Category: amides-buliding-blocks

Bruun, L. published the artcileA quantitative enzyme-linked immunoassay for the detection of 2,6-dichlorobenzamide (BAM), a degradation product of the herbicide dichlobenil, Name: 2,4-Dichlorobenzamide, the publication is Journal of Immunological Methods (2000), 240(1-2), 133-142, database is CAplus and MEDLINE.

2,6-Dichlorobenzamide (BAM) is the dominant degradation product in soil of the widely used herbicide dichlobenil. To detect BAM in water, a highly sensitive and specific ELISA was developed. As an alternative to conventional coating of ELISA plates, the assay is based on direct covalent immobilization. A surface was achieved which requires a short time for the immobilization of ligand, is stable under dry storage, and which permits assays with a low CV. The performance of the assay was demonstrated by an inter-well CV that was generally less than 6%, a detection limit (DL₁₅) of 0.02 μg/l and an IC₅₀ of 0.19 μg/l. Cross-reactivity was measured against nine analytes with structural homol. to BAM. The highest degree of cross-reactivity (10.8%) was seen with 2,6-dichlorothiobenzamide (Chlorthiamid). Considering an EU-limit of 0.1 μg/l as the permissible maximum for the presence of pesticides in drinking water, this ELISA-procedure is suitable for large-scale screening of water samples suspected of being contaminated with BAM.

Journal of Immunological Methods published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Name: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tsuchiya, Ayako published the artcileIntracellularly transported adenosine induces apoptosis in MCF-7 human breast cancer cells by accumulating AMID in the nucleus, Formula: C27H29N5O5, the publication is Cancer Letters (New York, NY, United States) (2012), 321(1), 65-72, database is CAplus and MEDLINE.

Extracellular adenosine induced apoptosis of MCF-7 human breast cancer cells in a concentration (10 μM-10 mM)- and treatment time (24-72 h)-dependent manner, and the effect was inhibited by the adenosine transporter inhibitor dipyridamole, but not an inhibitor of adenosine kinase, an inhibitor of AMP-activated protein kinase, or inhibitors for A₁, A_2a, A_2b, and A₃ adenosine receptors. No significant activation of caspase-7, -8, or -9 was obtained with adenosine. Adenosine promoted translocation of apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death (AMID) from the cytosol into the nucleus, although the total amount of AMID was not affected. Adenosine-induced MCF-7 cell death was abrogated by knocking-down AMID. The results of the present study indicate that intracellularly transported adenosine induces MCF-7 cell apoptosis by accumulating AMID in the nucleus in a caspase-independent manner.

Cancer Letters (New York, NY, United States) published new progress about 264622-53-9. 264622-53-9 belongs to amides-buliding-blocks, auxiliary class GPCR/G Protein,Adenosine Receptor, name is N-(4-Acetylphenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)phenoxy)acetamide, and the molecular formula is C12H20O6, Formula: C27H29N5O5.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rajendar, K. published the artcileMolecular Iodine-Mediated Domino Reaction for the Synthesis of Benzamides, 2,2-Diazidobenzofuran-3(2H)-ones and Benzoxazolones, SDS of cas: 2447-79-2, the publication is Advanced Synthesis & Catalysis (2013), 355(18), 3591-3596, database is CAplus.

A simple and efficient domino protocol has been developed for the preparation of biol. important benzamides, e.g., I, 2,2-diazidobenzofuran-3(2H)-ones, e.g., II, and benzoxazolones, e.g., III, from various structurally and electronically divergent acetophenones and ortho-hydroxyacetophenones in the presence of mol. iodine, sodium azide and sodium bicarbonate at 100 ⁰C in good to excellent yields.

Advanced Synthesis & Catalysis published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, SDS of cas: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Solankee, Anjani published the artcile2-Substituted phenyl-5-(ω-methoxycarbonyl propyl/pentyl)-Δ²-thiazolin-4-one. Part IV, HPLC of Formula: 14294-10-1, the publication is Journal of the Institution of Chemists (India) (1994), 66(3), 91-2, database is CAplus.

The title compounds I (R = substituted Ph, 3-pyridyl, morpholino, n = 3, 5) were prepared by treatment of 2-bromoadipic and 2-bromosuberic acid with thioamides followed by esterification of the corresponding acids. with MeOH and thionyl chloride.

Journal of the Institution of Chemists (India) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C9H8F2O2, HPLC of Formula: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Keshari, Twinkle published the artcileCarbon tetrabromide mediated oxidative cyclocondensation of ketones and thioureas: an easy access to 2-aminothiazoles, COA of Formula: C5H10N2OS, the publication is Tetrahedron Letters (2015), 56(41), 5623-5627, database is CAplus.

A simple, mild, and efficient one-pot method for the synthesis of substituted 2-aminothiazoles has been reported. The reaction involves the formation of sulfenyl bromide as an umpolung intermediate of nucleophilic sulfur, which is responsible for C-S bond formation leading to oxidative cyclization of ketones and thioureas to furnish the desired products. Carbon tetrabromide was used as a convenient and mild brominating reagent under basic condition at room temperature to give 2-aminothiazoles in good to excellent yields.

Tetrahedron Letters published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, COA of Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rakugi, Hiromi published the artcileEfficacy of sacubitril/valsartan versus olmesartan in Japanese patients with essential hypertension: a randomized, double-blind, multicenter study, Computed Properties of 137862-53-4, the publication is Hypertension Research (2022), 45(5), 824-833, database is CAplus and MEDLINE.

This phase III study assessed the efficacy and safety of sacubitril/valsartan compared with those of olmesartan in Japanese patients with essential hypertension. Patients (n = 1161, aged ≥20 years) with mild to moderate hypertension (mean sitting systolic blood pressure [msSBP] ≥150 to <180 mmHg) were randomized to receive sacubitril/valsartan 200 mg (n = 387), sacubitril/valsartan 400 mg (n = 385), or olmesartan 20 mg (n = 389) once daily for 8 wk. The primary assessment was a reduction in msSBP from baseline with sacubitril/valsartan 200 mg vs. olmesartan 20 mg at Week 8. Secondary assessments included msSBP reduction with sacubitril/valsartan 400 mg vs. olmesartan at Week 8 and reductions in mean sitting diastolic blood pressure (msDBP), mean sitting pulse pressure (msPP), and overall blood pressure (BP) control rate for all treatment groups at Week 8. Sacubitril/valsartan 200 mg provided a significantly greater reduction in msSBP from baseline than olmesartan at Week 8 (between-treatment difference: -5.01 mmHg [95% confidence interval: -6.95 to -3.06 mmHg, P < 0.001 for noninferiority and superiority]). Greater reductions in msSBP with sacubitril/valsartan 400 mg vs. olmesartan, as well as in msDBP and msPP with both doses of sacubitril/valsartan vs. olmesartan (P < 0.05 for all), were also observed Patients treated with sacubitril/valsartan achieved an overall higher BP control rate. The safety and tolerability profiles of sacubitril/valsartan were generally comparable to those of olmesartan. The adverse event rate with sacubitril/valsartan was not dose-dependent. Treatment with sacubitril/valsartan was effective and provided superior BP reduction, with a higher proportion of patients achieving target BP goals than treatment with olmesartan in Japanese patients with mild to moderate essential hypertension.

Hypertension Research published new progress about 137862-53-4. 137862-53-4 belongs to amides-buliding-blocks, auxiliary class GPCR/G Protein,Angiotensin Receptor, name is (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid, and the molecular formula is C24H29N5O3, Computed Properties of 137862-53-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Paulsen, Marianne H. published the artcileAn amphipathic cyclic tetrapeptide scaffold containing halogenated β^2,2-amino acids with activity against multiresistant bacteria, Product Details of C11H22N2O4, the publication is Journal of Peptide Science (2018), 24(10), n/a, database is CAplus and MEDLINE.

The present study describes the synthesis and biol. studies of a small series of head-to-tail cyclic tetrapeptides of the general structure c(Lys-β^2,2-Xaa-Lys) containing one lipophilic β^2,2-amino acid and Lys, Gly, Ala, or Phe as the Xaa residue in the sequence. The peptides were investigated for antimicrobial activity against gram-pos. and gram-neg. reference strains and 30 multiresistant clin. isolates including strains with extended spectrum β-lactamase-carbapenemase (ESBL-CARBA) production Toxicity was determined against human red blood cells. The most potent peptides showed high activity against the gram-pos. clin. isolates with min. inhibitory concentrations of 4-8 μg/mL and low hemolytic activity. The combination of high antimicrobial activity and low toxicity shows that these cyclic tetrapeptides containing lipophilic β^2,2-amino acids form a valuable scaffold for designing novel antimicrobial agents.

Journal of Peptide Science published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, Product Details of C11H22N2O4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Krajsovszky, Gabor published the artcileSuzuki-aza-Wittig, Suzuki-condensation and aza-Wittig-electrocyclic ring-closure tandem reactions for synthesis of fused nitrogen-containing ring systems, Recommanded Product: (2-Pivalamidophenyl)boronic acid, the publication is ARKIVOC (Gainesville, FL, United States) (2011), 229-253, database is CAplus.

Tandem combinations of Suzuki-aza-Wittig, Suzuki-condensation, and aza-Wittig-electrocyclic ring closure reactions for the synthesis of new pyridazino[4,5-c]isoquinolinone, pyridazino[4,5-c]quinolinone, and pyrimido[5,4-c]quinoline derivatives were described.

ARKIVOC (Gainesville, FL, United States) published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Recommanded Product: (2-Pivalamidophenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sathe, Pratima A. published the artcileTandem synthesis of aromatic amides from styrenes in water, SDS of cas: 2447-79-2, the publication is Tetrahedron Letters (2018), 59(29), 2820-2823, database is CAplus.

An expedient one-pot synthesis of aromatic amides from styrenes in the presence of N-bromosuccinimide and iodine by using aqueous ammonia in water is reported. The reaction proceeds through the formation of a α-bromoketone as an intermediate in the presence of NBS and water. The α-bromoketone on reaction with iodine forms bromodiiodoketone which on nucleophilic substitution with aqueous ammonia gives aromatic amide. Substituted aromatic amides were obtained in good yields with wide functional group compatibility.

Tetrahedron Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, SDS of cas: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Piskov, V. B. published the artcileConversion of carboxylic acids to amides, Related Products of amides-buliding-blocks, the publication is Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) (1973), 46(1), 220-1, database is CAplus.

Pelargonic, lauric, and (10) benzoic acid derivatives were converted to the resp. amides (≤99%) by heating with ≥2 equivalent of H2NSO3H in oleum or polyphosphoric acid at 100-20°; 3-02NC6H4CO2H and MeNHSO3H gave 89% 3-O2NC6H4CONHMe under similar conditions.

Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics