Category: amides-buliding-blocks

Zhou, Min published the artcileFingerprinting pharmaceuticals of multiple sources at a provincial watershed scale, COA of Formula: C24H29N5O3, the publication is Science of the Total Environment (2022), 153356, database is CAplus and MEDLINE.

Pharmaceutical residues in the aquatic environment have increasingly attracted public concerns but their fingerprint of sources remain unclear at a watershed scale. This study systematically explored pharmaceutical residues in effluent of 8 different type of sources in a provincial watershed in China using a multi-category protocol of pharmaceutical quantification. Seventy-seven out of 94 target compounds from 6 categories were quantified in effluent, up to 71,318 ng L^-1 in total from urban hospital sources with 20 antibiotics and 32 others. The spectrum of the quantified compounds in effluent significantly differentiated the urban (hospitals, domestic sewages, and WWTPs), rural (health centers and domestic sewages), and agricultural production sources (poultry and swine breeding yards, aquaculture ponds, and paddy fields). Compounds of non-steroidal anti-inflammation drugs (NSAIDs), cardiovascular drugs (CVs), and central nervous drugs (CNs) could fingerprint the three groups of sources. However, the three categories contributed 7 out of 10 compounds with high risk (risk quotient >1.0) to the aquatic environment identified by the eco-environmental risk assessment. No high-risk compounds were identified in effluent of urban WWTPs. Findings of this study suggest source identification and compound spectrum fingerprinting are crucial for studies on pharmaceutical residues in the aquatic environment, especially the complexity of pharmaceutical residues in source effluents for exploring source-sink dynamics at a watershed scale.

Science of the Total Environment published new progress about 137862-53-4. 137862-53-4 belongs to amides-buliding-blocks, auxiliary class GPCR/G Protein,Angiotensin Receptor, name is (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid, and the molecular formula is C12H10FeO4, COA of Formula: C24H29N5O3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Morita, Mikio published the artcileFacile synthesis of 2-azaazulenes from thiobenzoyl isocyanates using trimethylsilyldiazomethane, Related Products of amides-buliding-blocks, the publication is Tetrahedron (2008), 64(8), 1753-1758, database is CAplus.

The reaction of trimethylsilyldiazomethane with thiobenzoyl isocyanates, in situ generated from thiazole-4,5-diones, yielded diazo ketones, which were converted into 2-azaazulenes by the intramol. Buchner reaction.

Tetrahedron published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Albrecht, Brian K. published the artcileDiscovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase, Product Details of C8H9BFNO3, the publication is Journal of Medicinal Chemistry (2008), 51(10), 2879-2882, database is CAplus and MEDLINE.

Tumorigenesis is a multistep process in which oncogenes play a key role in tumor formation, growth, and maintenance. MET was discovered as an oncogene that is activated by its ligand, hepatocyte growth factor. Deregulated signaling in the c-Met pathway has been observed in multiple tumor types. Herein we report the discovery of potent and selective triazolopyridazine small mols. that inhibit c-Met activity.

Journal of Medicinal Chemistry published new progress about 849833-86-9. 849833-86-9 belongs to amides-buliding-blocks, auxiliary class Fluoride,Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid, and the molecular formula is C8H9BFNO3, Product Details of C8H9BFNO3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Keil, D. published the artcileSynthesis and characterization of 1,3-bis-(2-dialkylamino-5-thiazolyl)-substituted squaraines and their 2-(dialkylamino)thiazole precursors, Product Details of C5H10N2OS, the publication is Liebigs Annalen (1995), 979-84, database is CAplus.

By condensing of squaric acid with 2-(dialkylamino)-substituted thiazoles, a novel type of heterocyclic-substituted squaraines was prepared in moderate yield mostly. The squaraines are sparingly soluble in most organic solvents and exhibit narrow absorption bands in the visible range at ∼ 620-700 nm in solution. In dispersed form, the absorption bands of the squaraines are, however, broadened and shifted into the near IR region at ∼ 900 nm. These unique properties of the new squaraines suggest the use of these dyes as spectral sensitizers for laser-driven data recording or data storage media.

Liebigs Annalen published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Czerney, Peter published the artcileHeterocyclic substituted coumarins from β-chloropropeniminium salts, Application of Morpholine-4-carbothioamide, the publication is Journal fuer Praktische Chemie (Leipzig) (1982), 324(2), 255-66, database is CAplus.

The chloropropeniminium salts I (X = N⁺Me₂ ClO₄^–; R = H, 6-Br, 7-OH, 7-OMe, 7-NMe₂, 7-pyrrolidino, 8-OMe, 7-NEt₂, R¹ = H; RR¹ = 5,6-CH:CHCH:CH, 7,8-CH:CHCH:CH) and the aldehydes I (X = O) were prepared by treating 3-acetylcoumarins with DMF-POCl₃ in the presence of HClO₄ or H₂O, resp. I are versatile synthetic intermediates giving I (X = CR²CN, R² = cyano, CO₂Et, 2-benzimidazolyl, 4-O₂NC₆H₄) which were converted to the aminobutadienes. I were also cyclized to pyrylium, thiopyrylium, pyrazolyl, and thiazinyl derivatives

Journal fuer Praktische Chemie (Leipzig) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Application of Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Flaig, Ronald published the artcileSynthesis of N-substituted 2,4-diaminothiazoles and their salts, Product Details of C5H10N2OS, the publication is Heterocycles (1997), 45(5), 875-888, database is CAplus.

A series of N(2),N(4)-substituted 2,4-diaminothiazoles I (R¹R²N = morpholino, pyrrolidino, piperidino, diethylamino, n-butylamino, phenylamino, di-n-propylamino, R³R⁴N = morpholino, pyrrolidino, piperidino, diphenylamino, diethylamino, n-butylamio) and their corresponding mineral acid salts have been prepared by the reaction of POCl₃ with N-substituted S-(dialkylaminocarbonylmethylene)isothiouronium salts R¹R²NC(:NH₂)SCH₂CONR³R⁴ available from corresponding substituted thioureas R¹R²NC(S)NH₂ (II) and N,N-disubstituted chloroacetamides ClCH₂CONR³R⁴ or by the reaction of primary or secondary amines R³R⁴NH in excess with N(2)-unsubstituted or N(2)-disubstituted 2-amino-4-thiazolinimine hydrochlorides III available by the reaction of corresponding N-substituted thioureas II with chloroacetonitrile.

Heterocycles published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Keil, Dietmar published the artcilePreparation and characterization of N,N-disubstituted 2-amino-selenazoles, Recommanded Product: N,N-Dibenzylcyanamide, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (1999), 169-184, database is CAplus.

As a result of checking suited methods for preparing N,N-disubstituted 2-amino-selenazoles, e.g. I, as a nearly unknown class of highly reactive selenazoles a simple route starting from N,N-disubstituted selenoureas has been elaborated and used for the synthesis of a series of these compounds The necessary selenium-containing starting compounds N,N-disubstituted selenoureas are available from N,N-disubstituted cyanamides and hydrogen selenide.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Recommanded Product: N,N-Dibenzylcyanamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Keil, Dietmar published the artcileA simple route to N,N-disubstituted selenoureas from N,N-disubstituted cyanamides, Application In Synthesis of 2451-91-4, the publication is Synthesis (2004), 15-16, database is CAplus.

N,N-Disubstituted selenoureas I [R¹ = R² = Me, Et, Bn; R¹R² = O(CH₂CH₂)₂, (CH₂)₅, (CH₂)₄] can be obtained in good yields by addition of an acid to a mixture of freshly prepared sodium selenide and N,N-disubstituted cyanamides II.

Synthesis published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Application In Synthesis of 2451-91-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liebscher, Juergen published the artcileReaction of 3-chloroprop-2-eniminium salts with alkali rhodanides, SDS of cas: 14294-10-1, the publication is Zeitschrift fuer Chemie (1978), 18(9), 334-5, database is CAplus.

The pyrimidinethiones I (R = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 4-ClC₆H₄, 2-naphthyl; R¹ = 4-MeOC₆H₄, 2-MeOC₆H₄, 4-MeC₆H₄, 2-naphthyl, 3-MeOC₆H₄) were obtained by treating RCCl:CHCH:N⁺Me₂ ClO₄^– was alkali metal isothiocyanate and treating SCNCR:CHCH:N⁺Me₂ ClO₄^– (II) with R¹NH₂. Treatment of II with R₂²NH (NR₂² = morpholino, pyrrolidino, NMe₂) gave the thiazinium salts III (R³ = H). Reaction of III (R = 4-MeC₆H₄, NR₂² = NMe₂, R³ = H) with PhNMe₂ gave III (R = 4-MeC₆H₄, NR₂² = NMe₂, R³ = 4-Me₂NC₆H₄).

Zeitschrift fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, SDS of cas: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liebscher, Juergen published the artcileNitrile-formamide adducts. 4. Reaction of nitrile-formamide adducts. Synthesis of N-thioacylamide derivatives and aza analogs of thiopyrylium salts, Safety of Morpholine-4-carbothioamide, the publication is Zeitschrift fuer Chemie (1975), 15(11), 438-40, database is CAplus.

4-RC6H4CSN:CHNR1R2 (R = H, Me, OMe; NR1R2 = pyrrolidino, morpholino, NMe2) were obtained by treating 4-RC6H4CONHCH:N+R1R2 ClO4- with P2S5 or by treating 4-RC6H4CCl:NCH:N+R1R2 ClO4- (I) with Na2S or Na2S2O3. 4-RC6H4CSN:CHNR1R2 were hydrolyzed to 4-RC6H4CSNHCHO or condensed with I (R = H, Cl) to the thiazines II. The thiadiazines III were similarly obtained from I and R4NHCSNR1R2 (R4 = Bz, 4-O2NC6H4CO, 3-O2NC6H4CO, H).

Zeitschrift fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Safety of Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics