Category: amides-buliding-blocks

Bruffaerts, Jeffrey published the artcileFormamides as Isocyanate Surrogates: A Mechanistically Driven Approach to the Development of Atom-Efficient, Selective Catalytic Syntheses of Ureas, Carbamates, and Heterocycles, Recommanded Product: N-Methylformamide, the main research area is amine formamide ruthenium pincer complex catalyst dehydrogenative coupling DFT; urea green preparation; alc formamide ruthenium pincer complex catalyst dehydrogenative coupling DFT; carbamate green preparation; aminoalc formamide ruthenium pincer complex catalyst dehydrogenative coupling tandem; nitrogen heterocycle green preparation.

Despite the hazardous nature of isocyanates, they remain key building blocks in bulk and fine chem. synthesis. By surrogating them with less potent and readily available formamide precursors, we herein demonstrate an alternative, mechanistic approach to selectively access a broad range of ureas, carbamates, and heterocycles via ruthenium-based pincer complex catalyzed acceptorless dehydrogenative coupling reactions. The design of these highly atom-efficient procedures was driven by the identification and characterization of the relevant organometallic complexes, uniquely exhibiting the trapping of an isocyanate intermediate. D. functional theory (DFT) calculations further contributed to shed light on the remarkably orchestrated chain of catalytic events, involving metal-ligand cooperation.

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Song, Wangze published the artcileVisible Light-Induced Amide Bond Formation, Category: amides-buliding-blocks, the main research area is amide preparation green chem; thioacid aniline amide bond formation photoredox catalyst.

A metal-, base-, and additive-free amide bond formation reaction was developed under an organic photoredox catalyst. This green approach showed excellent functional selectivity without affecting other functional groups such as alcs., phenols, ethers, esters, halogens, or heterocycles. This method featured a broad substrate scope, good compatibility with water and air, and high yields (Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Long, Lipeng published the artcileHypervalent iodine(III) promoted tandem reaction of o-fluoroanilines with formamides to construct 2-aminobenzoxazoles, Synthetic Route of 123-39-7, the main research area is aminobenzoxazole preparation; fluoroaniline formamide tandem reaction hypervalent iodine.

A simple and practical synthesis of 2-aminobenzoxazoles I (R = H, Br, F, etc; R1 = H, Cl, COOMe, etc; R2 = R3 = H, Et, Ph, -(CH2)2O(CH2)2-, etc; R4 = H, I, CF3, etc; R5 = Cl, Br, Me, etc;) has been developed from com. available o-fluoroanilines 2-R-3-R1-4-R4-5-R5C6(F)NH2, and formamides HC(O)N(R2)(R3). This process can be performed in the absence of metal catalysts with high levels of functional group tolerance. Hypervalent iodine(III) was both an oxidant and a Lewis acid for this reaction. A variety of substituents can be introduced into each position of the benzoxazole backbone (C-4 to C-7), providing handles for further elaboration.

Organic Chemistry Frontiers published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Dong-Sheng published the artcileStop-Flow Microtubing Reactor-Assisted Visible Light-Induced Hydrogen-Evolution Cross Coupling of Heteroarenes with C(sp3)-H Bonds, Related Products of amides-buliding-blocks, the main research area is alkyl heteroarene preparation; heteroarene alkane photochem hydrogen evolution cross coupling.

Herein, assisted by stop-flow microtubing reactors, an operationally simple protocol for the visible light-induced hydrogen-evolution cross coupling of heteroarenes Ar-H (Ar = 4-methylquinolin-2-yl, phenanthridin-6-yl, 1,3-benzothiazol-2-yl, etc.) with unactivated C(sp3)-H bonds was developed in a metal- and external oxidant-free manner. A wide range of alkylated heteroarenes ArR1 (R1 = oxan-2-yl, Me, (1R,4S)-bicyclo[2.2.1]heptan-2-yl, etc.) was generated with common feedstock chems., including ethane. Mechanistic studies indicated that photoredox-induced hydrogen atom transfer processes followed by dehydrogenative rearomatization delivered the desired coupling products. The merits of this strategy were further demonstrated by the late-stage functionalization of various complex bioactive mols.

ACS Catalysis published new progress about Alkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Hao published the artcileEnantioselective Twofold C-H Annulation of Formamides and Alkynes without Built-in Chelating Groups, Recommanded Product: N-Methylformamide, the main research area is ferrocene based formamide preparation nickel catalyzed oxidative annulation alkyne; chiral benzyldiphenyl ferrocenopyridinone preparation crystal structure; mol structure chiral benzyldiphenyl ferrocenopyridinone; aluminum; annulation; ferrocenes; formamides; nickel.

Twofold C-H annulation of readily available formamides and alkynes without built-in chelating groups was achieved. Ni-Al bimetallic catalysis enabled by a bulky BINOL-derived chiral secondary phosphine oxide (SPO) ligand proved to be critical for high reactivity and high selectivity. This reaction uses readily available formamides as starting materials and provides a concise synthetic pathway to a broad range of chiral ferrocenes in 40-98% yield and 93-99% ee.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Rong-Hua published the artcileSelective C(sp3)-H Cleavage of Enamides for Synthesis of 2-Pyridones via Ligand-enabled Ni-Al Bimetallic Catalysis, Application of N-Methylformamide, the main research area is pyridone preparation regioselective; formyl enamide alkyne cyclization nickel aluminum catalyst.

Herein, a selective C(sp3)-H cleavage of N-formyl enamides R(R1)C=C(CH2(R2))N(CHO)R3 [R = H, Me; R1 = H, propan-2-yl, 4-methoxyphenyl, etc.; R2 = H; R1R2 = -((CH2)2)-, -((CH2)3)-, -(CH2CH(C6H5)CH2)-; R3 = Me, n-Pr, Ph, Bn, 3-methylbut-3-en-1-yl] without backbone modification, providing a series of 2-pyridones I [R4 = Me, Ph, thiophen-2-yl, etc.; R5 = n-Bu, Ph, thiophen-2-yl, etc.] in 58-99% yields was reported. A bifunctional phosphine oxide (PO) ligand-bridging Ni-Al bimetallic catalyst played key role in the reaction.

ACS Catalysis published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yan, Dong published the artcileSBA-15 Supported Chiral Phosphine-Gold(I) Complex: Highly Efficient and Recyclable Catalyst for Asymmetric Cycloaddition Reactions, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide, the main research area is mesoporous silica supported chiral phosphine gold complex preparation; furooxazine preparation enantioselective; alkyne nitrone cycloaddition silica supported gold catalyst.

Ordered mesoporous SBA-15 supported chiral phosphine gold (I) complexes were successfully developed. The gold(I) complexes were covalently immobilized on mercaptopropyl modified silica surface through radical reaction. In this way, the chiral carbon and chiral sulfur of the homogenous catalyst were perfectly remained in situ. And thus, the prepared catalysts demonstrated highly effective asym. cycloaddition activity to afford furooxazines I [R1 = n-Pr, n-Bu, Ph; R2 = Ph; R3 = Ph, 4-MeC6H4; R4 = Ph, 4-BrC6H4], which was likely because the chiral induction effect of the Au complex was hardly influenced by this immobilization method. Moreover, they could be easily recovered by simple filtration and directly used for the subsequent catalytic runs. The prepared catalyst was highly stable and efficient without obvious activity loss after eight cycles.

ChemCatChem published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chu, Haoke published the artcileAsymmetric Dearomatization of Indole by Palladium/PC-Phos-Catalyzed Dynamic Kinetic Transformation, HPLC of Formula: 343338-28-3, the main research area is asym dearomatization indole palladium PCPhos catalyzed dynamic kinetic transformation; preparation chiral spiroindolenine; alkynes; catalytic asymmetric dearomatization; chiral spiroindolenine; dynamic kinetic transformation; palladium.

A palladium-catalyzed intermol. dynamic kinetic asym. dearomatization of 3-arylindoles with internal alkynes was developed with the use of achiral Xantphos and chiral sulfinamide phosphine ligand (PC-Phos) as the co-ligands. This method could deliver various spiro[indene-1,3′-indole] compounds in good yields (up to 95% yield) with up to 98% ee. The salient features of the transformation include the use of readily available substrates, ease of scale-up and the versatile functionalization of the products. The mechanistic experiments gave some insights on active intermediates.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, HPLC of Formula: 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Molaei Yielzoleh, Fatemeh published the artcileTitanomagnetite functionalized by amino acid-based ionic liquid and cobalt (Fe3-xTixO4-SiO2@TrpBu+3I–Co(II)): A reusable bio-nanocomposite for the synthesis of aryl thioamides, Safety of N-Methylformamide, the main research area is cobalt titanomagnetite ionic liquid nanocomposite functionalized amino acid preparation; reusable bio nanocomposite preparation catalyst aryl thioamide; tributyltryptophanium cobalt titanomagnetite ionic liquid bio nanocomposite preparation catalyst.

An efficient and straightforward three-component reaction of alkynes (terminal and internal), elemental sulfur, and amides using novel bio-nanocomposite is described. The bio-nanostructure obtained from step-by-step coating the titanomagnetite core by silica, N,N,N-tributyltryptophanium iodide ionic liquid, and cobalt resp. The Fe3-xTixO4-SiO2@TrpBu+3I–Co(II) characterized though FT-IR, FESEM, EDAX, XRF, TGA/DTG, VSM, and XPS techniques. Its catalytic efficacy examined successfully in the solvent-free three-component reaction of alkynes (terminal and internal), S8, and amides to prepare the corresponding aryl thioamides via the C-C triple bond cleavage. The reusability examination of the Fe3-xTixO4-SiO2@TrpBu+3I–Co(II) bio-nanocomposite proceeded successfully within two runs. The recovered nanostructure characterized through EDAX and FESEM techniques that demonstrated no significant changes in the morphol. and constitutive elements.

Journal of Molecular Structure published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Pei-Chao published the artcilePd/PC-Phos-Catalyzed Enantioselective Intermolecular Denitrogenative Cyclization of Benzotriazoles with Allenes and N-Allenamides, Name: (S)-2-Methylpropane-2-sulfinamide, the main research area is regioselective enantioselective intermol denitrogenative cyclization benzotriazole allene allenamide; palladium sulfinamide phosphine catalyzed cyclization methyleneindoline preparation; allenamides; allenes; cyclization; heterocycles; palladium.

Reported herein is an asym. Pd/PC-Phos-catalyzed denitrogenative cyclization of benzotriazoles with allenes and N-allenamides, representing the first example of enantioselective denitrogenative cyclizations of benzotriazoles. A series of optically active 3-methyleneindolines were obtained in good yields with high ee values. The use of inexpensive and readily available starting materials, high regio- and enantioselectivity, a broad substrate scope, mild reaction conditions, no need for base, as well as versatile functionalization of the 3-methyleneindolines make this approach attractive.

Angewandte Chemie, International Edition published new progress about Allenes Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Name: (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics