Category: amides-buliding-blocks

Safety of N-Vanillylnonanamide《Molecular basis and potential applications of capsaicinoids and capsinoids against the elongation of etiolated wheat (Triticum aestivum L.) coleoptiles in foods》 was published in 2019. The authors were Chen, Kexian;Ying, Qian;Ge, Zhen;Chen, Hong;Qian, Chaowei;Li, Yunyou;Chen, Zhongxiu, and the article was included in《Food Chemistry》. The author mentioned the following in the article:

Capsaicinoids and capsinoids from dietary peppers have promising sensory properties and bioactivity, but the mol. basis of their penetration mechanism through cell lipid bilayers and its relationship to their bioavailability as food constituents are still poorly understood. Herein, statistically significant linear and quadratic quant. structure-activity relationships were constructed to derive the essential structural elements required for their bioactivity against the elongation of etiolated wheat coleoptiles that mainly occurs via penetration. The resultant optimal models had high predictivity and reliability (r² > 0.825 and r²_pred > 0.950), which elucidate the importance of steric structural elements. Besides, their mechanistic hypothesis and rational design strategy were proposed, and the correlation between this bioactivity and their food-sensory properties was supposed. Finally, the bioactivity of newly designed analogs with Me terminals and/or conjugated C=C links was screened. Hopefully, this work would benefit the better understanding of their penetration mechanism and facile identification of bioactive analogs for designing food/drug formulations. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Safety of N-Vanillylnonanamide It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Qiao;Yang, Zhe;Ni, Yueli;Bai, Honggang;Han, Qiaoqiao;Yi, Zihan;Yi, Xiaojia;Agbana, Yannick Luther;Kuang, Yingmin;Zhu, Yuechun published 《NF-κB and pSTAT3 synergistically drive G6PD overexpression and facilitate sensitivity to G6PD inhibition in ccRCC》. The research results were published in《Cancer Cell International》 in 2020.Formula: C6H7N3O The article conveys some information:

Glucose 6-phosphate dehydrogenase (G6PD) serves key roles in cancer cell metabolic reprogramming, and has been reported to be involved in certain carcinogenesis. Previous results from our laboratory demonstrated that overexpressed G6PD was a potential prognostic biomarker in clear cell renal cell carcinoma (ccRCC), the most common subtype of kidney cancer. G6PD could stimulate ccRCC growth and invasion through facilitating reactive oxygen species (ROS)-phosphorylated signal transducer and activator of transcription 3 (pSTAT3) activation and ROS-MAPK-MMP2 axis pathway, resp. However, the reasons for ectopic G6PD overexpression and the proliferation repressive effect of G6PD inhibition in ccRCC are still unclear. The impact of ROS accumulation on NF-κB signaling pathway and G6PD expression was determined by real-time RT-PCR and Western blot in ccRCC cells following treatment with ROS stimulator or scavenger. The regulatory function of NF-κB signaling pathway in G6PD transcription was analyzed by real-time RT-PCR, Western blot, luciferase and ChIP assay in ccRCC cells following treatment with NF-κB signaling activator/inhibitor or lentivirus infection. ChIP and Co-IP assay was performed to demonstrate protein-DNA and protein-protein interaction of NF-κB and pSTAT3, resp. MTS assay, human tissue detection and xenograft model were conducted to characterize the association between NF-κB, pSTAT3, G6PD expression level and proliferation functions. ROS-stimulated NF-κB and pSTAT3 signaling over-activation could activate each other, and exhibit cross-talks in G6PD aberrant transcriptional regulation. The underlying mechanism was that NF-κB signaling pathway facilitated G6PD transcription via direct DNA-protein interaction with p65 instead of p50. p65 and pSTAT3 formed a p65/pSTAT3 complex, occupied the pSTAT3-binding site on G6PD promoter, and contributed to ccRCC proliferation following facilitated G6PD overexpression. G6PD, pSTAT3, and p65 were highly expressed and pos. correlated with each other in ccRCC tissues, confirming that NF-κB and pSTAT3 synergistically promote G6PD overexpression. Moreover, G6PD inhibitor exhibited tumor-suppressor activities in ccRCC and attenuated the growth of ccRCC cells both in vitro and in vivo. ROS-stimulated aberrations of NF-κB and pSTAT3 signaling pathway synergistically drive G6PD transcription through forming a p65/pSTAT3 complex. Moreover, G6PD activity inhibition may be a promising therapeutic strategy for ccRCC treatment. To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Formula: C6H7N3O is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme,6-phosphogluconate dehydrogenase, it interferes with glycolysis.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Stoeger, Verena;Lieder, Barbara;Riedel, Johanna;Schweiger, Kerstin;Hoi, Julia;Ruzsanyi, Veronika;Klieber, Martin;Rust, Petra;Hans, Joachim;Ley, Jakob P.;Krammer, Gerhard E.;Somoza, Veronika published 《Wheat Protein Hydrolysate Fortified With L-Arginine Enhances Satiation Induced by the Capsaicinoid Nonivamide in Moderately Overweight Male Subjects》 in 2019. The article was appeared in 《Molecular Nutrition & Food Research》. They have made some progress in their research.Application of 2444-46-4 The article mentions the following:

Increasing the intake of satiety-enhancing food compounds represents a promising strategy for maintaining a healthy body weight Recently, satiating effects for the capsaicinoid nonivamide have been demonstrated. As various proteins and amino acids have also been demonstrated to decrease energy intake, oral glucose tolerance test (oGTT)-based bolus interventions of 75 g glucose + 0.15 mg nonivamide (NV control) are tested with/without combination of a wheat protein hydrolyzate (WPH: 2 g) and/or L-arginine (ARG: 3.2 g) for their satiating effects in 27 moderately overweight male subjects. Compared to NV control intervention, ARG and WPH + ARG treatment both reduce (p < 0.01) total calorie intake from a standardized breakfast by -5.9 ± 4.15% and -6.07 ± 4.38%, resp. For the WPH + ARG intervention, increased mean plasma serotonin concentrations (AUC: 350 ± 218), quantitated by ELISA, and delayed gastric emptying, assessed by ¹³C-Na-acetate breath test (-2.10 ± 0.51%, p < 0.05), are demonstrated compared to NV control. Correlation anal. between plasma serotonin and gastric emptying reveals a significant association after WPH ± ARG intervention (r = -0.396, p = 0.045). Combination of WPH and ARG enhances the satiating effect of nonivamide, providing opportunities to optimize satiating food formulations by low amounts of the individual food constituents. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Application of 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of cis-13-DocosenamideIn 2022, Yuan, Chang;Su, Siqian;Xu, Ruiguang;Liang, Shengwen;Cheng, Hairong;Yao, Zhibing;Jiang, Luxiang;Wang, Zuwu published 《Effect of wet flue gas desulfurization on the concentrations and component profiles of condensable particulate matter from ultralow emission coal-fired power plants》. 《Atmospheric Pollution Research》published the findings. The article contains the following contents:

This study investigated effect of wet flue gas desulfurization (WFGD) on the concentrations and component profiles of condensable particulate matter (CPM). This research was carried out in two ultralow emission coal-fired power plants (CFPPs), which were equipped with pulverized coal furnaces (PC), in Hunan province, China. The CPM concentrations were measured following the US EPA Method 202. The stack emissions of filterable particulate matter (FPM) met the Chinese ultralow emission standards, and the CPM concentrations from CFPP A and B were resp. 12.12 and 17.64 mg/Nm³. In the WFGD system, the removal efficiencies of the FPM and CPM were resp. 80% and 91% in CFPP A, 83% and 81% in CFPP B. SO^2-₄ accounted for the largest fraction of the total detected water-soluble ions in the CPM. Alkanes were the main component of the organic fraction in the CPM, which accounted for 95% in CFPP A and 92% in CFPP B. The removal efficiency of inorganic components from the CPM in CFPP A and B were 81% and 92%, resp., possibly because the water-soluble ions could be dissolved and removed in the slurry; however, due to the limited solubility of alkanes and esters, the removal efficiency of organic components from the WFGD in CFPP A and B were only 17% and 31%, resp. The emission factors (EFs) of the CPM for CFPP A and B range from 0.090 to 0.979 kg/(t of coal). And cis-13-Docosenamide (cas: 112-84-5) was used in the research process.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Application In Synthesis of cis-13-Docosenamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of C22H43NO《Different metabolites induced by deoxynivalenol in the serum and urine of weaned rabbits detected using LC-MS-based metabolomics》 was published in 2021. The authors were Li, Fuchang;Huang, Libo;Liu, Quancheng;Wang, Pengwei;Chen, Hongju;Wang, Chunyang, and the article was included in《Comparative Biochemistry and Physiology, Part C: Toxicology & Pharmacology》. The author mentioned the following in the article:

The main toxic effects of deoxynivalenol (DON) are the result of long-term accumulation, and there are no obvious clin. signs at the early stage. Specific metabolites in blood and urine can be used as biomarkers and become an important diagnostic indicator for DON poisoning monitoring. This study aimed to reveal the differences in DON-induced metabolites in the serum and urine of weaned rabbits. Thirty-two weaned rabbits were divided into two groups: control group and DON group. Both groups of rabbits were fed a basic diet. Rabbits in the DON group were administered 1.5 mg/kg b.w. DON by i.p. injection on an empty stomach in the morning every two days. Rabbits in the control group were injected with the same amount of saline every two days in the same way. After the 25-day trial, serum and urine samples from different exptl. periods were collected. The results based on the LC-MS/MS method showed that DON can be metabolized rapidly in blood, and urine is the main metabolic pathway for DON. Data based on metabolomics illustrated that underlying biomarkers in serum were mainly involved in glycerophospholipid metabolism, tryptophan metabolism and pentose and glucuronate interconversions, while those in urine samples were involved in caffeine metabolism, glycine, serine and threonine metabolism, and terpenoid backbone biosynthesis. Correlation anal. suggested that DON can induce changes in certain disease-related metabolites in serum and urine. In conclusion, the pathogenic mechanism of DON includes multiple levels, indicating that DON poisoning is caused by multiple factors acting on multiple links.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Synthetic Route of C22H43NO It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Mingyang;Lian, De;Zhao, Fugang;Tong, Xiong;Wu, Chaoyang;Gao, Xiangpeng published 《Structure-activity of chelating depressants for chalcopyrite/pyrite separation: DFT study and flotation experiment》. The research results were published in《Physicochemical Problems of Mineral Processing》 in 2021.Category: amides-buliding-blocks The article conveys some information:

Three types of chelating depressants were studied for chalcopyrite/pyrite separation, including S-S, S-O, and O-O types, via d. functional theory calculations and microflotation. The calculation results indicate that the depressant’s chelating atoms have large coefficient and great activity according to the mol. frontier orbital (HOMO and LUMO) and the orbital coefficients For S-S type of depressant, S atom in both keto or enol forms won’t affect their HOMO and LUMO patterns and the orbital contributions. For S-O type, the presence of N atom in the ring structure of a mol. will increase the reactivity of O-Cu while weak S-Cu. For O-O type, the electron supply capacity of benzene ring is higher than strain chain, and atom N in strain chain increased their electron supply capacity. The microflotation results basically confirmed the prediction based on the calculation The simulation results demonstrate that the interaction of a depressant with metals and minerals are affected obviously by the spatial structure and electronic structure of an atom in its mol.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Category: amides-buliding-blocks

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Rongrong;Wang, Shuang;Zhang, Jiawei;Miao, Jing;Chen, Gangliang;Dong, Jing;Wu, Linying;Yue, Haitao;Yang, Jie published 《Untargeted metabolomics allows to discriminate raw camel milk, heated camel milk, and camel milk powder》. The research results were published in《International Dairy Journal》 in 2022.Name: cis-13-Docosenamide The article conveys some information:

The metabolomic profiles of raw camel milk (RCM), heated camel milk (HCM) and camel milk powder (CMP) were analyzed by ultra-high-performance liquid chromatog. coupled with quadrupole time of flight mass spectrometer (UHPLC-Q-TOF/MS). One hundred and nineteen significantly changed metabolites with variable importance for the projection (VIP) > 1 (t-test p < 0.05) from the pos. mode were selected and identified in RCM, HCM and CMP. These metabolites included saccharides, glycosylamines, adenosines, and phospholipid. Among the saccharides, the content of D-lactose was the highest and slightly increased after thermal treatment. Dipeptides, including His-Pro and Lys-Trp, were significantly increased in HCM and CMP. As for glycosylamines, the content of N-acetylneuraminic acid was the highest. The amounts of larixinic acid increased dramatically in HCM and CMP (p < 0.001), which may improve the flavor of camel milk. The experimental procedure involved many compounds, such as cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Name: cis-13-Docosenamide It has a role as a human metabolite, a rat metabolite, a mammalian metabolite, a plant metabolite and an EC 3.1.1.7 (acetylcholinesterase) inhibitor.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ren, Fang;Yang, Xiao;Hu, Zhong-Wen;Wong, Vincent Kam Wai;Xu, Hong-Yan;Ren, Ji-Hua;Zhong, Shan;Jia, Xiao-Jiong;Jiang, Hui;Hu, Jie-Li;Cai, Xue-Fei;Zhang, Wen-Lu;Yao, Fang-Long;Yu, Hai-Bo;Cheng, Sheng-Tao;Zhou, Hong-Zhong;Huang, Ai-Long;Law, Betty Yuen Kwan;Chen, Juan published 《Niacin analogue, 6-Aminonicotinamide, a novel inhibitor of hepatitis B virus replication and HBsAg production.》. The research results were published in《EBioMedicine》 in 2019.SDS of cas: 329-89-5 The article conveys some information:

BACKGROUND: Hepatitis B surface antigen (HBsAg) is one of the important clinical indexes for hepatitis B virus (HBV) infection diagnosis and sustained seroconversion of HBsAg is an indicator for functional cure. However, the level of HBsAg could not be reduced by interferons and nucleoside analogs effectively. Therefore, identification of a new drug targeting HBsAg is urgently needed. METHODS: In this study, 6-AN was screened out from 1500 compounds due to its low cytotoxicity and high antiviral activity. The effect of 6-AN on HBV was examined in HepAD38, HepG2-NTCP and PHHs cells. In addition, the antivirus effect of 6-AN was also identified in mouse model. FINDINGS: 6-AN treatment resulted in a significant decrease of HBsAg and other viral markers both in vitro and in vivo. Furthermore, we found that 6-AN inhibited the activities of HBV SpI, SpII and core promoter by decreasing transcription factor PPARα, subsequently reduced HBV RNAs transcription and HBsAg production. INTERPRETATION: We have identified a novel small molecule to inhibit HBV core DNA, HBV RNAs, HBsAg production, as well as cccDNA to a minor degree both in vitro and in vivo. This study may shed light on the development of a novel class of anti-HBV agent. To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)SDS of cas: 329-89-5 is an aminopyridine, which is a specific pentose inhibitor and thus inhibits the NADP production.It can be used as a reactant for the synthesis of 6-substituted imidazo[1,2-a]pyridines with potential application as chemotherapeutic drugs.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 89-73-6《Synthesis and crystal structure of a heterobimetallic nickel-manganese 12-metallacrown-4 methanol disolvate monohydrate compound》 was published in 2020. The authors were Hall, Abigail J.;Zeller, Matthias;Zaleski, Curtis M., and the article was included in《Acta Crystallographica, Section E: Crystallographic Communications》. The author mentioned the following in the article:

The synthesis and crystal structure of the title compound [systematic name: di-μ-acetato-tetrakis(μ₄-N,2-dioxidobenzene-1-carboximidato)hexamethanoltetramanganese(III)nickel(II) methanol disolvate monohydrate], [Mn₄Ni(C₇H₄NO₃)₄(C₂H₃O₂)₂(CH₄O)₆]·₂CH₄O·H₂O or Ni(OAc)₂[12-MC_{Mn(III)N(shi)}-4](CH₃OH)₆·2CH₃OH·H₂O, where MC is metallacrown,^–OAc is acetate, and shi^3-is salicylhydroximate, are reported. The macrocyclic metallacrown is positioned on an inversion center located on the Ni^II ion that resides in the central MC cavity. The macrocycle consists of an Mn^III-N-O repeat unit that recurs four times to generate an overall square-shaped mol. Both the NiII and Mn^III ions are six-coordinate with an octahedral geometry. In addition, the Mn^III ions possess an elongated Jahn-Teller distortion along the z-axis of the coordination environment. The interstitial water mol. is slightly offset from and disordered about an inversion center. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) has also been shown to be active against wild-type strains of Candida glabrata, but not against resistant mutants. Related Products of 89-73-6 This drug may have therapeutic potential for bone cancer and metabolic disorders such as obesity.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of cis-13-DocosenamideIn 2021, Guerrero-Castillo, Pedro;Reyes, Sarita;Acha, Otilia;Sepulveda, Beatriz;Areche, Carlos published 《Agro-industrial waste seeds from Peruvian Pouteria lucuma as new source of phytosterols》. 《LWT–Food Science and Technology》published the findings. The article contains the following contents:

Pouteria lucuma fruit is commonly used to prepare desserts, but it is also sold as pulp or flour. Then, huge amounts of its seeds are produced as agro-industrial waste, frequently eliminated. This study aims at analyzing the presence of all metabolites in Pouteria lucuma seed oil (LSO) by GC-MS and GC-FID. Several compounds were tentatively identified, such as fatty acids, fatty alcs., carotenes, phytosterols and tocopherols from LSO. A representative result was the high amount of β-sitosterol with 851.49 ± 1.29 mg/100 g of LSO, followed by stigmasterol with 75.42 ± 1.02 mg/100 g. Fatty acids with the highest content were oleic acid (13.57 ± 1.50 g/100 g of LSO), 9E-octadecenoic acid (6.85 ± 1.15 g/100 g of LSO), palmitic acid (5.44 ± 1.18 g/100 g of LSO) and stearic acid (2.12 ± 1.03 g/100 g of LSO). Therefore, metabolites tentatively identified in Pouteria lucuma seed oil have been linked to healthy properties based on a high amount of β-sitosterol present. This evidence could determine this agro-industrial waste with having beneficial properties, thus providing great added value. To complete the study, the researchers used cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Reference of cis-13-Docosenamide It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics