Category: amides-buliding-blocks

Marjoram extract prevents ischemia reperfusion-induced myocardial damage and exerts anti-contractile effects in aorta segments of male wistar rats was written by Granado, M.;Gonzalez-Hedstrom, D.;Amor, S.;Fajardo-Vidal, A.;Villalva, M.;de la Fuente-Fernandez, M.;Tejera-Munoz, A.;Jaime, L.;Santoyo, S.;Garcia-Villalon, A. L.. And the article was included in Journal of Ethnopharmacology in 2022.Recommanded Product: 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide This article mentions the following:

Marjoram (Origanum majorana L.) is an herb traditionally used as a medicine in different countries, as Morocco and Iran, because of its beneficial cardiovascular effects. Some studies suggest that these effects are due, at least in part, to the presence of phenolic compounds such as rosmarinic acid (RA) and luteolin. To analyze the possible cardiprotective effects of a marjoram extract (ME) reducing myocardial damage after coronary ischemia-reperfusion (IR) and its possible antihypertensive effects reducing the response of aorta segments to the vasoconstrictors noradrenaline (NA) and endothelin-1 (ET-1). Male Wistar rats (300g) were used. After sacrifice, the heart was immediately removed and mounted in a perfusion system (Langendorff). The aorta was carefully dissected and cut in 2 mm segments to perform vascular reactivity experiments In the heart, ME perfusion after IR reduced heart rate and prevented IR-induced decrease of cardiac contractility, possibly through vasodilation of coronary arteries and through the upregulation of antioxidant markers in the myocardium that led to reduced apoptosis of cardiomyocytes. In the aorta, ME decreased the vasoconstrictor response to NA and ET-1 and exerted a potent anti-inflammatory and antioxidant effect. Neither RA nor 6-hydroxi-luteolin-O-glucoside, major compounds of this ME, were effective in improving cardiac contractility after IR or attenuating vasoconstriction to NA and ET-1 in aorta segments. In conclusion, ME reduces the myocardial damage induced by IR and the contractile response to vasoconstrictors in the aorta. Thus, it may be useful for the treatment of cardiovascular diseases such as myocardial infarction and hypertension. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Recommanded Product: 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Acetyl nitrate mediated conversion of methyl ketones to diverse carboxylic acid derivatives was written by Capilato, Joseph N.;Pellegrinelli, Peter J.;Bernard, Josephine;Schnorbus, Logan;Philippi, Shane;Mattiucci, Joseph;Hoy, Erik P.;Perez, Lark J.. And the article was included in Organic & Biomolecular Chemistry in 2021.COA of Formula: C9H10BrNO2 This article mentions the following:

The development of a novel acetyl nitrate mediated oxidative conversion of Me ketones to carboxylic acid derivatives is described. By analogy to the haloform reaction and supported by exptl. and computational investigation authors propose a mechanism for this transformation. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2COA of Formula: C9H10BrNO2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.COA of Formula: C9H10BrNO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Syntheses of stable-isotope labeled [M + 7] and [M + 6] 2-(methylamino)imidazole was written by Zhang, Yinsheng. And the article was included in Journal of Labelled Compounds & Radiopharmaceuticals in 2002.Name: 2,2-Diethoxyacetamide This article mentions the following:

Stable isotope-labeled 2-(methylamino)imidazole (M + 7 and M + 6) was required as an intermediate in the synthesis of mass labeled drug candidates. These two isotopomers were synthesized with total yields of 24 and 36%, resp. Labeled 2-aminoimidazole (M + 4) was prepared from labeled isothiourea (M + 3) and 2-aminoacetaldehyde di-Me acetal (M + 1 and M + 2). The (M + 1) version of 2-aminoacetaldehyde di-Me acetal was obtained in two steps starting with potassium [¹⁵N]phthalimide, while the (M + 2) version was prepared from the reduction of diethoxyacetamide with LiAlD₄. Two different approaches for the preparation of 2-(methylamino)imidazole from 2-aminoimidazole were explored. Attempts to prepare protected 2-aminoimidazole to couple with CH₃I (M + 4) to form the desired labeled 2-(methylamino)imidazole failed. However, methylation was achieved by applying N-formamidation followed by deutero-reduction These successful syntheses allowed us to selectively label with nitrogen, carbon or hydrogen isotopes at most of the positions of 2-(methylamino)imidazole. In the experiment, the researchers used many compounds, for example, 2,2-Diethoxyacetamide (cas: 61189-99-9Name: 2,2-Diethoxyacetamide).

2,2-Diethoxyacetamide (cas: 61189-99-9) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Name: 2,2-Diethoxyacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of reprocessable lignin-based non-isocyanate poly(imine-hydroxyurethane)s networks was written by Xue, Danwei;Xue, Bailiang;Tang, Rui;Shen, Chao;Li, Xinping;Zhao, Wei. And the article was included in Paper and Biomaterials in 2021.HPLC of Formula: 2387-23-7 This article mentions the following:

In this study, an environmentally friendly and non-toxic route to synthesize lignin-based non-isocyanate poly(imine-hydroxyurethane)s networks was explored. Specifically, the NH₂-terminated polyhydroxyurethanes (NPHUs) prepolymer was first synthesized from bis(6-membered cyclic carbonate) (BCC) and diamine via the ring-opening reaction. Subsequently, the corresponding lignin based non-isocyanate polyurethanes (NIPUs) with tunable properties were synthesized from NPHUs and levulinate lignin derivatives containing ketone groups via the Schiff base reaction. The structural, mech., and thermal properties of NIPUs with different stoichiometric feed ratios of BCC and levulinate lignin were characterized by Fourier transform IR spectroscopy, NMR, differential scanning calorimetry, dynamic mech. anal., and thermogravimetric anal.. The results indicated that the tensile strength, Young’s modulus, toughness, storage modulus, glass transition temperature, and thermal stability of lignin-based NIPUs gradually increased with increasing lignin content, and the highest Young’s modulus of 41.1 MPa was obtained when lignin content reached 45.53%. With good reprocessing properties, this synthetic framework of lignin-based NIPUs also provides sustainable non-isocyanate-based substitutions to traditional polyurethane networks. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7HPLC of Formula: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.HPLC of Formula: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Flavonoid-Rich Fraction from Croton blanchetianus (Euphorbiaceae) Leaves Exerts Peripheral and Central Analgesic Effects by Acting via the Opioid and Cholinergic Systems was written by de Oliveira, Alisson Macario;Widmer, Ramona;do Nascimento, Matheus Ferreira;Costa, Wendeo Kennedy;Paiva, Patricia Maria Guedes;Napoleao, Thiago Henrique. And the article was included in Chemistry & Biodiversity in 2022.Application of 10238-21-8 This article mentions the following:

The ethanolic extract from Croton blanchetianus leaves has been shown to have antinociceptive activity in mice. Here, we investigated the antinociceptive activity of an Et acetate fraction (EAF) from this extract in mice and the possible pathways involved in the analgesic effect. Adverse effects on behavior and motor coordination were also evaluated. The EAF was characterized by liquid chromatog. coupled with mass spectrometry and evaluated (12.5, 25, and 50 mg/kg per os) in the acetic acid-induced abdominal writhing, formalin, hot plate, and tail immersion assays. Naloxone, atropine, glibenclamide, prazosin, or yohimbine was pre-administered to mice to investigate the involved pathways in the formalin test. The open-field, rotarod, and elevated plus-maze tests were used to assess behavior and locomotion. The main components of the EAF were quercetin-3-O-(2-rhamnosyl) rutinoside, hyperoside, quercetin rutinoside pentoside, and quercetin hexoside deoxyhexoside. EAF showed antinociceptive effects in all models and was effective against both neurogenic and inflammatory pain. The reversion of the effects in the formalin test by naloxone and atropine revealed that the EAF acted via the opioid and cholinergic systems. In the open-field test, the behavior of the animals treated with the EAF was like that of control, except at the highest dose, when hypnosis, eyelid ptosis, decreased walking, hygiene, and rearing behaviors were observed No muscle relaxant effect was observed, but an anxiogenic effect was observed at all doses. This study provides new scientific evidence on the pharmacol. properties of C. blanchetianus leaves and their potential for the development of phytomedicines with analgesic properties. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Application of 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application of 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The Behavior of Silver Nanotextiles during Washing was written by Geranio, L.;Heuberger, M.;Nowack, B.. And the article was included in Environmental Science & Technology in 2009.COA of Formula: C10H16N2O4 This article mentions the following:

The widespread use of silver nanoparticles (Ag-NPs) in com. products, especially textiles, will likely result in an unknown spread of Ag into the environment. The quantification and characterization of the Ag released from nano-Ag-products is an important parameter needed to predict the effect of Ag-NPs on the environment. The aim of this study was to determine the amount and the form of Ag released during washing from nine fabrics with different ways of silver incorporation into or onto the fibers. The effect of pH, surfactants, and oxidizing agents was evaluated. The results show that little dissolution of Ag-NPs occurs under conditions relevant to washing (pH 10) with dissolved concentrations 10 times lower than at pH 7. However, bleaching agents such as hydrogen peroxide or peracetic acid (formed by the perborate/TAED system) can greatly accelerate the dissolution of Ag. The amount and form of Ag released from the fabrics as ionic and particulate Ag depended on the type of Ag-incorporation into the textile. The percentage of the total silver emitted during one washing of the textiles varied considerably among products (from less than 1 to 45%). In the washing machine the majority of the Ag (at least 50% but mostly >75%) was released in the size fraction >450 nm, indicating the dominant role of mech. stress. A conventional silver textile did not show any significant difference in the size distribution of the released silver compared to many of the textiles containing nano-Ag. These results have important implications for the risk assessment of Ag-textiles and also for environmental fate studies of nano-Ag, because they show that under conditions relevant to washing, primarily coarse Ag-containing particles are released. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4COA of Formula: C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.COA of Formula: C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-β expression and fibroblast recruitment was written by Choi, Sung Yoon;Kim, Byung Hwi;Huh, Beom Kang;Jeong, Woong;Park, Min;Park, Hyo Jin;Park, Ji-Ho;Heo, Chan Yeong;Choy, Young Bin. And the article was included in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2018.Electric Literature of C18H17NO5 This article mentions the following:

We describe surgical sutures enabled with the local, sustained delivery of a TGF-β inhibitory drug, tranilast. To fabricate drug-delivery sutures, we sep. prepared a tranilast-loaded strand using poly(lactic-co-glycolic acid), which was then phys. braided with a surgical suture already in clin. use. By this method, the drug-delivery sutures maintained the mech. strength and allowed the modulation of drug release profiles by simply altering the tranilast-loaded strand. The drug-delivery sutures herein released tranilast for up to 14 days. When applied to animal models, scarring was indeed reduced with diminished TGF-β expression and fibroblast numbers during the entire 21 day testing period. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Electric Literature of C18H17NO5).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C18H17NO5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Effect of Reactive Distillation on the Yield of Tetraacetylethylenediamine (TAED) was written by Kim, Eun-Seon;Park, Kyun Young;Heo, Jung-Moo;Kim, Byung Jo;Ahn, Kyo Duck;Lee, Jong-Gi. And the article was included in Industrial & Engineering Chemistry Research in 2010.Product Details of 10543-57-4 This article mentions the following:

Tetraacetylethylenediamine (TAED) was prepared by acetylation of diacetylethylenediamine (DAED) with acetic anhydride in a 5 L reactor coupled with a packed distillation column, 2.5 cm in inside diameter and 1 m in length. The reaction temperature was set at 135 °C and the reflux ratio at 6. The molar ratio of acetic anhydride to DAED was varied from 3 to 5. A TAED yield as high as 80% was obtained, higher by 15% than in the absence of distillation The temporal variation of the TAED yield was calculated using the kinetic parameters in the literature. Calculated and exptl. values showed good agreement. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Product Details of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Product Details of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Evaluation of antioxidant, antidiabetic and antihyperlipidaemic activity of methanolic extract of Casearia elliptica in alloxan induced male wistar diabetic rats was written by Tarun, Mudadla;Praveen, Vataka;Ramani, Seemusiri Usha;Devi, Yeddu Iswarya;Madhu, Chandaka. And the article was included in Indo American Journal of Pharmaceutical Sciences in 2022.SDS of cas: 10238-21-8 This article mentions the following:

Background: Diabetes mellitus is a group of metabolic disorders with the common manifestations, hyperglycemia. Alloxan causes a massive reduction in insulin release by the destruction of β cells of the islets of langerhans, there by inducing hyperglycemia. Alloxan has been shown to induce free radical production and cause tissue injury. The aim of the present investigation was to evaluate the antioxidant, antihyperlipidemic and antidiabetic activity of methanolic extract taken from Casearia elliptica. Methods: The methanolic extract of Casearia elliptica whole plant used for the study. The Phytochem. test, acute toxicity study and oral glucose test was performed. Diabetes was induced in rat by single intra-peritoneal injection of alloxan (120 mg/kg). Male albino Wistar rats were divided into five groups each consisting of six animals as follows:Group I- Administered vehicle serves as Normal control.,Group II- Administered Alloxan (120 mg/kg s.c.) serves as diabetic control,Group III- Administered Reference Standard, (Glibenclamide 10 mg/kg, orally once daily),Group IV- Diabetic rats treated with Casearia elliptica (250mg/kg b.wt), serves as treated group,Group V- Diabetic rats treated with Casearia elliptica (500mg/kg b.wt), serves as treated group. Bodyweight of each rat in the different groups was recorded daily. Biochem. and antioxidant enzyme parameters were determined on day 14. Histol. of different organ (heart, liver, kidney, and pancreas) was performed after sacrificing the rats with euthanasia. Results: Preliminary Phytochem. investigation of methanolic extracts of whole plant of Casearia elliptica was carried out and found that it contains fixed oil, saponins, alkaloids and carbohydrates. The maximum tolerated dose of root of Casearia elliptica was found as 2000 mg/kg after completion of toxicity study according to OECD guideline. The methanolic extract of whole plant of Casearia elliptica has potential anti-diabetic action in alloxan induced diabetic rats and the effect was found equally effective with glibenclamide at higher dose. Our study clearly reveals that MECE has some obvious therapeutic implications in treating hyperglycemia, atherogenic lipoprotein profile and also possess antioxidant activity. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8SDS of cas: 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.SDS of cas: 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Utility of a novel turn-off fluorescence probe for the determination of tranilast, an adjunctive drug for patients with severe COVID-19 was written by Dagher, Diaa;Elmansi, Heba;Nasr, Jenny Jeehan;El-Enany, Nahed. And the article was included in RSC Advances in 2022.Formula: C18H17NO5 This article mentions the following:

Tranilast (TR) could be investigated as a suitable anti-inflammatory and NLRP3 inflammasome inhibitor medication for the treatment of COVID-19 acute patients. Owing to its importance, our study was constructed for the determination of TR using a new, fast, sensitive, and reliable green spectrofluorimetric method. TR was quantified in this study by forming a complex with the acriflavine (AC) reagent. The reaction between TR and AC quenched the fluorescence of AC through the formation of an ion-association complex and the response was measured at 493 nm after excitation at 263 nm. It was observed that the quenching of the fluorescence of AC was linear (r = 0.9998) with the concentration of TR in the range of 1.0-15.0 μg mL-1. The limit of detection was 0.224 μg mL-1, and the limit of quantification was 0.679 μg mL-1. The fluorescence quenching mechanism was carefully studied and was confirmed to be able to analyze TR in its pure form and its prepared pharmaceutical dosage form. To validate the method, the international conference of harmonization (ICH) Q2R1 guidelines were followed. The statistical assessment of the proposed and comparison methods revealed no significant differences between them. Moreover, the green criteria of the method were evaluated and confirmed. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Formula: C18H17NO5).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Formula: C18H17NO5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics