LLC; US2008/146595; (2008); A1;,
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Continuously updated synthesis method about 811442-84-9

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 811442-84-9.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 811442-84-9, name is tert-Butyl (14-amino-3,6,9,12-tetraoxatetradecyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows., name: tert-Butyl (14-amino-3,6,9,12-tetraoxatetradecyl)carbamate

200 mg (0.594 mmol) of tert-butyl (14-amino-3,6,9,12-tetraoxatetradec-1-yl)carbamate, 111 mg (0.713 mmol) of (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid and 410 mul (2.4 mmol) of N,N-diisopropylethylamine were dissolved in 6 ml of dimethylformamide, and 339 mg (0.892 mmol) of HATU were added. The reaction mixture was stirred at RT for 1 h and purified directly by preparative RP-HPLC (column: Reprosil 250¡Á30; 10mu, flow rate: 50 ml/min, MeCN/water, 0.1% TFA). The solvents were evaporated under reduced pressure and the residue was dried under high vacuum. This gave 130 mg (43% of theory) of tert-butyl [17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]carbamate. LC-MS (Method 1): Rt=0.71 min; MS (ESIpos): m/z=474 (M+H)+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 811442-84-9.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; MARX, Leo; JOHANNES, Sarah Anna Liesa; STELTE-LUDWIG, Beatrix; DIETZ, Lisa; TERJUNG, Carsten; MAHLERT, Christoph; GREVEN, Simone; SOMMER, Anette; BERNDT, Sandra; (481 pag.)US2019/77752; (2019); A1;,
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Brief introduction of 49805-30-3

The synthetic route of 49805-30-3 has been constantly updated, and we look forward to future research findings.

Reference of 49805-30-3,Some common heterocyclic compound, 49805-30-3, name is 2-Azabicyclo[2.2.1]hept-5-en-3-one, molecular formula is C6H7NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1.6. Preparation of a (+-)-1-amino-4-(hydroxymethyl)-2-cyclopentene in an alcohol/ether mixture A 10 ml round-bottom flask was charged under at inert-gas atmosphere with 0.5 g (4.6 mmol) of (+-)-2-azabicyclo[2.2.1]hept-5-en-3-one and 0.59 g (18.4 mmol) of methanol in 7.5 ml of dioxane (abs.). 0.21 g (9.2 mmol) of lithium borohydride were added, and the mixture was heated for 4 h at 60 C. The mixture was then cooled to 5 C. using an ice/waterbath, and about 10 ml of semi-concentrated HCl was carefully added to the reaction mixture (vigorous reaction, gas evolution), as a result of which a yellowish clear solution formed. This solution was analyzed directly by a quantitative ion-chromatographic method It contained 0.60 mmol (13.1%) of (+-)-2-azabicyclo[2.2.1]hept-5-en-3-one (determined as HCl salt of the corresponding amino acid, which is the acidic hydrolysis product of (+-)-2-azabicyclo-[2.2.1]hept-5-en-3-one) and 3.06 mmol of product, corresponding to a yield of 66.8%, aminoalcohol

The synthetic route of 49805-30-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Lonza AG; US2002/10360; (2002); A1;,
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Research on new synthetic routes about 115643-59-9

The synthetic route of 115643-59-9 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115643-59-9, name is 2-Amino-6-fluorobenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 2-Amino-6-fluorobenzamide

Step 1 To a solution of 2-amino-6-fluorobenzamide (3.80 g, 24.7 mmol) and triethylamine (2.99 g, 29.6 mmol) in THF (50 mL) was added dropwise ethyl chloroglyoxylate (3.70 g, 27.1 mmol) under ice-cooling, and the mixture was stirred at room temperature for 3 hr. The mixture was partitioned between ethyl acetate and water, and the organic layer was washed with saturated brine, dried over sodium sulfate, and concentrated under reduced pressure. The residue was suspended in ethanol, and the insoluble material was collected by filtration to give ethyl ((2-(aminocarbonyl)-3-fluorophenyl)amino)(oxo)acetate as a white powder (4.95 g, 79%).

The synthetic route of 115643-59-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1953148; (2008); A1;,
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Extracurricular laboratory: Synthetic route of 177906-48-8

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, trans-N-Boc-1,4-cyclohexanediamine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 177906-48-8, The chemical industry reduces the impact on the environment during synthesis 177906-48-8, name is trans-N-Boc-1,4-cyclohexanediamine, I believe this compound will play a more active role in future production and life.

Method E The reaction mixture of Core C (1.00 eq) and amine n (4.00 eq) in DMSO (8 mL) was stirred at 160 C for 3 h. The reaction mixture was cooled to rt and poured onto ice-H20 (20 mL). The aqueous layer was extracted with EA (50 mL*3). The combined organic layers were washed with brine (50 mL*3), dried over Na2S04, filtered and concentrated. The residue was purified by column chromatography to give A-n. Step 1: Compound 27_2 was made according to the procedure descibed in method E with amine-27 (1.0 eq) and DIEA (10 eq) at 160C for 6 h and it was obtained as a yellow solid after purification by prep HPLC (TFA). Yield: 41.1% NMR (CDCb, 400 MHz) delta 8.18 (d, / = 5.2 Hz, 1H), 7.83 (s, 1H), 6.71 (d, / = 5.6 Hz, 1H), 4.87 (s, 1H), 4.41 (s, 1H), 3.89 – 3.82 (m, 4H), 3.49 (s, 1H), 3.19 (d, / = 6.3 Hz, 2H), 2.19 – 2.05 (m, 4H), 1.46 (s, 9H), 1.35 – 1.29 (m, 7H), 1.26 (m, 2H), 1.23 (m, 2H), 0.50 – 0.46 (m, 2H), 0.26 – 0.24 (m, 2H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, trans-N-Boc-1,4-cyclohexanediamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD; BEN NERIAH, Yinon; BRACHYA, Guy; BURSTAIN, Ido; MINZEL, Waleed; SNIR-ALKALAY, Irit; VACCA, Joseph; LI, Dansu; (129 pag.)WO2017/21969; (2017); A1;,
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