Category: amides-buliding-blocks

Alandini, Nurtalya published the artcileAmide Synthesis by Nickel/Photoredox-Catalyzed Direct Carbamoylation of (Hetero)Aryl Bromides, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is amide preparation nickel photoredox catalyst carbamoylation heteroaryl bromide; amides; cross-coupling; nickel catalysis; photoredox catalysis; radical chemistry.

Herein, the authors report a one-electron strategy for catalytic amide synthesis that enables the direct carbamoylation of (hetero)aryl bromides. This radical cross-coupling approach, which is based on the combination of nickel and photoredox catalysis, proceeds at ambient temperature and uses readily available dihydropyridines as precursors of carbamoyl radicals. The method’s mild reaction conditions make it tolerant of sensitive-functional-group-containing substrates and allow the installation of an amide scaffold within biol. relevant heterocycles. In addition, the authors installed amide functionalities bearing electron-poor and sterically hindered amine moieties, which would be difficult to prepare with classical dehydrative condensation methods.

Angewandte Chemie, International Edition published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cheng, Hai-Hsuan published the artcileEffects of copper on biological treatment of NMF- and MDG-containing wastewater from TFT-LCD industry, SDS of cas: 123-39-7, the main research area is wastewater copper methylformamide methyl diglycol; Copper inhibition; Copper-to-biomass ratio; Nitrification.

This study aimed to evaluate the effects of copper on N-methylformamide (NMF)- and Me diglycol (MDG)-containing wastewater treatment using batch experiments and a lab-scale anoxic-oxic (A/O) sequencing batch reactor (SBR). Batch exptl. results indicated that aerobic degradation of NMF followed Monod-type kinetics. Copper inhibition on nitrification also followed Monod-type inhibition kinetics with copper-to-biomass ratio instead of copper concentration Specific degradation rates of NMF and MDG under both aerobic and anoxic conditions decreased in the matrix of full-scale wastewater, and high copper dosage would further reduce the degradation rates. In the long-term presence of 0.5 mg/L copper, the A/O SBR could maintain stable and complete degradations of NMF and MDG, 95% of COD removal, and more than 50% of total nitrogen (TN) removal. High concentrations of copper spikes, including 40 mg/L and 110 mg/L, slowed down degradation rates for both NMF and MDG, but did not affect COD and TN removal efficiencies in the full 24 h-cycle operation. The long-term A/O SBR operation revealed that daily dosage of 0.5 mg/L copper was not detrimental to NMF/MDG degradations due to regularly wasting sludge, but 110 mg/L of copper spike obviously reduced NMF/MDG degradation rate although it could be recovered later by regularly wasting sludge and maintaining SRT at 20 days.

Chemosphere published new progress about Biological wastewater treatment, biological sequencing batch reactor. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, SDS of cas: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

O’Mahony, Donogh J. R. published the artcileA practical asymmetric synthesis of ortho-substituted 4-pyrazolyl-2-ethylamines, Formula: C4H11NOS, the main research area is pyrazolyl ethylamine preparation enantioselective.

A reliable three-step synthesis of ortho-substituted 4-pyrazolyl-2-ethylamines, e.g., I, starting from a pyrazole Me ketone, e.g., 1-{5-[(benzyloxy)methyl]pyrazolo[1,5-a]pyridin-3-yl}ethan-1-one, and N-tert-butanesulfinylamine is described. Strongly dehydrating conditions were required to form the N-tert-butanesulfinyl ketimines, but these intermediates were stable to aqueous work-up and chromatog. Reduction of N-tert-butanesulfinyl ketimines with L-selectride, or Super-hydride, in THF afforded excellent yields and diastereoselectivities of the sulfinamides II, which were converted into chiral amines with methanolic HCl. The 4-pyrazolyl-2-ethylamines resulted from these investigations are attractive building blocks for medicinal chemists, as they exhibit low mol. weight, and low calculated octanol-water partition coefficient (c Log P values), while disrupting planarity with three-dimensional character. For example, the amine products were utilized in structure-activity studies of the human transient receptor potential vanilloid 1 (TRPV1/VR1).

Tetrahedron Letters published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Formula: C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Huamin published the artcileCatalytic Enantiodivergent Michael Addition by Subtle Adjustment of Achiral Amino Moiety of Dipeptide Phosphines, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide, the main research area is chiral alkylpyridazinone preparation enantioselective; pyridazinone enone hydroamination Michal addition chiral dipeptide phosphine catalyst; Chemistry; Organic Chemistry; Organic Chemistry Methods.

Inspired by the biol. system, an unprecedented catalytic enantiodivergent Michael addition of pyridazinones I (R = H, 5-Cl, 6-Ph, 4,5-Br2, etc.) to enones R1C(O)CH:CHR2 (R1 = 4-chlorophenyl, naphthalen-2-yl, 1-benzothiophen-2-yl, etc.; R2 = CF3, C2F5, C(O)OEt, etc.) by subtle adjustment of achiral amino moiety of dipeptide phosphine catalysts II (R3 = Ph, 3,5-di-tert-butylphenyl; R4 = [3,5-bis(trifluoromethyl)phenyl]carbonyl, (2S)-2-([(tert-butoxy)carbonyl]amino)-3-methylbutanyl, 2-methylpropane-2-sulfinyl, etc.) was reported. These two dipeptide phosphine catalysts, II (R3 = phenyl; R4 = (2S)-2-([(tert-butoxy)carbonyl]amino)-3-methylbutanoyl; R3 = phenyl; R4 = (2S)-2-[(3,5-dinitrophenyl)formamido]-3-methylbutanoyl) could deliver both enantiomers of a series of N2-alkylpyridazinones S/R-III in good yields (up to 99%) with high enantioselectivities (up to 99% ee) via the catalyst-controlled enantiodivergent addition of pyridazinones I to enones R1C(O)CH:CHR2.

iScience published new progress about Dipeptides, phosphono analogs Role: CAT (Catalyst Use), USES (Uses). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rahman, Mahbubur Md. published the artcileMetal-Free Transamidation of Secondary Amides by N-C Cleavage, Application of 4-Methoxy-N-phenylbenzamide, the main research area is secondary amide transamidation nitrogen carbon bond cleavage.

Transamidation reactions represent a fundamental chem. process involving conversion of one amide functional group into another. Herein, the authors report a facile, highly chemoselective method for transamidation of N-tert-butoxycarbonylation (N-Boc) activated secondary amides that proceeds under exceedingly mild conditions in the absence of any additives. Because this reaction was performed in the absence of metals, oxidants, or reductants, the reaction tolerates a large number of useful functionalities. The reaction is compatible with diverse amides and nucleophilic amines, affording the transamidation products in excellent yields through direct nucleophilic addition to the amide bond. The utility of this methodol. is highlighted in the synthesis of Tigan, a com. antiemetic, directly from the amide bond. The authors expect that this new metal-free transamidation will have broad implications for the development of new transformations involving direct nucleophilic addition to the amide bond as a key step.

Journal of Organic Chemistry published new progress about Amides, secondary Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Application of 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gohari, Seyed Jamaladdin published the artcileNovel enantioselective synthesis of (S)-ketamine using chiral auxiliary and precursor Mannich base, Synthetic Route of 343338-28-3, the main research area is chlorophenyl methylamino cyclohexanone enantioselective preparation.

Chiral auxiliaries such as tert-butanesulfinamide (TBSA) was used for the asym. synthesis of (S)-ketamine. Condensation of TBSA with ketones provides corresponding tert-butanesulfinylimine in consistently high yields. The tert-butanesulfinyl group actuates the imine for nucleophilic addition, is a potent chiral directing group, and after nucleophilic addition is easily dissociated by intervention with acid solution A Mannich base, 2-(N-piperidinomethyl)-1-phenylcyclohexylamine was synthesized via Mannich reaction starting from cyclohexanone. Then, corresponding sulfiniylimine was obtained by the condensation of TBSA with formed aminoketone. By using salts such as Ti(OEt)4, N-tert-butanesulfinylketimine was obtained in 85% yield. Next, a new chiral center was generated using Grignard reagent as nucleophile at -78° (80% yield). Finally, after many steps, the (S)-ketamine was synthesized under ozonolysis conditions with good yield and enantioselectivity (75% yield and 75% ee).

Canadian Journal of Chemistry published new progress about Amines, keto Role: SPN (Synthetic Preparation), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Synthetic Route of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ohkubo, Katsutoshi published the artcileShape- and stereo-selective esterase activities of cross-linked polymers imprinted with a transition-state analogue for the hydrolysis of amino acid esters, Recommanded Product: N,N’-(Butane-1,4-diyl)diacrylamide, the main research area is nitrophenyl leucinate hydrolysis kinetics polymeric catalyst; histidyl polymer preparation catalyst hydrolysis leucinate; isokinetic relationship catalytic hydrolysis nitrophenyl leucinate.

Various cross-linked (with N,N’-ethylene (C2), butylene (C4), hexamethylene (C6), or decamethylene (C10)-bisacrylamide) polymer catalysts containing L-histidine and quaternary trimethylammonium groups were imprinted with a racemic transition-state analog of Ph 1-benzyloxycarbonyl-3-methylpentylphosphonate for the hydrolysis of p-nitrophenyl N-(benzyloxycarbonyl)-L (or D)-leucinate [Z-L (or D)-Leu-PNP]. Among these polymer catalysts, N,N’-C4-bisacrylamide-cross-linked polymer catalyst, which was copolymerized with styrene monomer, exhibited notable substrate-stereospecificity for the Z-L-Leu-PNP hydrolysis in the hydrolysis of enantiomeric L (or D)-N-protected [such as tert-butyloxycarbonyl (Boc-), acetyl (C2-), decanoyl (C10-) or benzyloxycarbonyl (Z-)] amino acid (Leu, Ala, or Phe) p-nitrophenyl esters in 10 volume % MeCN-Tris buffer (pH 7.15) at 30°C.

Journal of Molecular Catalysis A: Chemical published new progress about Amino acid esters Role: RCT (Reactant), RACT (Reactant or Reagent). 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, Recommanded Product: N,N’-(Butane-1,4-diyl)diacrylamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yu, Xiaoqiang published the artcileSynthesis of Quinazolin-4(3H)-ones via the Reaction of 2-Halobenzamides with Nitriles, COA of Formula: C6H5BrN2O, the main research area is quinazolinone preparation; halobenzamide nitrile nucleophilic addition aromatic substitution copper acetate catalyst.

This paper described a convenient method to synthesize quinazolin-4(3H)-ones, e.g. I, from simple and readily available 2-halobenzamides and nitriles. The Lewis acid Cu-catalyzed nucleophilic addition of 2-halobenzamide to nitriles followed by SNAr reaction proceeded smoothly in the presence of t-BuOK as a base to produce the quinazolinone derivatives

Journal of Organic Chemistry published new progress about Benzamides Role: RCT (Reactant), RACT (Reactant or Reagent) (halo). 13958-99-1 belongs to class amides-buliding-blocks, name is 3-Bromoisonicotinamide, and the molecular formula is C6H5BrN2O, COA of Formula: C6H5BrN2O.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fan, Pei published the artcileNickel/Photo-Cocatalyzed C(sp2)-H Allylation of Aldehydes and Formamides, Formula: C2H5NO, the main research area is unsaturated ketone amide preparation stereoselective; aldehyde formamide allyl acetate alc allylation nickel photocatalyst.

Herein, a nickel/photo-cocatalyzed C(sp2)-H allylation of aldehydes and formamides wherein both allyl acetates and allyl alcs. can be used as the allylating agents is reported. In this reaction, radical-type umpolung of the formyl moiety is enabled by tetrabutylammonium decatungstate as a hydrogen-atom-transfer photocatalyst, whereas nickel serves to cleave the C-O bond of allyl acetates or allyl alcs. The synergistic effect of these two catalysts provides new access to various β,γ-unsaturated ketones and amides with high selectivities.

Organic Letters published new progress about Acetates Role: RCT (Reactant), RACT (Reactant or Reagent) (allyl). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Joseph, Devaneyan published the artcileReaction of Amide and Sodium Azide for the Synthesis of Acyl Azide, Urea, and Iminophosphorane, Product Details of C14H13NO2, the main research area is acyl azide sym aromatic urea iminophosphorane preparation; amide sodium azide phosphine substitution Curtius rearrangement.

Amides reacted with NaN3 to give the acyl azides in DMF at 25°C and produce the sym. ureas in THF/H2O at 80°C via the sequential reaction of acyl substitution and Curtius rearrangement. All acyl azides were also obtained from the secondary amides via sequential reaction of p-toluenesulfonyl chloride and NaN3. In addition, keto-stabilized iminophosphoranes were prepared from a one-pot reaction of amides, NaN3, and phosphines.

Organic Letters published new progress about Acyl azides Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Product Details of C14H13NO2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics