amides-buliding-blocks Archives - Page 280 of 1299

Nihal, Minakshi’s team published research in Cell Cycle in 13 | CAS: 380315-80-0

Cell Cycle published new progress about 380315-80-0. 380315-80-0 belongs to amides-buliding-blocks, auxiliary class Apoptosis,p53, name is N-((4-Acetamidophenyl)carbamothioyl)-4-(tert-butyl)benzamide, and the molecular formula is C20H23N3O2S, Application In Synthesis of 380315-80-0.

Nihal, Minakshi published the artcileSIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis, Application In Synthesis of 380315-80-0, the publication is Cell Cycle (2014), 13(4), 632-640, database is CAplus and MEDLINE.

Silent information regulator type-1 (SIRT1) is the best-studied member of the Sirtuin (Sir2) family of nicotinamide dinucleotide (NAD)-dependent class III histone deacetylases (HDACs), but has not yet been explored in cutaneous T-cell lymphoma (CTCL). We analyzed five CTCL cell lines and lesional tissues using flow cytometry, immunostaining, immunoblotting, cell death, viability, and apoptosis assays, small-mol. inhibitors, and shRNA knockdown. We found strong SIRT1 expression among CTCL lines relative to normal lymphocytes. CTCL cells in lesional tissues also expressed SIRT1 strongly. SIRT1 knockdown resulted in reduced cellular metabolism and proliferation, increased apoptosis, and PARP cleavage products. Tenovin-1, which reversibly inhibits class III HDACs (SIRT1 and SIRT2), reduced SIRT enzymic activity and SIRT1 expression and led to increased apoptosis. These alterations were accompanied by increased forkhead box O3 (FoxO3) in several cell lines and increased nuclear p53, as well as acetylated p53 in wtp53 MyLa CTCL line. A combination of class I/II and class III HDACIs (vorinostat and tenovin-1) produced significantly greater growth inhibition, cell death via apoptosis, as well as superior p53 promoter upregulation in wtp53 MyLa cells as compared with either agent alone. This occurred in a partially p53-dependent manner, as these effects were blunted by p53 knockdown. Our results indicate that SIRT1 is strongly expressed in CTCL. Its inhibition results in reduced growth and increased apoptosis of CTCL cells. Furthermore, our findings suggest that some CTCL patients, such as those with wtp53, might benefit more from treatment with a combination of different classes of HDACIs than with a single agent.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Malnes, Daniel’s team published research in Chemosphere in 294 | CAS: 137862-53-4

Chemosphere published new progress about 137862-53-4. 137862-53-4 belongs to amides-buliding-blocks, auxiliary class GPCR/G Protein,Angiotensin Receptor, name is (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid, and the molecular formula is C24H29N5O3, HPLC of Formula: 137862-53-4.

Malnes, Daniel published the artcileOccurrence and mass flows of contaminants of emerging concern (CECs) in Sweden’s three largest lakes and associated rivers, HPLC of Formula: 137862-53-4, the publication is Chemosphere (2022), 133825, database is CAplus and MEDLINE.

Contaminants of emerging concern (CECs) are a concern in aquatic environments due to possible adverse effects on the environment and humans. This study assessed the occurrence and mass flows of CECs in Sweden’s three largest lakes and 24 associated rivers. The occurrence and distribution of 105 CECs was investigated, comprising 71 pharmaceuticals, 13 perfluoroalkyl substances (PFASs), eight industrial chems., four personal care products (PCPs), three parabens, two pesticides, and four other CECs (mostly anthropogenic markers). This is the first systematic study of CECs in Sweden’s main lakes and one of the first to report environmental concentrations of the industrial chems. tri-Bu citrate acetate and 2,2′-dimorpholinyldiethyl-ether. The ∑CEC concentration was generally higher in river water (31-5200 ng/L; median 440 ng/L) than in lake water (36-900 ng/L; median 190 ng/L). At urban lake sites, seasonal variations were observed for PCPs and parabens, and also for antihistamines, antidiabetics, antineoplastic agents, antibiotics, and fungicides. The median mass CEC load in river water was 180 g/day (range 4.0-4300 g/day), with a total mass load of 5000 g/day to Lake Vanern, 510 g/day to Lake Vattern, and 5600 g/day to Lake Malaren. All three lakes are used as drinking water reservoirs, so further investigations of the impact of CECs on the ecosystem and human health are needed.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hibino, Masaki’s team published research in Chemical Communications (Cambridge, United Kingdom) in 56 | CAS: 186046-83-3

Chemical Communications (Cambridge, United Kingdom) published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Synthetic Route of 186046-83-3.

Hibino, Masaki published the artcileCationic guanine: positively charged nucleobase with improved DNA affinity inhibits self-duplex formation, Synthetic Route of 186046-83-3, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(17), 2546-2549, database is CAplus and MEDLINE.

Oligonucleotides represent powerful DNA-recognition tools, but the formation of undesirable “self-duplexes” becomes more probable with increasing DNA affinity. Herein, we have developed a modified nucleobase with “self-avoiding” properties. Facile methylation of guanine yields a cationic N⁷-methylguanine, which suppresses the formation of self-duplexes while improving DNA affinity through electrostatic interaction.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhang, Bonan’s team published research in Anticancer research in 2020 | CAS: 123-39-7

Anticancer research published new progress about SBRT; SRT; Stereotactic body radiation therapy; oligometastatic prostate cancer; prostate neoplasm; review. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Zhang, Bonan published the artcileA Review of Stereotactic Body Radiation Therapy in the Management of Oligometastatic Prostate Cancer., Recommanded Product: N-Methylformamide, the main research area is SBRT; SRT; Stereotactic body radiation therapy; oligometastatic prostate cancer; prostate neoplasm; review.

BACKGROUND/AIM: Management strategies such as surgery and systemic therapy (androgen-deprivation therapy and chemotherapy) are considered a standard of care for patients with oligometastatic prostate cancer and have shown some positive results in many patients. However, they are often accompanied by side-effects that can negatively affect patients. The aim of this study is to review the potential of stereotactic body radiation therapy (SBRT) in the management of oligometastatic prostate cancer and to compare treatment outcomes with SBRT to those under standard of care management regarding progression-free survival (PFS), androgen-deprivation therapy (ADT)-free survival and local control rate (LCR) as well as a comparison of toxicity profiles. MATERIALS AND METHODS: MEDLINE (PubMed), EMBASE, and Clinicaltrials.gov databases were searched to identify prospective randomised controlled trials as well as retrospective studies investigating SBRT and standard of care management for oligometastatic prostate cancer. Data on treatment outcomes and toxicity profiles were extracted. RESULTS: A total of 18 studies were included: 14 reported on the use of SBRT and four reported on the use of standard of care management. For SBRT, median PFS was 7.36-24 months. Median ADT-free survival was 12.3-39.7 months. The LCR varied, with some reports of 100% at 6 months and others of 92% at 5 years. No significant grade 3 toxicity was reported, with only five grade 3 events reported in two studies. For standard of care management, most of the studies reported 3-year PFS of 46.9-58.6%, with one study reporting a median PFS of 38.6 months. No standard of care study reported on LCR and ADT-free survival. Although different toxicity grading systems were used depending on the treatment modality, there were some reports of grade 3 events using standard of care management. CONCLUSION: SBRT appears to be a safe and effective modality for treating oligometastatic prostate cancer, having the potential to defer palliative ADT. Although LCR is excellent compared to conventional therapies, the PFS rate is reportedly inferior to standard of care therapies. No significant grade 3 toxicity was observed with SBRT.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Shingare, M. S.’s team published research in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 1979-09-30 | CAS: 35203-88-4

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about thiazole amino sulfamoylphenyl; chlorosulfonation arylthiazole; sulfonamide; phenylsulfonamide; aminothiazole. 35203-88-4 belongs to class amides-buliding-blocks, name is 3-Acetylbenzenesulfonamide, and the molecular formula is C8H9NO3S, Quality Control of 35203-88-4.

Shingare, M. S. published the artcileSynthesis of sulfonamides derived from 2-acetamido-4-(3′-chlorosulfonyl-4′-aryl)thiazoles, Quality Control of 35203-88-4, the main research area is thiazole amino sulfamoylphenyl; chlorosulfonation arylthiazole; sulfonamide; phenylsulfonamide; aminothiazole.

Chlorosulfonation of 2-acetamido-4-arylthiazoles yielded 2-acetamido-4-(3-chlorosulfonyl-4-substituted aryl)thiazoles, which were converted into the corresponding sulfonamides I (R = Me, Cl, Br) and N-substituted phenyl-sulfonamides II (R1 = H, Me, Cl, OMe, OEt, Br). II were hydrolysed to the resp. 2-aminothiazoles. The position of sulfonamido group in I was confirmed by NMR spectra and chem. methods.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Utine, Canan Asli’s team published research in Eye & contact lens in 2018 | CAS: 359-38-6

Eye & contact lens published new progress in MEDLINE about 359-38-6, 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, COA of Formula: C2H3F2NO.

Utine, Canan Asli published the artcileEffects of Preoperative Topometric Indices on Visual Gain After Intracorneal Ring Segment Implantation For Keratoconus., COA of Formula: C2H3F2NO, the main research area is .

OBJECTIVES: To assess the corneal topometric parameters that can be predictive for better visual gain after intracorneal ring segment (ICRS) implantation in eyes with keratoconus. METHODS: A total of 42 eyes of 32 patients who underwent ICRS implantation at Dokuz Eylul University, Deparment of Ophthalmology, Cornea Divison were included. Changes in uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), refractive errors, and corneal topometric indices measured using Scheimpflug topography (Pentacam, Oculus) were evaluated retrospectively. RESULTS: After creation of intrastromal tunnels of 5.01±0.03 mm inner diameter, 5.71±0.03 mm outer diameter and at 384.21±34.12 μm depth, 1 or 2 ICRS of 150 to 350 µm thickness and 90 to 210° arc length were implanted. Preoperative UDVA of 0.09±0.10 and CDVA of 0.29±0.14 Snellen lines improved postoperatively to 0.42±0.26 and 0.62±0.24, respectively (P<0.001 for both). Preoperative spherical equivalent of -6.35±4.58D and refractive astigmatism of -5.89±2.40D decreased to -3.59±3.86 and -2.25±1.66D, retrospectively (P<0.001 for both). Strong negative correlations were detected between preoperative mean simulated keratometry (SimKavg)/index of surface variance (ISV) and changes in UDVA/CDVA (P<0.01, for all). Postoperative change in ISV was positively correlated with thicknesses of implanted rings. Change in topographical keratoconus classification was positively and change in index of vertical asymmetry was negatively correlated with number of implanted rings (P<0.05 for all). CONCLUSIONS: Preoperative ISV value seems to be beneficial in predicting visual gain after ICRS implantation, in addition to SimKavg. Future work on new nomograms for ICRS selection that include ISV, besides refractive, topographic, and cone location data, is warranted. Eye & contact lens published new progress in MEDLINE about 359-38-6, 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, COA of Formula: C2H3F2NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dubouis, Arnaud’s team published research in Annals of vascular surgery in 2020-07-04 | CAS: 123-39-7

Annals of vascular surgery published new progress in MEDLINE about 123-39-7, 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Dubouis, Arnaud published the artcileResults of the Surgical Management of Acute Limb Ischemia in the Nonagenarians., Formula: C2H5NO, the main research area is .

BACKGROUND: The aging of the population leads us to treat older patients, in particular presenting with acute limb ischemia (ALI). However, there has been little evaluation of this pathology in the nonagenarians. The objectives of this work are thus to evaluate the 1-month and 1-year mortality of the nonagenarians treated for ALI, which made possible to determine the 1-year survival and to highlight the factors influencing the mortality. METHODS: This is a monocentric retrospective study including all the patients aged 90 years old or more surgically treated for ALI between January 2012 and December 2016. In all the patients, we recorded the 1-month mortality and the 1-year survival and the demographic, clinical, and paraclinical data. RESULTS: We operated 83 nonagenarians, with a majority of women (59, 71.1%), using general anesthesia in 20 patients (16.6%), including 10 cases of upper limb acute ischemia (12.0%). The overall mortality rate at 1 month was 22.9%, and the 1-year survival rate was 43.4%. Major amputation rate was 9.6% at 1 year. The survival of the patients operated for upper or lower limb ischemia was similar (P = 0.82). Univariate analysis showed that the 1-year survival was lower in patients having a history of cerebrovascular problems (P = 0.0003), heart failure (P = 0.0027), dementia (P = 0.0452), or in patients that were institutionalized (P = 0.0125), invalid (P = 0.0001), or presented with a complete acute ischemia (P = 0.0002). In multivariate analysis, 3 risk factors remained statistically significant: a previous history of cerebrovascular accident (hazard ratio [HR] = 3.05 [1.54-6.02]; P = 0.0014), cardiac failure (HR = 2.21 [1.23-3.97]; P = 0.0083), and complete ALI (HR = 3.07 [1.64-5.75]; P = 0.0005). CONCLUSIONS: Our study showed that a history of cerebrovascular accident, cardiac failure, or complete ALI is a poor prognostic factor for the 1-year survival of nonagenarians dealt operated for ALI. These elements should be taken into account when deciding either to operate or not in this precise context.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Otlyotov, Arseniy A.’s team published research in Journal of Computational Chemistry in 2022-10-15 | CAS: 123-39-7

Journal of Computational Chemistry published new progress about Clusters. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.

Otlyotov, Arseniy A. published the artcileConformational energies of microsolvated Na+ clusters with protic and aprotic solvents from GFNn-xTB methods, Synthetic Route of 123-39-7, the main research area is sodium methanol water cluster conformational potential correlation function; cluster-continuum theory; conformational analysis; microsolvation; semiempirical methods; sodium cation clusters.

Performance of contemporary tight-binding semiempirical GFNn-xTB methods for the conformational energies of singly charged sodium clusters Na+(S)n (n = 4-8) with 3 protic and 8 aprotic solvents is examined against the reference RI-MP2/CBS method. The median Pearson correlation coefficients of ρ = 0.84 (GFN2-xTB) and ρ = 0.82 (GFN1-xTB) do not give the clear preference to any tested approach. GFN1-xTB method demonstrates more stable performance than its GFN2-xTB successor with the average mean absolute errors (MAEs)/mean signed errors (MSEs) of 1.2/0.2 and 2.3/1.6 kcal mol-1, resp. Conformational energies produced by the computationally efficient DFT functional PBE and double-ζ basis set complemented with -D3(BJ) dispersion correction are suitable for the preliminary sampling (median ρ = 0.93), but should be used with a caution for the calculations of the average ensemble properties (MAE/MSE = 1.7/1.1 kcal mol-1). Higher-ranking PBE0-D3(BJ) and ωB97M-V with triple-ζ basis sets yield significantly lower MAEs/MSEs of 0.55/0.20 and 0.51/0.23 kcal mol-1, resp.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lin, Li-Dan’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2019 | CAS: 123-39-7

Chemical Communications (Cambridge, United Kingdom) published new progress about Clusters. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Lin, Li-Dan published the artcileDevelopment of a new Lindqvist-like Fe6 cluster secondary building unit for MOFs, Name: N-Methylformamide, the main research area is hydroxymethyl pyridinylpropanediol iron Lindqvist cluster preparation crystal mol structure.

This work demonstrates a new Lindqvist-like [FeIII6(μ6-O)L4Cl6]2- (Fe6, L = 2-(hydroxymethyl)-2-(pyridin-4-yl)-1,3-propanediol) cluster for the construction of a novel class of Fe-cluster organic frameworks. The novel Fe6 cluster can be used to build not only a homometallic MOF, but also a heterometallic MOF by introducing copper halide clusters to the reaction system. In particular, the heterometallic MOF achieved a skillful combination of Fe6 SBU and cuprous-halide clusters for the first time. Our synthesis strategy opens up an effective avenue to novel Fe-cluster-based MOF materials.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Suganthi R., Josephine Usha’s team published research in Materials Today: Proceedings in 2020 | CAS: 123-39-7

Materials Today: Proceedings published new progress about Crystals. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.

Suganthi R., Josephine Usha published the artcileThe growth and characterization techniques of organometallic nonlinear optical crystal – Manganese mercury thiocyanate – Bis (N -methyl formamide), Synthetic Route of 123-39-7, the main research area is manganese mercury thiocyanate methyl formamide optical crystal growth.

Manganese mercury thiocyanate – bis (N -Me formamide) has been prepared to be a novel organometallic nonlinear optical crystal. The cell parameters of the grown crystals were obtained by single-crystal XRD anal. The second harmonic generation and optical transmittance of the grown crystal are studied by Kurtz and Perry powder technique and UV spectroscopic absorbance spectrum. The thermal anal. reveals that MMTN crystal possesses good physicochem. stability. The dielec. responses of the grown crystals are studied as a function of the temperature and the results are discussed.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics