Category: amides-buliding-blocks

Ough, Cornelius S. published the artcileIdentification of new volatile amines in grapes and wines, Quality Control of 360-92-9, the publication is Journal of Agricultural and Food Chemistry (1981), 29(5), 938-41, database is CAplus and MEDLINE.

A number of amines were identified for the 1st time in grapes. These include MeNH₂ [74-89-5], EtNH₂ [75-04-7], Et₂NH [109-89-7], PrNH₂ [107-10-8], isobutylamine [78-81-9], α-amylamine [96-15-1], isoamylamine [107-85-7], pyrrolidine [123-75-1], and 2-phenethylamine [64-04-0]. The trifluoroacetamides of the isolated amines were separated on Carbowax 20M or SE54 fused silica capillary columns and identified by retention times and mass spectra. Two amines, di-Et and α-amyl, were identified in wine for the 1st time. Mass spectra of the pure trifluoroacetyl derivatives of these amines are given. In a recent review, P. Schreier (1979) compiled a list of the volatile amines found in wines. The volatile amines he summarized plus others detected in wines are given.

Journal of Agricultural and Food Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Quality Control of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Arya, V. P. published the artcilePsychoactive agents: part VIII. Isothiazoles: part VIII. Synthesis and biological activity of 4-(2-amino-4-thiazolyl)isothiazoles, Product Details of C5H10N2OS, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1978), 16B(5), 402-4, database is CAplus.

RR¹NH (NRR¹ = morpholino, hexahydro-1-azepinyl, octahydro-1-azocinyl, 3-azabicyclo[3.2.2]nonan-3-yl, 4-(4-fluorophenyl)piperazin-1-yl) were treated with tert-BuNCS to give RR¹NCSNHCMe₃, which ws debutylated to give RR¹NCSNH₂. This and R²CSNH² (R² = NH₂, NHMe, NHBu, NHCH₂CH:CH₂, NHCH₂Ph, etc.) were cyclized with I (R³ = H, Me, Et) to give the corresponding II. Among II, 4-(2-amino-4-thiazolyl)-3,5-dimethylisothiazole showed the highest analgesic activity and 4-(2-amino-4-thiazolyl)-3-methylisothiazole had the highest antiinflammatory activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mehuys, Els published the artcilePrevalence and management of drug interactions between nonsteroidal anti-inflammatory drugs and antithrombotics in ambulatory care, Application In Synthesis of 169590-42-5, the publication is British Journal of Clinical Pharmacology (2022), 88(8), 3896-3902, database is CAplus and MEDLINE.

Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and antithrombotic agents is associated with increased risks of both bleeding and thromboembolism. In this prospective intervention study, community pharmacists screened for NSAID-antithrombotic interactions and contacted the prescribing physician to discuss interaction management. We included 782 interactions; these were found in an older, polymedicated patient population (mean age: 68 y, median of 5 other drugs). Ibuprofen (in 43.0% of cases) and low-dose aspirin (78.8%) were the most frequently involved NSAID and antithrombotic, resp. Anticoagulants were involved in 16.1% of interaction cases. For 61% of cases, the interacting drugs were prescribed by the same physician. The pharmacist-physician discussion about how to manage the interaction mostly resulted in no change of pharmacotherapy (60.7%); the most frequent reason given by physicians was that the NSAID was for short-term use only. In 39.3% of cases the discussion resulted in a pharmacotherapy change; replacing the NSAID by paracetamol was the most common change.

British Journal of Clinical Pharmacology published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, Application In Synthesis of 169590-42-5.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bastos, Gustavo A. published the artcileA convenient Hofmann reaction of carboxamides and cyclic imides mediated by trihaloisocyanuric acids, SDS of cas: 2447-79-2, the publication is Tetrahedron Letters (2021), 153422, database is CAplus.

A simple, efficient and pot-economic approach in a single vessel has been developed for conversion of aromatic and aliphatic carboxamides into primary amines with one fewer carbom atom (Hofmann reaction) in 38-89% yield by reacting with trichloro- or tribromoisocyanuric acid and sodium hydroxide in aqueous acetonitrile. Under the same reaction conditions, cyclic imides gave amino acids (69-83%). The role of the trihaloisocyanuric acids is the in situ generation of N-haloamides, key-intermediates for the Hofmann reaction. The scalability of the methodol. was demonstrated by a multigram-scale transformation of phthalimide into anthranilic acid in 77% yield.

Tetrahedron Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, SDS of cas: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kheradmand, Farrah published the artcileLeukotriene A₄ hydrolase: the janus enzyme shows its ugly side in smokers, Synthetic Route of 321673-30-7, the publication is American Journal of Respiratory and Critical Care Medicine (2014), 190(1), 5-7, database is CAplus and MEDLINE.

This paper describes the cigarette smoke chem. acetylates proline-glycine-proline, enhancing its chemotactic activity and protecting it from degradation by LTA4H. And also biochem. and preliminary murine studies suggest that cigarette smoke can selectively abrogate the peptidase activity of LTA4H, with minimal effect on the hydrolase activity.

American Journal of Respiratory and Critical Care Medicine published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Synthetic Route of 321673-30-7.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Chavan, Sunil S. published the artcileIonic liquid-catalyzed 4,6-disubstituted-3-cyano-2-pyridone synthesis under solvent-free conditions, Safety of 2-Cyano-N-ethylacetamide, the publication is Catalysis Letters (2011), 141(11), 1693-1697, database is CAplus.

A green protocol for the synthesis of 4,6-disubstituted-3-cyano-2-pyridones from cyanoacetamides and 1,3-dicarbonyl compounds or chalcones using guanidine-based ionic liquid as catalyst was developed. In solvent-free conditions at 30 °, 1,1,3,3-tetramethylguanidine lactate had the highest catalytic activity among the ionic liquids including 1,1,3,3-tetramethylguanidine acetate, 1,1,3,3-tetramethylguanidine propionate, 1,1,3,3-tetramethylguanidine n-butyrate, and 1,1,3,3-tetramethylguanidine trifluoroacetate. The catalyst was recovered and recycled several times without significant loss of catalytic activity.

Catalysis Letters published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Safety of 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Appukkuttan, Prasad published the artcileMicrowave-assisted transition-metal-catalyzed synthesis of N-shifted and ring-expanded buflavine analogues, Formula: C11H16BNO3, the publication is Chemistry – A European Journal (2007), 13(22), 6452-6460, database is CAplus and MEDLINE.

Buflavine analogs I (R = H, MeO) and II (R = H, MeO) are prepared using microwave-assisted Suzuki-Miyaura coupling reactions and ring-closing metathesis reactions as key steps. Suzuki-Miyaura coupling of the bromostyrenes III (R = H, MeO) with an (allyl)(pivaloyl)aminoboronic acid provides a biaryl which undergoes selective ring-closing metathesis in the presence of either the first or the second-generation Grubbs catalysts followed by olefin hydrogenation to yield I (R = H, MeO); attempted reduction of a related vinylnitrostyrene gives inseparable mixtures of the desired biphenylamines along with phenanthridines generated by reductive cyclization. Suzuki-Miyaura coupling of III (R = H, MeO) with 2-formylbenzeneboronic acid, reductive amination with allylamine followed by reductive methylation of the amines, ring-closing metathesis with the second-generation Grubbs catalyst, and olefin hydrogenation provides II (R = H, MeO).

Chemistry – A European Journal published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Formula: C11H16BNO3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Appukkuttan, Prasad published the artcileMicrowave-Enhanced Synthesis of N-Shifted Buflavine Analogues via a Suzuki-Ring-Closing Metathesis Protocol, Related Products of amides-buliding-blocks, the publication is Organic Letters (2005), 7(13), 2723-2726, database is CAplus and MEDLINE.

A novel, microwave-enhanced six-step synthesis was devised for the synthesis of N-shifted buflavine analogs, I (R = H, OMe). Microwave-enhanced Suzuki-Miyaura cross-coupling and ring-closing metathesis reactions were used as the key steps. Microwave irradiation was found to enhance the ring-closing metathesis reaction to generate the otherwise difficultly obtainable medium-sized ring system of the target mols.

Organic Letters published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Henry, Ronald A. published the artcileMiscellaneous derivatives of morpholine, Product Details of C5H10N2OS, the publication is Journal of the American Chemical Society (1950), 2806, database is CAplus.

Molar proportions of Ph₂NCOCl and morpholine (I) reacted directly. The mixture heated with H₂O and NaHCO₃ precipitated diphenylcarbamyl morpholide, m. 110-11° (from EtOH). I with RNCS gave the following thioureas: Ph, m. 130.5°; o-tolyl, m. 144.5-5.5°; p-tolyl, m. 151-1.5°; allyl, m. 56-7°. I in EtOH refluxed with picryl chloride gave 90% 4-picrylmorpholine (II), m. 147.5-8.5°, resolidified, and m. at 166-6.5° (from EtOH). II with (NH₄)₂S gave 4-picramylmorpholine, decompose 256° (from EtOH). A solution of I.HCl and KCNS evaporated to dryness, then extracted with absolute EtOH, gave (4-morpholinyl)thiocarbonamide, m. 111.5-12.5°. [O(CH₂.CH₂)₂NCS]₂S₂ (III) and KCN in 40% EtOH refluxed 30 min., then diluted with 50 ml. H₂O, precipitated [O(CH₂.CH₂)₂NCS]₂S, m. 126-6.5° (from EtOH). III and I heated at 120° for 4 hrs., then extracted with H₂O gave [O(CH₂.CH₂)₂N]₂CS.H₂O, m. 89.5-90° (from H₂O).

Journal of the American Chemical Society published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

O’Callaghan, C. N. published the artcileAnticancer agents XIII. Synthesis and antitumor activity of 2-iminochromene derivatives, SDS of cas: 15029-36-4, the publication is Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science (1979), 79B(6), 87-98, database is CAplus.

Iminochromenes I (R = H, 6-OMe, 7-OMe, 6-NO₂, 6,8-Br₂, 8-OEt, 8-OMe; R¹ = H, alkyl, hydroxyalkyl, NHCSNHMe, optionally substituted Ph, anilino, acylamino, morpholino) were prepared by condensing salicylaldehydes with NCCH₂CONHR¹. II (R² = OMe, OEt, OPr, R³ = H; R² = H, R³ = OMe, OEt, OPr) were obtained by condensing salicylaldehydes with 1-cyanoacetyl-3,5-dimethylpyrazole. I, II, and related compounds had antitumor activity. Thus, I (R = 6-OMe, R¹ = H) gave a mean survival time 131% of controls as 108 mg/kg in P 388 lymphocytic leukemia-infected mice.

Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, SDS of cas: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics