Category: amides-buliding-blocks

On July 3, 2014, Spear, Kerry L.; Campbell, Una published a patent.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Preparation of piperidinylindoline derivatives for use as nervous system agents. And the patent contained the following:

Title compounds I [R1 = halo, OH, CN, (un)substituted alkyl, aryl, etc.; R2 = H, halo, OH, alkyl, etc.; or R1 and R2 are taken together with the C atom to which they are attached to form an (un)substituted alkenyl, cycloalkyl or heterocyclyl; R3 = H, OH, halo, CN, alkyl, etc.; R5 = (un)substituted alkyl, cycloalkyl, aryl, heteroaryl, etc.; each X independently = CH or N; Y = absent, O, NH, N-alkyl, or (un)substituted alkylene], and their pharmaceutically acceptable salts, are prepared and disclosed as nervous system agents. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in CAMP assays on CHO cells expressing the human NOP/MOP receptors (data given). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to piperidinylindoline preparation nervous system agent, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2020, Kim, Da-Hye; Park, Chang Gyun; Kim, Young Jun published an article.Formula: C2H4ClNO The title of the article was Characterizing the potential estrogenic and androgenic activities of two disinfection byproducts, mono-haloacetic acids and haloacetamides, using in vitro bioassays. And the article contained the following:

Exposure to disinfection byproducts (DBPs) is potentially related to cytotoxic, genotoxic, mutagenic, and tumorigenic effects in humans, in addition to their adverse effects on the environment. However, their impacts on endocrine disruption, especially reproductive toxicity, remain largely unknown. In this study, the estrogenic and androgenic activities of DBPs and corresponding antagonistic activities were investigated using a yeast-based reporter assay, focusing on haloacetic acids and haloacetamides. We also examined the cytotoxicity of DBPs and mechanisms of antagonistic activities. Of the DBPs assayed, iodoacetamide (IAM) and bromoacetamide (BAM) were the most cytotoxic, with LC50 values of 0.0462 and 0.0537 mM, resp., followed by chloroacetic acid (CAA; LC50 = 4.87 mM) and chloroacetamide (CAM; LC50 = 5.28 mM). Iodoacetic acid (IAA) and bromoacetic acid (BAA) were the least cytotoxic, with LC50 values of 5.52 and 6.35 mM, resp. IAA (EC10 = 0.00573 mM; EC50 = 0.0215 mM) exhibited most potent estrogenic activity, and CAA (EC10 = 0.0434 mM) and BAM (EC10 = 0.0150 mM) showed weak estrogenic and androgenic activities, resp. By contrast, IAM exhibited anti-estrogenic effects. These results suggest that DBPs interact with hormone receptors. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to pituitary cell iodoacetamide bromoacetamide cytotoxicity estrogenic androgenic, cytotoxicity, disinfection byproducts, endocrine disrupting potency, yes/yas assay, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 13, 2021, Kawamata, Yu; Hayashi, Kyohei; Carlson, Ethan; Shaji, Shobin; Waldmann, Dirk; Simmons, Bryan J.; Edwards, Jacob T.; Zapf, Christoph W.; Saito, Masato; Baran, Phil S. published an article.Synthetic Route of 5455-98-1 The title of the article was Chemoselective Electrosynthesis Using Rapid Alternating Polarity. And the article contained the following:

Challenges in the selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically been overcome either by using reagents/catalysts that tunably interact with a substrate or through modification to shield undesired sites of reactivity (protecting groups). Although electrochem. offers precise redox control to achieve unique chemoselectivity, this approach often becomes challenging in the presence of multiple redox-active functionalities. Historically, electrosynthesis has been performed almost solely by using d.c. (DC). In contrast, applying a.c. (AC) has been known to change reaction outcomes considerably on an anal. scale but has rarely been strategically exploited for use in complex preparative organic synthesis. Here we show how a square waveform employed to deliver elec. current-rapid alternating polarity (rAP)-enables control over reaction outcomes in the chemoselective reduction of carbonyl compounds, one of the most widely used reaction manifolds. The reactivity observed cannot be recapitulated using DC electrolysis or chem. reagents. The synthetic value brought by this new method for controlling chemoselectivity is vividly demonstrated in the context of classical reactivity problems such as chiral auxiliary removal and cutting-edge medicinal chem. topics such as the synthesis of PROTACs. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Synthetic Route of 5455-98-1

The Article related to electrochem chemoselective reduction ketone rapid alternating polarity, Heterocyclic Compounds (One Hetero Atom): General and other aspects.Synthetic Route of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 15, 2022, Dou, Shuzhen; Wang, Zhongshun; Chen, Qiye; Lu, Nan published an article.Electric Literature of 144-80-9 The title of the article was One-step fabrication of high-density Si nanotips as SALDI-MS substrate for highly sensitive detection. And the article contained the following:

The high sensitivity of surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) anal. depends on the enhancement of the signal intensity and the reduction of the background. Here, high-d. Si nanotips were prepared as SALDI-MS substrate by taking template-free reactive ion etching for sensitive detection. The high-d. Si nanotips act as tiny antennas to concentrate the laser energy and generate photo-induced electrons on a small area, which promotes desorption and ionization of mol., enhancing the signal intensity. Addnl., the high stability of Si nanotips under laser irradiation ensures low background interference. The applicability of the substrate was demonstrated by the detection of various small mols., e.g., fatty acids, amino acids, environmental pollutants and drugs. In addition, this substrate can be successfully applied for detecting trace small mols. in complex sample, such as 10-9 M verapamil in serum and 10-12 M crystal violet in lake water. Moreover, the banned fungicides left on the fish skin was also detected. The substrate is compatible with imaging, and the endogenous and exogenous substances in fingerprint were visualized by MS imaging. These results demonstrate the easily prepared high-d. Si nanotips SALDI-MS substrate is of high detection sensitivity and great value toward large-scale practical applications. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Electric Literature of 144-80-9

The Article related to silicon nanotip verapamil stearic acid sarcosine saldi ms fabrication, Biochemical Methods: Spectral and Related Methods and other aspects.Electric Literature of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xue, Weifeng; Zhang, Haiqin; Wang, Mei; Liu, Ying; Liu, Mengyao; Shen, Baozhen published an article in 2022, the title of the article was Metabolomics-based non-targeted screening analysis of 34 PPCPs in bovine and piscine muscles.Application of 144-80-9 And the article contains the following content:

The metabolomics-based anal. strategy has showed superiority on the non-targeted screening of contaminants, especially for unknown and unexpected (U&U) contaminants in the field of food safety, but data anal. is often the bottleneck of the strategy. In this study, a novel metabolomics-based anal. method via searching for marker compounds was developed on the basis of ultrahigh-performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) results to accurately, rapidly and comprehensively achieve the non-targeted screening of 34 pharmaceutical and personal care products (PPCPs) as U&U contaminants spiked in bovine and piscine muscle matrixes. Three concentration groups (20, 50 and 100 ng mL-1) were intentionally designed to simulate the control and exptl. groups for the discovery of marker compounds, for which multivariate and univariate analyses were adopted. In multivariate anal., each concentration group was fully separated from the other two groups in PCA and OPLS-DA plots, laying a foundation to distinguish marker compounds among groups. The S-plot, permutation and variable importance in projection (VIP) in OPLS-DA were employed to screen and identify marker compounds, which were further verified by pairwise t-test and fold change judgement in univariate anal. The results indicate that 34 PPCPs spiked in two muscle matrixes were all identified as marker compounds, proving the validity and practicability of this novel metabolomics-based non-targeted screening method, which will exhibit great superiority and broad application prospects, especially in the face of massive PPCPs and various animal matrixes in the field of food safety control. In addition, the limits of detection (LODs) for 34 PPCPs were calculated to be 0.2-2.6μg kg-1 and 0.3-2.1μg kg-1 in bovine and piscine muscle matrixes, resp. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Application of 144-80-9

The Article related to muscle pharmaceutical personal care product metabolomics screening, Biochemical Methods: Spectral and Related Methods and other aspects.Application of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chau, Nguyen Dang Giang; Van Hop, Nguyen; Long, Hoang Thai; Duyen, Ngo Thi My; Raber, Georg published an article in 2020, the title of the article was Multi-residue analytical method for trace detection of new-generation pesticides in vegetables using gas chromatography-tandem mass spectrometry.Formula: C2H4ClNO And the article contains the following content:

A GC-MS/MS method with low solvent consumption and easy operation was developed to simultaneously determine ten new-generation pesticides, namely fenobucarb, acetochlor, pretilachlor, fipronil, trifloxystrobin, fluazifop-p-Bu, isoprothiolane, tebuconazole, cypermethrin and difenoconazole in leafy vegetables. Influences from ultrasonic sample extraction and the clean-up steps to reduce matrix effects were investigated. Under suitable conditions, good linearity (deviation of back calculated concentration from true concentration lower than 20%) was achieved for all studied pesticides; the method detection limits (MDLs) ranged from 1.4 to 3.6 ng g-1 wet weight For mustard green and green onion the method yielded good recoveries at two spiking levels (201 and 100 ng g-1) ranging from 80% to 111% (n = 5). The repeatability, expressed as relative standard deviation (RSD), was lower than 11% (n = 5). The method was successfully used to quantify pesticide residues in 207 vegetable samples (green onions, mustard greens, and lettuce) collected in Thua Thien Hue and Quang Binh Provinces, Central Vietnam. The insecticide cypermethrin was found at critical levels in 98% of the vegetable samples. Green onions had high pesticide residues with a significant number of samples containing pesticides at concentrations exceeding the maximum residue levels (MRLs). The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to onion mustard green lettuce pesticide gas chromatog mass spectrometry, gc-ms/ms, method development, pesticides residues, solid phase extraction, ultrasonic extraction, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 3, 2014, Sugawara, Yasuhisa; Sakata, Koji; Tomioka, Yasuhiro; Demizu, Hiroyuki; Satoh, Hiroki published a patent.Formula: C11H9NO3 The title of the patent was Solid electrolytic capacitor. And the patent contained the following:

Provided is a solid electrolytic capacitor having a low initial equivalent series resistance (ESR) in which the ESR increase with time can be suppressed. It is a solid electrolytic capacitor, including an electroconductive polymer layer, a graphite layer on the electroconductive polymer layer, and a silver layer on the graphite layer, wherein the electroconductive polymer layer and the graphite layer, and/or, the graphite layer and the silver layer are bonded by a chem. bond. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Formula: C11H9NO3

The Article related to capacitor electrolytic solid low equivalent series resistance, Electric Phenomena: Capacitors, Dielectrics, Insulators, Electrets and other aspects.Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mohareri, Mohammad Moein; Ghaffari, Mehdi; Sattarzadeh, Elham; Kakaei, Saeed published an article in 2021, the title of the article was Preparation and application of Fe3O4@Acetamidoxanthate as a unique nanosorbent in heavy metal removing.Computed Properties of 79-07-2 And the article contains the following content:

Chelating agents are one of the most important substances in metal extraction, but separation is the main problem in the use of these agents as an adsorbent. After the adsorption of metals by an external magnet, magnetic NPs provide the possibility of easy collecting and isolating the adsorbent nanomaterial for many applications. Given the immense importance of magnetic NPs, there has been widespread interest in accessing the above adsorbent. In the present study, an attempt was made to synthesize acetamido xanthate which was coupled to NPs and has the potential to be used as a nano-adsorbent for the removal of heavy metals. This novel nano sorbent was characterized by SEM (SEM), Fourier transforms IR (FT-IR), and NMR (NMR) spectroscopy. The effect of some parameters such as temperature, time, pH, and the amount of adsorbent on the extraction reaction was investigated. The optimized condition for extraction of cerium was temperature of 30°C, pH=8, reaction time of 45 min using 7.5mg of the prepared nanosorbent, that in such condition the yield of reaction achieved up to 97%. The prepared adsorbent showed high efficiency in the adsorption of heavy metals specifically. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Computed Properties of 79-07-2

The Article related to iron oxide acetamidoxanthate nanosorbent heavy metal removing, Waste Treatment and Disposal: Physical Treatment Of Aqueous Wastes and other aspects.Computed Properties of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ali, Mohammad; Zarchi, Karimi; Tarabsaz, Ali published an article in 2015, the title of the article was Ring Opening of Epoxides by Using Cross-Linked Poly(4-Vinylpyridine)-Supported Thiocyanate in the Presence of Polymer-Supported Sulfuric Acid Under Solvent-Free Conditions.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:

Cross-linked poly(4-vinylpyridine)-supported thiocyanate ion, [P4-VP]SCN, is introduced as recyclable polymeric reagent for the efficient and regioselective conversion of epoxides to thiocyanohydrins in the presence of cross-linked poly(4-vinylpyridine)-supported sulfuric acid, [P4-VP]H2SO4, as a solid proton source and as catalyst under solvent-free conditions. The ring-opening reaction of epoxides take place very fast under solvent-free conditions and the regioselective thiocyanohydrins are prepared in high yields at 65°C. The present method offers advantages such as short reaction time, simple reaction work-up, and the polymeric reagents can be regenerated and reused several times without significant loss of their activity. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to epoxide ring opening polymer supported reagent solvent free, Plastics Manufacture and Processing: Chemical Properties Of Resins and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 2022, Tong, Ruoming; Fu, Rui; Yang, Zhe; Jiang, Yuanxing; Jiang, Kun; Sun, Xuhui published an article.Computed Properties of 79-07-2 The title of the article was Efficient degradation of sulfachloropyridazine by sulfite activation with CuO-Al2O3 composites under neutral pH conditions: Radical and non-radical. And the article contained the following:

In this work, CuO-Al2O3 composites were synthesized at higher temperatures to control the leaching of metal ions, which can activate sulfite (S(IV)) to degrade organic contaminants by generating reactive oxygen species (ROSs). The synthesized catalysts were characterized by X-ray diffraction, SEM, high-resolution transmission electron microscopy, Brunauer-Emmett-Teller, Raman spectroscopy, and Fourier transform IR spectrophotometry. Sulfachloropyridazine (SCP) was almost completely removed (>99%) at pH 6.8, and the leaching amount of Cu accounted for 0.027% of the total amount of Cu after the reaction. Notably, singlet oxygen (1O2) was found for the first time in the activated sulfite system, which removed organic pollutants together with sulfate (SO4·- ) and hydroxyl (·OH) radicals. And Al2O3 plays an important role in the catalyst, including anti-sintering, reducing the leaching of copper ions, and promoting the generation of oxygen vacancies. Based on the types of ROSs and XPS results, a possible ROSs generation mechanism was proposed. In addition, the stability of the catalyst and the effect of different factors on the degradation of SCP, including operating parameters and water quality, were further investigated. The intermediates were detected by using gas chromatog.-mass spectrometry and a developmental toxicity assessment of the intermediates was defined based on the Toxicity Estimation Software Tool (TEST). Overall, this paper not only provides a new strategy for sulfite activation but also promotes more attention to non-radical processes in activated sulfite systems. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Computed Properties of 79-07-2

The Article related to copper aluminum oxide sulfachloropyridazine degradation, Waste Treatment and Disposal: Physical Treatment Of Aqueous Wastes and other aspects.Computed Properties of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics