Category: amides-buliding-blocks

Poludennaya, V. M. et al. published their research in Khimicheskie Volokna in 1969 | CAS: 5339-69-5

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Reference of 5339-69-5

Effect of plasticizers on the properties of polycaprolactam was written by Poludennaya, V. M.;Volkova, N. S.;Arkhangel’skii, D. N.;Konkin, A. A.. And the article was included in Khimicheskie Volokna in 1969.Reference of 5339-69-5 This article mentions the following:

High-mol.-weight polycaprolactam (I) gives stronger cord, but it has increased viscosity (η) and presents difficulties in spinning. The addition of ≤20% PhSO2NHPr-iso, p-EtC6H4SO2NHPr-iso, or 2,4-Et2C6H3SO2NHPr-iso to ε-caprolactam, prior to the polymerization, decreased η of I melt without decreasing its mol. weight Thus I of mol. weight 30,000 without the plasticizer had η = 11,000 poises; the addition of 5-7% plasticizer decreased η to 6000-5000 poises, which is sufficient for spinning I melt in standard equipment. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Reference of 5339-69-5).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Reference of 5339-69-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Solladie, Guy et al. published their research in Tetrahedron Letters in 1999 | CAS: 106675-70-1

N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.COA of Formula: C6H12N2O4

Stereoselective sulfoxide directed reduction of 1,2-diketo-derivatives to enantiomerically pure syn and anti 1,2-diols: correction of the relative configuration by X-ray and chemical correlation to goniobutenolides A and B was written by Solladie, Guy;Hanquet, Gilles;Rolland, Catherine. And the article was included in Tetrahedron Letters in 1999.COA of Formula: C6H12N2O4 This article mentions the following:

In a report [G. Solladie; 1997] on the enantioselective synthesis of syn and anti 1,2-diols from oxalyldi(N-methyl-N-methoxyamide), a sample inversion for 13C NMR anal. led to an incorrect attribution of relative configurations. Correction of the configurations of these diols, I and II (R = Me, Ph, allyl, CH:CH2), was made by x-ray anal. and chem. correlation to two known natural products, goniobutenolides A and B. Thus, the relative configuration of diols obtained by stereoselective sulfoxide directed reduction of β-hydroxy-γ-keto sulfoxides of type III is erythro with DIBAL-H or DIBAL-H/Yb(O2CCF3)3 and threo with DIBAL-H/ZnI2. In the experiment, the researchers used many compounds, for example, N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1COA of Formula: C6H12N2O4).

N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.COA of Formula: C6H12N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zeng, Wei et al. published their research in Journal of the American Chemical Society in 2007 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.HPLC of Formula: 19311-91-2

Copper(II)-Catalyzed Enantioselective Intramolecular Carboamination of Alkenes was written by Zeng, Wei;Chemler, Sherry R.. And the article was included in Journal of the American Chemical Society in 2007.HPLC of Formula: 19311-91-2 This article mentions the following:

The enantioselective oxidative cyclizations of γ-alkenyl arenesulfonamides, e.g. I [R1 = H, Me, Ph; R12 = (CH2)4, (CH2)5; R2 = H, Me, Cl, MeO], and a δ-alkenyl arylsulfonamide for the synthesis of nitrogen heterocycles are presented. The reactions are catalyzed by chiral copper(II) complexes, and MnO2 is used as the inexpensive stoichiometric oxidant. A variety of five-membered heterocycles, e.g. II, and a tetrahydroisoquinoline have been synthesized in good to excellent yields with good to excellent levels of enantioselectivity. This is the first reported copper-catalyzed enantioselective carboamination of alkenes. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2HPLC of Formula: 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.HPLC of Formula: 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Suzuki, Hirotsugu et al. published their research in Organic & Biomolecular Chemistry in 2020 | CAS: 116332-61-7

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C10H10F3NO2

Dealkoxylation of N-alkoxyamides without an external reductant driven by Pd/Al cooperative catalysis was written by Suzuki, Hirotsugu;Shiomi, Takahiro;Yoneoka, Kenji;Matsuda, Takanori. And the article was included in Organic & Biomolecular Chemistry in 2020.Computed Properties of C10H10F3NO2 This article mentions the following:

Lewis acid-assisted palladium-catalyzed dealkoxylation of N-alkoxyamides has been developed. This reaction proceeded smoothly with a range of N-alkoxyamides in the absence of an external reductant, thereby establishing a convenient and reductant-free protocol. In addition, a gram-scale reaction could be achieved. Preliminary mechanistic investigations indicated that β-hydrogen elimination from a palladium alkoxide intermediate generated an intramol. hydride source. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Computed Properties of C10H10F3NO2).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C10H10F3NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ghinato, Simone et al. published their research in Chemistry – A European Journal in 2022 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: 19311-91-2

Chemo- and Regioselective Anionic Fries Rearrangement Promoted by Lithium Amides under Aerobic Conditions in Sustainable Reaction Media was written by Ghinato, Simone;De Nardi, Federica;Bolzoni, Paola;Antenucci, Achille;Blangetti, Marco;Prandi, Cristina. And the article was included in Chemistry – A European Journal in 2022.Recommanded Product: 19311-91-2 This article mentions the following:

A straightforward and efficient protocol to promote the metalation/anionic Fries rearrangements of O-aryl carbamates, using for the first time a lithium amide as metalating agent under aerobic/ambient-friendly reaction conditions, was reported. This approach enabled the sustainable preparation of salicylamide derivatives such as I [R = Et, i-Pr; R1 = H, 5-MeO, 3-Ph, etc.] with high levels of chemoselectivity within ultrafast reaction times, working at room temperature in the presence of air/moisture, and using environmentally responsible cyclopentyl Me ether as a solvent. Furthermore, the regioselective manipulation of O-2-tolyl carbamates had been accomplished using interchangeably alkyllithiums or lithium amides, with an unexpected beneficial contribution from the employment of biorenewable protic eutectic mixtures as non-innocent reaction media. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Recommanded Product: 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Chao-Jie et al. published their research in European Journal of Medicinal Chemistry in 2021 | CAS: 119023-25-5

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Application of 119023-25-5

Discovery of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one derivatives as potential anticancer agents by inhibiting cell proliferation and inducing apoptosis in hepatocellular carcinoma cells was written by Wang, Chao-Jie;Guo, Xinxin;Zhai, Rui-Qin;Sun, Changning;Xiao, Guokai;Chen, Jin;Wei, Mei-Yan;Shao, Chang-Lun;Gu, Yuchao. And the article was included in European Journal of Medicinal Chemistry in 2021.Application of 119023-25-5 This article mentions the following:

Hepatocellular carcinoma (HCC) is the most common form of liver cancer and the fourth leading cause of cancer-related death worldwide. First-line drugs such as sorafenib provide only a modest benefit to HCC patients. In this study, the gram-scale synthesis of 2-benzoylquinazolin-4(3H)-one skeleton was achieved successfully via the I2/DMSO catalytic system. A series of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one derivatives was synthesized and evaluated for their cytotoxic activities against four cancer cell lines, HepG2, Bel-7402, A549, and U251. Among these compounds, I was the most effective one with IC50 values of 1.22μM and 1.71μM against HepG2 and Bel-7402 cells, resp. Mechanistic studies showed that I inhibited hepatocellular carcinoma cell proliferation via arresting cell cycle. Addnl., I induced HepG2 cells apoptosis by inducing reactive oxygen species production and elevating the expression of apoptosis-related proteins. More importantly, I displayed significant in vivo anticancer effects in the HepG2 xenograft models. This suggests that I is a promising lead compound with the potential to be developed as a chemotherapy agent for hepatocellular carcinoma. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Application of 119023-25-5).

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Application of 119023-25-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reverdin, Frederic et al. published their research in Arch. sci. phys. nat. gen. in 1907 | CAS: 1146-43-6

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C13H13NO3S

The Nitration of Some Derivatives of p-Aminophenol, (Continued) was written by Reverdin, Frederic;Dinner, Fritz. And the article was included in Arch. sci. phys. nat. gen. in 1907.Electric Literature of C13H13NO3S This article mentions the following:

The nitration of acetyl and benzoyl derivatives of the hydroxy- and amino- groups of sulphotoluene were studied. 1-o-Acetyl-4-N-toluenesulphoneamino phenol, m. 138-139°, by acetylation of N-toluenesulphoneaminophenol (J. pr. Chem., [2] 51, 438), easily saponifiable, with HNO3, sp. gr. 1.52, at 0° to 10°, yielded dinitrotoluenesulphoneaminophenol, C7H7SO2NH(1)C6H2(NO2)2(2,6)(OH)(4), m. 157-158°, the structure following from the fact that heating with concentrate H2SO4 gave dinitroammophenol, m. 231°, C6H2(OH)(NO2)2NH2(1)(3)(5)(4). Nitration preceded saponification, since the free phenol could not be nitrated. Nitration with HNO3 and H2SO4 in acetic anhydride caused decomposition and formation of nitroaminophenols. 1-o-Benzoyl-4-N-toluenesulphoneaminophenol, m. 170°, on nitration yielded a tetranitro derivative, m. 189-190°, probably C6H2(1)OC7H4ONO2(3,5)(NO2)7(4)NHSO2CH3C2H3NO2, with HNO3 and H2SO4, nitroaminophenols were formed. 1-o-toluene-p-sulphone-4-acetylaminophenol, m. 146° (Ber., 34, 237), on nitration yielded a mononitro-, m. 146°, or a dinitroderivative, m. 134°, for the latter acetic anhydride must be present, the structures of which were proved by saponification. With stronger acids, saponification took place at the same time as nitration. 1-o-Toluenesulphone-4-N-benzoylaminophenol, m. 218°, gave a trinitroderivative, m. 145-150°, 1 nitro group in the ring, 2 in the side chains, together with small quantities of mono- and dinitroderivatives. The colors of the various nitroaminophenols with soda served to identify them. Some conclusions with regard to the directive influence in the nitration of the groups present in the ring are given, the groups on the amino appearing to exert the greatest influence. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Electric Literature of C13H13NO3S).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C13H13NO3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Perumal, Nithiyaa et al. published their research in Biomedicine & Pharmacotherapy in 2022 | CAS: 10238-21-8

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Synthetic Route of C23H28ClN3O5S

Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination was written by Perumal, Nithiyaa;Nallappan, Meenakshii;Shohaimi, Shamarina;Kassim, Nur Kartinee;Tee, Thiam Tsui;Cheah, Yew Hoong. And the article was included in Biomedicine & Pharmacotherapy in 2022.Synthetic Route of C23H28ClN3O5S This article mentions the following:

Type 2 Diabetes Mellitus accounts for 90% of most diabetes cases. Many com. drugs used to treat this disease come with adverse side effects and eventually fail to restore glucose homeostasis. Therefore, an effective, economical and safe antidiabetic remedy from dietary source is considered. Taraxacum officinale (L.) Weber ex F. H.Wigg and Momordica charantia L. were chosen since both are used for centuries as traditional medicine to treat various ailments and diseases. In this study, the antidiabetic properties of a polyherbal combination of T. officinale and M. charantia ethanol extracts are evaluated. The bioactive solvent extracts of the samples selected from in vitro antidiabetic assays; α-amylase, α-glucosidase, and dipeptidyl peptidase-4 (DPP-4) inhibition, and glucose-uptake in L6 muscle cells were combined (1:1) to form the polyherbal combination. The antidiabetic efficacy of polyherbal combination was evaluated employing the above stated in vitro antidiabetic assays and in vivo oral glucose tolerance test and streptozotocin-nicotinamide (STZ-NA) induced diabetic rat model. A quadrupole time-of-flight liquid chromatog.-mass spectrometry (Q-TOF LCMS) anal. was done to identify active compounds The polyherbal combination exerted improved antidiabetic properties; increased DPP-4, α-amylase, and α-glucosidase inhibition. The polyherbal combination tested in vivo on diabetic rats showed optimum blood glucose-lowering activity comparable to that of Glibenclamide and Metformin. This study confirms the polyherbal combination of T. officinale and M. charantia to be rich in various bioactive compounds, which exhibited antidiabetic properties. Therefore, this polyherbal combination has the potential to be further developed as complex phytotherapeutic remedy for the treatment of Type 2 Diabetes Mellitus. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Synthetic Route of C23H28ClN3O5S).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Synthetic Route of C23H28ClN3O5S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kato, Motoyasu et al. published their research in Drug Design, Development and Therapy in 2020 | CAS: 53902-12-8

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Quality Control of 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid

Tranilast inhibits pulmonary fibrosis by suppressing TGFβ/SMAD2 pathway was written by Kato, Motoyasu;Takahashi, Fumiyuki;Sato, Tadashi;Mitsuishi, Yoichiro;Tajima, Ken;Ihara, Hiroaki;Nurwidya, Fariz;Baskoro, Hario;Murakami, Akiko;Kobayashi, Isao;Hidayat, Moulid;Shimada, Naoko;Sasaki, Shinichi;Mineki, Reiko;Fujimura, Tsutomu;Kumasaka, Toshio;Niwa, Shin-ichiro;Takahashi, Kazuhisa. And the article was included in Drug Design, Development and Therapy in 2020.Quality Control of 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid This article mentions the following:

Purpose: Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of extracellular matrix (ECM) protein in the lungs. Transforming growth factor (TGF) β- induced ECM protein synthesis contributes to the development of IPF. Tranilast, an antiallergy drug, suppresses TGFβ expression and inhibits interstitial renal fibrosis in animal models. However, the beneficial effects of tranilast or its mechanism as a therapy for pulmonary fibrosis have not been clarified. Methods: We investigated the in vitro effect of tranilast on ECM production and TGFβ/SMAD2 pathway in TGFβ2-stimulated A549 human alveolar epithelial cells, using quant. polymerase chain reaction, Western blotting, and immunofluorescence. In vitro observations were validated in the lungs of a murine pulmonary fibrosis model, which we developed by i.v. injection of bleomycin. Results: Treatment with tranilast suppressed the expression of ECM proteins, such as fibronectin and type IV collagen, and attenuated SMAD2 phosphorylation in TGFβ2-stimulated A549 cells. In addition, based on a wound healing assay in these cells, tranilast significantly inhibited cell motility, with foci formation that comprised of ECM proteins. Histol. analyses revealed that the administration of tranilast significantly attenuated lung fibrosis in mice. Furthermore, tranilast treatment significantly reduced levels of TGFβ, collagen, fibronectin, and phosphorylated SMAD2 in pulmonary fibrotic tissues in mice. Conclusion: These findings suggest that tranilast inhibits pulmonary fibrosis by suppressing TGFβ/SMAD2-mediated ECM protein production, presenting tranilast as a promising and novel anti-fibrotic agent for the treatment of IPF. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Quality Control of 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Quality Control of 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Spicka, Nina et al. published their research in Textile Research Journal in 2013 | CAS: 10543-57-4

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Category: amides-buliding-blocks

Complete enzymatic pre-treatment of cotton fabric with incorporated bleach activator was written by Spicka, Nina;Tavcer, Petra Forte. And the article was included in Textile Research Journal in 2013.Category: amides-buliding-blocks This article mentions the following:

The feasibility of a complete enzymic one-bath pre-treatment of the cotton fabric at low temperature was investigated in this study. The cotton fabric was enzymically desized, scoured and bleached with an enzyme mixture of starch-degrading enzymes, pectinases and glucose oxidases, resp. Starch-degrading enzymes hydrolyzed the sizing agent into glucose. Glucose oxidases catalyzed the oxidation of β-D-glucose to D-glucono-ω-lactone and simultaneously generated hydrogen peroxide. The desizing and hydrogen peroxide generation each took one hour. For bleaching, hydrogen peroxide was converted into peracetic acid by incorporating the bleach activator tetraacetylethylenediamine (TAED). Bleaching took place at 50°C and neutral pH, where peracetic acid is most effective. Pectinases were added into the pre-treatment bath to remove pectins from fibers and improve their wettability. Whiteness values, water absorbency, polymerization degree and tenacity at maximum load were measured on pre-treated samples. The total organic carbon, pH and biodegradability were measured on residual pre-treatment baths. It was established that hydrogen peroxide can be efficiently enzymically produced from the sizing agent and converted with TAED to form peracetic acid to bleach the cotton fabric. Cotton fabrics with a medium degree of whiteness, W = 51, and good water absorbency can be obtained at low water and energy consumption. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Category: amides-buliding-blocks).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics