Category: amides-buliding-blocks

Murugesan, Kathiravan published the artcileA General Catalyst Based on Cobalt Core-Shell Nanoparticles for the Hydrogenation of N-Heteroarenes Including Pyridines, HPLC of Formula: 1453-82-3, the publication is Angewandte Chemie, International Edition (2020), 59(40), 17408-17412, database is CAplus and MEDLINE.

Herein, we report the synthesis of specific silica-supported Co/Co₃O₄ core-shell based nanoparticles prepared by template synthesis of cobalt-pyromellitic acid on silica and subsequent pyrolysis. The optimal catalyst material allows for general and selective hydrogenation of pyridines, quinolines, and other heteroarenes including acridine, phenanthroline, naphthyridine, quinoxaline, imidazo[1,2-a]pyridine, and indole under comparably mild reaction conditions. In addition, recycling of these Co nanoparticles and their ability for dehydrogenation catalysis are showcased.

Angewandte Chemie, International Edition published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, HPLC of Formula: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bagley, Mark C. published the artcileSimple microwave-assisted method for the synthesis of primary thioamides from nitriles, Related Products of amides-buliding-blocks, the publication is Synlett (2004), 2615-2617, database is CAplus.

Primary thioamides are prepared in excellent yield from the corresponding nitrile by treatment with ammonium sulfide in methanol, at room temperature for electron-deficient aromatic nitriles or under microwave irradiation at 80 °C or 130 °C in 15-30 min for other aromatic and aliphatic nitriles. This procedure avoids the use of gaseous H₂S under high pressure, proceeds in the absence of base and provides thioamides usually without the need for chromatog. purification

Synlett published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yusov, A. S. published the artcileSynthesis and Analgesic and Anti-Inflammatory Activities of (3,3-Dipropyl-6,7-Dimethoxy-3,4-Dihydroisoquinolin-1(2H)-Ylidene)-Acetamide Hydrochlorides, SDS of cas: 15029-36-4, the publication is Pharmaceutical Chemistry Journal (2019), 53(1), 35-39, database is CAplus.

Cyclocondensation of 4-(3,4-dimethoxybenzyl)heptan-4-ol with N-substituted cyanoacetamide was used to synthesize (3,3-dipropyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2(2H)-ylidene)acetamides. The hydrochlorides of the resulting enaminoamides exist in the imino form. All hydrochlorides displayed analgesic effects in the hotplate test at the level of sodium metamizole, and the most active were the amide with the N-substituted 2-(3,4-dimethyoxyphenyl)ethyl radical, which had greater levels of analgesic activity than metamizole and nimesulide. Many of the resulting amides displayed anti-inflammatory effects in a carragheenan model which were comparable in magnitude to those of sodium metamizole.

Pharmaceutical Chemistry Journal published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C23H43NP2, SDS of cas: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Smith, N. published the artcileAdenosine receptor subtypes in the airways responses to 5′-adenosine monophosphate inhalation of sensitized guinea-pigs, Recommanded Product: N-(4-Acetylphenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)phenoxy)acetamide, the publication is Clinical and Experimental Allergy (2008), 38(9), 1536-1547, database is CAplus and MEDLINE.

Endogenous adenosine levels are raised in the lungs during asthma attacks. 5′-Adenosine monophosphate (5′-AMP) inhalation in asthmatics causes bronchoconstriction and in sensitized guinea-pigs induces early (EAR) and late asthmatic responses (LAR), airway hyper-reactivity (AHR) and inflammatory cell recruitment to the lungs. The aim of this study was to investigate the roles of A₁, A_2A, A_2B and A₃ adenosine receptors in these responses to inhaled 5′-AMP in sensitized guinea-pigs. Comparisons were made with the effect of dexamethasone treatment on 5′-AMP-induced responses. Functional airways responses to inhaled 5′-AMP (3 and 300 mM) of actively sensitized, conscious guinea-pigs were determined by whole-body plethysmog. following administration of selective adenosine receptor antagonists or their vehicles. AHR to inhaled histamine (1 mM) and inflammatory cell influx in bronchoalveolar lavage fluid were determined 5′-AMP at 3 mM caused an immediate bronchoconstriction (EAR), whereas 300 mM caused bronchodilatation. Both responses were followed at 6 h by a LAR, together with inflammatory cell influx and AHR to histamine. The A_2A receptor antagonist, ZM241385, further enhanced cell influx after 5′-AMP inhalation (3 and 300 mM), and blocked the immediate bronchodilator response to 300 mM 5′-AMP, exposing an EAR. The A_2B receptor antagonist, MRS1706 (in the presence of ZM241385), inhibited the LAR, AHR and cell influx, following inhalation of 5′-AMP (300 mM). The A₃ receptor antagonist, MRS1220, inhibited 5′-AMP-induced inflammatory cell influx. The A₁ receptor antagonist, DPCPX (in the presence of ZM241385), inhibited the EAR following 5′-AMP inhalation (300 mM). Dexamethasone inhibited the LAR, AHR and cell influx following inhalation of 5′-AMP (300 mM). All four adenosine receptor subtypes play various roles in the airways responses to inhaled 5′-AMP in sensitized guinea-pigs.

Clinical and Experimental Allergy published new progress about 264622-53-9. 264622-53-9 belongs to amides-buliding-blocks, auxiliary class GPCR/G Protein,Adenosine Receptor, name is N-(4-Acetylphenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)phenoxy)acetamide, and the molecular formula is C10H10O6, Recommanded Product: N-(4-Acetylphenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)phenoxy)acetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Haefele, J. W. published the artcileSynthesis and properties of mercaptans having different degrees of acidity of the sulfhydryl group, Related Products of amides-buliding-blocks, the publication is Proceedings of the Scientific Section of the Toilet Goods Association (1959), 52-9, database is CAplus.

The title compounds were prepared as skin sensitizing materials (Voss, CA 53, 20529e). Mercaptoalkanoic acid amides were made by acylation of amines with the corresponding esters (method 1) or acid chlorides in which the SH group was protected as the Ac derivative (method 2). Another reaction used was the addition of AcSH to olefinic double bonds followed by ammonolysis with NH₄OH. Thus, reaction overnight at room temperature of 180 g. Et thioglycolate with 111 g. methylamine in 375 ml. MeOH yielded 123.3 g. N-methylthioglycolamide, b₅ 91-4°, pK 8.05. Method (1) with increased reaction times and higher temperatures also gave: 73.3% N,N-dimethylthioglycolamide, b₅ 75-8°, pK 8.10; N-ethylthioglycolamide, 63.5%, b₄ 92-3°, pK 8.14 (disulfide m. 101°); N-isopropylthioglycolamide, 6%, b₄ 112° (disulfide m. 94°); N-amylthioglycolamide, 6%, b₄ 131° (disulfide m. 113°); N-hexylthioglycolamide, 70.5%, b₂ 134° (disulfide m. 109°); N-decylthioglycolamide, 72.0%, b_0.5 163° (disulfide m. 118°); N-hydroxyethylthioglycolamide, 96.1% (81.5% purity), pK 8.10 (disulfide m. 86°); N-methoxyethylthioglycolamide, 51.3%, b₂ 115°, pK 8.10; N-(diethylaminoethyl)thioglycolamide, 36.6%, b₂ 122-5°; N,N-bis(2-hydroxyethyl)mercaptoacetamide, 86.0% purity; N-(1,1-dimethylolmethyl)mercaptoacetamide, 86.0% purity; N-(trimethylolmethyl)mercaptoacetamide, 66.0% purity; 2-mercaptopropionamide, 93% purity; thioglycolic hydrazide, 96.5% yield, m. 52-3°, pK 8.05 (disulfide m. 93-4°); 3-mercaptopropionamide, 91% purity; 2-mercaptopropionic hydrazide, 88% purity; 3-mercaptopropionic hydrazide, 96% purity. Acetylthioacetyl chloride (0.2 mole) (from the acid and SOCl₂) and 0.2 mole Et glycinate were added simultaneously at a slow rate to a well stirred suspension of 87 g. CaSO₄ and 100 g. K₂CO₃ in 400 ml. ether at 10-15° to yield after 3 hrs. crystalline Et N-(acetylthioacetyl)glycinate, m. 78.5° (ether); this (0.032 mole) with 0.09 mole aqueous NH₄OH gave 100% conversion to the free thiol. Tetra-O-acetylglucosamine and acetylthioacetyl chloride in CHCl₃ at 0° yielded on precipitation with ligroine 77% N-(acetylthioacetyl)tetra-O-acetylglucosamine, m. 190-1°. Similarly, di-Et N-(acetylthioacetyl)aminomalonate was obtained in 52% yield, m. 91.5° (ether). Mercaptosuccinimide, pK 6.65, was prepared by addition of thiolacetic acid to maleimide in the presence of benzoyl peroxide to give an initial product, m. 91°, hydrolyzed with HCl in MeOH. At 100° in an autoclave, 113 g. morpholine and 78 g. ethylene sulfide gave after 16 hrs. 77.9% N-mercaptoethylmorpholine, b_0.9 72-3°, n²⁰_D 1.5045. Addition of 68.5 g. ethylene sulfide to 81 g. pyrrolidine in 400 ml. dry dioxane followed by stirring and refluxing 6 hrs. yielded 111 g. N-mercaptoethylpyrrolidine, b₂₂ 81°, n²⁰_D 1.5004, on distillation of the mixture In the same way were obtained: N-mercaptoethylpiperidine, b₁₈ 88°, n²⁰_D 1.5011; N-mercaptoethylpyrrolidone (no data); 3-aza-6-oxaheptanethiol, b₃ 57°, n²⁰_D 1.4770; 3-aza-5-(diethylamino)pentanethiol, b_0.3 53°, n²⁰_D 1.4793. N-(S-Acetylthioethyl)pyrrolidinium chloride was prepared in 81.6% yield by reaction of N-mercaptoethylpyrrolidine with AcCl in benzene and precipitation with hexane, m. 152°. The free base, b_0.2 65°, n²⁰_D 1.5011, with excess MeI in ether at room temperature gave after 8 days 85% N-(S-acetylthioethyl)-N-methylpyrrolidinium iodide, m. 159-60° (EtOH). N-Mercaptoethyl-N-methylpyrrolidinium iodide, m. 66-7°, 44.8% yield, pK 7.7, resulted on hydrolysis with MeOH-HCl 6 days at room temperature An analogous route yielded: 92.2% N-(S-acetylthioethyl)morpholinium chloride, m. 204°; N-(S-acetylthioethyl)morpholine, 59.5%, b_1.5 87°, n²⁰_D 1.5050; N-(S-acetylthioethyl)-N-methylmorpholinium iodide, 85.5%, m. 136-9°; N-mercaptoethyl-N-methylmorpholinium iodide, 11.4%, m. 140-3°, pK 7.52. N-Mercaptoethyltrifluoroacetamide, 9.1% yield, b_1.2 57-61°, pK 7.28, was obtained by reaction of NaOMe from 2 g. Na in 50 ml. MeOH with 10.5 g. mercaptoethylamine-HCl and 28 ml. Et trifluoroacetate in a sealed tube at 100° 16 hrs. Mercaptoethylurea was prepared from mercaptoethylamine and 2 moles KOCN with concentrated HCl to give β-ureidoethyl thiocarbamate, ionization constant 0.8 × 10^-9. S-Acetylthioethyl Me sulfone was prepared by refluxing 61 g. Me vinyl sulfone with 48 g. thiolacetic acid and 1 crystal benzoyl peroxide 20 hrs., extracting with 400 ml. EtOH, and distilling the extract to yield 35 g. reddish brown oil, b_0.3 124-38°, crystallized from EtOH to give 16 g. yellow solid, m. 59-60°. Hydrolysis with MeOH-HCl 5 days at room temperature gave 85.9% mercaptoethyl Me sulfone, pale yellow oil, b_0.1 105-7°, n²⁰_D 1.5240, d₂₀ 1.3208, pK 7.92; disulfide m. 152°. Further prepared were hydroxyethyl thioglycolate, b_20-30 86-91°, dimethoxyethyl thiomalate, b_0.5 130-4°, and N-(S-acetylthioethyl)pyrrolidone, m. 37°.

Proceedings of the Scientific Section of the Toilet Goods Association published new progress about 1869-45-0. 1869-45-0 belongs to amides-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide, and the molecular formula is C4H6F3NOS, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Haefele, J. W. published the artcileSynthesis and properties of mercaptans with different SH-acidities, Safety of 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide, the publication is Kosmetik-Parfum-Drogen Rundschau (1961), 1-4, database is CAplus.

cf. CA 54, 17233g.-The ionization constants of the SH groups of the following mercaptans were determined by potentiometric titration (pK given): thioglycolic acid (I), 10.2; βmercaptopropionic hydrazide, 10.2; EtSH, 10.0; βmercaptoethanol, 9.5; mercaptopropionamide, 9.4; thioglycerol, 9.3; 2mercaptoethylurea, 9.1; N-(mercaptoethyl)acetamide, 8.7; “mercaptoethylnitrile,” 8.6; 2-mercaptoethylamine, 8.6; glutathione, 8.7; cysteine, 8.3; thioglycolamide (II), 8.2; thiosalicylic acid, 8.2; thiolactamide, 8.1; thiophenol, 8.0; mercaptoethyl methyl sulfone, 7.9; hydroxyethyl thioglycolate, 7.8; thiomalimide, 6.7; “dimethoxyethyt thiomalate,” 6.0; thioacetic acid, 4.3. Passing NH₃ into an alc. solution of an ester of thioglycolic acid, cooling, and washing by decantation gave NH₄SCH₂CONH₂, aqueous solution pH 8.5-8.9; warming the solution to 55-60° in vacuo vaporized the NH₃ and lowered the pH to 6.0-6.4. II added to acrylonitrile (III) in acid medium, while I added only in alk. medium (Earle, CA 47, 7374g). Similarly, reduced hair added to III in acid medium, confirming the relative acidity of the keratin SH group.

Kosmetik-Parfum-Drogen Rundschau published new progress about 1869-45-0. 1869-45-0 belongs to amides-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide, and the molecular formula is C4H6F3NOS, Safety of 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Haefele, J.W. published the artcileProperties and reactions of hair after treatment with mercaptans of differing sulfhydryl acidities, HPLC of Formula: 1869-45-0, the publication is Proc. Sci. Sec. Toilet Goods Assoc. (1961), 31-9, database is CAplus.

cf. CA 54, 17233g.-Mercaptans of high sulfhydryl acidity have good hair-curling power and lower hair-damage potential than thioglycolic acid. However all compounds tested which have these properties are sensitizers. Thioglycolic acid has the great advantage that it is not a sensitizer. Three types of compounds represented by the following mercaptans were tested: thioglycolic acid, mercaptoethylacetamide, and thioglycolamide.

Proc. Sci. Sec. Toilet Goods Assoc. published new progress about 1869-45-0. 1869-45-0 belongs to amides-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide, and the molecular formula is C4H6F3NOS, HPLC of Formula: 1869-45-0.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Luning Prak, Eline T. published the artcileNo increase in inflammation in late-life major depression screened to exclude physical illness, COA of Formula: C17H14F3N3O2S, the publication is Translational Psychiatry (2022), 12(1), 118, database is CAplus and MEDLINE.

Depression is a common and debilitating disorder in the elderly. Late-life depression (LLD) has been associated with inflammation and elevated levels of proinflammatory cytokines including interleukin (IL)-1β, tumor necrosis factor-alpha, and IL-6, but often depressed individuals have comorbid medical conditions that are associated with immune dysregulation. To determine whether depression has an association with inflammation independent of medical illness, 1120 adults were screened to identify individuals who had clin. significant depression but not medical conditions associated with systemic inflammation. In total, 66 patients with LLD screened to exclude medical conditions associated with inflammation were studied in detail along with 26 age-matched controls (HC). At baseline, circulating cytokines were low and similar in LLD and HC individuals. Furthermore, cytokines did not change significantly after treatment with either an antidepressant (escitalopram 20 mg/day) or an antidepressant plus a COX-2 inhibitor or placebo, even though depression scores improved in the non-placebo treatment arms. An anal. of cerebrospinal fluid in a subset of individuals for IL-1β using an ultrasensitive digital ELISA revealed low levels in both LLD and HC at baseline. Our results indicate that depression by itself does not result in systemic or intrathecal elevations in cytokines and that celecoxib does not appear to have an adjunctive antidepressant role in older patients who do not have medical reasons for having inflammation. The neg. finding for increased inflammation and the lack of a treatment effect for celecoxib in this carefully screened depressed population taken together with multiple pos. results for inflammation in previous studies that did not screen out phys. illness support a precision medicine approach to the treatment of depression that takes the medical causes for inflammation into account.

Translational Psychiatry published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, COA of Formula: C17H14F3N3O2S.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sevov, Christo S. published the artcileEvolutionary Design of Low Molecular Weight Organic Anolyte Materials for Applications in Nonaqueous Redox Flow Batteries, Product Details of C10H14N2O, the publication is Journal of the American Chemical Society (2015), 137(45), 14465-14472, database is CAplus and MEDLINE.

The integration of renewable energy sources into the elec. grid requires low-cost energy storage systems that mediate the variable and intermittent flux of energy associated with most renewables. Nonaqueous redox-flow batteries have emerged as a promising technol. for grid-scale energy storage applications. Because the cost of the system scales with mass, the electroactive materials must have a low equivalent weight (ideally 150 g/(mol·e^–) or less), and must function with low mol. weight supporting electrolytes such as LiBF₄. However, soluble anolyte materials that undergo reversible redox processes in the presence of Li-ion supports are rare. We report the evolutionary design of a series of pyridine-based anolyte materials that exhibit up to two reversible redox couples at low potentials in the presence of Li-ion supporting electrolytes. A combination of cyclic voltammetry of anolyte candidates and independent synthesis of their corresponding charged-states was performed to rapidly screen for the most promising candidates. Results of this workflow provided evidence for possible decomposition pathways of first-generation materials and guided synthetic modifications to improve the stability of anolyte materials under the targeted conditions. This iterative process led to the identification of a promising anolyte material, N-Me 4-acetylpyridinium tetrafluoroborate. This compound is soluble in nonaqueous solvents, is prepared in a single synthetic step, has a low equivalent weight of 111 g/(mol·e^–), and undergoes two reversible 1e^– reductions in the presence of LiBF₄ to form reduced products that are stable over days in solution

Journal of the American Chemical Society published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C3H8N2S, Product Details of C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bromilow, John published the artcileCarbon-13 substituent chemical shifts in the side-chain carbons of aromatic systems: the importance of π-polarization in determining chemical shifts, Name: 3-Methoxybenzothioamide, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) (1981), 753-9, database is CAplus.

¹³C substituent chem. shifts of the CO sites in the side chains of two-hundred and four m– and p-substituted benzenes were measured using a dual substituent parameter LFER, which showed that inductive effects are predominant. The reverse inductive contribution observed is explained in terms of a π-polarization mechanism. Critical support for this mechanism was obtained from an addnl. series where the CO group was complexed with Lewis acids. The concepts of extended and localized π-polarization are discussed.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Name: 3-Methoxybenzothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics