Category: amides-buliding-blocks

Comparative study on application of cationic glutin agent and TAED in cotton fabric bleaching was written by Tang, Jun-ling;Wang, Xue-yan. And the article was included in Yinran Zhuji in 2015.Related Products of 10543-57-4 This article mentions the following:

A self-made cationic glutin agent and a com. bleaching activator tetraacetylethylenediamine (TAED) were added to the hydrogen peroxide bleaching bath resp., then two new bleaching systems were set up. Whiteness, capillary effect, strength and dyeing effect of cotton fabric treated by the new bleaching systems and traditional system were compared. The results showed that the cationic glutin agent was better than com. bleaching activator TAED in application, it was not only beneficial to promote the effect of hydrogen peroxide bleaching, but also improve the capillary effect and dyeing performances of bleached cotton fabric. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Related Products of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Phytochemical Analysis and hypoglycemic potential of Filago hurdwarica (Wall. ex DC.) Wagenitz in alloxan induced diabetic mice. was written by Rahman, S;Jan, Gul;Jan, F Gul;Rahim, H Ur. And the article was included in Brazilian journal of biology = Revista brasleira de biologia in 2022.Formula: C23H28ClN3O5S This article mentions the following:

Plants have profound therapeutic benefits, more economical treatments, fewer side effects, and a relatively cheap cost, making them a source of drugs for protective, preventative, curative, or conducive purposes and creating novel phytomedicines. Plant derived medicines are relatively safe compared to synthetic medicines. Many plants have proved to successfully aid in the treatment of diabetes including Filago hurdwarica (Wall. ex DC.) Wagenitz. The current investigations were therefore designed to assess the phytochemical, antioxidant, antidiabetic, and antihyperlipidemic activities of F. hurdwarica. The phytochemical investigations and antioxidant activities of different extracts were carried out using standard chemical tests, DPPH, and H2O2 scavenging assays. F. hurdwarica plant extract in Hydromethanolic solution were prepared by Soxhletation method and stored in refrigerator at 4°C for two days before use. Swiss Albino mice were made diabetic by a single dose of alloxan (150 mg/kg). Hydromethanolic plant extract and fractions of F. hurdwarica were screened for antidiabetic activity and given to the alloxan-induced diabetic mice at a concentration of 150-250 mg/kg of body weight in different groups of 6 diabetic mice each orally once a day for 15 days. Glibenclamide is also given to another group to as a standard drug to support the result at a dose of 10 mg/kg of body weight orally once a day for 15 days. Blood glucose levels and body weights of mice were measured on 0, 4, 7, 11 and 15th days. The study found that the extract was safe up to the dose level of 2000 mg/kg and the dose response effect of chloroform extract (150-250 mg/kg) of F. hurdwarica showed expressive antihyperglycemic effects and also improved other altered biochemical parameters associated with diabetes. The FTIR and XRD spectra demonstrated the occurrence of phenols, alcohols, alkenes, alkyl halides, ketones, and aromatic compounds and confirmed the amorphous nature of the extract. GC-MS spectral analysis showed the tentative presence of 31 phytochemical constituents in the chloroform extract of F. hurdwarica with different retention time. To conclude, the chloroform extract (250 mg/kg) of F. hurdwarica revealed considerable antioxidant, antihyperglycemic, and antihyperlipidemic potential and is safe for treating diabetes and related complications. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Formula: C23H28ClN3O5S).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Formula: C23H28ClN3O5S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

One-pot transition-metal-free synthesis of Weinreb amides directly from carboxylic acids was written by Niu, Teng;Wang, Ke-Hu;Huang, Danfeng;Xu, Changming;Su, Yingpeng;Hu, Yulai;Fu, Ying. And the article was included in Synthesis in 2014.Recommanded Product: 106675-70-1 This article mentions the following:

Weinreb amides were prepared directly from carboxylic acids, N,O-dimethylhydroxylamine, and phosphorus trichloride in one pot at 60° in toluene in high yields, thus avoiding the separation of the moisture and air sensitive intermediate P[NMe(OMe)]₃ in advance. Sterically hindered carboxylic acids also give the corresponding Weinreb amides in excellent yields. Various functional groups are tolerated on the carboxylic acid. The method, which is a simple process and gives high yields, is suitable for large-scale production In the experiment, the researchers used many compounds, for example, N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1Recommanded Product: 106675-70-1).

N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 106675-70-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Design, synthesis and biological activity of novel sulfonylurea derivatives containing dimethoxymethyl-substituted pyrimidine moiety was written by Chen, Wei;Wei, Wei;Liu, Ming;Hua, Xuewen;Li, Yuxin;Li, Yonghong;Zhang, Xiao;Li, Zhengming. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2015.Category: amides-buliding-blocks This article mentions the following:

Sulfonylureas (SUs) as one kind of the most active herbicides targeted on acetolactate synthase (ALS). ALS was found not only in plants, but also in fungi and bacteria. In order to study the multi-biol. activity of sulfonylurea (SU), a series of novel SU derivatives containing dimethoxymethyl pyrimidine moiety were designed and synthesized according to bioisosteric principles. The bioassay results indicated that the title compounds exhibited favorable herbicidal activity. Compounds I (R = Cl, CO₂Me) showed 100% pre-emergence inhibition activity against Brassica napus at the dosage of 75 g/ha, which was near to that of Monosulfuron and Chlorsulfuron (100%). In addition, some of the title compounds also exhibited moderate antifungal activity. Compounds I (R = CF₃) and II showed over 80% antifungal activity against three fungi in vitro at the concentration of 50 mg/L, and closed to that of Chlorothalonil and Carbendazim. It provided useful information for designing new SUs with highly herbicidal activity and fungicidal activity. In the experiment, the researchers used many compounds, for example, 2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6Category: amides-buliding-blocks).

2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nitrogen-15 nuclear magnetic resonance spectroscopy. Natural abundance nitrogen-15 spectra of the cis and trans isomers of secondary alkylformamides was written by Nakanishi, Hiroshi;Roberts, John D.. And the article was included in Organic Magnetic Resonance in 1981.COA of Formula: C4H7NO This article mentions the following:

The ¹⁵N NMR chem. shifts of 17 N-alkylformamides, e.g. HCONHMe, were measured at the natural abundance level and the ratios of cis and trans isomers were determined Substituent effects on the ¹⁵N chem. shifts of formamides are compared with those of other N-containing compounds There is a consistent pattern of behavior of the 1 bond spin-spin coupling constants, those of the trans isomers of N-alkylformamides being greater than those of the cis isomers. In the experiment, the researchers used many compounds, for example, N-Cyclopropylformamide (cas: 58644-54-5COA of Formula: C4H7NO).

N-Cyclopropylformamide (cas: 58644-54-5) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.COA of Formula: C4H7NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

N,N,N-Trimethyl-5-[(2,3,5,6-tetrafluorophenoxy)carbonyl]pyridin-2-aminium trifluoromethanesulfonate a precursor for the synthesis of 2,3,5,6-tetrafluorophenyl 6-[¹⁸F]-fluoronicotinate was written by Davis, Ryan A.;Fettinger, James C.. And the article was included in Acta Crystallographica, Section C: Structural Chemistry in 2018.Product Details of 2387-23-7 This article mentions the following:

The synthesis, recrystallization, and X-ray deterimination of N,N,N-trimethyl-5-[(2,3,5,6-tetrafluorophenoxy)carbonyl]pyridin-2-aminium trifluoromethanesulfonate (PyTFP-precursor), C₁₅H₁₃F₄N₂O₂⁺·CF₃SO₃^–, is described. This triflate salt precursor is required for the synthesis of 2,3,5,6-tetrafluorophenyl 6-[¹⁸F]-fluoronicotinate ([¹⁸F]FPyTFP), a prosthetic group used to radiolabel peptides for positron emission tomog. (PET), as peptides are increasingly being used as PET-imaging probes in nuclear medicine. Radiolabeling of peptides is typically done using a ‘prosthetic group’, a small synthon to which the radioisotope is attached in the first step, followed by attachment to the peptide in the second step. During the synthesis of the PyTFP-precursor, displacement of a Cl atom with trimethylamine gas and anion replacement with a triflate counter-ion is critical, as incomplete replacement would hinder radioisotopic incorporation of nucleophilic fluorine-18 and result in diminished radiochem. yields. The structural determination of the PyTFP-precursor by X-ray crystallog. helped confirm the anion exchange of chloride with triflate. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Product Details of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Product Details of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Purineless death as a link between growth rate and cytotoxicity by methotrexate was written by Hryniuk, William M.. And the article was included in Cancer Research in 1972.Product Details of 7413-34-5 This article mentions the following:

In murine S-phase lymphoblasts, Na methotrexate (Na I) [7413-34-5] produces a purineless state, the degree of which depends upon the growth rate of the population. The purineless state probably contributes to the lethal effect of I, and may explain in part the relation between growth rate and cytotoxicity of antifolates. I decreased cloning efficiency and inhibited DNA, RNA, and protein synthesis in L5178Y murine lymphoblasts from cultures proliferating at different rates. The effects of I increased with the proliferative rate. Hypoxanthine [68-94-0] completely prevented the biochem. effects of I and partially protected the cells against lethal effects of I. In the experiment, the researchers used many compounds, for example, Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5Product Details of 7413-34-5).

Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Product Details of 7413-34-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Using Oxone and TAED activator in non-chlorine bleaching of soda bagasse pulp was written by Zeinaly, Farhad;Gabov, Konstantin;Kanani Sula, Hadi;Babavand, Arash;Fardim, Pedro. And the article was included in Nordic Pulp & Paper Research Journal in 2019.Synthetic Route of C10H16N2O4 This article mentions the following:

Bagasse fiber has been used in the production of bleached chem. pulp by the Pars paper company. In this company, a conventional three-stage sequence of hypochlorite, alk. extraction and second hypochlorite (HEH) is applied in pulp bleaching. Pulp bleaching is one of the most important environmental pollutant stages in the pulp and paper industry. In this research, the bleaching of soda bagasse pulp by applying oxone and TAED-activator in non-chlorine bleaching sequences has been investigated. The unbleached pulp, with kappa number of 20, 955 mL/g viscosity and 37% brightness, was prepared from Pars Paper Company. Results indicated that, the TAED at the first and second stages were more effective than in the oxone stages. Moreover, the sequences, which contained TAED- and oxone-second-stage, could reach the min. level of kappa (1.7), but the highest brightness (80%) was attained by using only TAED with a comparatively high level of pulp viscosity (752). In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Synthetic Route of C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Synthetic Route of C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

One-pot synthesis of N,N’-dialkylureas via carbonylation of amines with CO₂ applying Y_0.08Zr_0.92O_1.96 mixed oxide (YSZ-8) as a heterogeneous catalyst was written by Sun, Dalei;Xie, Kaihong;Fang, Yanxiong;Yang, Xianghua. And the article was included in Catalysts in 2018.Quality Control of 1,3-Dicyclohexylurea This article mentions the following:

One-pot synthesis of N,N’-dialkylureas were successfully achieved from catalytic carbonylation of aliphatic primary amines with CO₂ as the carbon source and Y_0.08Zr_0.92O_1.96 mixed oxide (Yttria-stabilized zirconia, YSZ-8) as the heterogeneous catalyst. The yield of the target product was obtained up to 80.60% from a 48 h reaction with an aliphatic primary amine and 3.0 MPa CO₂ in N-methyl-2-pirrolidinone at 160 °C. A multi-pronged mechanistic study was carried out where factors that might influence the reaction efficiency were studied, including catalyst structure, substrates basicity, CO₂ pressure, solvent polarity and reaction time. The presence of oxygen vacancies in YSZ-8 was found to be essential for the carbonylation process by creating addnl. reduction potential for the activation of CO₂ which would lead to the key intermediate species. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Quality Control of 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Quality Control of 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Toxicity and analgetic activity of some congeners of salicylamide was written by Way, E. Leong;Takemori, Akira E.;Smith, Glenn E. Jr.;Anderson, Hamilton H.;Brodie, Donald C.. And the article was included in Journal of Pharmacology and Experimental Therapeutics in 1953.Application of 19311-91-2 This article mentions the following:

Eighty-one congeners of salicylamide (I), with small substituted groups in various positions on the benzene ring or on the phenolic O and amino N, were evaluated in rats as to toxicity and ability to elevate the pain-response threshold to pressure stimulus. Most of the compounds appear to be central nervous system depressants and some possess marked hypnotic properties. The relation between structure and activity is discussed. 2-Allyloxybenzamide was about 3 times as potent as I. N,N-Dimethyl-3-phenyl-salicylamide, 3-phenylsalicylamide, and N-(2-hydroxy-ethyl)-3-phenylsalicylamide were less toxic and more potent than I. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Application of 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application of 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics