Category: amides-buliding-blocks

On October 31, 2010, Mannocci, Luca; Melkko, Samu; Buller, Fabian; Molnar, Ilona; Gapian Bianke, Jean-Paul; Dumelin, Christoph E.; Scheuermann, Jorg; Neri, Dario published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Isolation of Potent and Specific Trypsin Inhibitors from a DNA-Encoded Chemical Library. And the article contained the following:

Collections of chem. compounds, individually attached to unique DNA fragments serving as amplifiable identification bar codes, are generally referred to as “DNA-encoded chem. libraries”. Such libraries can be used for the de novo isolation of binding mols. against target proteins of interest. Here, we describe the synthesis and use of a DNA-encoded library based on benzamidine analogs, which allowed the isolation of a trypsin inhibitor with an IC50 value of 3.0 nM, thus representing a >10 000-fold potency improvement compared to the parental compound The novel trypsin inhibitor displayed an excellent selectivity toward other serine proteases. This study indicates that DNA-encoded libraries can be used for the facile “affinity maturation” of suboptimal binding compounds, thus facilitating drug development. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

The Article related to trypsin inhibitor benzamidine derivative dna encoded library, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 19, 2017, Naya, Masami; Hamano, Yoshimi; Kokado, Kenta; Sada, Kazuki published an article.Formula: C6H13NO The title of the article was Organic Reaction as a Stimulus for Polymer Phase Separation. And the article contained the following:

Mol. design of stimuli-sensitive polymers has been attracting considerable interest of chemists because of their latent ability to achieve smart materials. Heat, light, pH, and chems. have been often utilized as a stimuli-inducing polymer phase transition from solution to aggregation and vice versa. In this report, as a new trigger for lower critical solution temperature (LCST)-type polymer phase transition, we introduce organic reaction of small organic mols., not to the polymer chain itself. The addition of the reactant for the “effector”, which can interact with the polymer chain for increasing the compatibility of the polymer chain with the media, caused a polymer phase separation, due to reduction of the solvation ability of the effector to the polymer chain. In other words, decrease of the “effector” concentration induced the polymer phase separation Within our knowledge, this is the first report to connect a polymer phase separation with organic reaction dynamics. This process will be the first step for the development of artificial allosteric enzyme mimics from a combination of a simple synthetic polymer and a product or reactant in organic reactions. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Formula: C6H13NO

The Article related to organic polymer stimuli sensitive phase separation, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Formula: C6H13NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jacquet, Emmanuel; Alard, Olivier; Gounelle, Matthieu published an article in 2015, the title of the article was The formation conditions of enstatite chondrites: Insights from trace element geochemistry of olivine-bearing chondrules in Sahara 97096 (EH3).SDS of cas: 97-09-6 And the article contains the following content:

We report in situ LA-ICP-MS trace element analyses of silicate phases in olivine-bearing chondrules in the Sahara 97096 (EH3) enstatite chondrite. Most olivine and enstatite present rare earth element (REE) patterns comparable to their counterparts in type I chondrules in ordinary chondrites. They thus likely share a similar igneous origin, likely under similar redox conditions. The mesostasis however frequently shows neg. Eu and/or Yb (and more rarely Sm) anomalies, evidently out of equilibrium with olivine and enstatite. We suggest that this reflects crystallization of oldhamite during a sulfidation event, already inferred by others, during which the mesostasis was molten, where the complementary pos. Eu and Yb anomalies exhibited by oldhamite would have possibly arisen due to a divalent state of these elements. Much of this igneous oldhamite would have been expelled from the chondrules, presumably by inertial acceleration or surface tension effects, and would have contributed to the high abundance of opaque nodules found outside them in EH chondrites. In two chondrules, olivine and enstatite exhibit neg. sloped REE patterns, which may be an extreme manifestation of a general phenomenon (possibly linked to near-liquidus partitioning) underlying the overabundance of light REE observed in most chondrule silicates relative to equilibrium predictions. The silicate phases in one of these two chondrules show complementary Eu, Yb, and Sm anomalies providing direct evidence for the postulated occurrence of the divalent state for these elements at some stage in the formation reservoir of enstatite chondrites. Our work supports the idea that the peculiarities of enstatite chondrites may not require a condensation sequence at high C/O ratios as has long been believed. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

The Article related to trace element chondrule enstatite chondrite, Mineralogical and Geological Chemistry: Cosmochemistry and Meteorites and other aspects.SDS of cas: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 7, 2020, Koopmans, Carsten; Laemmerhold, Kai; Guertler, Christoph; Frick-Delaittre, Elena; Wolf, Aurel; Simon, Joachim; Wang, Min; Thiel, Daniel; Leitner, Walter published a patent.Related Products of 5455-98-1 The title of the patent was Production of thermoplastic polyoxazolidinone polymers and thermoplastic polyoxazolidinone. And the patent contained the following:

A process for producing thermoplastic polyoxazolidinone, comprising (i) reaction of a diisocyanate compound (A) with a bisepoxide compound (B) in the presence of a catalyst (C) and a compound (D) in a solvent (E) forming an intermediate compound (F) and (ii) reaction of a compound (G) with the intermediate (F) formed in step (i), where the bisepoxide compound (B) comprises isosorbide diglycidyl ether, where compound (D) is ≥1 compounds selected from monofunctional isocyanate and monofunctional epoxide, and where compound (G) is an alkylene oxide. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Related Products of 5455-98-1

The Article related to thermoplastic polyoxazolidinone polymer, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Related Products of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 21, 2019, Koopmans, Carsten; Guertler, Christoph; Wolf, Aurel; Frick-Delaittre, Elena; Rangheard, Claudine; Breuer, Timo; Laemmerhold, Kai published a patent.SDS of cas: 5455-98-1 The title of the patent was Method for the production of thermoplastic polyoxazolidinone polymers. And the patent contained the following:

A process for producing thermoplastic polyoxazolidinone, comprising the following steps: (i) Reaction of a diisocyanate compound (A) with a bisepoxide compound (B) in the presence of a catalyst (C) and a compound (D) in a solvent (E) forming an intermediate compound (F) and (ii) Reaction of a compound (G) with the intermediate (F) formed in step (i), wherein compound (D) is one or more compounds selected from the group consisting of monofunctional isocyanate and monofunctional epoxide, and wherein compound (G) is an alkylene oxide. The invention is also related to the resulting thermoplastic polyoxazolidinone. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).SDS of cas: 5455-98-1

The Article related to thermoplastic polyoxazolidinone polymer, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.SDS of cas: 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 20, 2019, there was a patent about glycidyl ethers.Category: amides-buliding-blocks The title of the patent was Method for the production of thermoplastic polyoxazolidinone polymers. And the patent contained the following:

A process for producing thermoplastic polyoxazolidinone, comprising the following steps: (i) Reaction of a diisocyanate compound (A) with a bisepoxide compound (B) in the presence of a catalyst (C) and a compound (D) in a solvent (E) forming an intermediate compound (F) and (ii) Reaction of a compound (G) with the intermediate (F) formed in step (i), wherein compound (D) is one or more compounds selected from the group consisting of monofunctional isocyanate and monofunctional epoxide, and wherein compound (G) is an alkylene oxide. The invention is also related to the resulting thermoplastic polyoxazolidinone. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Category: amides-buliding-blocks

The Article related to thermoplastic polyoxazolidinone polymer, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 23, 2021, Fan, Qinghua; Zhang, Shanshan; Chen, Fei; He, Yanmei published a patent.Recommanded Product: 167316-28-1 The title of the patent was Asymmetric hydrogenation kinetic resolution of racemic polysubstituted dihydroisoquinoline. And the patent contained the following:

The invention discloses an asym. hydrogenation kinetic resolution method of racemic polysubstituted dihydroisoquinoline, which can realize the resolution of racemic polysubstituted dihydroisoquinoline compounds, and obtain a single optical isomer of polysubstituted chiral tetrahydroisoquinoline compounds and polysubstituted chiral dihydroisoquinoline compounds with certain optical purity. The asym. hydrogenation kinetic resolution method comprises the following steps: in the presence of chiral diamine metal catalyst, the mixture containing enantiomers of polysubstituted dihydroisoquinoline compounds is asym. hydrogenated with hydrogen. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).Recommanded Product: 167316-28-1

The Article related to asym hydrogenation kinetic resolution racemic polysubstituted dihydroisoquinoline, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Recommanded Product: 167316-28-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yingcharoen, Prapussorn; Natongchai, Wuttichai; Poater, Albert; D’ Elia, Valerio published an article in 2020, the title of the article was Intertwined chemistry of hydroxyl hydrogen-bond donors, epoxides and isocyanates in the organocatalytic synthesis of oxazolidinones versus isocyanurates: rational catalytic investigation and mechanistic understanding.Synthetic Route of 102-07-8 And the article contains the following content:

The use of hydroxyl hydrogen bond donors (HBDs) was investigated in cycloaddition of isocyanates to epoxides to afford 3-aryl-2-oxazolidinones I [R1 = H, 2-Me, 4-NO2, etc.; R2 = Et, CH2OCH2CH=CH2, CH2OCH2Ph, etc.] as a class of heterocycles with promising applications in pharmaceutical chem. In this work, a systematic investigation of readily available HBDs as catalytic components of binary systems for latter cycloaddition reaction was carried out. Such a study showed crucial role of HBDs’ pKa1 value in driving selectivity of reaction toward oxazolidinones as opposed to formation of oligomeric isocyanurates or ureas, with most acidic HBDs (pKa1: 3-4) displaying best catalytic performance. Mechanistic investigation with the support of DFT calculations allowed deeper insight into reaction dynamics and origin of exptl. observed chemoselectivity for cyclization vs. cyclo-oligomerization at different reaction temperatures, shedding light on a strictly intertwined chem. between the HBDs, isocyanates and epoxides. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Synthetic Route of 102-07-8

The Article related to aryl oxazolidinone chemoselective preparation dft reaction mechanism, isocyanate epoxide cycloaddition organocatalyst hydrogen bond donor, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Synthetic Route of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 7, 2022, Rostami, Ali; Ebrahimi, Amirhossein; Sakhaee, Nader; Golmohammadi, Farhad; Al-Harrasi, Ahmed published an article.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Microwave-Assisted Electrostatically Enhanced Phenol-Catalyzed Synthesis of Oxazolidinones. And the article contained the following:

An electrostatically enhanced phenol is utilized as a straightforward, sustainable, and potent one-component organocatalyst for the atom-economic transformation of epoxides to oxazolidinones under microwave irradiation Integrating a pos. charged center into phenols over a modular one-step preparation gives rise to a bifunctional system with improved acidity and activity, competent in rapid assembly of epoxides and isocyanates under microwave irradiation in a short reaction time (20-60 min). A careful assessment of the efficacy of various pos. charged phenols and anilines and the impact of several factors, such as catalyst loading, temperature, and the kind of nucleophile, on catalytic reactivity were examined Under neat conditions, this one-component catalytic platform was exploited to prepare more than 40 examples of oxazolidinones from a variety of aryl- and alkyl-substituted epoxides and isocyanates within minutes, where up to 96% yield and high degree of selectivity were attained. DFT calculations to achieve reaction barriers for different catalytic routes were conducted to provide mechanistic understanding and corroborated the exptl. findings in which concurrent epoxide ring-opening and isocyanate incorporation were proposed. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to oxazolidinone preparation microwave irradiation, epoxide isocyanate cycloaddition electrostatically enhanced phenol catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 7, 2022, Rostami, Ali; Ebrahimi, Amirhossein; Sakhaee, Nader; Golmohammadi, Farhad; Al-Harrasi, Ahmed published an article.Computed Properties of 102-07-8 The title of the article was Microwave-Assisted Electrostatically Enhanced Phenol-Catalyzed Synthesis of Oxazolidinones. And the article contained the following:

An electrostatically enhanced phenol is utilized as a straightforward, sustainable, and potent one-component organocatalyst for the atom-economic transformation of epoxides to oxazolidinones under microwave irradiation Integrating a pos. charged center into phenols over a modular one-step preparation gives rise to a bifunctional system with improved acidity and activity, competent in rapid assembly of epoxides and isocyanates under microwave irradiation in a short reaction time (20-60 min). A careful assessment of the efficacy of various pos. charged phenols and anilines and the impact of several factors, such as catalyst loading, temperature, and the kind of nucleophile, on catalytic reactivity were examined Under neat conditions, this one-component catalytic platform was exploited to prepare more than 40 examples of oxazolidinones from a variety of aryl- and alkyl-substituted epoxides and isocyanates within minutes, where up to 96% yield and high degree of selectivity were attained. DFT calculations to achieve reaction barriers for different catalytic routes were conducted to provide mechanistic understanding and corroborated the exptl. findings in which concurrent epoxide ring-opening and isocyanate incorporation were proposed. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Computed Properties of 102-07-8

The Article related to oxazolidinone preparation microwave irradiation, epoxide isocyanate cycloaddition electrostatically enhanced phenol catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Computed Properties of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics