Category: amides-buliding-blocks

Madadian, Edris published the artcileThermal degradation of emerging contaminants in municipal biosolids: The case of pharmaceuticals and personal care products, Quality Control of 137862-53-4, the publication is Chemosphere (2022), 303(Part_2), 135008, database is CAplus and MEDLINE.

The presence of emerging contaminants in water and wastewater resources is of ongoing concern for public health and safety. Pharmaceutical compounds are designed to be biol. active and therefore may have effects on nontarget organisms in terrestrial and aquatic environments, even at trace concentrations The presence of pharmaceutical and personal care products (PPCPs) in wastewater treatment plants is reported in various countries worldwide, mostly in the levels of nanograms to micrograms per L. The present study investigates the thermal degradation of municipal sewage sludge containing PPCPs at various heating rates. The examined characteristics of the samples include thermal decomposition behavior, volatile release characteristics, and pyrolytic product composition Thermal characterization of the PPCPs was conducted using differential scanning calorimetry. The gaseous products and typical functional groups of the released volatiles detected by Fourier-transform IR spectroscopy mainly contained CO₂, CO, small-chain hydrocarbons, and oxygen- and nitrogen-containing functional groups together with other species. In addition, the potential of bioenergy production was investigated as a spin-off opportunity during thermal degradation of biosolids. Study results showed that PPCP concentrations can be lowered significantly by thermal treatment of municipal biosolids. Antifungal/antibacterial agents together with opioids, in particular triclosan and tramadol, showed less resistance to thermal degradation while antibiotics could be more recalcitrant to heat treatment. The thermodn. results provide an important reference for future reactor design and the thermochem. treatment of biosolids as well as their conversion to value-added products.

Chemosphere published new progress about 137862-53-4. 137862-53-4 belongs to amides-buliding-blocks, auxiliary class GPCR/G Protein,Angiotensin Receptor, name is (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid, and the molecular formula is C24H29N5O3, Quality Control of 137862-53-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sattler, H. J. published the artcileStructure-activity relations in analeptics of nicethamide type. I. Diethylamides of homologs and vinylogs of nicotinic and isonicotinic acids, Computed Properties of 530-40-5, the publication is Arzneimittel-Forschung (1974), 24(5), 743-6, database is CAplus and MEDLINE.

The diethylamides I and II (bond in 3 or 4 position, Z = bond, CH2, CH2CH2, or CH:CH) were prepared and showed respiratory analeptic activities in rabbits. I were prepared in 68-76% yield by reaction of the corresponding pyridinecarboxylic acid with ClCO2Et and Et2NH. II were prepared by reaction of acetylpyridines with MeONa and HCO2Et and subsequently with Et2NH.

Arzneimittel-Forschung published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Computed Properties of 530-40-5.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sattler, Hans J. published the artcileNMR spectroscopy of heterocycles, 2. Ring alkylated and isomeric nicetamide derivatives, COA of Formula: C10H14N2O, the publication is Archiv der Pharmazie (Weinheim, Germany) (1976), 309(3), 222-8, database is CAplus and MEDLINE.

Barriers to amide group rotation (ΔG*) in I (R = H, Me; R1 = H, Me; R2 = H, CONEt2; R3 = H, Me), II, and III (R = H, Me, CONEt2) were determined via 1H NMR spectral data. The ΔG* values ranged from 14.9 to 17.5 kcal/mole.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, COA of Formula: C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zigeuner, G. published the artcileHeterocycles, part 51. Syntheses of 4-dialkylamino-5,6-dihydro-2(1H)-pyridinethiones and 4-alkylamino or 4-arylamino compounds, Related Products of amides-buliding-blocks, the publication is Monatshefte fuer Chemie (1976), 107(6), 1361-7, database is CAplus.

(Dialkylamino)dihydro-2(1H)-pyridinethiones I (R = Me or R2 = CH2CH2OCH2CH2) were prepared by heating the heterocycles II (X = NH, S) with dialkylformamides or by the reaction of secondary amines with thiazinthiones III (R1 = OH, morpholino), with MeCOCH2CMe2NHCSNR2 or with MeCOCH2CMe2N:C:S. A general method for the preparation of I is the reaction of R2NH.HNCS, R2NCSNH2, or dialkylammonium chlorides and KCNS with MeCOCH:CHMe or MeCOCH2CH2OH.

Monatshefte fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C7H16Cl2Si, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Holm, Regina published the artcileMultifunctional Cationic PeptoStars as siRNA Carrier: Influence of Architecture and Histidine Modification on Knockdown Potential, Product Details of C11H22N2O4, the publication is Macromolecular Bioscience (2020), 20(1), 1900152, database is CAplus and MEDLINE.

RNA interference provides enormous potential for the treatment of several diseases, including cancer. Nevertheless, successful therapies based on siRNA require overcoming various challenges, such as poor pharmacokinetic characteristics of the small RNA mol. and inefficient cytosolic accumulation. In this respect, the development of functional siRNA carrier systems is a major task in biomedical research. To provide such a desired system, the synthesis of 3-arm and 6-arm PeptoStars is aimed for. The different branched polypept(o)idic architectures share a stealth-like polysarcosine corona for efficient shielding and a multifunctional polylysine core, which can be independently varied in size and functionality for siRNA complexation-, transport and intra cellular release. The special feature of star-like polypept(o)ides is in their uniform small size (<20 nm) and a core-shell structure, which implies a high stability and stealth-like properties and thus, they may combine long circulation times and a deep penetration of cancerous tissue. Initial toxicity and complement studies demonstrate well tolerated cationic PeptoStars with high complexation capability toward siRNA (N/P ratio up to 3:1), which can lead to potent RNAi for optimized systems. Here, the synthetic development of 3-arm and 6-arm polypept(o)idic star polymers, their modification with endosomolytic moieties, and first in vitro insights on RNA interference are reported on.

Macromolecular Bioscience published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, Product Details of C11H22N2O4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Shreykar, Milind R. published the artcileResonance induced proton transfer leading to NIR emission in coumarin thiazole hybrid dyes: Synthesis and DFT insights, Application of Morpholine-4-carbothioamide, the publication is Tetrahedron Letters (2016), 57(37), 4174-4177, database is CAplus.

Two novel coumarin thiazole hybrid dyes (E)-2-(3-(2-(4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-morpholinothiazol-5-yl)vinyl)-5,5-dimethylcyclohex-2-en-1-ylidene)malononitrile (CSI) and (E)-2-(3-(2-(4-(4-methoxy-2-oxo-2H-chromen-3-yl)-2-morpholinothiazol-5-yl)vinyl)-5,5-dimethylcyclohex-2-en-1-ylidene)malononitrile (MeOCSI) were synthesized. CSI exhibits near IR emission with large Stokes shift. The dye CSI shows resonance induced excited state intramol. proton transfer (RI-ESIPT). DFT and TD-DFT calculations clearly support and define the finding.

Tetrahedron Letters published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C3H3Br2ClO, Application of Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tayade, Rajratna P. published the artcileNovel Thiazole Based Styryl Dyes with Benzimidazole Unit – Synthesis, Photophysical and TD-DFT Studies, COA of Formula: C5H10N2OS, the publication is Journal of Fluorescence (2017), 27(1), 167-180, database is CAplus and MEDLINE.

Three new Y-shaped styryl dyes were designed and synthesized from thiazole carbaldehyde with different active methylene compounds as acceptor moieties. All the dyes were characterized by IR, ¹HNMR, MS/LCMS/HRMS. Spectroscopic properties and non-linear optical properties styryl derivatives were analyzed and the effect of change in solvent polarity on their absorption and emissive properties has been investigated. The dye with (1-phenylethylidene) propanedinitrile unit shows red shift absorption/emission profile among all the dyes. D. Functional Theory and Time Dependent-D. Functional Theory computations have been used for comparative study with the exptl. data and also to understand the structural, mol., electronic and photophys. parameters of the styryl dyes. The computational method was also employed to investigate the nonlinear optical properties of the styryl dyes in different organic solvent. The unsubstituted benzimidazolyl thiazole styryl dyes possess good non-linear optical properties.

Journal of Fluorescence published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C6H12O2, COA of Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tayade, Rajratna P. published the artcileSynthesis of Novel Thiazole Based Carbaldehyde as Potential Sensor for Fluoride Anion and their Spectroscopic Properties, Safety of Morpholine-4-carbothioamide, the publication is Journal of Fluorescence (2017), 27(3), 1117-1128, database is CAplus and MEDLINE.

A novel thiazole based carbaldehyde bearing benzimidazole fluorophore as the receptor unit for F^– anion was prepared by multistep synthesis. D. functional theory was used to understand the structural and electronic properties of the receptor. The anion sensing activities of receptor I were studied for various anions in acetonitrile solvent. The receptor showed fluorescence enhancement in the presence of fluoride anion due to intramol. charge transfer (ICT) mechanism. No significant changes were observed upon addition of less basic anions such as OAc^–, Cl^–, Br^–, I^–, HSO₄^–. After the interaction of fluoride anion with the receptor I leads to an 88 nm red shift in emission maxima. [TBA]OH and ¹H NMR titration experiments indicated that deprotonation of N-H in the benzimidazole due to interaction with fluoride anions.

Journal of Fluorescence published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C10H10O2, Safety of Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Thorat, Kishor G. published the artcilePyrrole-thiazole based push-pull chromophores: An experimental and theoretical approach to structural, spectroscopic and NLO properties of the novel styryl dyes, Quality Control of 14294-10-1, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2017), 1-17, database is CAplus.

Novel push-pull fluorophores constituted by two donors (substituted pyrrole and morpholine) linked to acceptor through thiazole electron spacer have been synthesized. The fluorophores are investigated for linear and non-linear optical properties by UV-VIS absorption and fluorescence spectroscopies, and by means of TD-DFT (B3LYP/6-31G(d)) method, with the aim of elucidating the ability of the morpholine/pyrrole-donor-thiazole-spacer based D-π-A fluorophores as organic NLO materials. The bond length alternation and generalized Mulliken-Hush (GMH) anal. is performed to understand the involvement of the donor in effective transfer of the charge to acceptor. Values of first-order hyperpolarizabilities (β_CT or β₀), obtained by the solvatochromic method (Lippert Mataga model), and the transition dipole moments (μ_eg) used to characterize and evaluate the non-linear optical performances of the D-π-A fluorophores in various microenvironments. The D-π-A fluorophores possess good values of β_CT or β₀ in different organic solvents and hold high thermal stabilities therefore can be used as potential organic NLO materials.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C12H17NS2, Quality Control of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Anilkumar, Gopinadhan N. published the artcileII. Novel HCV NS5B polymerase inhibitors: discovery of indole C2 acyl sulfonamides, COA of Formula: C7H8FNO2S, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(1), 713-717, database is CAplus and MEDLINE.

Development of SAR at the C2 position of indole lead I, a palm site inhibitor of HCV NS5B polymerase (NS5B IC₅₀ = 0.053 μM, replicon EC₅₀ = 4.8 μM), is described. Initial screening identified an acyl sulfonamide moiety as an isostere for the C2 carboxylic acid group. Further SAR investigation resulted in identification of acyl sufonamide analog II (NS5B IC₅₀ = 0.039 μM, replicon EC₅₀ = 0.011 μM) with >100-fold improved replicon activity.

Bioorganic & Medicinal Chemistry Letters published new progress about 489-17-8. 489-17-8 belongs to amides-buliding-blocks, auxiliary class Fluoride,Sulfamide,Amine,Benzene, name is 4-Fluoro-2-methylbenzenesulfonamide, and the molecular formula is C7H8FNO2S, COA of Formula: C7H8FNO2S.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics