Category: amides-buliding-blocks

Tang, Zheng published the artcileAltering elastic-plastic mechanical response of a series of isostructural metal-organic complexes crystals, Quality Control of 1453-82-3, the publication is Science China: Chemistry (2022), 65(4), 710-718, database is CAplus.

The mech. compliant single crystals have attracted massive attention. However, the related reports on the single crystals composed of metal-organic complexes remain scarce. In this study, we synthesized a series of isostructural single crystals of ZnII complexes that manifest mech. bending in response to external stress. In these crystals, the mech. responses can be shifted between elastic bending and plastic bending by the control of the intermol. interactions through a rational structural modification in the substituent group of pyridine ligands. As the mol. reorientation corresponding to ligand variation elongates the interfacial distance between mol. slip planes, and the structural disorder of ligands disperses the interplanar intermol. interactions, the shift from elastic bending to plastic bending of the metal-organic complex-based single crystal was realized. The different mech. responses of single crystals were comprehensively investigated both exptl. and theor.

Science China: Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C4H11NO, Quality Control of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liu, Juan published the artcileInfluence of Monomers’ Structure on the Assembly and Material Property of Pillar[5] arene-Based Supramolecular Polymer Gels, Formula: C6H6N2O, the publication is Chinese Journal of Chemistry (2021), 39(12), 3421-3428, database is CAplus.

Pillar[5]arene-based supramol. polymer gels (SPGs) show broad application prospects. To investigate the influence of the supramol. monomers’ structure on the assembly and properties of corresponding pillar[5]arene-based SPGs, a series of monomers based on different functionalized pillar[5]arene derivatives with various structures were synthesized. There are per-methylated pillar[5]arene (H1), bromobutane-functionalized pillar[5]arene (H2), 4-hydroxybenzaldehyde-functionalized pillar[5]arene (H3), Et thioglycolate-functionalized pillar[5]arene (H4), thioacetylhydrazine-functionalized pillar[5]arene (H5), bola-type bis-pillar[5]arene (H6) and tripodal-type tri-pillar[5]arene (H7). Meanwhile, a neutral tripodal-guest TG was also employed to co-assemble with these pillar[5]arene-based monomers by host-guest interactions. As a result, under the same conditions (10%, DMSO-H2O, w/v, 10 mg·mL-1 = 1%), H1 and H2 cannot assemble into SPGs with TG. Interestingly, mono-p[5] derivatives H3-H5 could assemble into SPGs with TG. More importantly, bis-p[5] H6 and tri-p[5] H7 could assemble into supramol. polymer network gel (SPNG) and supramol. polymer organic framework gel (SOFG) with TG, resp. These gels all show blue aggregation-induced emission (AIE) properties. Among these SPGs, the SPNG shows the best viscoelastic behavior and self-healing properties. The result is attributed to the flexible network structure of SPNGs. In addition, the xerogels of SOFG and SPNG have shown nice adsorption and separation properties for organic dyes in water solution

Chinese Journal of Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Formula: C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Li, Yin published the artcileTemperature-Dependent Terahertz Spectra of Isonicotinamide in the Form I Studied Using the Quasi-Harmonic Approximation, Related Products of amides-buliding-blocks, the publication is ChemPhysChem (2022), 23(6), e202100849, database is CAplus and MEDLINE.

Anharmonicity of mol. vibrational motions is closely associated with the thermal property of crystals. However, the origin of anharmonicity is still not fully understood. Low-frequency vibrations, which are usually defined in the terahertz (THz) range, show excellent sensitivity to anharmonicity. In this work, anharmonicity of isonicotinamide in the form I was investigated by using temperature-dependent terahertz time-domain spectroscopy and the quasi-harmonic approximation (QHA) approach at PBE-D3 and PBE-MBD levels. Both DFT calculations suggest the variation of π-π stacking conformation dominates in the thermal expansion of the unit cell. Frequency shifts of the modes in THz range obtained by QHA approach are found to be qual. consistent with exptl. observations, demonstrating QHA approach is a useful tool for the interpretation of frequency shifts of modes induced by temperature

ChemPhysChem published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Karikalan, Natarajan published the artcileSimultaneous in-situ extraction and electrochemical detection of antidepressant drug imipramine and its active metabolite in human biofluid samples, COA of Formula: C17H14F3N3O2S, the publication is Sensors and Actuators, B: Chemical (2022), 131960, database is CAplus.

The rapidly advancing modern healthcare system necessitates the development of cutting-edge technologies for therapeutic drug monitoring. Protein-bound drugs challenge the rapid quantification of anal. methods that require addnl. separation and cleanup processes, which delay the development of point-of-care testing platform. Here, a human serum albumin (HSA)/iron molybdate (FeM;Fe2(MoO4)3)/reduced graphene oxide (rGO) is reported for the in-situ extraction and determination of imipramine (IMP) drug and its active metabolite desipramine (DMP) in human serum and plasma samples. HSA was used for the extraction of drugs from the complex plasma proteins, and the extracted drugs were directly detected by FeM/rGO without addnl. sample cleanup. The developed sensor, which was optimized for the drug therapeutic window under normal conditions, exhibited a linear range of 10-756 ng/mL as well as a remarkable limit of detection and sensitivity of approx. 4 ± 2 ng/mL and 0.0124 ± 0.0003μA cm-2 ng-1 mL, resp., for IMP-DMP. The spike-and-recovery method was used to validate the developed sensor in real sample anal. Based on the results, the sensing mechanism was elucidated: protein-protein interaction facilitates drug transportation from the plasma protein to electrode surface. Thereby, the HSA-FeM/rGO modified electrode recovered more drugs in biofluids compared with HSA unmodified electrode.

Sensors and Actuators, B: Chemical published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, COA of Formula: C17H14F3N3O2S.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bose, D. Subhas published the artcileA simple method for the synthesis of nitriles from primary amides under neutral conditions, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Synthetic Communications (1999), 29(23), 4235-4239, database is CAplus.

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) is a very useful reagent for the preparation of nitriles in good yields under neutral conditions. For example, dehydration of 2,4-dimethoxybenzamide gave 2,4-dimethoxybenzonitrile. Elimination reaction of 4-chlorobenzenecarbothioamide gave 4-chlorobenzonitrile.

Synthetic Communications published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sivasubramanian, Rama published the artcileThe Bioequivalence Between Valsartan Oral Solution and Suspension Formulations Developed for Pediatric Use, Application of (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid, the publication is Clinical Pharmacology in Drug Development (2022), 11(7), 843-848, database is CAplus and MEDLINE.

The bioequivalence of valsartan 160 mg oral solution compared to suspension was assessed in a single-dose, open-label, randomized, 2-period, 2-way crossover study in 82 healthy adults. The participants were randomly assigned (1:1) to receive a single dose of the solution or suspension formulation in each of the two treatment periods. Serial blood samples for pharmacokinetic evaluation were collected up to 48 h post-dose. The pharmacokinetic parameters were estimated by noncompartmental methods and analyzed as per bioequivalence criteria of statistical anal. The peak plasma concentration of valsartan was reached with median time of 1 and 3 h with solution and suspension formulation, resp. Compared to suspension formulation, the mean peak plasma concentration with solution formulation was higher by 32(90CI, 1.27-1.38) while the geometric mean ratios (1.09) and the associated 90CIs (1.05-1.13) of both the areas under the concentration time-curves (from time zero to the last quantifiable concentration and from time zero to infinity) were contained in the required range of 0.80 to 1.25. No new safety signals were observed with either of the formulations.

Clinical Pharmacology in Drug Development published new progress about 137862-53-4. 137862-53-4 belongs to amides-buliding-blocks, auxiliary class GPCR/G Protein,Angiotensin Receptor, name is (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid, and the molecular formula is C18H10, Application of (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Baran, Nicole published the artcilePesticides in groundwater at a national scale (France): Impact of regulations, molecular properties, uses, hydrogeology and climatic conditions, Computed Properties of 79-07-2, the publication is Science of the Total Environment (2021), 148137, database is CAplus and MEDLINE.

Contaminants in groundwater are a major issue worldwide. Temporal trends of such occurrences in French groundwaters were evaluated for several active substances of pesticides belonging to different chem. classes, to identify key factors explaining groundwater contamination. Our study relied on exploitation of a French national database (ADES, created in the mid-1990s and remarkable for the available data, including over 88 million analyses). Temporal changes in the frequency of exceeding a reference value of 0.1μg/L for several substances were determined at yearly and monthly scales. Such trends were examined by distinguishing different periods according to changes in regulations (new approval, withdrawal, or dose reduction), and were combined with data on effective rainfall as a proxy for groundwater recharge, on aquifer lithol., and on sales of active substances as a proxy for actual applications. A review of monthly data shows that a rapid transfer of pesticides with contrasting physico-chem. properties can occur after application in many aquifers, regardless of their lithol. For substances such as metolachlor, showing a sharp increase in sales, a clear relationship exists between quantities sold and frequency of exceeding the reference value. For other active substances, such as isoproturon or chlortoluron, frequencies of exceedance are governed by both sales and effective rainfall. Finally, the occurrence of active substances in groundwater several years after their withdrawal from the market is explained by at least three major mechanisms: the transfer time from soil into groundwater, processes of remobilization from soil and/or unsaturated zone, and no or low degradation in the saturated zone. While these processes are well documented for atrazine and different types of aquifers, they can be virtually unknown for other active substances.

Science of the Total Environment published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Computed Properties of 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Marchlewski, L. published the artcileAbsorption of ultra-violet light by some organic substances. XXIX, Formula: C10H14N2O, the publication is Bulletin International de l’Academie Polonaise des Sciences et des Lettres, Classe des Sciences Mathematiques et Naturelles, Serie A: Sciences Mathematiques (1933), 95-8, database is CAplus.

The α, β and γ isomers of C₅H₄NCONEt₂ in aqueous solution give similar absorption spectra in the ultra-violet, but the spectra are quite different from that of C₅H₅N (cf. C. A. 23, 5405). Each shows one absorption band with maximum and min. as follows: α isomer, maximum at 2625 A. U., min. at 2455 A. U.; β isomer, maximum at 2615 A. U., min. at 2475 A. U.; γ isomer, maximum at 2580 A. U., min. at 2430 A. U.

Bulletin International de l’Academie Polonaise des Sciences et des Lettres, Classe des Sciences Mathematiques et Naturelles, Serie A: Sciences Mathematiques published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Formula: C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yavorskii, N. P. published the artcileComplexes of cadmium thiocyanate and bromide with nitrogen-containing drugs, Formula: C10H14N2O, the publication is Farmatsiya (Moscow, Russian Federation) (1970), 19(2), 49-53, database is CAplus.

A study of complex formation of Cd thiocyanate (I) and CdBr2 with N-containing bases is presented. Piperazine, isoniazid, and amidopyridine form complexes XCd(CNS)2 (X = base) with I, with hexamethylenetetramine X.2Cd(CNS)2, and with nicotine X2.Cd(CNS)2.2HCNS. With CdBr2, complexes of the type X.CdBr2.2HBr are obtained with N-containing bases. The formed complexes with I and with CdBr2 are poorly H2O soluble The reaction sensitivity for I ranges from 5 to 40,000 γ/ml, and for CdBr2 from 10 to 30,000 γ/ml of the investigated bases. Complexes of preparations used in the form of salts have a common composition

Farmatsiya (Moscow, Russian Federation) published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C30H24BrCuN2P, Formula: C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sato, Yuki published the artcileInvolvement of cholesterol membrane transporter Niemann-Pick C1-like 1 in the intestinal absorption of lutein, Quality Control of 321673-30-7, the publication is Journal of Pharmacy & Pharmaceutical Sciences (2012), 15(2), 256-264, database is CAplus and MEDLINE.

Purpose: Lutein is a carotenoid mainly found in green leafy vegetables and is located in the macula lutea in the human eye. Since humans cannot synthesize lutein de novo, it must be digested as food. The physiol. importance of an orally administered compound depends on its interaction with target tissues. It is therefore important to clarify the absorption mechanism in the intestine. Cholesterol membrane transporters Niemann-Pick C1 Like 1 (NPC1L1) and scavenger receptor class B type 1 (SR-B1) are involved in the intestinal absorption of highly lipophilic compounds including cholesterol. Ezetimibe, a selective inhibitor of intestinal NPC1L1, is the widespread lipid-lowering agent. It is important to investigate the possibility of food-drug interactions in order to prevent undesirable and harmful clin. consequences. The aim of this work was to determine whether NPC1L1, SR-B1 and other transporters are involved in absorption of lutein. Methods: Caco-2 cells were used for accumulation and permeability study of lutein. Lutein concentration was determined by an HPLC system. The cDNA of transporters was isolated from total RNA of Caco-2 cells and the expression of these transporters was confirmed by RT-PCR (reverse transcription – polymerase chain reaction). Results: Ezetimibe inhibited up to 40% of lutein accumulation by Caco-2 cell monolayers. Block lipid transport 1 (BLT-1), a selective chem. inhibitor of SR-B1, also inhibited lutein accumulation by Caco-2 cells. On the other hand, ATP-depletion reagents (sodium fluoride and sodium azide or carbonyl cyanide m-chlorophenylhydrazone) did not influence the accumulation or permeation of lutein significantly. Conclusions: The results show that lutein absorption is, at least in part, mediated by influx transporters NPC1L1 and SR-B1 rather than mediated by efflux transporters such as ABC (ATP-binding cassette) transporters.

Journal of Pharmacy & Pharmaceutical Sciences published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Quality Control of 321673-30-7.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics