Category: amides-buliding-blocks

Yousef, Farah; Mansour, Oussama; Herbali, Jehad published the artcile< Rigid docking application to investigate sulfonylurea family members' binding site with their receptor KIR6.2SUR1>, Electric Literature of 94-20-2, the main research area is sulfonylurea glibenclamide chlorpropamide antihyperglycemic agent KIR62 SUR1 mol docking.

Sulfonylurea family members have been used as a second preferred line in the treatment of Type II Diabetes Mellitus (TIIDM) for decades. Only one crystal structure for its receptor Kir6.2SUR1 binding with one of sulfonylurea member; Glibenclamide (GBM), is available in Protein Data Bank (PDB) database. The aim of this manuscript is to study in-silico other sulfonylurea family members’ interactions with their receptor Kir6.2SUR1 using a docking software in the default settings. We have checked the validity of the software for the study. Then, rigid docking had been applied on 14 compounds of sulfonylurea group which they have anti-hyperglycemia activity. Next, we have compared their interactions to GBM interactions with Kir6.2SUR1. As a result, many compounds of this family had bound to Kir6.2SUR1 receptor in the same pocket as GBM. These results confirmed a perspective we have discussed about sulfonylurea structure activity relationship.

International Journal of Pharma and Bio Sciences published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Electric Literature of 94-20-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Venkateswarlu, Somepalli; Satyanarayana, Meka; Srinivas, Kolla; Aadisudhakar, Kodumuri N. V. V. published the artcile< Synthesis of isomeric angularly fused dihydroquinazolinoquinazolinones and an unusual oxidative rearrangement>, Reference of 5004-88-6, the main research area is dihydroquinazolino quinazolinone preparation cyclization oxidative rearrangement.

Cyclization of 2-(2-aminophenyl)-2,3-dihydroquinazolin-4(1H)-ones onto N1-nitrogen and onto N3-nitrogen leading to 11b,12-dihydro-(13H)-quinazolino[3,4-a]quinazolin-13-ones, e.g., I, and 13,13a-dihydro-(8H)-quinazolino[4,3-b]quinazolin-8-ones, e.g., II, resp., is described for the first time. An unusual dehydrogenative rearrangement of compound I to (8H)-quinazolino[4,3-b]quinazolin-8-one is also described.

Tetrahedron Letters published new progress about Aromatic amides Role: RCT (Reactant), RACT (Reactant or Reagent) (2-aminoaryl). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Reference of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Thakral, Naveen K.; Thakral, Seema; Stephenson, Gregory A.; Sedlock, Robert; Suryanarayanan, Raj published the artcile< Compression-Induced Polymorphic Transformation in Tablets: Role of Shear Stress and Development of Mitigation Strategies>, Application of C10H13ClN2O3S, the main research area is Compression polymorphic transformation tablets shear stress; hydrostatic pressure; phase transformation; shear stress; tablet; viscoelastic excipients.

Our goals were to evaluate the effects of (i) hydrostatic pressure alone and (ii) its combined effect with shear stress during compaction, on the polymorphic transformation (form C → A) of a model drug, chlorpropamide. The powder was either subjected to hydrostatic pressure in a pressure vessel or compressed in a tablet press, at pressures ranging from 25 to 150 MPa. The overall extent of phase transformation was determined by powder X-ray diffractometry, whereas 2D-X-ray diffractometry enabled quantification of the spatial distribution of phase composition in tablets. Irresp. of the pressure, the extent of transformation following compaction was higher than that because of hydrostatic pressure alone, the difference attributed to the contribution of shear stress experienced during compaction. At a compression pressure of 25 MPa, there was a pronounced gradient in the extent of phase transformation when monitored from radial tablet surface to core. This gradient decreased with increase in compression pressure. Four approaches were attempted to minimize the effect of compression-induced phase transformation: (a) site-specific lubrication, (b) use of a viscoelastic excipient, (c) ceramic-lined die, and (d) use of cavity tablet. The ceramic-lined die coupled with site-specific lubrication was most effective in minimizing the extent of compression-induced phase transformation.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Compression. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Application of C10H13ClN2O3S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kerdphon, Sutthichat; Sanghong, Patthadon; Chatwichien, Jaruwan; Choommongkol, Vachira; Rithchumpon, Puracheth; Singh, Thishana; Meepowpan, Puttinan published the artcile< Commercial Copper-Catalyzed Aerobic Oxidative Synthesis of Quinazolinones from 2-Aminobenzamide and Methanol>, Computed Properties of 5004-88-6, the main research area is quinazolinone preparation copper catalyst aerobic oxidation aminobenzamide methanol.

The focus of this study was the development of a new synthetic method for quinazolinones based on the principles of Green Chem. Quinazolinones were synthesized from 2-aminobenzamide using methanol as both the C1 source and a green solvent in the presence of base Cs2CO3. Addnl., a com. available, economical copper complex was used as a catalyst in the reaction. The desired products were achieved in moderate to high yield with up to 99% isolated yield.

European Journal of Organic Chemistry published new progress about Benzamides Role: RCT (Reactant), RACT (Reactant or Reagent) (2-Aminobenzamide). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Computed Properties of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mishra, Ashish A.; Bhanage, Bhalchandra M. published the artcile< Electronic And Steric Effect Favored Selective Synthesis Of Asymmetric (-) N-Aryl Mandelamides>, SDS of cas: 1192620-83-9, the main research area is asym aryl mandelamide preparation enantioselective; aryl benzoyl formamide asym transfer hydrogenation ruthenium catalyst.

This work reports selective synthesis of asym. (-) α-Hydroxyl Amides like N-aryl mandelamides (S)-4-RC6H4NHC(O)CH(OH)R1 [R = H, Me; R1 = Ph, 2-fluorophenyl, 2,4,6-tris(propan-2-yl)phenyl, etc.] via asym. transfer hydrogenation (ATH) of α-keto Amides like N-aryl benzoyl formamides 4-RC6H4NH(C(O))2R1 using Ru-Tethered TsDPEN catalyst I. The electronic and steric effect at ortho position leading to high enantioselectivity for ATH of carbonyl, sandwiched between two sp2 carbon is studied. A wide range of mono and di ortho substituted α-hydroxyl amide is synthesized using this protocol with good enantioselectivity.

ChemistrySelect published new progress about Amides, hydroxy Role: SPN (Synthetic Preparation), PREP (Preparation). 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, SDS of cas: 1192620-83-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yu, Zhou; Fan, Wufa; Wang, Luting; He, Haisheng; Lv, Yongjiu; Qi, Jianping; Lu, Yi; Wu, Wei published the artcile< Slowing down lipolysis significantly enhances the oral absorption of intact solid lipid nanoparticles>, SDS of cas: 96829-58-2, the main research area is solid lipid nanoparticle lipolysis oral absorption.

Only a limited amount of orally administered lipid nanoparticles are absorbed as intact particles due to lipolysis by lipases in the gastrointestinal tract. It is hypothesized that by counteracting lipolysis, more particles will survive gastrointestinal digestion and be absorbed as intact particles. In this study, incorporation of a lipase inhibitor orlistat (OLST), as well as polyethylene glycol (PEG) coating, is employed to slow down the lipolysis using solid lipid nanoparticles (SLNs) as model particles. To explore the in vivo behaviors of the particles, near-IR fluorescent probes with absolute aggregation-caused quenching (ACQ) properties are used to label and track the unmodified, PEG-coated and OLST-loaded SLNs. The in vitro lipolysis study indicates very fast first-order degradation of unmodified SLNs and significantly decreased degradation of OLST-SLNs. Live imaging reveals the same trend of slowed-down lipolysis in vivo which correlates well with the in vitro lipolysis. The scanning of ex vivo gastrointestinal segments confirms the considerably prolonged residence time of OLST-SLNs, mirroring the significantly decreased lipolysis rate. The observation of fluorescence in the blood, though very weak, and in the liver speaks of the oral absorption of intact SLNs. Similarly, slowing down lipolysis also contributes to the significantly enhanced cumulative lymphatic transport of OLST-SLNs (7.56% vs. 1.27% for the unmodified SLNs).

Biomaterials Science published new progress about Biomacromolecular compounds Role: TEM (Technical or Engineered Material Use), USES (Uses). 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, SDS of cas: 96829-58-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharma, Shikha; Ghosh, Sunil K.; Sharma, Joti N. published the artcile< Sorption of ruthenium by dipropylmethyl-2-(N,N-diisobutyl) acetamidoammonium iodide impregnated Amberlite XAD-4 resin from nitric acid medium>, Safety of 2-Chloro-N,N-diisobutylacetamide, the main research area is ruthenium dipropylmethyldiisobutyl acetamidoammonium iodide Amberlite impregnation nitric acid sorption.

Dipropylmethyl-2-(N,N-diisobutyl)acetamidoammonium iodide has been impregnated on Amberlite XAD-4 resin and investigated for sorption of Ru from nitric acid medium. Equilibrium sorption data for Ru uptake were represented well by the Langmuir isotherm equation (R2 = 0.98) compared to Freundlich isotherm equation (R2 = 0.86). The maximum monolayer coverage (Q0) value of 6.25 mg/g as obtained from Langmuir isotherm was close to the exptl. value (5.63 mg/g). The heterogeneity parameter (1/n) = 0.37 obtained from the slope of Freundlich isotherm indicates slight heterogeneity in sorption process. Aqueous solutions of 5% ammonia or 10% sodium hydroxide were found suitable for desorption. The method can be applied for separation of Ru from acidic waste solutions

Separation Science and Technology (Philadelphia, PA, United States) published new progress about Desorption. 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Safety of 2-Chloro-N,N-diisobutylacetamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

van Loevezijn, Arnold; Venhorst, Jennifer; Iwema Bakker, Wouter I.; de Korte, Cor G.; de Looff, Wouter; Verhoog, Stefan; van Wees, Jan-Willem; van Hoeve, Martijn; van de Woestijne, Rob P.; van der Neut, Martina A. W.; Borst, Alice J. M.; van Dongen, Maria J. P.; de Bruin, Natasja M. W. J.; Keizer, Hiskias G.; Kruse, Chris G. published the artcile< N'-(Arylsulfonyl)pyrazoline-1-carboxamidines as Novel, Neutral 5-Hydroxytryptamine 6 Receptor (5-HT6R) Antagonists with Unique Structural Features>, Recommanded Product: 3-Fluorobenzenesulfonamide, the main research area is arylsulfonylpyrazolinecarboxamidine hydroxytryptamine 6 receptor antagonist.

The 5-HT6 receptor (5-HT6R) has been in the spotlight for several years regarding CNS-related diseases. We set out to discover novel, neutral 5-HT6R antagonists to improve off-target selectivity compared to basic amine-containing scaffolds dominating the field. High-throughput screening identified the N’-(sulfonyl)pyrazoline-1-carboxamidine scaffold as a promising neutral core for starting hit-to-lead. Medicinal chem., mol. modeling, small mol. NMR and X-ray crystallog. were subsequently applied to optimize the leads into antagonists displaying high 5-HT6R affinity with optimal off-target selectivity. Unique structural features include a pseudoarom. system and an internal hydrogen bond freezing the bioactive conformation. While physicochem. properties and CNS availability were generally favorable, significant efforts had to be made to improve metabolic stability. The optimized structure 42 (I) is an extremely selective, hERG-free, high-affinity 5-HT6R antagonist showing good human in vitro metabolic stability. Rat pharmacokinetic data were sufficiently good to enable further in vivo profiling.

Journal of Medicinal Chemistry published new progress about 5-HT antagonists (5-HT6). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Recommanded Product: 3-Fluorobenzenesulfonamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gao, Zhenhua; Guo, Huichuang; Guo, Yongbiao; Zhu, Xiaxia published the artcile< General and Efficient Synthesis of Quinazolinones under CF3COOH Catalysis and Solvent-Free Conditions>, Computed Properties of 112253-70-0, the main research area is quinazolinone green preparation; benzamide ortho ester condensation trifluoroacetic acid catalyst.

Herein, the general and facile synthesis of quinazolinones I [R = H, 7-OH, 4-F, etc.; X = N, NH; R1 = H, Ph, 4-MeC6H4, etc.] by condensation of ortho ester as C1 synthon wirh 2-aminobenzamides and CF3COOH as the catalyst under solvent-free conditions was reported. This represented one of the most mild, practical and user-friendly methodologies with easy-separation procedure.

ChemistrySelect published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Computed Properties of 112253-70-0.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Ruifeng; Guo, Wei; Wang, Gaolei; Chen, Xiulei; Li, Zhong; Xu, Xiaoyong published the artcile< Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole against Meloidogyne incognita>, Recommanded Product: 2-Amino-4-bromobenzamide, the main research area is benzotriazinone benzothiadiazole derivative preparation nematocide Meloidogyne; 1,2,3-benzotriazin-4-one; Benzo[d][1,2,3]thiadiazole; Meloidogyne incognita; Nematicidal activity; Plant activator.

Based on the characteristic of benzo[d][1,2,3]thiadiazole to induce the systemic acquired resistance and improve the immunity of plants, benzo[d][1,2,3]thiadiazole was introduced into 1,2,3-benzotriazin-4-one, thirty-one novel 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole were designed and synthesized. Nematicidal activity showed that most of the synthesized compounds exhibited great inhibitory activity in vivo against Meloidogyne incognita at 20 mg/L. Among 31 tested compounds, I and II showed an excellent nematicidal activity with the inhibition rate of 50.4% and 53.1% at the concentration of 1.0 mg/L, resp. The influence of substituent type and position was studied. The relation between structure and activity was also preliminary analyzed.

Bioorganic & Medicinal Chemistry Letters published new progress about Meloidogyne incognita. 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Recommanded Product: 2-Amino-4-bromobenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics