Category: amides-buliding-blocks

She, Shan et al. published their research in Chemistry – A European Journal in 2017 | CAS: 2387-23-7

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Related Products of 2387-23-7

Buildup of Redox-Responsive Hybrid from Polyoxometalate and Redox-Active Conducting Oligomer: Its Self-Assemblies with Controllable Morphologies was written by She, Shan;Huang, Zehuan;Yin, Panchao;Bayaguud, Aruuhan;Jia, Hongli;Huang, Yichao;Wei, Yen;Wei, Yongge. And the article was included in Chemistry – A European Journal in 2017.Related Products of 2387-23-7 This article mentions the following:

A redox-responsive hybrid of polyoxometalate and conducting oligomer including its self-assemblies with controllable morphologies are reported. To this end, a hybrid mol., containing a Lindqvist hexamolybdate as the polar head group and N,N’-bis(4′-amino-2,6-dimethylphenyl)-1,4-quinonediimine as the redox-responsive and aggregating group, was prepared This hybrid exhibits redox-responsive behavior with controllable assembling morphol. transition from spherical vesicles to short cylindrical vesicles. Besides, the hybrid-based self-assemblies are transferred to the surface, thus the surface wettability can be well-tuned owing to the morphol. transitions of the self-assemblies. By marrying conducting materials with polyoxometalate chem., this research opens a new horizon of polyoxometalate-based self-assembled systems with potential applications in functional materials. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Related Products of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Related Products of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Asachi, Maryam et al. published their research in Powder Technology in 2018 | CAS: 10543-57-4

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Application of 10543-57-4

Experimental evaluation of the effect of particle properties on the segregation of ternary powder mixtures was written by Asachi, Maryam;Hassanpour, Ali;Ghadiri, Mojtaba;Bayly, Andrew. And the article was included in Powder Technology in 2018.Application of 10543-57-4 This article mentions the following:

Segregation of components, especially the low content level of a highly active substance, has serious deleterious effects on powder formulation. This study investigates the effect of particle properties, particularly size, shape, d. and cohesion, on the segregation of laundry detergent powders. Tetraacetylethylenediamine (TAED) particles, spray-dried synthetic detergent powder referred to as Blown Powder (BP) and Enzyme Placebo Granules (EP granules) are used as a model formulation. The segregation of components is evaluated using image processing of the photog. records taken from the front face of a two-dimensional heap of powders. Coefficient of variation concept is considered as segregation index. It is shown that EP granules, the component used as low-level ingredient (< 2 wt%) in the ternary mixture, are prone to extensive segregation due to their higher d. as compared to BP and TAED particles. Desired properties for segregation minimisation of EP granules have been further investigated. It is found that the segregation of EP granules can be reduced noticeably by applying a thin layer of a sticky liquid on them before mixing with the rest of powders with full particle size distribution of the components. Polyethylene glycol has been used for this purpose. Addition of 2.5 wt% gives an optimum level to reduce the segregation of EP granules without compromising the flowability of the mixture as well as EP granules themselves. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Application of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Application of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kumar, Singam Naveen et al. published their research in Organic Letters in 2018 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Electric Literature of C11H15NO2

From Carbamate to Chalcone: Consecutive Anionic Fries Rearrangement, Anionic Si → C Alkyl Rearrangement, and Claisen-Schmidt Condensation was written by Kumar, Singam Naveen;Bavikar, Suhas Ravindra;Pavan Kumar, Chebolu Naga Sesha Sai;Yu, Isaac Furay;Chein, Rong-Jie. And the article was included in Organic Letters in 2018.Electric Literature of C11H15NO2 This article mentions the following:

A highly efficient one-pot procedure was developed for the synthesis of various 2′-hydroxychalcones from Ph diethylcarbamate, featuring consecutive Snieckus-Fries rearrangement, anionic Si → C alkyl rearrangement, and Claisen-Schmidt condensation in a single operation. The applicability of this protocol was demonstrated by the highly efficient synthesis of the anti-inflammatory natural product lonchocarpin. The mechanism insight is also provided. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Electric Literature of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Electric Literature of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lemmerer, Miran et al. published their research in Angewandte Chemie, International Edition in 2022 | CAS: 116332-61-7

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.HPLC of Formula: 116332-61-7

HFIP Mediates a Direct C-C Coupling between Michael Acceptors and Eschenmoser’s salt was written by Lemmerer, Miran;Riomet, Margaux;Meyrelles, Ricardo;Maryasin, Boris;Gonzalez, Leticia;Maulide, Nuno. And the article was included in Angewandte Chemie, International Edition in 2022.HPLC of Formula: 116332-61-7 This article mentions the following:

A direct C-C coupling process that merges Michael acceptors and Eschenmoser’s salt was presented. Although reminiscent of the Morita-Baylis-Hillman reaction, this process requires no Lewis base catalyst. The underlying mechanism was unveiled by a combination of kinetic, isotopic labeling experiments as well as computational investigations, which showcased the critical role of HFIP as a superior mediator for proton-transfer events as well as the decisive role of the halide counterion. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7HPLC of Formula: 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.HPLC of Formula: 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Jianzhong et al. published their research in Science (Washington, DC, United States) in 2020 | CAS: 2670-38-4

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Reference of 2670-38-4

Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles was written by Liu, Jianzhong;Zhang, Cheng;Zhang, Ziyao;Wen, Xiaojin;Dou, Xiaodong;Wei, Jialiang;Qiu, Xu;Song, Song;Jiao, Ning. And the article was included in Science (Washington, DC, United States) in 2020.Reference of 2670-38-4 This article mentions the following:

The Schmidt reaction has been an efficient and widely used synthetic approach to amides and nitriles since its discovery in 1923. However, its application often entails the use of volatile, potentially explosive, and highly toxic azide reagents. Here, we report a sequence whereby triflic anhydride and formic and acetic acids activate the bulk chem. nitromethane to serve as a nitrogen donor in place of azides in Schmidt-like reactions. This protocol further expands the substrate scope to alkynes and simple alkyl benzenes for the preparation of amides and nitriles. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Reference of 2670-38-4).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Reference of 2670-38-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Johansen, Martin B. et al. published their research in Organic & Biomolecular Chemistry in 2020 | CAS: 116332-61-7

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Category: amides-buliding-blocks

Copper-catalyzed and additive free decarboxylative trifluoromethylation of aromatic and heteroaromatic iodides was written by Johansen, Martin B.;Lindhardt, Anders T.. And the article was included in Organic & Biomolecular Chemistry in 2020.Category: amides-buliding-blocks This article mentions the following:

A copper-catalyzed decarboxylative trifluoromethylation of (hetero)aromatic iodides RI (R = 4-cyanophenyl, naphthalen-1-yl, 1-benzyl-1H-pyrazol-4-yl, etc.) has been developed. Importantly, this new copper-catalyzed reaction operates in the absence of any ligands and metal additives. The protocol shows good functional group tolerance and is compatible with heteroaromatic systems. The reaction proved scalable to a 15 mmol scale with increased yield. Finally, late-stage installation of the trifluoromethyl functionality afforded the 2,2,2-trifluoro-N-(3-(4-iodophenoxy)-3-phenylpropyl)-N-methylacetamide variant of the antidepressant agent, Prozac, demonstrating the applicability of the developed method. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Category: amides-buliding-blocks).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Burmistrov, S. I. et al. published their research in Zhurnal Obshchei Khimii in 1952 | CAS: 1146-43-6

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Formula: C13H13NO3S

N-Arylsulfonylquinone imines was written by Burmistrov, S. I.;Titov, E. A.. And the article was included in Zhurnal Obshchei Khimii in 1952.Formula: C13H13NO3S This article mentions the following:

N-Arylsulfonyl-p-quinone imines, derivatives of p-quinone, liberated iodine quantitatively from acid KI solutions; they form indophenols with PhOH and 1-C10H7OH; the arylsulfonyl group is cleaved as an anion of arylsulfinic acid. To 64.2 g. p-HOC6H4NH2.HCl, 84.8 g. Na2CO3, and 400 ml. H2O was added 76.2 g. p-MeC6H4SO2Cl, and the mixture heated on a steam bath 2.5 hrs., then cooled, yielding 103 g. p-(p-tolylsulfonamido)phenol, m. 144.5° (from H2O). This (10 g.) added at room temperature to 5.7 g. K2Cr2O7.2H2O in 175 ml. 20% H2SO4 and stirred 50 min., then dilute with H2O, yielded a precipitate which was washed with H2O and EtOH to remove unreacted material; crystallization of the product in small portions from EtOH gave 79-84% N-(p-tolylsulfonyl)-p-quinoneimine (I), m. 126.5°, orange-yellow, giving a blue color with PhOH and a violet color with 1-naphthol in ammoniacal solution Heating with 20% H2SO4 gives p-quinone. The imine can be also prepared by oxidation with CrO3 in AcOH, but PbO2 gave very low yields. The use of PhSO2Cl in the above sequence gave pink p-(phenylsulfonamido)phenol, m. 155°; this oxidized as above, gave yellow 70% N-(phenylsulfonyl)-p-quinone imine, m. 137°. Similarly was prepared N-(p-tolylsulfonamido)-1-naphthol, m. 183° (from xylene), which oxidized to the corresponding naphthoquinone imine, m. 156°, in contrast to the 1st 2 analogs, does not liberate iodine quantitatively from KI nor does it give blue color with PhOH in NH4OH solution, but does give a blue color with 1-naphthol. Shaking 4.36 g. I with 2.4 g. PhOH in NH4OH, followed by filtration after the color is stabilized, and neutralization of the solution with AcOH gave red-brown indophenol, p-OC6H4:NC6H4OH, m. 160°; evaporation of the aqueous solution gave p-C6H4SO2H, m. 85°. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Formula: C13H13NO3S).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Formula: C13H13NO3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yan, Dingyuan et al. published their research in Nature Communications in 2018 | CAS: 1146-43-6

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 1146-43-6

A selenium-catalysed para-amination of phenols was written by Yan, Dingyuan;Wang, Guoqiang;Xiong, Feng;Sun, Wei-Yin;Shi, Zhuangzhi;Lu, Yi;Li, Shuhua;Zhao, Jing. And the article was included in Nature Communications in 2018.Recommanded Product: 1146-43-6 This article mentions the following:

Se-catalyzed para-amination of phenols was reported while, in contrast, the reactions with sulfur donors were stoichiometric. A catalytic amount of phenylselenyl bromide smoothly converts N-aryloxyacetamides to N-acetyl p-aminophenols. When the para position was substituted (for example, with tyrosine), the dearomatization occurred and 4,4-disubstituted cyclodienone products were obtained. A combination of exptl. and computational studies was conducted and suggested the weaker Se-N bond plays a key role in the completion of the catalytic cycle. Our method extends the selenium-catalyzed processes to the functionalization of aromatic compounds Finally, the mild nature of the para-amination reaction was demonstrated by generating an AIEgen 2-(2′-hydroxyphenyl)benzothiazole (HBT) product in a fluorogenic fashion in a PBS buffer. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Recommanded Product: 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Jingjing et al. published their research in Journal of Biochemical and Molecular Toxicology in 2022 | CAS: 53902-12-8

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Synthetic Route of C18H17NO5

The key role of organic anion transporter 3 in the drug-drug interaction between tranilast and methotrexate was written by Wang, Jingjing;Yuan, Wenjing;Shen, Qingqing;Wu, Qipeng;Jiang, Zhenzhou;Wu, Wei;Zhang, Luyong;Huang, Xin. And the article was included in Journal of Biochemical and Molecular Toxicology in 2022.Synthetic Route of C18H17NO5 This article mentions the following:

Tranilast, N-(3,4-dimethoxycinnamoyl)-anthranilic acid, is an anti-allergic drug and is considered for use in the treatment of rheumatoid arthritis. Methotrexate, an antimetabolite and folate antagonist to treat some cancers, is also a first-line drug for RA. The aim of this study was to understand whether tranilast could inhibit renal uptake transporters (Oat1, Oat3, and Oct2) and whether MTX combined with TL would have drug-drug interactions. The results of kidney slices and HEK293T-OAT3 cell uptake experiments showed that TL (10μM) could inhibit the uptake of penicillin G and MTX, which are substrates of OAT3. When TL (10 mg/kg) was combined with MTX (5 mg/kg), the area under the curve and peak concentration of MTX increased by 46.46% and 113.51%, respectivley, while the pharmacokinetic process of tranilast (10 mg/kg) was not changed by methotrexate (5 mg/kg). TL could increase plasma exposure of MTX by inhibiting Oat3 in vitro and in vivo. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Synthetic Route of C18H17NO5).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Synthetic Route of C18H17NO5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chiang, Po-Chang et al. published their research in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2019 | CAS: 2387-23-7

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Related Products of 2387-23-7

Investigation of drug delivery in rats via subcutaneous injection: Case study of pharmacokinetic modeling of suspension formulations was written by Chiang, Po-Chang;Nagapudi, Karthik;Fan, Peter W.;Liu, Jia. And the article was included in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2019.Related Products of 2387-23-7 This article mentions the following:

With the rising cost of drug research, “do more with less” has become a new emphasis in the pharmaceutical industry. Consequently, the early anal. of pharmacokinetic/pharmacodynamic, efficacy, and safety parameters for a new drug target is critical for ensuring informed decision-making as soon as possible during the drug discovery process. When absorption, distribution, metabolism, and excretion properties of compounds are suboptimal which is especially true during the early stages of drug discovery, obtaining the desired exposure can be challenging via the most common routes (oral, i.v.). Therefore, s.c. (SC) injection is often explored as an alternate route of delivery. Although SC injection is used widely in the industry, information about how to model and predict the absorption of drugs administered via SC injection is not readily available. In the current research, we analyzed the absorption behavior of 12 model compounds covering a wide range of physicochem. properties following SC injection. We introduced a compound-specific parameter, the absorption factor from single SC injections of suspension doses of each compound, to aid in modeling and predicting of drug absorption profiles. The pharmacokinetic models derived in this study are capable of describing and predicting the absorption properties of SC injection for individual compounds In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Related Products of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Related Products of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics