Category: amides-buliding-blocks

Li, Dan published the artcileSynthesis and herbicidal activity of N-isoindoline-1,3-dione-substituted phenyl-N’-benzoyl ureas, Related Products of amides-buliding-blocks, the publication is Yingyong Huagong (2007), 36(6), 530-533, database is CAplus.

A method for the synthesis of the title compounds [i.e., N-[[[(halo)-5-(1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]amino]carbonyl]benzamide derivatives] is reported here. In search of safer and more efficiency herbicidal compounds, flumioxazin [i.e., 2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione] was chosen as lead compound and eleven N-isoindoline-1,3-dione-substituted phenyl-N’-benzoyl ureas were designed and synthesized. Their structures were confirmed by IR, NMR, LC/MC and elemental anal. A preliminary bioassay showed that most of these title compounds had better herbicidal activity than the lead compound Several compounds displayed more than 80% inhibition to broad-leaf weeds, such as Abutilon theophrasti, Chenopodium album L., Amaranthus ascendens L. at 75 g/hm².

Yingyong Huagong published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rasu, Loorthuraja published the artcileA Fortuitous, Mild Catalytic Carbon-Carbon Bond Hydrogenolysis by a Phosphine-Free Catalyst, Application of N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Australian Journal of Chemistry (2016), 69(5), 561-564, database is CAplus.

The putative catalyst trans-[Ru((S,S)-skewphos)(H)₂((R,R)-dpen)] (skewphos=2,4-bis(diphenylphosphino)pentane; dpen=1,2-diphenylethylenediamine) transforms the trifluoroacetyl amide 2,2,2-trifluoro-1-(piperidin-1-yl)ethanone under mild conditions (4 atm H₂, room temperature, 4-24h, 1 mol-% Ru, 15 mol-% KOtBu in tetrahydrofuran) to generate the formylated amine 1-formylpiperidine and fluoroform via C-C bond hydrogenolysis. Catalysts are also prepared by reacting cis-[Ru(η³-C₃H₅)(MeCN)₂(COD)]BF₄ (COD=1,5-cyclooctadiene) with diamine ligands in situ. Low-temperature NMR studies provided insight into this reaction.

Australian Journal of Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Application of N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Fischbach, Melanie published the artcileProtease Probes that Enable Excimer Signaling upon Scission, SDS of cas: 186046-83-3, the publication is Angewandte Chemie, International Edition (2014), 53(44), 11955-11959, database is CAplus and MEDLINE.

Peptide-based probes that fluoresce upon proteolytic cleavage are invaluable tools for monitoring protease activity. The read-out of protease activity through pyrene excimer signaling would be a valuable asset because the large Stokes shift and the long lifetime of the excimer emission facilitate measurements in autofluorescent media such as blood serum. However, proteolytic cleavage abolishes rather than installs the proximity relations required for excimer signaling. Herein, the authors introduce a new probe architecture to enable the switching on of pyrene excimer emission upon proteolytic scission. The method relies on hairpin-structured peptide nucleic acid (PNA)/peptide hybrids with pyrene units and anthraquinone-based quencher residues positioned in a zipper-like arrangement within the PNA stem. The excimer hairpin peptide beacons afforded up to a 50-fold enhancement of the pyrene excimer emission. Time-resolved measurements allowed the detection of matrix metalloprotease 7 in human blood serum.

Angewandte Chemie, International Edition published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, SDS of cas: 186046-83-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yadav, Suman published the artcileAerobic oxidation of primary amines to amides catalyzed by an annulated mesoionic carbene (MIC) stabilized Ru complex, Synthetic Route of 1453-82-3, the publication is Catalysis Science & Technology (2021), 11(21), 7018-7028, database is CAplus.

Catalytic aerobic oxidation of primary amines to the amides, using the precatalyst [Ru(COD)(L¹)Br₂] bearing an annulated π-conjugated imidazo[1,2-a][1,8]naphthyridine-based mesoionic carbene ligand L¹, was disclosed. This catalytic protocol was distinguished by its high activity and selectivity, wide substrate scope and modest reaction conditions. A variety of primary amines, RCH₂NH₂ (R = aliphatic, aromatic and heteroaromatic), were converted to the corresponding amides using ambient air as an oxidant in the presence of a sub-stoichiometric amount of KO^tBu in ^tBuOH. A set of control experiments, Hammett relationships, kinetic studies and DFT calculations were undertaken to divulge mechanistic details of the amine oxidation using [Ru(COD)(L¹)Br₂]. The catalytic reaction involveed abstraction of two amine protons and two benzylic hydrogen atoms of the metal-bound primary amine by the oxo and hydroxo ligands, resp. A β-hydride transfer step for the benzylic C-H bond cleavage was not supported by Hammett studies. The nitrile generated by the catalytic oxidation undergoes hydration to afford the amide as the final product.

Catalysis Science & Technology published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C11H15NOS, Synthetic Route of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Neumann, Wilhelm P. published the artcileSyntheses with the compounds R₃M-Hg-MR₃. Part XVII. N-Silyl and N-germylpyridinyl radicals and their stabilization reactions, Recommanded Product: N,N-Diethylisonicotinamide, the publication is Chemische Berichte (1979), 112(3), 936-49, database is CAplus.

The reactions of pyridines functionally substituted in the 2-, 3-, or 4-position with (Me₃Si)₂Hg (I) or (Me₃Ge)₂Hg are described. With I the initially formed N-silylpyridinyls yield mostly N,ω-bis(silyl) derivatives (e.g., II from N,N-diethyl-4-pyridinecarboxamide) and tetrahydro-4,4′- or -2,2′-bipyridines, depending on mesomeric and steric conditions. Pyridine 2- or 3-acyl derivatives yield O-silylated hydropyridoins (Me₃SiOCRR¹)₂ (R = 2-pyridyl, R¹ = H or Me; R = 3-pyridyl, R¹ = Ph). 2-Cyanopyridine forms a persistent N-silylpyridinyl. N-Germylpyridinyls are formed only for pyridines of low electron d. or in cases involving strong mesomeric stabilization. ESR data are given for most of the radicals.

Chemische Berichte published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Recommanded Product: N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hartmann, Horst published the artcileHeterocyclic dyes and precursors. XVII. Preparation and characterization of 1,1-disubstituted thioureas, Product Details of C5H10N2OS, the publication is Journal fuer Praktische Chemie (Leipzig) (1973), 315(1), 144-8, database is CAplus.

Reaction of RR1NH with R2CONCS (R2 = EtO or Ph) gave RR1NCSNHCOR2 (I), which were heated in concentrated HCl to give RR1NCSNH2 (II, R = Me, Et. Pr, Bu, PhCH2, or Ph; R1 = Me, Et, Pr, Bu, or PhCH2; RR1N = morpholino, piperidino, or 1-pyrrolidinyl).

Journal fuer Praktische Chemie (Leipzig) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Deal, Brooke published the artcileBehavioral and inflammatory sex differences revealed by celecoxib nanotherapeutic treatment of peripheral neuroinflammation, Name: 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, the publication is Scientific Reports (2022), 12(1), 8472, database is CAplus and MEDLINE.

Abstract: Neuropathic pain affects millions of people worldwide, yet the mol. mechanisms of how it develops and persists are poorly understood. Given that males have historically been utilized as the primary sex in preclin. studies, less is known about the female neuroinflammatory response to injury, formation of pain, or response to pain-relieving therapies. Macrophages contribute to the development of neuroinflammatory pain via the activation of their cyclooxygenase-2 (COX-2) enzyme, which leads to the production of prostaglandin E₂ (PGE₂). PGE₂ activates nociception and influences addnl. leukocyte infiltration. Attenuation of COX-2 activity decreases inflammatory pain, most commonly achieved by nonsteroidal anti-inflammatory drugs (NSAIDs), yet NSAIDs are considered ineffective for neuropathic pain due to off target toxicity. Using chronic constriction injury of the rat sciatic nerve, we show that males and females exhibit quant. the same degree of mech. allodynia post injury. Furthermore, a low-dose nanotherapeutic containing the NSAID celecoxib is phagocytosed by circulating monocytes that then naturally accumulate at sites of injury as macrophages. Using this nanotherapeutic, we show that treated males exhibit complete reversal of hypersensitivity, while the same dose of nanotherapeutic in females provides an attenuated relief. The difference in behavioral response to the nanotherapy is reflected in the reduction of infiltrating macrophages at the site of injury. The observations contained in this study reinforce the notion that female neuroinflammation is different than males.

Scientific Reports published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, Name: 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ongaro, Alberto published the artcileDesign and synthesis of a peptide derivative of ametantrone targeting the major groove of the d(GGCGCC)₂ palindromic sequence, Related Products of amides-buliding-blocks, the publication is New Journal of Chemistry (2020), 44(9), 3624-3631, database is CAplus.

In oncol., some DNA intercalating agents have been used in chemotherapy for years to eradicate cancer cells, but these drugs generally suffer from a lack of selectivity for malignant tissues and consequently induce major side-effects. We report herein the design and synthesis of an antitumor intercalating agent ametantrone complemented with two identical peptide arms including a central Lys residue in order to selectively target palindromic sequences of DNA of malignant cells. The peptide arms are linked to the ametantrone core through 1,2,3-triazole. According to our docking prediction, this compound should be double-stranded β-sheet structured, and it has been designed to interact with two guanine residues upstream from a central d(CpG)₂ intercalation site on each DNA strand, owing to the H-bonds involving the Lys terminal side chain ammonium group of the peptide arms. This new ametantrone derivative has been obtained thanks to a convergent synthetic pathway, whose key steps were double nucleophilic substitution performed on the ametantrone core, followed by “double-site” 1,3-dipolar cycloaddition affording the 1,4-disubstituted triazole linker almost quant. Preliminary binding assays performed by mass spectrometry proved its accuracy for DNA palindromic sequences. The cytotoxicity of this compound was evaluated on three cancer cell lines and one healthy cell line, and compared to that of mitoxantone, a dihydroxylated analog of ametantrone. Such a peptide derivative was about ten-fold less cytotoxic than mitoxantrone on these cancer cell lines, but about fifty times less cytotoxic on healthy cells. This study could open new avenues towards the design of targeted intercalating agents.

New Journal of Chemistry published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mameli, E. published the artcileAminolysis of ethylxanthogenamide, Related Products of amides-buliding-blocks, the publication is Atti ist. veneto sci., Classe sci. mat. e nat. (1952), 101-2, database is CAplus.

EtOCSNH₂ in H₂O-EtOH in the cold with pyrrolidine at pH 12-13 gave (CH₂)₄NCSNH₂, with piperidine at pH 13 (CH₂)₅NCSNH₂, at pH 11 EtOCSN(CH₂)₅ with morpholine at pH 13, O(C₂H₄)₂NCSNH₂, at pH 11 EtOCSN(C₂H₄)₂O + [O(C₂H₄)₂NC(:NH)NH₂]₂.H₂.

Atti ist. veneto sci., Classe sci. mat. e nat. published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mameli, E. published the artcileAminolysis of ethylxanthogenacetic acid, Formula: C5H10N2OS, the publication is Atti ist. veneto sci., Classe sci. mat. e nat (1952), 99-100, database is CAplus.

EtOCSSCH₂CO₂H gives with pyrrolidine 90% EtOCSN(CH₂)₄, with piperidine 90% EtOCSN(CH₂)₅, with sulfanilamide 70% EtOCSNHC₆H₄SO₂NH₂-p, with diethanolamine 60% EtOCSN(C₂H₄OH)₂. EtOCSSCH₂CO₂H gives with NH₃ mainly EtOCSNH₂ and small quantities of SC(SCH₂CO₂H)₂.

Atti ist. veneto sci., Classe sci. mat. e nat published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics