Category: amides-buliding-blocks

Research on effect of TAED on pearl bleaching was written by Luo, Jianqiu;Yang, Lei;Chen, Jin;Lao, Zan. And the article was included in Huagong Jishu Yu Kaifa in 2011.Category: amides-buliding-blocks This article mentions the following:

In order to speed up the process of pearl bleaching, a method that used Tetra Acetyl Ethylene Diamine(TAED) as the bleaching activator during the pearl bleaching was explored. The results of the study showed that TAED had a great effect on catalyzing pearl bleaching. It was due to the reaction between TAED and HOO^– to generate the diacetyl ethylene diamine(DAED) and acetic root anion which had more strong blanching ability than H₂O₂. Besides, different concentrations of TAED had observation effects on surface condition of pearl. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Category: amides-buliding-blocks).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Convenient synthesis of sulfonamides from amines and p-toluenesulfonyl chloride mediated by crosslinked poly(4-vinylpyridine) was written by Zarchi, Mohammad Ali Karimi;Aslani, Mariam. And the article was included in Journal of Applied Polymer Science in 2012.COA of Formula: C13H13NO3S This article mentions the following:

A general, mild, and convenient method has been developed for the synthesis of various N-substituted and N,N-disubstituted sulfonamides, as a class of sulfa drugs, from the corresponding amines and p-toluenesulfonyl chloride in the presence of readily available crosslinked poly(4-vinylpyridine) as a catalyst, base or polymeric substrates. The use of polymeric catalyst simplifies routine sulfonylation of amines because it eliminates the traditional purification The polymer can be removed quant. and it can be regenerated and reused for several cycles without losing its activity. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6COA of Formula: C13H13NO3S).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.COA of Formula: C13H13NO3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Silver/Scandium-Cocatalyzed Bicyclization of β-Alkynyl Ketones Leading to Benzo[c]xanthenes and Naphtho[1,2-b]benzofurans was written by Chen, Ke;Liu, Shuai;Wang, Dan;Hao, Wen-Juan;Zhou, Peng;Tu, Shu-Jiang;Jiang, Bo. And the article was included in Journal of Organic Chemistry in 2017.Synthetic Route of C13H13NO3S This article mentions the following:

The combination of AgTFA and Sc(OTf)₃ enables the bimetallic synergistic catalysis of β-alkynyl ketones and para-quinone methides (p-QMs), allowing direct synthesis of 17 examples of benzo[c]xanthenes, e.g., I (X-rays single crystal structure shown), with generally good yields through a benzannulation/1,6-addition/cyclization sequence. Exchanging p-QMs for quinone imine ketal resulted in 10 examples of tetracyclic naphtho[1,2-b]benzofurans via a similar benzannulation/1,4-addition/cyclization cascade. During these reaction processes, AgTFA and Sc(OTf)₃ could be perfectly compatible, together with the realization of C(sp³)-H functionalization adjacent to carbonyl group on the β-alkynyl ketone unit. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Synthetic Route of C13H13NO3S).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Synthetic Route of C13H13NO3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. was written by Yang, Yang;Wang, Huanan;Kouadir, Mohammed;Song, Houhui;Shi, Fushan. And the article was included in Cell death & disease in 2019.HPLC of Formula: 53902-12-8 This article mentions the following:

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome has been implicated in a wide range of diseases, including Alzheimer’s disease, Prion diseases, type 2 diabetes, and some infectious diseases. It has been found that a variety of stimuli including danger-associated molecular patterns (DAMPs, such as silica and uric acid crystals) and pathogen-associated molecular patterns (PAMPs) can activate NLRP3 inflammasome, but the specific regulatory mechanisms of NLRP3 inflammasome activation remain unclear. Understanding the mechanisms of NLRP3 activation will enable the development of its specific inhibitors to treat NLRP3-related diseases. In this review, we summarize current understanding of the regulatory mechanisms of NLRP3 inflammasome activation as well as inhibitors that specifically and directly target NLRP3. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8HPLC of Formula: 53902-12-8).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.HPLC of Formula: 53902-12-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A facile synthesis of 6H-[1,3,5]triazino[2,1-b]quinazolin-6-ones was written by Abbott, Shaun;Cloutier, Josee;Houde, Karine;Penney, Christopher;Zacharie, Boulos. And the article was included in Synthesis in 2011.Computed Properties of C7H7FN2O This article mentions the following:

Triazinoquinazolinone derivatives are synthesized by cyclization of aminobenzamide-substituted triazine compounds in the presence of a proton source such as trifluoroacetic acid or hydrochloric acid. The reaction is mild, general, and gives high yield (>90%) of the cyclized product. This procedure allows, for the first time, access to triazinoquinazolinone compounds bearing different functionalities on the benzene and triazine moieties that are not available by other routes. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Computed Properties of C7H7FN2O).

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Computed Properties of C7H7FN2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Direct transformation of N,N-disubstituted amides and isopropyl esters to nitriles was written by Suzuki, Yusuke;Yoshino, Takumi;Moriyama, Katsuhiko;Togo, Hideo. And the article was included in Tetrahedron in 2011.Recommanded Product: 192436-83-2 This article mentions the following:

Various N,N-di-Me amides, N-methoxy-N-Me amides, and iso-Pr esters were smoothly transformed into the corresponding nitriles in good to moderate yields by the treatment with diisobutylaluminium hydride, followed by treatment with mol. iodine in aq ammonia. The present reactions are novel one-pot and practical methods for the transformation of N,N-disubstituted amides and iso-Pr esters into nitriles, through the formation of hemiaminal O-AlBu₂ and hemiacetal O-AlBu₂, resp. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Recommanded Product: 192436-83-2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: 192436-83-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Magnetic hydroxyapatite nanomaterial-cyclodextrin tethered polymer hybrids as anticancer drug carriers was written by Ramasamy, Sivaraj;Dhamecha, Dinesh;Kaliyamoorthi, Kiruthiga;Pillai, Archana Sumohan;Alexander, Aleyamma;Dhanaraj, Premnath;Menon, Jyothi U.;Enoch, Israel V. Muthu Vijayan. And the article was included in Materials Advances in 2021.Recommanded Product: 2387-23-7 This article mentions the following:

Osteosarcoma, the most common bone cancer, leads to a poor survival rate of patients. Drug targeting employing hydroxyapatite (HAp)-based nanocarriers represents a fascinating choice for non-invasive treatment of osteosarcoma. Herein, we report strontium-doped (Sr-HAp) and iron- and strontium-co-doped (Sr,Fe-HAp) hydroxyapatite nanoparticles as novel materials that deliver doxorubicin to bone cancer cells. A platinum-complexed and cyclodextrin-functionalized chitosan derivative is utilized to coat the NPs. Sr-HAp (aspect ratio ~20) and Sr,Fe-HAp (aspect ratio ~3) nanoparticles are formed as nanowhiskers and nanorods, resp., as revealed by transmission electron microscopy. Strontium ferrite NPs are synthesized and their properties are compared with those of the Sr/Sr,Fe-doped HAp NPs. These ferrite NPs show ferromagnetic behavior, as opposed to Sr-HAp and Sr,Fe-HAp. The latter two resp. display paramagnetic and superparamagnetic behaviors. The loading percentage of the anticancer drug, Doxorubicin (Dox), in the nanocarriers is high and the release of Dox is sustained at physiol. pH. The Dox-loaded nanocarriers are tested for their in vitro cytotoxicity against lung, cervical, liver, and bone cancer cell lines. In general, the efficacy of Dox is not diminished on loading in the nanocarriers. In addition, the Dox-carriers demonstrate a time- and dose-dependent cytotoxicity. The efficacy is enhanced in the case of Dox-loaded carriers on MG-63 (osteosarcoma) cell lines. The anticancer activity is tested in vivo on both male and female albino mice. Enhanced chemotherapeutic potential is observed for Dox-loaded Sr,Fe-HAp in a metastatic model of MG-63. The platinum derivative polymer possesses its own therapeutic effect and contributes to the general activity. The novel polymer-HAp nanohybrid represents an effective nanocarrier for the treatment of osteosarcoma. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Recommanded Product: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Visible light-promoted synthesis of ureas and formamides from amines and CO₂ was written by Zhang, Qian;Hou, Jing;Huang, Yan;Zhan, Le-wu;Li, Bin-dong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Electric Literature of C13H24N2O This article mentions the following:

A divergent visible-light-induced Ph₃P-promoted method for the synthesis of ureas and formamides from amines and CO₂ is reported. Without external additions, a range of ureas could be directly accessed under ambient temperature and pressure. Using triisopropylsilanethiol as the hydrogen source, formamides could be produced. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Electric Literature of C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Electric Literature of C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Efficient synthesis and biological activity of novel indole derivatives as VEGFR-2 tyrosine kinase inhibitors was written by Zhang, C.;Xu, D.;Wang, J.;Kang, C.. And the article was included in Russian Journal of General Chemistry in 2017.Application of 2387-23-7 This article mentions the following:

Series of novel indole derivatives, e.g. I were synthesized as potent inhibitors for the vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase. Among those, compound I demonstrated the highest growth inhibition rate of 66.7% against the VEGFR-2 tyrosine kinase at 10 μM which indicates that indole-benzothiazole might be the favorable structure. The binding mode of compound I with VEGFR-2 tyrosine kinase was evaluated by mol. docking. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Application of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Application of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The effect of surface-active agents on the properties of lead chromates was written by Ermilov, P. I.;Fedorov, V. N.. And the article was included in Lakokrasochnye Materialy i Ikh Primenenie in 1964.Synthetic Route of C9H13NO2S This article mentions the following:

The effect of anionic, cationic, and nonionic surface-active agents (I) on the properties of Pb chromates was investigated. To synthesize 100 g. of nitric Pb chromates, 69.5 g. PbO, 19.6 g. HNO₃, 37.4 g. Na₂Cr₂O₇, and 2.54 g. H₂SO₄ were used. In all experiments, the precipitation and crystallization were conducted at 25° with thorough agitation. I (0.1-3.5% based on dry chromate) were introduced during the dissolving of PbO in HNO₃. After washing and filtration, one part of the chromate was dried at 80° to 1% residual moisture content. The other part, containing 40-45% moisture, was mixed with raw linseed oil (II) for 4-5 min. The separated H₂O was decanted, a fresh portion of raw II was added, and the mixture agitated to a constant moisture content. A purified Na octylbenzenesulfonate (III), and Duomeen T dioleate, [RNH₂C₃H₆NH₃] [C₁₇H₃₃COO], were used as anionic I. Katamine A, [RC₆H₄CH₂N⁺Et₃]Cl^–, and preparation BSA, RC₆H₄SO₂NHCHMe₂, were used as cationic I. As nonionic I, OP-4, C₈H₁₇C₆H₄O(CH₂CH₂O)₄H, and TB-7, tritert-butylphenol, were employed. Analyses of the resulting chromates showed that I have no effect on the chem. composition or on the completeness of reaction of the chromates. In all cases, the chromate contained 27.2-28.0% CrO₃, 68.4-69.0% PbO, and 0.3-0.4% H₂O-soluble salts. The light fastness of all samples containing I was good. Anionic and nonionic I, used in amounts of 0.25-0.50% (based on the weight of the chromate), noticeably inhibit the crystal growth, thus increasing the dispersibility of the pigment. When the amount of I is increased, their effectiveness decreases. Anionic I (0.25%) decrease the oil absorption of the chromate from 17 to 9-11 g./100 g. Nonionic I, especially TB-7, decrease the oil absorption slightly, while cationic I increase it. The hiding power of the pigment is improved with I. Especially effective are 0.25% III, 1% Duomeen T, 1% OP-4, and 0.25% TB-7. All of the investigated I, except Katamin A and OP-4, reduce the moisture content of the chromate to 6.5-6.8% after agitating the wet pigment for 7-9 min. with raw II. This eliminates the necessity of drying and crushing the pigment and speeds up the grinding process. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Synthetic Route of C9H13NO2S).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Synthetic Route of C9H13NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics