Category: amides-buliding-blocks

Raheem, Islam Ali Abdel; Razek, Amro Abdul; Elgendy, Abeer Abdelaziz; Saleh, Noha Mohamed; Shaaban, Mona Ibrahem; Abd El-Had, Faten K. published an article in 2019, the title of the article was Design, evaluation and antimicrobial activity of egyptian propolis-loaded nanoparticles: intrinsic role as a novel and naturally based root canal nanosealer.Synthetic Route of 685-91-6 And the article contains the following content:

Propolis is a unique natural adhesive product collected by honeybees. It contains a diversity of bioactive compounds with reported functional properties such as antioxidants, antibacterial, antifungal, anti-inflammatory, antiviral and anticancer activity. Dental caries is a worldwide problem that caused by microbial growth usually progress from tooth enamel to the underlying pulpal tissues and root canal. This situation could be controlled by a sequence of steps to remove microorganisms and fill root canal with a suitable long-lasting root canal sealer. Unfortunately, leachable and degradation products of the currently used sealers compromised their antimicrobial activity by inflammatory modulation associated with irritation and toxicity of periapical tissues. Hence, propolis was selected to be designed as a natural root canal sealer due to its amazing functional properties. Moreover, its handling properties were enhanced and potentiated by its incorporation in polymeric nanoparticles (NPs). Frist, propolis was collected, extracted and analyzed for its bioactive compounds After that, propolis-loaded NPs of PLGA (ProE-loaded NPs) were developed and fully characterized regarding physicochem. properties, in vitro release and in vitro cytotoxicity. Then, root canal sealers were fabricated and assayed for their antimicrobial activity. Both cytotoxicity and antimicrobial activity were compared to those of a model sealer; AH Plus. The results revealed that spherical nanoscopic NPs with narrow size distribution were obtained. ProE-loaded NPs exhibited accepted entrapment efficiency (>80) and prolonged release. In vitro cytotoxicity study confirmed the safety of ProE-loaded NPs. Also, the developed sealers showed antimicrobial activity vs. bacterial strains of Enterococcus faecalis and Streptococcus mutans and antifungal activity against Candida albicans. ProE-loaded NPs could be incorporated in and represented as a root canal sealer with prolonged release and enhanced cytocompatibility as well as antimicrobial activities. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Synthetic Route of 685-91-6

The Article related to egyptian propolis nanoparticle antimicrobial activity root canal nanosealer, plga, antimicrobial activity, in vitro cytotoxicity, polymeric nanoparticles, propolis, sealer and other aspects.Synthetic Route of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 8, 2020, Yang, Wenbo; Sukhanov, Andrei A.; Lim, Jong Hyeon; Li, Xiaoxin; Meng, Yinshan; Zhao, Jianzhang; Sun, Haoling; Lee, Jin Yong; Gurzadyan, Gagik G.; Voronkova, Violeta K. published an article.Recommanded Product: 102-07-8 The title of the article was N^N Pt(II) Bisacetylide Complexes with Oxoverdazyl Radical Ligands: Preparation, Photophysical Properties, and Magnetic Exchange Interaction between the Two Radical Ligands. And the article contained the following:

To study the effect of a stable radical on the photophys. properties of a phosphorescent Pt(II) coordination framework and the intramol. magnetic interaction between radical ligands in the N^N Pt(II) bisacetylide complexes, authors prepared a series of N^N Pt(II) bis(acetylide) complexes with oxoverdazyl radical acetylide ligands. The linker between the Pt(II) center and the spin carrier was systematically varied, to probe the effect on the sign and magnitude of the spin exchange interactions between the radical ligands and photophys. properties. The complexes were studied with steady-state and femtosecond/ns transient absorption spectroscopy, continuous-wave ESR spectroscopy, and d. functional theory (DFT) computations. The transient absorption spectral studies show that the doublet excited state of the radicals are short-lived (τD ≈ 2 ps) and nonfluorescent. Moreover, the intrinsic long-lived triplet excited state (τT = 1.2μs) of the Pt(II) coordination center was efficiently quenched by the radical (τT = 6.9 ps for one representative radical Pt(II) complex). The intramol. magnetic interaction between the radical ligands through the diamagnetic Pt(II) atom was studied with temperature-dependent EPR spectroscopy; antiferromagnetic exchange interaction (-J S1S2, J = -5.4 ± 0.1 cm-1) for the complex with the shortest radical-radical distance through bridge fragments was observed DFT computations give similar results for the sign and magnitude of the J values. For complexes with larger inter-radical distance, however, very weak coupling between the radical ligands was observed (|J| < 0.7 cm-1). The results are useful for the study of the effect of a radical on the photophys. properties of the phosphorescent transition-metal complexes. A series of Pt(II) complexes containing oxoverdazyl radical ligands was prepared The length of the linker between Pt(II) center and spin carrier exerts significant effect on photophys. and magnetic property. The intrinsic long-lived triplet excited state of the Pt(II) coordination center was efficiently quenched by the presence of the radical. Antiferromagnetic interaction between the two radical ligands was observed The sign and the magnitude of the electronic spin-spin exchange was reproduced with DFT computations. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 102-07-8

The Article related to oxoverdazyl radical platinum bisacetylide preparation mol structure calculation electrochem, photophys magnetic exchange oxoverdazyl radical platinum bisacetylide complex and other aspects.Recommanded Product: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 15, 2022, Misaela, Francisco-Marquez; Alexander, Perez de la Luz; Catalina, Soriano-Correa; Carolina, Barrientos-Salcedo; Ignacio, Sainz-Diaz C. published an article.Formula: C8H10N2O3S The title of the article was Tautomerism and IR spectroscopy of arylsulfonamides by quantum mechanical calculations. And the article contained the following:

The mol. structures of sulfonamides are interesting for evaluating their mobility in soils and preparing composite complexes for optimizing the use of these drugs. In this work, the mol. structures of several arylsulfonamides along with conformational anal. and tautomerism were investigated theor. The spectroscopical properties of several arylsulfonamides, were also studied at mol. level by using a computational modeling at quantum mechanics level. Besides, the controversial exptl. results found in the IR (IR) spectroscopy bands assignments of solid sulfonamides pushed us up to study computationally the crystal structure of sulfamethazine for clarifying previous assignment discrepancies. The previously proposed polymorphism in the crystal structure of this drug has been also clarified in this work. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Formula: C8H10N2O3S

The Article related to aryl sulfonamide tautomerism crystal polymorphism ir spectra, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Formula: C8H10N2O3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 2, 2015, Cheng, Guolin; Li, Tuan-Jie; Yu, Jin-Quan published an article.Electric Literature of 5455-98-1 The title of the article was Practical Pd(II)-Catalyzed C-H Alkylation with Epoxides: One-Step Syntheses of 3,4-Dihydroisocoumarins. And the article contained the following:

Pd(II)-catalyzed ortho-alkylation of benzoic acids with both terminal and internal epoxides affords 3,4-dihydroisocoumarins I [ R1 = Me, F, Cl, etc; R = H, Me, Bn, etc] in one step. The presence of potassium countercations is crucial for this reaction. Monoprotected amino acid ligands significantly promote this reaction, enabling the development of a practical C-H alkylation reaction using 0.5 mol % Pd catalyst. The inversion of stereochem. in the C-H alkylation step is consistent with a redox-neutral SN2 nucleophilic ring-opening process as opposed to a Pd(II)/Pd(IV) pathway. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Electric Literature of 5455-98-1

The Article related to benzoic acid epoxide alkylation palladium catalyst, dihydroisocoumarin preparation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Electric Literature of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 4, 2015, Zhou, Xiaomeng; Wang, Qing; Zhao, Weihua; Xu, Songsong; Zhang, Wei; Chen, Junmin published an article.Electric Literature of 27115-50-0 The title of the article was Palladium-catalyzed ortho-arylation of benzoic acid derivatives via C-H bond activation using an aminoacetic acid bidentate directing group. And the article contained the following:

A highly efficient protocol for the palladium-catalyzed ortho-arylation of benzoic acid derivatives by aryl iodides is described with an aminoacetic acid based N,O bidentate directing group. This protocol can be applied to various benzoyl aminoacetic acids and aryl iodides with both electron-donating and electron-withdrawing groups. Remarkably, the nature of a new directing group drives selective C-H bond activation to afford only monoarylation products in good to excellent yields. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to benzoyl aminoacetic acid aryl iodide ortho arylation palladium catalyst, arylbenzoic amide acid preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ghafouri, Moloud; Moghadam, Majid; Mehrani, Kheirollah; Daneshvar, Anahita published an article in 2018, the title of the article was Supported ruthenium hydride catalysts for direct conversion of alcohols to carboxylic acids using styrene oxide as oxidant.Formula: C10H11NO3 And the article contains the following content:

In the present work, the ability of two ruthenium hydride catalysts supported on multiwall carbon nanotubes, [Ru-H@EDT-MWCNT], and gold nanoparticles cored triazine dendrimer, [Ru-H@AuNPs-TD], in the direct conversion of alcs. to carboxylic acids via transfer hydrogenation using styrene oxide as oxidant is reported. Different alcs. were successfully converted to their corresponding carboxylic acids. The results showed that these two heterogeneous catalysts are more efficient than the homogeneous counterpart. In addition, the catalysts were reused several times. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Formula: C10H11NO3

The Article related to ruthenium hydride catalyst supported alc styrene oxide, carboxylic acid preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 22, 2021, Li, Yanxiong; Xu, Liang; Meng, Faming; Yu, Yonghai published a patent.Recommanded Product: 65645-88-7 The title of the patent was Preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine and chiral catalyst thereof. And the patent contained the following:

The invention relates to preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine and chiral catalyst thereof, which has the advantages of high yield and simple method, low cost, environmentally friendly and safety. The (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine was prepared by the following steps: mixing 1-(3-ethoxy-4-methoxy Phenyl)-2-(methylsulfonyl)vinylamine, chiral catalyst I, acid and solvent, performing isomerization to obtain the final product; where R=hydrogen atom, C1-20 linear alkyl, C3-20 branched chain alkyl, C3-10 cycloalkyl, C3-10 heterocyclyl, C1-20 alkoxy, trifluoromethyl, halogen, amino, cyano, hydroxyl, nitro, ester, amide, substituted or unsubstituted C6-20 aryl, substituted or unsubstituted C5-20 heteroaryl. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Recommanded Product: 65645-88-7

The Article related to preparation ethoxymethoxyphenylmethylsulfonylethylamine chiral catalyst isomerization, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Recommanded Product: 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Polonski, T. published an article in 1983, the title of the article was Optical activity of lactones and lactams – II. Chiroptical properties of 4-oxazolidinones.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide And the article contains the following content:

Several optically active 4-oxazolidinones (e.g., I) were obtained from amides or N-methylamides of α-hydroxy acids. Solvent and substituent effects on their CD were studied. The predominance of the envelope conformation was established for these compounds, the degree of puckering being enhanced by polar solvents. The folded form with the aromatic ring facing the oxazolidinone ring was observed for 5-benzyloxazolidinone derivatives The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to cd oxazolidinone conformation, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vallejo-Sanchez, Daniel; Amo-Ochoa, Pilar; Beobide, Garikoitz; Castillo, Oscar; Froeba, Michael; Hoffmann, Frank; Luque, Antonio; Ocon, Pilar; Perez-Yanez, Sonia published an article in 2017, the title of the article was Chemically Resistant, Shapeable, and Conducting Metal-Organic Gels and Aerogels Built from Dithiooxamidato Ligand.Application of 685-91-6 And the article contains the following content:

Metal-organic gels (MOGs) appear as a blooming alternative to well-known metal-organic frameworks (MOFs). Porosity of MOGs has a microstructural origin and not strictly crystalline like in MOFs; therefore, gelation may provide porosity to any metal-organic system, including those with interesting properties but without a porous crystalline structure. The easy and straightforward shaping of MOGs contrasts with the need of binders for MOFs. In this contribution, a series of MOGs based on the assembly of 1D-coordination polymer nanofibers of formula [M(DTA)]n (MII: Ni, Cu, Pd; DTA: dithiooxamidato) are reported, in which properties such as porosity, chem. inertness, mech. robustness, and stimuli-responsive elec. conductivity are brought together. The strength of the M-S bond confers an unusual chem. resistance, withstanding exposure to acids, alkalis, and mild oxidizing/reducing chems. Supercritical drying of MOGs provides ultralight metal-organic aerogels (MOAs) with densities as low as 0.03 g cm-3 and plastic/brittle behavior depending on the nanofiber aspect ratio. Conductivity measurements reveal a semiconducting behavior (10-12 to 10-7 S cm-1 at 298 K) that can be improved by doping (10-5 S cm-1). Moreover, it must be stressed that conductivity of MOAs reversibly increases (up to 10-5 S cm-1) under the presence of acetic acid. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application of 685-91-6

The Article related to metal organic aerogel built dithiooxamidato ligand chem resistant, Electric Phenomena: Conduction and Conductivity, Semiconductivity, Resistance, Current Carriers, Galvanomagnetic and Acoustoelectric Effects and other aspects.Application of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 4, 2017, Matsuzawa, Akinobu; Noda, Hidetoshi; Kumagai, Naoya; Shibasaki, Masakatsu published an article.Reference of N,N-Diethylacetamide The title of the article was Direct Catalytic Asymmetric Aldol Addition of an α-CF3 Amide to Arylglyoxal Hydrates. And the article contained the following:

Direct asym. aldol addition of an α-CF3 amide to arylglyoxal hydrates was promoted by a chiral catalyst comprising a soft Lewis acidic Cu(I), a chiral bisphosphine ligand, and DBU. The 7-azaindoline moiety of the amide facilitates its enolization and stabilizes the thus-generated Cu enolate, furnishing enantioenriched aldol adducts. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Reference of N,N-Diethylacetamide

The Article related to asym aldol addition alpha trifluoromethyl amide arylglyoxal hydrate, copper catalyzed addition azaindoline moiety enantioenriched aldol adduct preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Reference of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics