Category: amides-buliding-blocks

Kishore Kumar, G. D. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2010 | CAS: 192436-83-2

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′Râ€? or, equivalently, an acyl (alkanoyl) group RC(=O)âˆ?joined to an amine group. The presence of the amide group –C(=O)Nâ€?is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cmâˆ?. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Formula: C9H10BrNO2

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors was written by Kishore Kumar, G. D.;Chavarria, Gustavo E.;Charlton-Sevcik, Amanda K.;Arispe, Wara M.;MacDonough, Matthew T.;Strecker, Tracy E.;Chen, Shen-En;Siim, Bronwyn G.;Chaplin, David J.;Trawick, Mary Lynn;Pinney, Kevin G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Formula: C9H10BrNO2 This article mentions the following:

A small library of 36 functionalized benzophenone thiosemicarbazone analogs was prepared by chem. synthesis and evaluated for their ability to inhibit the cysteine proteases cathepsin L and cathepsin B. The six most active inhibitors of cathepsin L (IC50 < 85 nM) in this series were I (R = 2-F, 3-F3C, 4-F, 2,3-F2, 3,5-F2, 2,3,4,5-F4). These six analogs were selective for their inhibition of cathepsin L vs. cathepsin B (IC50 > 10,000 nM). The most active analog in the series, thiosemicarbazone I (R = 2-F), also efficiently inhibited cell invasion of the DU-145 human prostate cancer cell line. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Formula: C9H10BrNO2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′Râ€? or, equivalently, an acyl (alkanoyl) group RC(=O)âˆ?joined to an amine group. The presence of the amide group –C(=O)Nâ€?is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cmâˆ?. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Formula: C9H10BrNO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Braschi, Ilaria et al. published their research in Journal of Agricultural and Food Chemistry in 1997 | CAS: 82097-01-6

2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)Nâ€?is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cmâˆ?. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Quality Control of 2-(2-Chloroethoxy)benzenesulfonamide

Kinetics and hydrolysis mechanism of triasulfuron was written by Braschi, Ilaria;Calamai, Luca;Cremonini, Mauro Andrea;Fusi, Paolo;Gessa, Carlo;Pantani, Ottorino;Pusino, Alba. And the article was included in Journal of Agricultural and Food Chemistry in 1997.Quality Control of 2-(2-Chloroethoxy)benzenesulfonamide This article mentions the following:

The hydrolysis of the sulfonylurea herbicide triasulfuron [(2-(2-chloroethoxy)-N-[[4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]benzenesulfonamide] was studied in aqueous buffers of pH values 2, 3, 4, 5, 6, 7, and 9. The reaction was of first-order and pH-dependent. Triasulfuron was more persistent in neutral or weakly basic than in acidic solution Five metabolites have been isolated and identified. At all pH values studied, the primary pathway of degradation was the cleavage of the sulfonylurea bridge. However, minor degradation pathways have also been observed like O-demethylation and opening of the triazine ring. The product distribution was pH-dependent. In the experiment, the researchers used many compounds, for example, 2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6Quality Control of 2-(2-Chloroethoxy)benzenesulfonamide).

2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)Nâ€?is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cmâˆ?. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Quality Control of 2-(2-Chloroethoxy)benzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zeinaly, Farhad et al. published their research in Nordic Pulp & Paper Research Journal in 2017 | CAS: 10543-57-4

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Category: amides-buliding-blocks

The use of TAED in the last phase of CMP peroxide bleaching was written by Zeinaly, Farhad;Tabrizi, Ali Kazemi;Shakhes, Jalal;Zeinali, Nooshin. And the article was included in Nordic Pulp & Paper Research Journal in 2017.Category: amides-buliding-blocks This article mentions the following:

The alk. peroxide process is one of the bleaching processes used to bleach high-yield pulps. The two disadvantages concerning the bleaching of these pulps are pulp color reversion at the end of bleaching process, and the incomplete consumption of the peroxide. The effect of using TAED (tetra acetyl ethylene diamine), as an activator in the last phase of bleaching, on the process, as well as on the bleached pulp properties was the target of the present study. Single-stage alk. peroxide process was applied for bleaching of mixed hardwood chemi-mech. pulp (CMP, 85% yield). The treatments involved three different charges of peroxide (1.5, 2 and 3%) and of alkali (1.12, 1.5 and 2.25%, sodium hydroxide), with and without addition of TAED during the last phase of bleaching i.e. the last 10 min. The results indicated that the bleached pulp brightness and the bleaching process selectivity increased with the increase of the chems. charge, but with a descending tendency. The use of TAED, not only reduced the level of the alk. darkening, but also produced further improvement in the brightness and selectivity, and a reduction in the effluent COD load. Furthermore, the residual peroxide levels in TAED-activated treatments were low and negligible. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Category: amides-buliding-blocks).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Parker, Kathlyn A. et al. published their research in Journal of Organic Chemistry in 1987 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Name: N,N-Diethylsalicylamide

Directed hydroxylation of aromatics was written by Parker, Kathlyn A.;Koziski, Kathleen A.. And the article was included in Journal of Organic Chemistry in 1987.Name: N,N-Diethylsalicylamide This article mentions the following:

Regiospecific hydroxylation of an aromatic ring was accomplished by directed lithiation followed by oxygenation. Thus, EtCHMeLi was added to benzamide I (R = H) and Me2NCH2CH2NMe2 in THF. Then O was bubbled through the mixture to give 52% I (R = OH). In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Name: N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Name: N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Samejima, Masayoshi et al. published their research in Yakugaku Zasshi in 1960 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Synthetic Route of C11H15NO2

Solubilizing agents. V. Pyridinecarboxamides was written by Samejima, Masayoshi. And the article was included in Yakugaku Zasshi in 1960.Synthetic Route of C11H15NO2 This article mentions the following:

2-HO2CC5H4N.HCl (120 g.) in 313 g. MeOH and 150 g. concentrated H2SO4 refluxed 5 hrs., the MeOH removed, the residue neutralized with Na2CO3, and the product extracted with C6H6 gave 117 g. 2-MeO2CC5H4N, b11 109-11°. Li (20.9 g.) in 1200 ml. Et2O treated dropwise with 58 ml. PhBr, 139.7 g. 2-MeC5H4N added dropwise, the mixture refluxed 30 min., the product poured onto 1000 g. solid CO2, the Et2O removed, the residue in 1200 ml. EtOH at 0° saturated with dry HCl gas, the EtOH removed, the residue in 750 ml. CHCl3, 338 g. K2CO3, and 188 g. H2O heated, and the CHCl3 layer distilled gave 83.1 g. 2-EtO2CCH2C5H4N, b6 109-12°. 3-HO2CC5H4N (61.8 g.) and 47.1 g. PhOH heated at 110-20°, the mixture treated dropwise with 76.7 g. POCl3, heated at 130-40° until evolution of HCl gas ceased, the product poured into ice H2O, neutralized with Na2CO3, and extracted with C6H6 gave 67.5 g. 3-PhO2CC5H4N, m. 71-2° (EtOH-petr. ether). The above esters and 4-MeO2CC5H4N treated with NH4OH or amines and the products distilled gave x-RHNOCC5H4N (I) (x, R, % yield, and b.p./mm. or m.p. given): 2, H, 90, 105-6°; 2, Me, 77, 118-20°/4; 2, Et, 90, 128-9°/4; 2, Bu, 86, 122-3°/2; 2, HOC2H4, 69, 190-1°/4; 3, Me, 71, 104-5°; 3, Et, 89, 146-7°/3; 3, Bu, 85, 173-4°/3.5; 3, HOC2H4, 71, 90-1° 4, H, 86, 133-4°; 4, Me, 73, 113-14°; 4, Et, 69, 65-6°; 4, Bu, 84, 155-6°/1; 4, HOC2H4, 70, 133-4°. 2-RNHOCH2CC5H4N (II) (R, % yield, b.p./mm. or m.p. given): H, 77, 118-20°; Me, 78, 137°/1; Et, 67, 61-2°; HOC2H4, 67, 94-5°. 3-PhO2CC5H4N (10 g.) and 5 g. PhNH2 (or 2-H2NC5H4N) fused 3 hrs. at 200-10°, the PhOH removed in vacuo, and the product extracted with Et2O gave 3-RNHOCC5H4N (III) (R, % yield, and m.p. given): Ph, 67, 122-3°; 2-pyridyl, 79, 139-41°. Solubilization effects of I, II, and III were studied by use of adrenochrome monosemicarbazone (IV), o-HOC6H4CONH2 (V), p-MeC6H4NH2 (VI), and caffeine (VII). There was practically no difference by the position in isomers of I. II showed increased solubilization activity, the effect being better in lower homologs with Me and Et groups. III was found to give a far stronger effect, while introduction of two alkyls into the N in the acid amide group resulted in increased solubility in the case of V and VI, but 30-40% decrease in the case of IV and VII. II showed a lowering of solubilization activity by 10-40% compared to 3-H2NOCC5H4N. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Synthetic Route of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Synthetic Route of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pais, M. A. et al. published their research in Neftekhimiya in 1975 | CAS: 5339-69-5

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.HPLC of Formula: 5339-69-5

Activity coefficients of sulfurous compounds in different extractants was written by Pais, M. A.;Bondarenko, M. F.;Abramovich, Z. I.;Kruglov, E. A.. And the article was included in Neftekhimiya in 1975.HPLC of Formula: 5339-69-5 This article mentions the following:

The activity coefficients of sulfur compounds such as cyclo- and dialkyl sulfides (I), mercaptans (II), and alkylthiophenes (III) in 10 extractants were determined by gas-liquid chromatog. The relative separation selectivities of the S compounds and hydrocarbons were calculated The separation selectivities decreased in the following order: III �alkylbenzenes (IV) �I > normal-paraffins > II. The activity coefficients of cyclic S compounds such as thiophane (V) and III varied with temperature increase in a manner similar to that shown by the corresponding IV in the same extractants. Thus, the activity coefficients of IV, V, and III increased in sulfolane [126-33-0] and tricresyl phosphate [1330-78-5] with increasing temperature In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5HPLC of Formula: 5339-69-5).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.HPLC of Formula: 5339-69-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Matsumura, Tsuyoshi et al. published their research in Orphanet journal of rare diseases in 2022 | CAS: 53902-12-8

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′Râ€? or, equivalently, an acyl (alkanoyl) group RC(=O)âˆ?joined to an amine group. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 53902-12-8

Tranilast for advanced heart failure in patients with muscular dystrophy: a single-arm, open-label, multicenter study. was written by Matsumura, Tsuyoshi;Hashimoto, Hiroya;Sekimizu, Masahiro;Saito, Akiko M;Motoyoshi, Yasufumi;Nakamura, Akinori;Kuru, Satoshi;Fukudome, Takayasu;Segawa, Kazuhiko;Takahashi, Toshiaki;Tamura, Takuhisa;Komori, Tetsuo;Watanabe, Chigusa;Asakura, Masanori;Kimura, Koichi;Iwata, Yuko. And the article was included in Orphanet journal of rare diseases in 2022.SDS of cas: 53902-12-8 This article mentions the following:

BACKGROUND: The transient receptor potential cation channel subfamily V member 2 (TRPV2) is a stretch-sensitive calcium channel. TRPV2 overexpression in the sarcolemma of skeletal and cardiac myocytes causes calcium influx into the cytoplasm, which triggers myocyte degeneration. In animal models of cardiomyopathy and muscular dystrophy (MD), TRPV2 inhibition was effective against heart failure and motor function. Our previous pilot study showed that tranilast, a TRPV2 inhibitor, reduced brain natriuretic peptide (BNP) levels in two MD patients with advanced heart failure. Thus, this single-arm, open-label, multicenter study aimed to evaluate the safety and efficacy of tranilast for heart failure. METHODS: The study enrolled MD patients with advanced heart failure whose serum BNP levels wereâ€?gt;â€?00 pg/mL despite receiving standard cardioprotective therapy. Tranilast was administered orally at 100 mg, thrice daily. The primary endpoint was the change in log (BNP) (Δlog [BNP]) at 6 months from baseline. The null hypothesis was determined based on a previous multicenter study of carvedilol results in a mean population Δlog (BNP) of 0.18. TRPV2 expression on peripheral blood mononuclear cell surface, cardiac events, total mortality, left ventricular fractional shortening, human atrial natriuretic peptide, cardiac troponin T, and creatine kinase, and pinch strength were also assessed. RESULTS: Because of the poor general condition of many patients, only 18 of 34 patients were included and 13 patients could be treated according to the protocol throughout the 6-month period. However, there were no serious adverse events related to tranilast except diarrhea, a known adverse effect, and the drug was administered safely. TRPV2 expression on the mononuclear cell surface was elevated at baseline and reduced after treatment. Cardiac biomarkers such as BNP, human atrial natriuretic peptide, and fractional shortening remained stable, suggesting a protective effect against the progression of heart failure. In the per protocol set group, Δlog [BNP] was -â€?.2 and significantly lower than that in the null hypothesis. CONCLUSIONS: Tranilast is safe and effective in inhibiting TRPV2 expression, even in MD patients with advanced heart failure. Further trials are needed to evaluate the efficacy of tranilast in preventing myocardial damage, heart failure, motor impairment, and respiratory failure. Clinical trial registration The study was registered in the UMIN Clinical Trials Registry (UMIN-CTR: UMIN000031965, URL: http://www.umin.ac.jp/ctr/ ) [March 30, 2018] and the Japan Registry of Clinical Trials (jRCT, registration number: jRCTs031180038, URL: https://jrct.niph.go.jp/ ) [November 12, 2021]. Patient registration was started in December 19, 2018. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8SDS of cas: 53902-12-8).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′Râ€? or, equivalently, an acyl (alkanoyl) group RC(=O)âˆ?joined to an amine group. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 53902-12-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Despopoulos, Agamemnon et al. published their research in American Journal of Physiology in 1962 | CAS: 53297-70-4

4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Computed Properties of C7H10N2O2S

Molecular features of sulfonamide transport in renal excretory processes was written by Despopoulos, Agamemnon;Callahan, Paul X.. And the article was included in American Journal of Physiology in 1962.Computed Properties of C7H10N2O2S This article mentions the following:

Renal tubular excretory transport of selected sulfonamides is assumed to require a physicochem. interaction between the substrate and a postulated intracellular receptor mol. It is proposed that substrate specificity in this transport system depends on the presence of the intramolecular sequence, SO2N–, in the sulfonamide. Reactivity of this group requires ionization at N, localization of the net neg. charge at N, and electronegativity at each O sufficient for the formation of H bonds. Presence of these 3 features in favorable combination permits transport. These proposals are supported by analysis of the physicochem., biochem., and physiol. behavior of 52 sulfonamides both in surviving rabbit renal cortical slices and in intact mongrel dogs. Although transport of sulfonamides is treated as an independent biochem. mechanism, its relation to the renal hippurate transport system is recognized and similar responses of both classes of substrates to probenecid or to acetate are demonstrated exptl. In the experiment, the researchers used many compounds, for example, 4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4Computed Properties of C7H10N2O2S).

4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Computed Properties of C7H10N2O2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mostafavi, Mahdiyeh et al. published their research in Biochemical Engineering Journal in 2022 | CAS: 10238-21-8

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Electric Literature of C23H28ClN3O5S

Development of a bioluminescence assay for BIR2- caspase3 interaction through split luciferase complementary assay was written by Mostafavi, Mahdiyeh;Ataei, Farangis;Hamidieh, Amir Ali;Hosseinkhani, Saman. And the article was included in Biochemical Engineering Journal in 2022.Electric Literature of C23H28ClN3O5S This article mentions the following:

Harnessing of firefly luciferase biochem. enabled to develop bioluminescent assay for different intracellular protein-protein interactions. Caspase-3 and XIAP are two important players in maintaining the balance of cell death and survival. Linker-BIR2 from XIAP is known to be sufficient for inhibition of caspase-3. Here, caspase-3 and Linker-BIR2 were used for designing two reporters based on split luciferase complementary assay to develop a luminescent probe. Caspase3-CLuc and BIR2-NLuc fragments were ligated in pET-28a (+), overexpressed in E. coli BL21 (DE3) and purified to homogeneity. Interaction between caspase-3 and BIR2 was evaluated by different exptl. methods such as luciferase and caspase-3 activity, directed mutagenesis and ELISA, which approved their specific interaction. Next, the developed reporters were employed for analyzing four compounds (Sulphadimidin, Glyburide, Carboplatin and Cetirizine) that showed effects on caspase-3 and BIR2 interaction with the largest effect for Carboplatin. Mol. docking was also showed the largest binding affinity for Glyburide. In conclusion, the developed assay showed specific interaction with light generation, and ability to analyze some chems. in vitro. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Electric Literature of C23H28ClN3O5S).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Electric Literature of C23H28ClN3O5S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ascher, K. R. S. et al. published their research in Rivista di Parassitologia in 1963 | CAS: 383-31-3

4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 383-31-3

N,N-Dialkyl-p-halobenzenesulfonamides: their insecticidal properties and joint action with DDT was written by Ascher, K. R. S.. And the article was included in Rivista di Parassitologia in 1963.Reference of 383-31-3 This article mentions the following:

A series of para substituted N,N-dialkylbenzenesulfonamides (I) was tested as to their inherent toxicity and their joint action with DDT on resistant and susceptible housefly (Musca domestica vicina) strains. The most toxic compounds on tarsal contact were p-chloro and p-fluoro substituted with maximum potency in the N,N-di-Pr derivatives Knockdown was higher at 28-29° than at 24°. Toxicity was greater for the normal than for the resistant strain. Tests of the gaseous phase action showed the F compounds had better fumigant action than the resp. Cl compounds No synergism was found when I compounds combined with DDT were used on normal flies. Synergism was evident in the Cl series, especially the N,N-di-Et derivative, on the resistant strain. Synergism was also obtained using DDE which indicated that the synergism was a support effect for the toxic action of the substituted benzenesulfonamides. 48 references. In the experiment, the researchers used many compounds, for example, 4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3Reference of 383-31-3).

4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 383-31-3

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics