Category: amides-buliding-blocks

Shoair, Abdel Ghany F. published the artcileElectrochemical and catalytic properties of oxo-ruthenate(VI) in aqueous alkaline medium, HPLC of Formula: 1453-82-3, the publication is International Journal of Electrochemical Science (2021), 16(5), 210545, database is CAplus.

The complex K₂[Ru^(III)Cl₅(H₂O)] has been prepared and characterized by different spectroscopic techniques (IR and UV-VIS). The electrochem. properties of this complex were investigated at different pH′s using Robinson buffer solutions The cyclic voltammograms exhibited three redox different oxidation and potential peaks due to generation of Ru(III), Ru(IV), Ru(V) and Ru(VI) ions. The catalytic activity of K₂[Ru^(III)Cl₅(H₂O)] towards the hydration of some aromatic and three heterocyclic nitriles to their corresponding amides was investigated with excess of three co-oxidants K₂S₂O₈, NaOCl and KBrO₃. A number of factors have been investigated and the best yields were obtained with K₂S₂O₈ as a co-oxidant in a 1.0 M KOH at 80 °C. Both spectroscopic and electrochem. techniques were used to establish the nature of active species in this catalytic reaction and the active catalyst was found to be K₂[Ru^(VI)O₃(OH)₂], as well as to explain the possible reaction mechanism. The suggested mechanism included the coordination of nitrile to ruthenium center followed by liberation of the corresponding amide and the active complex again.

International Journal of Electrochemical Science published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C9H5ClO2, HPLC of Formula: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Fishwick, Colin W. G. published the artcileAn efficient route to S-N-(9-fluorenylmethyoxycarbonyl)-4′-(1-azi-2,2,2-trifluoroethyl)phenylalanine, Product Details of C6H10F3NO, the publication is Tetrahedron Letters (1994), 35(26), 4611-14, database is CAplus.

An extremely efficient synthesis of optically pure photoactivatable phenylalanine derivative I is described. The key step involves a highly diastereoselective alkylation of chiral glycine equivalent II with benzyl iodide III to give benzylated product IV.

Tetrahedron Letters published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Product Details of C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kalita, Gauravjyoti D. published the artcileBimetallic Au-Pd nanoparticles supported on silica with a tunable core@shell structure: enhanced catalytic activity of Pd(core)-Au(shell) over Au(core)-Pd(shell), Recommanded Product: Isonicotinamide, the publication is Nanoscale Advances (2021), 3(18), 5399-5416, database is CAplus.

A facile ligand-assisted approach of synthesizing bimetallic Au-Pd nanoparticles supported on silica with a tunable core@shell structure is presented. Maneuvering the addition sequence of metal salts, both Aucore-Pdshell (Au@Pd-SiO₂) and Pdcore-Aushell (Pd@Au-SiO₂) nanoparticles were synthesized. The structures and compositions of the core-shell materials were confirmed by probe-corrected HRTEM, TEM-EDX mapping, EDS line scanning, XPS, PXRD, BET, FE-SEM-EDX and ICP anal. The synergistic potentials of the core-shell materials were evaluated for two important reactions viz. hydrogenation of nitroarenes to anilines and hydration of nitriles to amides. In fact, in both the reactions, the Au-Pd materials exhibited superior performance over monometallic Au or Pd counterparts. Notably, among the two bimetallic materials, the one with Pd_core-Au_shell structure displayed superior activity over the Au_core-Pd_shell structure which could be attributed to the higher stability and uniform Au-Pd bimetallic interfaces in the former compared to the latter. Apart from enhanced synergism, high chemoselectivity in hydrogenation, wide functional group tolerance, high recyclability, etc. are other advantages of our system. A kinetic study has also been performed for the nitrile hydration reaction which demonstrates first order kinetics. Evaluation of rate constants along with a brief investigation on the Hammett parameters has also been presented.

Nanoscale Advances published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Recommanded Product: Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Matsumoto, Takuya published the artcileA catalytic one-step synthesis of peptide thioacids: the synthesis of leuprorelin via iterative peptide-fragment coupling reactions, Related Products of amides-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(86), 12222-12225, database is CAplus and MEDLINE.

A catalytic one-step synthesis of peptide thioacids was developed. The oxygen-sulfur atom exchange reaction converted the carboxy group at the C-terminus of the peptides into a thiocarboxy group with suppressed epimerization. This method was successfully applied to the synthesis of the peptide drug leuprorelin via an iterative fragment-coupling protocol.

Chemical Communications (Cambridge, United Kingdom) published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Telore, Rahul D. published the artcilePush-pull fluorophores with viscosity dependent and aggregation induced emissions insensitive to polarity, Product Details of C5H10N2OS, the publication is Dyes and Pigments (2015), 359-367, database is CAplus.

A series of push-pull chromophoric extended styryls from 5,5′-(9-ethyl-9H-carbazole-3,6-diyl)bis(2-morpholinothiazole-4-carbaldehyde) were synthesized by Knoevenagal condensation reaction with active methylene compounds The intermediate carbaldehyde was synthesized from carbazole through multistep reactions. The intramol. charge transfer of synthesized highly conjugated sym. D-π-A (D-donor, A-acceptor) extended styryls with rigid structure have been investigated by means of photophys. properties. The photophys. properties like absorption, emission and quantum yield of styryl derivatives were evaluated in various solvents of different polarities. All these synthesized extended styryls have exhibited aggregation induced emission with enhanced fluorescence intensity. This series of compounds can also be used as fluorescence mol. rotors for viscosity sensing. The sensitivity of viscosity towards UV absorption as well as fluorescence emission has also been investigated.

Dyes and Pigments published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10O, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rusu, Georgeta published the artcileAntibacterial activity of urotropin salts of the oxazolidine series, Product Details of C7H5Cl2NO, the publication is Revista Medico-Chirurgicala (1988), 92(1), 133-6, database is CAplus.

Six urotropin salts of the oxazolidine series (I; R = Ph, substituted Ph) were prepared and their antimicrobial properties were determined Good activity was evident against Staphylococcus aureus, Bacillus subtilis, and Candida albicans.

Revista Medico-Chirurgicala published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Product Details of C7H5Cl2NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Edwards, Paul T. published the artcileProton Transfer on the Edge of the Salt/Cocrystal Continuum: X-Ray Photoelectron Spectroscopy of Three Isonicotinamide Salts, Recommanded Product: Isonicotinamide, the publication is Crystal Growth & Design (2021), 21(11), 6332-6340, database is CAplus.

XPS has emerged as a technique that allows for characterization and classification of hydrogen bonding and proton transfer interactions in organic crystal structures, in a way that is complementary to crystallog. by X-ray or neutron diffraction. Here, we analyze the nitrogen 1s core-level binding energies (BEs) of isonicotinamide (IN) systems with proton transfer between donor and acceptor groups at short distances. We show how a careful calibration of the BE scale places these salt systems correctly on the edge of the so-called salt-cocrystal continuum. We show how performing a fitting anal. of the data that is consistent with elemental anal., expected stoichiometry, and quantification of adventitious carbon contamination facilitates the determination of absolute BEs with accuracy and reproducibility within ±0.1 eV. The determined N 1s core-level BEs of the protonated IN acceptors suggest that the local geometric arrangements of the donor, acceptor, and proton can influence the N 1s core-level BE significantly.

Crystal Growth & Design published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Recommanded Product: Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

De Marzo, Vincenzo published the artcileNetwork meta-analysis of medical therapy efficacy in more than 90,000 patients with heart failure and reduced ejection fraction, Name: (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid, the publication is Journal of Internal Medicine (2022), 292(2), 333-349, database is CAplus and MEDLINE.

Meta-anal. of Following the availability of new drugs for chronic heart failure (HF) with reduced ejection fraction (HFrEF), we sought to provide an updated and comparative synthesis of the evidence on HFrEF pharmacotherapy efficacy. We performed a Bayesian network meta-anal. of phase 2 and 3 randomized controlled trials (RCTs) of medical therapy in HFrEF patient cohorts with more than 90% of the participants with left ventricular ejection fraction less than 45% and all-cause mortality reported. Sixty-nine RCTs, accounting for 91,741 subjects, were evaluated. The step-wise introduction of new drugs progressively decreased the risk of all-cause death, up to reaching a random-effects hazard ratio (HR) of 0.43 (95% credible intervals [CrI] 0.27-0.63) with beta blockers (BB), angiotensin-converting enzyme inhibitors (ACEi), and mineralocorticoid receptor antagonist (MRA) vs. placebo. The risk was further reduced by adding sodium-glucose cotransporter-2 inhibitors (SGLT2i; HR 0.38, 95% CrI 0.22-0.60), ivabradine (HR 0.39, 95% CrI 0.21-0.64), or vericiguat (HR 0.40, 95% CrI 0.22-0.65) to neurohormonal inhibitors, and by angiotensin receptor-neprilysin inhibitor (ARNI), BB, and MRA (HR 0.36, 95% CrI 0.20-0.60). In a sensitivity anal. considering the ARNI and non-ARNI subgroups of SGLT2i RCTs, the combination SGLT2i + ARNI + BB + MRA was associated with the lowest HR (0.28, 95% CrI 0.16-0.45 vs. 0.40, 95% CrI 0.24-0.60 for SGLT2i + BB + ACEi + MRA). Consistent results were obtained in sensitivity analyses and by calculating surface under the cumulative ranking area, as well as for cardiovascular mortality (information available for 56 RCTs), HF hospitalization (45 RCTs), and all-cause hospitalization (26 RCTs). Combination medical therapy including neurohormonal inhibitors and newer drugs, especially ARNI and SGLT2i, confers the maximum benefit with regard to HFrEF prognosis.

Journal of Internal Medicine published new progress about 137862-53-4. 137862-53-4 belongs to amides-buliding-blocks, auxiliary class GPCR/G Protein,Angiotensin Receptor, name is (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid, and the molecular formula is C24H29N5O3, Name: (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Pensato, Soccorsa published the artcileγ-Hydroxymethyl PNAs: Synthesis, interaction with DNA and inhibition of protein/DNA interactions, Synthetic Route of 186046-83-3, the publication is Bioorganic Chemistry (2010), 38(5), 196-201, database is CAplus and MEDLINE.

The ability of peptide nucleic acids (PNAs) to interact with double-stranded DNA has been recently investigated. In a decoy approach these interactions are of great importance as may lead to inhibition of interactions of DNA sequences to specific transcription factors and may be employed as a strategy for the inhibition of gene transcription alternative to the antisense strategy (targeting transcription factors mRNAs) and the transcription factor decoy approach (targeting transcription factors). The ability of PNA and PNAs with modified monomers to bind to DNA and to interfere in the formation of DNA/transcription factor complex was explored. A procedure is reported for the synthesis of Fmoc-γ-hydroxymethyl PNA, and the synthesis and CD anal. of PNA oligomers containing the modified monomer in different positions, and EMSA assays are described to test the (a) binding to double-stranded DNA and (b) inhibition of DNA-protein interactions.

Bioorganic Chemistry published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Synthetic Route of 186046-83-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Younis, Osama published the artcileSolid-State Luminescent Materials Containing Both Indole and Pyrimidine Moieties: Design, Synthesis, and Density Functional Theory Calculations, Recommanded Product: 2-Chloroacetamide, the publication is ACS Omega (2022), 7(17), 15016-15026, database is CAplus and MEDLINE.

Heterocyclic compounds with effective solid-state luminescence offer a wide range of uses. It has been observed that combining pyrimidine and indole moieties in a single mol. can enhance material behavior dramatically. Here, different heterocyclic compounds with indole and pyrimidine moieties have been synthesized effectively, and their structures have been validated using NMR, IR, and mass spectroscopy. The photoluminescence behavior of two substances was investigated in powder form and solutions of varying concentrations After aggregation, one mol. displayed a red shifted luminescence spectrum, whereas another homolog showed a blueshift. Thus, d. functional theory calculations were carried out to establish that introducing a terminal group allows modifying of the luminescence behavior by altering the mol. packing. Because of the non-planarity, intermol. interactions, and tiny intermol. distances within the dimers, the materials demonstrated a good emission quantum yield (Φ_em) in the solid state (ex. 25.6%). At high temperatures, the compounds also demonstrated a stable emission characteristic.

ACS Omega published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C9H8BNO2, Recommanded Product: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics