Category: amides-buliding-blocks

On April 30, 2013, Mange, Yatin J.; Isloor, Arun M.; Malladi, Shridhar; Isloor, Shrikrishna; Fun, Hoong-Kun published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Synthesis and antimicrobial activities of some novel 1,2,4-triazole derivatives. And the article contained the following:

In the present investigation, a series of new Schiff bases were synthesized by the condensation of N-[(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-4-H/Me-benzamides with various substituted aromatic aldehydes in ethanol-dioxane mixture using catalytic amount of sulfuric acid. The starting materials N-[(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-4-H/Me-benzamides were in turn synthesized by the fusion of (4-H/Me-benzoyl)-glycines with thiocarbohydrazide. Newly synthesized compounds were characterized by IR, NMR, mass spectra and elemental analyses. All the compounds were evaluated for their antibacterial and antifungal activity using the Min. Inhibition Concentration (MIC) method by serial dilution technique. Few of the compounds were found to be biol. active. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

The Article related to thiocarbohydrazide aroylglycine cyclocondensation, aminomercaptotriazole arylamidomethyl preparation condensation aryl aldehyde, schiff base triazolethiol preparation antibacterial antifungal and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2021, Yadav, Mangal S.; Singh, Sumt K.; Agrahari, Anand K.; Singh, Anoop S.; Tiwari, Vinod K. published an article.Reference of 1,3-Diphenylurea The title of the article was N -Acylbenzotriazoles as Proficient Substrates for an Easy Access to Ureas, Acylureas, Carbamates, and Thiocarbamates via Curtius Rearrangement Using Diphenylphosphoryl Azide (DPPA) as Azide Donor. And the article contained the following:

A diverse range of ureas RNHC(O)NHC(O)R1 [R = Ph, 2-IC6H4, 3-BrC6H4, etc.; R1 = Ph, 2-IC6H4], N-acylureas R1NHC(O)NHR2 [R1 = Ph, 3-BrC6H4, 2-MeOC6H4, etc; R2 = Ph, 2-BrC6H4, 2-IC6H4], carbamates and thiocarbamates R1NHC(O)R2 [R1 = Ph, 3,5-di-MeC6H3, 3-MeC6H4; R2 = OPh, SPh, S(2-MeC6H4), etc.] was synthesized in good to excellent yields by reacting N-acylbenzotriazoles individually with amines/amides/phenols/thiols in the presence of diphenylphosphoryl azide (DPPA) as a suitable azide donor in anhydrous toluene at 110°C for 3-4 h. In this route, DPPA was found to be a good alternative to trimethylsilyl azide and sodium azide for the azide donor in Curtius degradation The high reaction yields, one-pot and metal-free conditions, straightforward nature, easy handling, use of readily available reagents and in many cases avoidance of column chromatog. were the notable features of the devised protocol. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Reference of 1,3-Diphenylurea

The Article related to urea or acylurea preparation, acylbenzotriazole amine or amide curtius rearrangement dppa, carbamate or thiocarbamate preparation, phenol or thiol acylbenzotriazole curtius rearrangement dppa and other aspects.Reference of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 29, 2020, Serrano, Joao L.; Soeiro, Pedro F.; Reis, Melani A.; Boto, Renato E. F.; Silvestre, Samuel; Almeida, Paulo published an article.Electric Literature of 102-07-8 The title of the article was Synthesis and process optimization of symmetric and unsymmetric barbiturates C5-coupled with 2,1-benzisoxazoles. And the article contained the following:

An unexpected formation of sym. 3-substituted 2,1-benzisoxazoles I [X = O, S; R = R1 = H, Ph, Me] through reduction of 5-(2-nitrobenzylidene)barbiturates II has been described. This reductive intramol. heterocyclization probably involves a nitroso intermediary. To improve the previous reaction conditions, the nature of the reducing agent and additives, reaction time and solvents were evaluated. By applying the optimized conditions, several sym. I [X = O, S; R = R1 = H, Ph, Me] and unsym. barbiturates C5-coupled with 2,1-benzisoxazoles I [X = S; R = Ph; R1 = H, 3-chlorophenyl, 4-chlorophenyl, 4-fluorophenyl, 4-iodophenyl] were prepared with an yield of 52-87%. From this set, seven compounds I (X = S, R = R1 = Me; X = O, R = R1 = Ph; X = S, R = Ph, R1 = H, 3-chlorophenyl, 4-chlorophenyl, 4-fluorophenyl, 4-iodophenyl) were novel and the unsym. nature of the (thio)barbituric acid moiety was explored. For that, the total synthesis, starting from the resp. urea or thiourea, was successfully performed, and 11 thiobarbiturates, benzylidene barbiturate and thiobarbiturate precursors are described. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Electric Literature of 102-07-8

The Article related to benzisoxazole preparation, nitrobenzylidene barbiturate reductive heterocyclization, 2,1-benzisoxazoles, anthranils, barbituric acid derivatives, nitroaromatic reduction, process optimization and other aspects.Electric Literature of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 18, 2009, Martins, Jose E. D.; Wills, Martin published an article.Electric Literature of 167316-28-1 The title of the article was Ir(III) complexes of diamine ligands for asymmetric ketone hydrogenation. And the article contained the following:

The use of a combination of IrCl3 with a series of ligands derived from the C2-sym. diamine diphenylethanediamine (DPEN) forms a catalyst capable of the asym. hydrogenation of ketones in up to 85% ee. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).Electric Literature of 167316-28-1

The Article related to arylalkanol asym preparation, arylketone asym hydrogenation iridium chiral diamine, chiral diaminepreparation iridium asym hydrogenation catalyst, diamine sulfonylation reductive amination and other aspects.Electric Literature of 167316-28-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 4, 2022, Kumar, Vishal; Dhawan, Sanjeev; Bala, Renu; Girase, Pankaj Sanjay; Singh, Parvesh; Karpoormath, Rajshekhar published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was Metal-free direct annulation of 2-aminophenols and 2-aminothiophenols with unactivated amides through transamidation: Access to polysubstituted benzoxazole and benzothiazole derivatives. And the article contained the following:

Simple yet novel oxidant, metal and solvent-free green protocol for synthesizing differently 2-substituted 1,3-benzoxazoles I [R1 = Me, Ph, Bn, etc.; R2 = H, 6-Me, 5-Cl, etc.; X = O] and benzothiazoles I [R1 = Me; R2 = H, 5-Cl; X = S] from 2-aminophenol hydrochloride salt, unactivated amide as in situ carbon source was reported. Further, the hydrogen ion of hydrochloride played a crucial role in amide activation followed nucleophilic attack that through eliminations of amine as a side product, and de-hydrolysis step leads to final annulation. This versatile strategy was applicable to a wide variety of differently substituted o-aminophenols, unactivated aliphatic and aromatic amides, yielding the corresponding product in good to excellent yields in a single step. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to benzoxazole green preparation, aminophenol hydrochloride salt unactivated amide annulation, benzothiazole green preparation, aminothiophenol hydrochloride salt unactivated amide annulation and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2022, Liman, Recep; Ali, Muhammad Muddassir; Istifli, Erman Salih; Cigerci, Ibrahim Hakki; Bonciu, Elena published an article.Formula: C2H4ClNO The title of the article was Genotoxic and cytotoxic effects of pethoxamid herbicide on Allium cepa cells and its molecular docking studies to unravel genotoxicity mechanism. And the article contained the following:

Pethoxamid is chloroacetamide herbicide. Pethoxamid is commonly used to kill different weeds in various crops. Pethoxamid can leach in the water and soil and can cause toxic effects to other non-target species. Current study is therefore aimed to perform the investigation of the cytotoxic and genotoxic effects of pethoxamid on Allium cepa cells. The root growth, mitotic index (MI), chromosomal aberrations (CAs), and DNA damage were assessed through root growth inhibition, A. cepa ana-telophase, and alk. comet assays, resp. Furthermore, mol. docking was performed to evaluate binding affinity of pethoxamid on DNA and very-long-chain fatty acid (VLCFA) synthases. In root growth inhibition test, onion root length was statistically significantly decreased in a concentration dependent manner. Concentration- and time-dependent decreases in MI were observed, whereas increase in CAs such as disturbed ana-telophase, chromosome laggards, stickiness, anaphase bridges, and DNA damage was caused by the pethoxamid on A. cepa root cells. Mol. docking revealed that pethoxamid binds selectively to GC-rich regions in the minor groove of the DNA structure and showed remarkable binding affinity against all synthases taking part in the sequential biosynthesis of VLCFAs. It was concluded that the pethoxamid-induced genotoxicity and cytotoxicity may be through multiple binding ability of this herbicide with DNA and VLCFA synthases. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to pethoxamid herbicide allium cepa cell mol docking genotoxicity, binding affinity, chromosomal aberrations, dna damage, long-chain fatty acids, mitotic index, molecular docking, pethoxamid and other aspects.Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 30, 2021, Yang, Jing; Chen, Xiaoqian; Yin, Daqiang; Yin, Haowen; Zhang, Ying; Liu, Min; Zhao, Weigang; Zhang, Lu; Liu, Yanan; Yang, Xichen; Zhong, Zhijie published an article.Quality Control of 2-Chloroacetamide The title of the article was Applicability of Enchytraeus bulbosus as a model species in ecotoxicology and risk assessment. And the article contained the following:

Enchytraeus bulbosus is listed in the ISO and OECD standard guidelines as a possible test species of enchytraeid. However, in contrast to other listed species, its applicability in ecotoxicol. studies as well as its sensitivity is widely unknown. Therefore, copper, pentachlorophenol(PCP), carbendazim, and chloroacetamide have been investigated by performing two-generation studies with multiple endpoints. Comparable toxicity trends to the existing studies were shown for copper and PCP in the two-generation studies of E. bulbosus. Dose-related abnormal swelling of clitella were found for the first time with PCP and chloroacetamide treatments. Sensitivity comparisons of E. bulbosus to other terrestrial test species were also conducted. E. bulbosus showed high sensitivity, it has comparable sensitivity as other sensitive species of genus Enchytraeus ( E. albidus or E. luxuriosus)to different chems., and was more sensitive than E. crypticus and earthworm species ( Eisenia fetida or Eisenia andrei). Combined with the phylogenetic and biol. characterization, the results lead to the conclusion that E.bulbosus is a suitable model species in ecotoxicol. and the chem. risk assessment (especially in multi-generation) because it has a short generation time, comparatively moderate fecundity, ideal and reasonable sensitivity. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Quality Control of 2-Chloroacetamide

The Article related to copper pentachlorophenol carbendazim chloroacetamide enchytraeus ecotoxicol risk assessment, carbendazim, chloroacetamide, copper, enchytraeus bulbosus, pentachlorophenol, two generations and other aspects.Quality Control of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2020, Paronikyan, Ervand G.; Dashyan, Shushanik Sh.; Mamyan, Suren S. published an article.HPLC of Formula: 79-07-2 The title of the article was Synthesis of pyrano[3,4-c]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyridines, representatives of a new fused heterocyclic system. And the article contained the following:

New effective synthesis of functionalized pyrano[3,4-c]thieno-[3,2-e][1,2,4]triazolo[4,3-a]pyridines I (Y = COOEt, C(O)NH2, CN) is described. The synthesis comprises nucleophilic substitution of 8-morpholino-6-thioxopyrano[3,4-c]pyridine-5-carbonitrile with hydrazine hydrate followed by sequential heterocyclization with formic acid and chloroacetic acid derivatives The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).HPLC of Formula: 79-07-2

The Article related to pyranothienotriazolopyridine preparation, morpholino thioxopyranopyridine carbonitrile hydrazine hydrate nucleophilic substitution, formic chloroacetic acid derivative heterocyclization and other aspects.HPLC of Formula: 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Boscari, Carolina Nasser; Mazzuia, Giovanna Rodrigues; Wisniewski, Celio; Borges, Keyller Bastos; Figueiredo, Eduardo Costa published an article in 2017, the title of the article was Molecularly imprinted probe for solid-phase extraction of hippuric and 4-methylhippuric acids directly from human urine samples followed by MEKC analysis.SDS of cas: 27115-50-0 And the article contains the following content:

Hippuric acid (HA) and 4-methylhippuric acid (4-MHA) are metabolites as well as biol. indicators for toluene and xylenes, resp., and their determination in urine samples is very important, in order to monitor the occupational exposition to these solvents, ensuring a safe working environment. Thus, this paper describes the synthesis and characterization of a probe impregnated with molecularly imprinted polymers (MIPs) for the solid-phase extraction of HA and 4-MHA directly from untreated urine samples followed by micellar electrokinetic chromatog. (MEKC) analyses. The MIP probe selectivity was compared to the non-imprinted polymer probe. The MEKC separations were carried out in 50 mmol/L sodium tetraborate pH 10.0/0.5 mmol/L cetyltrimethylammonium bromide aqueous solution, with a constant voltage of -15 kV. The system variables were optimized to provide ideal conditions for the extraction and desorption of the analytes, as well as for the MEKC analyses. The method was linear from 0.5 to 5.0 g/L for both analytes, with correlation coefficients > 0.994. Precisions and accuracies, expressed as relative standard deviation and relative error, were < 20.0 and within -15.4 to 16.6%, resp., in accordance with the United States Food and Drug Administration recommendation. The MIP probe has proven to be simple, cheap, resistant, and synthetically reproducible, being successfully used to analyze both HA and 4-MHA from real samples. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).SDS of cas: 27115-50-0

The Article related to hippurate methylhippurate molecularly imprinted polymer solid phase extraction mekc, capillary electrophoresis, hippuric acid, methylhippuric acid, molecularly imprinted polymer, urine and other aspects.SDS of cas: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 7, 2015, Lill, Andreas P.; Roedl, Carmen B.; Steinhilber, Dieter; Stark, Holger; Hofmann, Bettina published an article.Computed Properties of 27115-50-0 The title of the article was Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy. And the article contained the following:

Different inflammatory diseases and allergic reactions are mediated by leukotrienes, which arise from the oxygenation of arachidonic acid catalyzed by 5-lipoxygenase (5-LO). One promising approach for an effective anti-leukotriene therapy (leukotriene antagonists) is the inhibition of this key enzyme. This study presents the synthesis and development of a potent and direct 5-LO inhibitor based on the well characterized 5-benzylidene-2-phenylthiazolone C06, whose further pharmacol. investigation was precluded due to its low solubility Through optimization of C06, evaluation of a structure-activity relationship including profound assessment of the thiazolone core and consideration of the solubility, the 5-benzyl-2-phenyl-4-hydroxythiazoles represented by ST-1829 [i.e., 5-(4-chlorobenzyl)-2-p-tolyl-4-thiazolol] were developed. ST-1829 showed an improved 5-LO inhibitory activity in cell-based (IC50 values 0.14 μM) and cell-free assays (IC50 values 0.03 μM) as well as a prominent enhanced solubility Furthermore, ST-1829 kept its promising inhibitory potency in the presence of blood serum, excluding excessive binding to serum proteins. These facts combined with the non-cytotoxic profile mark a major step towards an effective anti-inflammatory therapy. The synthesis of the target compounds was achieved using 2-thioxo-4-thiazolidinone, 4-methylbenzoic acid, aldehydes, nitriles as simple starting materials. The title compounds thus formed included 2-(4-chlorophenyl)-5-[(4-methoxyphenyl)methyl]-4-thiazolol, 5-[(4-methoxyphenyl)methylene]-2-(4-methylphenyl)-4-thiazolone and related substances. Analogs included (3E)-3-[(4-methoxyphenyl)methylene]-5-(4-methylphenyl)-2(3H)-furanone, (4Z)-4-[(4-methoxyphenyl)methylene]-2-(4-methylphenyl)-5(4H)-oxazolone. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Computed Properties of 27115-50-0

The Article related to thiazole thiazolone thiazolol preparation leukotriene antagonist, 5-lipoxygenase, anti-leukotriene therapy, hydroxythiazoles, inflammation, solubility, structure–activity relationship and other aspects.Computed Properties of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics