Category: amides-buliding-blocks

Super electron donors derived from diboron was written by Zhang, Li;Jiao, Lei. And the article was included in Chemical Science in 2018.SDS of cas: 116332-61-7 This article mentions the following:

Single-electron transfer is an important process in organic chem., in which a single-electron reductant (electron donor) acts as a key component. Compared with metal-based electron donors, organic electron donors have some unique advantages, such as tunable reduction ability and mild reaction conditions. The development of novel organic electron donors with good reduction ability together with ease of preparation is in high demand. Based on the pyridine-catalyzed radical borylation reaction developed in authors laboratory, they have discovered that, the reaction system consisting of a diboron(4) compound, methoxide and a pyridine derivative could smoothly produce super electron donors in situ. Two boryl-pyridine based species, the major one being a trans-2H,2’H-[2,2′-bipyridine]-1,1′-diide borate complex and the minor one being a pyridine radical anion-borate complex, were observed and carefully characterized. These complexes were organic super electron donors unprecedented in literature, and their formation mechanisms were studied by DFT calculations The diboron/methoxide/pyridine system enables the preparation of organic super electron donors from easily accessible starting materials under mild conditions, which has the potential to be a general and practical single-electron reducing agent in organic synthesis. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7SDS of cas: 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.SDS of cas: 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Antipyretic activity of new salicylate and gentisate derivatives was written by Preziosi, P.. And the article was included in Bollettino – Societa Italiana di Biologia Sperimentale in 1953.Synthetic Route of C11H15NO2 This article mentions the following:

Salicylic hydrazide, acetylsalicylic hydrazide, N,N-diethylsalicylamide, gentisamide, ο-ethoxybenzamide, salicylamide, diacetylgentisic acid, and ο-(diethylaminoethoxy)benzamide were tested for antipyretic activity on rabbits. Fever was induced by intravenous injection of pyrogen and the material being tested was introduced peritoneally. Results show decreasing activity of the materials in the order listed. All of the compounds with the exception of the last 2 produced a temperature drop within 3-4 hours. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Synthetic Route of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Synthetic Route of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chemical analysis and potential endocrine activities of aluminium coatings intended to be in contact with cosmetic water was written by Bou-Maroun, Elias;Dahbi, Laurence;Gomez-Berrada, Marie-Pierre;Pierre, Philippine;Rakotomalala, Sandrine;Ferret, Pierre-Jacques;Chagnon, Marie-Christine. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2017.Related Products of 2387-23-7 This article mentions the following:

The objective of the work was to check the presence of Non-Intended Added Substances (NIAS) with hormonal activities in aluminum coatings extracts coded: AA, BBF, MC and RR, furnished by four different suppliers. Water samples were prepared at room temperature or at 40° for three months to verify the storage effect on the coatings. Solid phase extraction was used to concentrate and to extract coating substances. Hormonal activities were checked in vitro using reporter gene bioassays. Except BBF, all extracts induced a weak but significant estrogenic agonist activity in the human cell line. Using an estrogenic antagonist (ICI-182, 780), the answer was demonstrated specific in the bioassay. RR was the only extract to induce a concentration dependent anti-androgenic response in the MDA-KB2 cell line. Anal. performed using GC-MS and HPLC-MS detected 12 substances in most of the extracts 8 NIAS were present. Among them, 4 were identified with certainty: HMBT, BGA, DCU and BPA. Estrogenic potency was BPA > DCU > BGA > HMBT. HMBT was also anti-androgenic at high concentration Combining chem. anal. and bioassays data, the authors demonstrated that in the RR and the RR40 extracts, the observed estrogenic response was mainly due to BPA, the anti-androgenic activity of RR could be due to a synergism between HMBT and BPA. For MC and AA, estrogenic responses appear to be due to the presence of DCU. Except BBF, storage conditions tended to increase estrogenic activities in all extracts However, in term of risk assessment, activities observed were negligible. This work demonstrated that sensitive bioassays are pertinent tools in complement to chem. anal. to monitor and check the presence of NIAS with hormonal activity in coating extracts In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Related Products of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Related Products of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Analysis of procarbazine and metabolites by gas chromatography-mass spectrometry was written by Gorsen, Robert M.;Weiss, A. J.;Manthei, R. W.. And the article was included in Journal of Chromatography, Biomedical Applications in 1980.Product Details of 13255-50-0 This article mentions the following:

Procarbazine-HCl (I) [366-70-1], and several metabolites, and an internal standard were analyzed by gas chromatog.-mass spectrometry on a 3% OV-1 column. Procarbazine and 4 metabolites were derivatized with acetic anhydride. A sensitive, specific and quant. assay was established by selected ion monitoring using a synthetic analog of the drug as an internal standard The limits of detection were approx. 1 ng/mL of plasma while the limits of quantitation were 10 ng/mL of plasma. Studies on the degradation of procarbazine-HCl in 0.05 M phosphate buffer (pH 7.4) were compared to in vivo studies. At 1 h after incubation of procarbazine-HCl in buffer, the azo and aldehyde metabolites were detected in the highest concentrations representing 27.2% and 20.3% of total drug and metabolites. In the in vivo studies, analyses of rat plasmas indicated that 1 h after an oral dose of procarbazine-HCl the aldehyde metabolite [13255-50-0] represented 72% of the total drug and metabolites, and that relatively little of the azo metabolite was present. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Product Details of 13255-50-0).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Product Details of 13255-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of Difluoromethyl Ketones from Weinreb Amides, and Tandem Addition/Cyclization of o-Alkynylaryl Weinreb Amides was written by Phetcharawetch, Jongkonporn;Betterley, Nolan M.;Soorukram, Darunee;Pohmakotr, Manat;Reutrakul, Vichai;Kuhakarn, Chutima. And the article was included in European Journal of Organic Chemistry in 2017.Related Products of 192436-83-2 This article mentions the following:

[Difluoro(phenylsulfanyl)methyl]trimethylsilane (PhSCF₂SiMe₃) underwent a fluoride-induced nucleophilic addition to the carbonyl group of Weinreb amides to provide the corresponding difluoro(phenylsulfanyl)methyl ketones I (R = Ph, 3-MeOC₆H₄, 2-BrC₆H₄, cyclohexyl, n-heptyl, etc.). These were converted into difluoromethyl ketones through selective reductive cleavage of the phenylsulfanyl group. The reaction of o-alkynyl Weinreb amides derived from benzoic acid derivatives resulted in the formation of cyclized products II (R = Ph, 4-MeOC₆H₄, 4-BrC₆H₄, etc.) through a 5-exo-dig cyclization. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Related Products of 192436-83-2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 192436-83-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Au^I-Catalyzed Direct Hydroamination/Hydroarylation and Double Hydroamination of Terminal Alkynes was written by Patil, Nitin T.;Lakshmi, Pediredla G. V. V.;Singh, Vipender. And the article was included in European Journal of Organic Chemistry in 2010.Reference of 54166-95-9 This article mentions the following:

An efficient method for formal Markownikoff hydroamination/hydroarylation and double hydroamination of terminal alkynes has been developed. For example, treatment of terminal alkynes with amino aromatics or diamines in the presence of 2-5 mol-% of Ph₃PAuNTf₂ in toluene at 100 °C gave the corresponding products in excellent yields. The method was shown to be applicable to a broad range of substrates and, more importantly, unlike our previously reported method, a tethered hydroxy group in the alkyne is not necessary. The mechanism of the reaction is also discussed. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Reference of 54166-95-9).

6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Reference of 54166-95-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Human health and ecological risk assessment of 98 pharmaceuticals and personal care products (PPCPs) detected in Indian surface and wastewaters was written by Sengar, Ashish;Vijayanandan, Arya. And the article was included in Science of the Total Environment in 2022.Formula: C23H28ClN3O5S This article mentions the following:

The release of pharmaceuticals and personal care products (PPCPs) in environmental waters has become an urgent issue due to their pseudo-persistent traits. The present study was undertaken to conduct a screening-level risk assessment of 98 PPCPs, detected in different water matrixes (treated wastewater, surface water, and groundwater) of India, for evaluating ecol. risk (risk to fish, daphnia, and algae), human health risk, and antimicrobial resistance (AMR) selection risk by following risk quotient (RQ) based methodol. In the present study, 47% of the detected PPCPs in Indian waters were found to exert a possible risk (RQ > 1) to either aquatic species and human health, or cause AMR selection risk. 17 out of 25 antibiotics detected in the environmental waters were found to pose a threat of AMR selection. 11 out of 49 pharmaceuticals were found to exert human health risk from ingesting contaminated surface water, whereas only 2 pharmaceuticals out of 25 were found to exert risk from the intake of groundwater. Very high RQs (>1000) for few pharmaceuticals were obtained, signifying a great potential of the detected PPCPs in causing severe health concern, aquatic toxicity, and AMR spread. Within India, special attention needs to be given to the pharmaceutical hubs, as the environmental waters in these regions were found to be severely contaminated with drug residues resulting in extremely high RQs. The present study will be helpful in prioritizing the detected PPCPs in the environmental waters of India, for which immediate attention and enforceable guidelines are required. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Formula: C23H28ClN3O5S).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Formula: C23H28ClN3O5S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Imino exchange reaction in a dearomatization strategy: synthesis of N-acyl diarylamines and phenothiazines from two anilines was written by Zhang, Li;Wang, Huiqing;Yang, Bo;Fan, Renhua. And the article was included in Organic Chemistry Frontiers in 2014.Quality Control of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide This article mentions the following:

N-Sulfonyl cyclohexadienimines generated from an iodine(III)-induced oxidative dearomatization of N-sulfonyl protected para-substituted anilines are ready to undergo an imino exchange reaction with another aniline, which provides an alternative way to access N-acyl diarylamines and phenothiazines. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Quality Control of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Quality Control of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of TAED/H₂O₂ system for low temperature bleaching of crude cellulose extracted from jute fiber was written by Wen, Zuoqiang;Zou, Linbo;Wang, Weiming. And the article was included in IOP Conference Series: Materials Science and Engineering in 2018.Category: amides-buliding-blocks This article mentions the following:

Tetraacetylethylenediamine (TAED) activated hydrogen peroxide system had been applied for bleaching of crude cellulose extracted from jute fiber. Comparing with conventional hydrogen peroxide bleaching system, those results showed that bleaching temperature and time could be effectively reduced, and a preferable whiteness could be produced under faint alk. condition. And the optimum conditions for activated bleaching system could be summarized as molar ratio of H₂O₂/TAED 1:0.7, pH 8, pure hydrogen peroxide 0.09 mol/L, temperature 70°C and time 60min. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Category: amides-buliding-blocks).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Study of self-association of benzenesulfonamides in carbon tetrachloride by the NMR method was written by Krasnogorskaya, N. N.;Shcherbakova, E. S.;Gur’yanova, E. N.;Gabdikeeva, A. R.;Poletaeva, M. G.. And the article was included in Zhurnal Prikladnoi Spektroskopii in 1989.Related Products of 5339-69-5 This article mentions the following:

Self-association of title compounds PhSO₂NHR (R = Bu, Me₂CH) in CCl₄ was studied by ¹H NMR. It occurs via intermol. NH···O hydrogen bonds. The degree of self-association increases with concentration and decreases with a rise in temperature Thermodn. parameters for associated mols. were determined In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Related Products of 5339-69-5).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Related Products of 5339-69-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics