Category: amides-buliding-blocks

Sapozhnikova, Yelena;Nunez, Alberto;Johnston, John Retired published 《Screening of chemicals migrating from plastic food contact materials for oven and microwave applications by liquid and gas chromatography – Orbitrap mass spectrometry》 in 2021. The article was appeared in 《Journal of Chromatography A》. They have made some progress in their research.SDS of cas: 112-84-5 The article mentions the following:

Contamination of food with chems. migrating from food contact materials (FCMs) is an important area of food safety. This study was aimed to investigate migration of chems. from plastic FCMs used for microwave and conventional oven heating. Migration tests were conducted for samples of microwave trays, microwave oven bags, and oven bags. GC- and LC-Orbitrap mass spectrometry (MS) was used for non-targeted screening and identification of chems. with mass error <5 ppm. A non-targeted identification approach was validated with isotopically labeled chems. to establish acceptable criteria for identification of migrated compounds A total of 74 migrated compounds were tentatively identified: 24 chems. by GC-Orbitrap MS with electron ionization (EI), plus 35 and 19 by LC-Orbitrap MS electrospray ionization (ESI) with pos. and neg. polarities, resp. Four migrated chems. were identified by more than one instrumental anal. Both intentionally added substances (IAS), i.e. additives used in the production of polymeric materials and plastics, and non-intentionally added substances (NIAS), i.e. derivatives and degradation/oxidation products of IAS, were identified among the migrated chems. The levels of 25 migrated chems. were significantly different (p < 0.05) between microwave treatments and conventional oven treatments, where 20 migrants had higher levels for microwave compared with 5 for conventional oven treatments. For several identified chems., no previous reports on their migration from FCMs were found. The experimental procedure involved many compounds, such as cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.SDS of cas: 112-84-5 It has a role as a human metabolite, a rat metabolite, a mammalian metabolite, a plant metabolite and an EC 3.1.1.7 (acetylcholinesterase) inhibitor.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Name: N,2-Dihydroxybenzamide《Zinc nanoparticles: Mode of action and efficacy against boscalid-resistant Alternaria alternata isolates》 was published in 2022. The authors were Malandrakis, Anastasios A.;Kavroulakis, Nektarios;Chrysikopoulos, Constantinos V., and the article was included in《Science of the Total Environment》. The author mentioned the following in the article:

The antifungal potential of ZnO-NPs against Alternaria alternata isolates with reduced sensitivity to the succinate dehydrogenase inhibitor (SDHI) boscalid, resulting from target site modifications, was evaluated in vitro and in vivo. ZnO-NPs could effectively inhibit mycelial growth in a dose-dependent way in both boscalid (BOSC) sensitive (BOSC-S) and resistant (BOSC-R) isolates. The fungitoxic effect of ZnO-NPs against the pathogen was significantly enhanced when combined with boscalid compared to the individual treatments in all phenotype cases (BOSC-S/R) both in vitro and in vivo. Fungitoxic effect of ZnO-NPs could be, at least partly, attributed to zinc ion release as indicated by the pos. correlation between sensitivities to the nanoparticles and their ionic counterpart ZnSO₄ and the alleviation of the ZnO-NPs fungitoxic action in the presence of the strong chelating agent EDTA. The superior effectiveness of ZnO-NPs against A. alternata, compared to ZnSO_4, could be due to nanoparticle properties interfering with cellular ion homeostasis mechanisms. The observed additive action of the oxidative phosphorylation-uncoupler fluazinam (FM) against all phenotypes indicates a possible role of ATP-dependent ion efflux mechanism in the mode of action of ZnO-NPs. A potential role of ROS production in the fungitoxic action of ZnO-NPs was evident by the additive/synergistic action of salicylhydroxamate (SHAM), which blocks the alternative oxidase antioxidant action. Mixture of ZnO-NPs and boscalid, resulting in a “capping” effect for the nanoparticles and significantly reducing their mean size, probably accounted for the synergistic effect of the mixture against both sensitive and resistant A. alternata isolates. Summarizing, results indicated that ZnO-NPs can be effectively used against A. alternata both alone or in combination with boscalid, providing an effective tool for combating SDHI-resistance and reducing the environmental fingerprint of synthetic fungicides. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) is widely used for a variety of roles in biology and medicine as a chelating therapy.Name: N,2-DihydroxybenzamideIt inhibits bacterial or fungi growth by interfering with iron uptake. It is also active as a inhibitor of enzyme involved in tumour growths.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Prasathkumar, Murugan;Raja, Kannan;Vasanth, Krishnan;Khusro, Ameer;Sadhasivam, Subramaniam;Sahibzada, Muhammad Umar Khayam;Gawwad, Mohamed Ragab Abdel;Al Farraj, Dunia A.;Elshikh, Mohamed S. published 《Phytochemical screening and in vitro antibacterial, antioxidant, anti-inflammatory, anti-diabetic, and wound healing attributes of Senna auriculata (L.) Roxb. leaves》 in 2021. The article was appeared in 《Arabian Journal of Chemistry》. They have made some progress in their research.Recommanded Product: 112-84-5 The article mentions the following:

This study was aimed to determine total phytochem. components as well as in vitro antibacterial, antioxidant, anti-inflammatory, anti-diabetic, and wound healing attributes of Senna auriculata (L.) Roxb. leaves extract Among different solvent extracts tested, methanolic extract revealed maximum alkaloid, flavonoids, phenolic, and tannin contents of 90.41 ± 0.15 mg atropine equivalent/g, 156.64 ± 0.97 mg quercetin equivalent/g, 155.44 ± 1.65 mg gallic acid equivalent/g, and 121.31 ± 2.34 mg gallic acid equivalent/g of extract, resp. Antibacterial activity of methanolic extract was determined against indicator pathogens using agar well diffusion assay which exhibited potential activity against Bacillus subtilis. Antioxidant, anti-inflammatory, anti-diabetic, and wound healing attributes of methanolic extract were analyzed using standard methodologies. The extract exhibited potential antioxidant traits by scavenging ABTS (IC₅₀ value – 224.2 μg/mL) and DPPH (IC₅₀ value – 76.24 μg/mL) in a concentration dependent manner. Further, the extract demonstrated significant anti-inflammatory activities at varied doses with IC₅₀ value of 55.7 μg/mL. The methanolic extract exhibited promising rates of α-amylase and α-glucosidase inhibition with IC₅₀ values of 49.45 and 38.72 μg/mL, resp. Further, the extract showed no toxicity on L929 mouse fibroblast cell lines (99.66 ± 0.14% cell viability). Most importantly, the treatment of cell monolayer of L929 mouse fibroblast cell lines with methanolic extract showed high rate (100%) of wound healing trait. GC-MS anal. of methanolic extract revealed the presence of Mome inositol, 13-Docosenamide, (Z)-, Cycloheptasiloxane, tetradecamethyl-, and Octadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester as predominant compounds In conclusion, the biol. properties of S. auriculata leaves suggested its vast role as ideal antibacterial, antioxidant, anti-inflammatory, anti-diabetic, and wound healing agents in future. The experimental procedure involved many compounds, such as cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Recommanded Product: 112-84-5 It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Goel, Reema;Reilly, Samantha M.;Valerio, Luis G. Jr. published 《A Computational Approach for Respiratory Hazard Identification of Flavor Chemicals in Tobacco Products》. The research results were published in《Chemical Research in Toxicology》 in 2022.SDS of cas: 2444-46-4 The article conveys some information:

Flavor chems. contribute to the appeal and toxicity of tobacco products, including electronic nicotine delivery systems (ENDS). The assortment of flavor chems. available for use in tobacco products is extensive. In this study, a chem.-driven computational approach was used to evaluate flavor chems. based on intrinsic hazardous structures and reactivity of chems. A large library of 3012 unique flavor chems. was compiled from publicly available information. Next, information was computed and collated based on their (1) physicochem. properties, (2) Global Harmonization System (GHS) health hazard classification, (3) structural alerts linked to the chem.’s reactivity, instability, and/or toxicity, and (4) common substructure shared with FDA’s harmful and potentially harmful constituents (HPHCs) flavor chems. that are respiratory toxicants. Computational anal. of the constructed flavor library flagged 638 chems. with GHS classified respiratory health hazards, 1079 chems. with at least one structural alert, and 2297 chems. with substructural similarity to FDA’s established and proposed list of HPHCs. A subsequent anal. was performed on a subset of 173 chems. in the flavor library that are respiratory health hazards, contain structural alerts as well as flavor HPHC substructures. Four general toxicophore structures with an increased potential for respiratory toxicity were then identified. In summary, computational methods are efficient tools for hazard identification and understanding structure-toxicity relationship. With appropriate context of use and interpretation, in silico methods may provide scientific evidence to support toxicol. evaluations of chems. in or emitted from tobacco products.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.SDS of cas: 2444-46-4 It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Jifeng;He, Min;Guo, Wenjun;Zhang, Yanhong;Sui, Xin;Lin, Jianan;Liu, Xiaoran;Li, Hui;Li, Jing;Yang, Qing;Kan, Mo;Zhang, Zhuang;Ming, Sitong;Qu, Xiaobo;Li, Na published 《Microbiome-metabolomics reveals endogenous alterations of energy metabolism by the dushen tang to attenuate D-galactose-induced memory impairment in rats》 in 2021. The article was appeared in 《BioMed Research International》. They have made some progress in their research.Formula: C22H43NO The article mentions the following:

Aging affects the brain function in elderly individuals, and Dushen Tang (DST) is widely used for the treatment of senile diseases. In this study, the protective effect of DST against memory impairment was evaluated through the Morris water maze (MWM) test and transmission electron microscopy (TEM). A joint anal. was also performed using LC-MS metabolomics and the microbiome. The MWM test showed that DST could significantly improve the spatial memory and learning abilities of rats with memory impairment, and the TEM anal. showed that DST could reduce neuronal damage in the hippocampus of rats with memory impairment. Ten potential biomarkers involving pyruvate metabolism, the synthesis and degradation of ketone bodies, and other metabolic pathways were identified by the metabolomic anal., and it was found that 3-hydroxybutyric acid and lactic acid were involved in the activation of cAMP signaling pathways. The 16S rDNA sequencing results showed that DST could regulate the structure of the gut microbiota in rats with memory impairment, and these effects were manifested as changes in energy metabolism These findings suggest that DST exerts a good therapeutic effect on rats with memory impairment and that this effect might be mainly achieved by improving energy metabolism These findings might lead to the potential development of DST as a drug for the treatment of rats with memory impairment.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Formula: C22H43NO It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hernandez-Esquivel, Alma Alejandra;Castro-Mercado, Elda;Garcia-Pineda, Ernesto published 《Comparative Effects of Azospirillum brasilense Sp245 and Pseudomonas aeruginosa PAO1 Lipopolysaccharides on Wheat Seedling Growth and Peroxidase Activity》 in 2021. The article was appeared in 《Journal of Plant Growth Regulation》. They have made some progress in their research.Electric Literature of C7H7NO3 The article mentions the following:

The effects of lipopolysaccharides (LPS) from Azospirillum brasilense Sp245, a plant growth-promoting rhizobacteria, and Pseudomonas aeruginosa PAO1, a pathogenic bacterium, on plant growth and peroxidase (POD) activity were assessed on wheat seedlings. A. brasilense LPS (100μg/mL) increased total length, and total fresh weight in wheat seedlings 4 days after treatment. P. aeruginosa LPS did not show effect on plant growth. A. brasilense LPS increased root hairs length similar to whole cells, while P. aeruginosa LPS increased root hairs d. and slightly root hairs length. Both LPS increased POD activity and hydrogen peroxide (H2O2) content in root; however, the LPS from the pathogenic bacterium generated higher increments. The peroxidase inhibitor salicylhydroxamic acid (SHAM) inhibited plant growth, which was not recovered by the addition of LPS neither A. brasilense nor P. aeruginosa. POD activity stimulated by LPS was calcium-dependent as confirmed by the addition of the calcium channel blocker LaCl3. The results suggest that plant cells sense differentially LPS from beneficial or pathogenic bacteria and that calcium is needed to respond to the presence of both LPS.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Electric Literature of C7H7NO3

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gubala, Dajana;Fox, Laura J.;Harniman, Robert;Hussain, Hadeel;Robles, Eric;Chen, Meng;Briscoe, Wuge H. published 《Heads or tails: Nanostructure and molecular orientations in organised erucamide surface layers》 in 2021. The article was appeared in 《Journal of Colloid and Interface Science》. They have made some progress in their research.Product Details of 112-84-5 The article mentions the following:

Despite the widespread industrial usage of erucamide as a slip additive to modify polymer surface properties, a controversy appears to have persisted regarding the nanostructure of erucamide surface layers, particularly the mol. orientation at the outermost layer. The erucamide nanostructure and mol. orientation, along with its surface coverage, hydrophobicity, and adhesive response, can be tuned by simply varying the erucamide concentration in the solution from which the spin coated layer is prepared Synchrotron X-ray reflectivity (XRR) allowed a comprehensive characterization of the out-of-plane structural parameters (e.g. mol. packing and thickness) of the erucamide layers prepared via spin coating from nonaqueous solution on silica. Complementary Atomic Force Microscopy (AFM) imaging with high lateral resolution revealed localised in-plane structures. Contact angle measurements provided information on the wettability of erucamide-coated surfaces. Peak Force Quant. Nanomech. Mapping (QNM) allowed a correlation between the erucamide nanostructure with the surface nanomech. properties (i.e. adhesive response). Our results reveal erucamide surface nanostructures on silica as patchy monolayers, isolated circular bilayers/rounded rectangle-like aggregates and overlapping plate-like multilayers as the erucamide concentration in the spin coating solution was varied. In all the cases, XRR and AFM results were consistent with the picture that the erucamide tails were oriented outwards. The QNM adhesion force mapping of all the observed morphologies also supported this mol. orientation at the outermost erucamide monolayer. The wettability study further confirmed this conclusion with the observed increase in the surface hydrophobicity and coverage upon increasing erucamide concentration, with the macroscopic water contact angle θ = 92.9° ± 2.9° at the highest erucamide concentration of 2 wt%.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Product Details of 112-84-5

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: cis-13-Docosenamide《Effects of nanocrystallization on surface migration of polypropylene/slip agent composites in accelerated aging》 was published in 2022. The authors were Won, Jong Sung;Lee, Jae Min;Lee, Pil Gyu;Choi, Hyeong Yeol;Kwak, Tae Joon;Lee, Seung Goo, and the article was included in《Journal of Materials Science》. The author mentioned the following in the article:

The accelerated thermal aging of plastics causes the migration of additives onto specimen surfaces. This is commonly called the “blooming” or “whitening” phenomenon and has long been an issue in the automotive applications of thermoplastic composites. Still, there is a lack of scientific reports regarding crystallization behavior to our best knowledge. This study investigates the mechanism and characteristics of slip agent migration onto injection-molded composite surfaces depending on the behavior of nanocrystn. with thermal aging and develops a method to evaluate the correlation between the internal and external crystallization size and migration of the composites. Slip agent migration was investigated by increasing the spherulite size of PP/slip agent composites, as measured by X-ray diffraction anal. at different periods. It was found that as the crystalline area increased, the low mol. weight slip agents present in the amorphous region migrated to the specimen surface owing to the absence of interactions with the polymer. In addition, surface elemental anal., lightness, and roughness confirmed that the slip agents migrated to the surface in accelerated thermal aging conditions. The findings of this work provide a better understanding of the correlation between thermal aging and the migration phenomenon of slip agents on the surfaces of thermoplastic composites.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Recommanded Product: cis-13-Docosenamide It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Parkhitko, Andrey A.;Priolo, Carmen;Coloff, Jonathan L.;Yun, Jihye;Wu, Julia J.;Mizumura, Kenji;Xu, Wenping;Malinowska, Izabela A.;Yu, Jane;Kwiatkowski, David J.;Locasale, Jason W.;Asara, John M.;Choi, Augustine M. K.;Finkel, Toren;Henske, Elizabeth P. published 《Autophagy-Dependent Metabolic Reprogramming Sensitizes TSC2-Deficient Cells to the Antimetabolite 6-Aminonicotinamide》. The research results were published in《Molecular Cancer Research》 in 2014.COA of Formula: C6H7N3O The article conveys some information:

The mammalian target of rapamycin complex 1 (mTORC1) is hyperactive in many human cancers and in tuberous sclerosis complex (TSC). Autophagy, a key mTORC1-targeted process, is a critical determinant of metabolic homeostasis. Metabolomic profiling was performed to elucidate the cellular consequences of autophagy dysregulation under conditions of hyperactive mTORC1. It was discovered that TSC2-null cells have distinctive autophagy-dependent pentose phosphate pathway (PPP) alterations. This was accompanied by enhanced glucose uptake and utilization, decreased mitochondrial oxygen consumption, and increased mitochondrial reactive oxygen species (ROS) production Importantly, these findings revealed that the PPP is a key autophagy-dependent compensatory metabolic mechanism. Furthermore, PPP inhibition with 6-aminonicotinamide (6-AN) in combination with autophagy inhibition suppressed proliferation and prompted the activation of NF-κB and CASP1 in TSC2-deficient, but not TSC2-proficient cells. These data demonstrate that TSC2-deficient cells can be therapeutically targeted, without mTORC1 inhibitors, by focusing on their metabolic vulnerabilities. Implications: This study provides proof-of-concept that therapeutic targeting of diseases with hyperactive mTORC1 can be achieved without the application of mTORC1 inhibitors. Mol Cancer Res; 12(1); 48-57. ©2013 AACR. The experimental procedure involved many compounds, such as 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)COA of Formula: C6H7N3O is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM). 6-Aminonicotinamide also reduces cardiovascular oxidative injury following ischemia/reperfusion.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Huihui;Hao, Shilai;Chen, Zheng;O-Thong, Sompong;Fan, Jiajun;Clark, James;Luo, Gang;Zhang, Shicheng published 《Mesophilic and thermophilic anaerobic digestion of aqueous phase generated from hydrothermal liquefaction of cornstalk: Molecular and metabolic insights》. The research results were published in《Water Research》 in 2020.Recommanded Product: 6-Aminonicotinamide The article conveys some information:

The critical challenge of hydrothermal liquefaction (HTL) for bio-oil production from biomass is the production of large amounts of aqueous products (HTL-AP) with high organic contents. The present study investigated the anaerobic digestion (AD) performances of HTL-AP under both thermophilic and mesophilic conditions, and mol. and metabolic anal. were conducted to provide insights into the different performances. The results showed that thermophilic AD had lower COD removal efficiency compared to mesophilic AD (45.0% vs. 61.6%). Liquid chromatog. coupled with organic carbon detection and organic nitrogen (LC-OCD-OND) anal. showed that both high mol. weight (HMW) and low mol. weight (LMW) compounds were degraded to some extent and more LMW acids (LMWA) and recalcitrant aromatic compounds were degraded in the mesophilic reactor, which was the main reason of higher COD removal efficiency. Ph compounds (e.g. phenol and 2 methoxyphenol), furans and pyrazines were the recalcitrant chems. detected through GC-MS anal. Fourier transform ion cyclone resonance mass spectrometry (FT-ICR-MS) anal. demonstrated the complexity of HTL-AP and the proportions of phenolic or condensed aromatic compounds increased especially in the thermophilic effluents. Metabolites anal. showed that the reasons contributing to the differences of mesophilic and thermophilic AD were not only related to the degradation of organic compounds (e.g. benzoate degradation via CoA ligation) in HTL-AP but also related to the microbial autogenesis (e.g. fatty acid biosynthesis) as well as the environmental information processing. In addition, the enrichment of Mesotoga, responsible for the high degradation efficiency of LMWA, and Pelolinea, involved in the degradation of Ph compounds, were found in mesophilic reactor, which was consistent with higher removal of corresponding organics To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Recommanded Product: 6-Aminonicotinamide is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme,6-phosphogluconate dehydrogenase, it interferes with glycolysis.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics