Category: amides-buliding-blocks

Fluoro-Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors was written by Colella, Marco;Tota, Arianna;Takahashi, Yusuke;Higuma, Ryosuke;Ishikawa, Susumu;Degennaro, Leonardo;Luisi, Renzo;Nagaki, Aiichiro. And the article was included in Angewandte Chemie, International Edition in 2020.Category: amides-buliding-blocks This article mentions the following:

The external quenching method based on flow microreactors allows the generation and use of short-lived fluoro-substituted methyllithium reagents, such as fluoromethyllithium, fluoroiodomethyllithium, and fluoroiodostannylmethyllithium. Highly chemoselective reactions were developed, opening new opportunities in the synthesis of fluorinated mols. using fluorinated organometallics. In the experiment, the researchers used many compounds, for example, 3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1Category: amides-buliding-blocks).

3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Acute Toxicity Evaluation of the Disinfectant Containing Percarbonate and Tetraacetylethylenediamine by Measuring Behavioral Responses of Small Fish Using Image Analysis was written by Seo, Seung-Yoon;Park, Yeon-Ho;Jung, Sang-Kyu;Kim, Jinku. And the article was included in Biotechnology and Bioprocess Engineering in 2022.Category: amides-buliding-blocks This article mentions the following:

Disinfectants containing percarbonate and tetraacetylethylenediamine (TAED) has been developed as an effective and relatively safe disinfectant to destroy viruses and bacteria in animals and humans, however it is known that most disinfectants can cause danger to living organisms including humans. In the current study, acute toxicity of the disinfectant composed of percarbonate and TAED was assessed by measuring behavioral responses as well as lethal concentrations of aquatic organisms such as medaka and zebrafish when they were exposed to it. First, the breeding water properties were determined by measuring dissolved oxygen (DO) and pH changes over time up to 96 h in acute toxicity tests using the medaka, and the lethal concentration 50% (LC50, 88.39 ppm) was calculated using the lethality rate of the fish. This experiment was conducted in compliance with traditional OECD guidelines. Second, the assessment of behavioral responses (locomotive activity and swimming speed) with the zebrafish were assessed by the image anal. to capture the images per s for three hours, and the collected data were processed using image anal. to calculate the locomotive activity and swimming speed. Finally, the LC50 (135.76 ppm) of the disinfectant to the fish was also measured after three hours. Overall, the data revealed that LC50 of the disinfectant may be affected by the pH of the water exposed to the disinfectant, not by the DO in the water. In addition, the results from the image anal. indicated that the behavioral responses of the fish can further assess the acute toxicity of the disinfectant at concentrations below the LC50 and there was a relationship (R2 = 0.85) between the behavioral responses and the survival rate of the fish. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Category: amides-buliding-blocks).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of Tridentate Chiral Spiro Aminophosphine-Oxazoline Ligands and Application to Asymmetric Hydrogenation of α-Keto Amides was written by Zhang, Feng-Hua;Wang, Chen;Xie, Jian-Hua;Zhou, Qi-Lin. And the article was included in Advanced Synthesis & Catalysis in 2019.Related Products of 106675-70-1 This article mentions the following:

A new type of tridentate chiral spiro aminophosphine-oxazoline ligands (SpiroOAP) were synthesized through four steps. The SpiroOAP ligands are highly efficient for the asym. hydrogenation of α-keto amides, providing a variety of synthetically useful α-hydroxy amides with excellent enantioselectivity (up to 98% ee) and turnover numbers (up to 10,000). In the experiment, the researchers used many compounds, for example, N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1Related Products of 106675-70-1).

N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Related Products of 106675-70-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Identification of toxic substances by means of Feldstein’s extraction method, thin-layer chromatography, and uv spectrometry. I. Basic substances was written by Drost, R. H.;Reith, Jan F.. And the article was included in Pharmaceutisch Weekblad in 1967.Quality Control of N,N-Diethylsalicylamide This article mentions the following:

Biol. material was extracted with 1,2-dichloroethane, according to Feldstein, and separated into strongly acid, weakly acid, neutral, basic, and basic substances with a phenol group. The basic substances were separated by thin-layer chromatog. on activated kieselgel G with CHCl3-Et2NH (90:10), CHCl3-Me2CO-Et2NH (50:40:10), CHCl3-cyclohexane-Et2NH (40:50:10), cyclohexane-Et2NH (90:10), and C6H6-EtOAc-Et2NH (70:20:10). The spots were located with uv light and the compounds identified by their reaction with a platinic chloride-KI spray and by the uv spectrum of a dichloroethane extract The Rf values, color reactions, and spectral data are given for 32 substances. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Quality Control of N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Quality Control of N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Transient receptor potential vanilloid 2 mediates the inhibitory effect of far-infrared irradiation on adipogenic differentiation of tonsil-derived mesenchymal stem cells was written by Kim, Ha Yeong;Oh, Se-Young;Choi, Young Min;Park, Jung-Hyun;Kim, Han Su;Jo, Inho. And the article was included in Stem Cell Research in 2021.Recommanded Product: 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid This article mentions the following:

Far-IR (FIR) irradiation inhibits adipogenic differentiation of tonsil-derived mesenchymal stem cells (TMSCs) by activating Ca2+-dependent protein phosphatase 2B (PP2B), but it stimulates osteogenic differentiation in a PP2B-independent pathway. We investigated the potential involvement of transient receptor potential vanilloid (TRPV) channels, a well-known Ca2+-permeable channel, in the effects of FIR irradiation on adipogenic or osteogenic differentiation of TMSCs. TMSCs, in the absence or presence of activators or inhibitors, were exposed to FIR irradiation followed by adipogenic or osteogenic differentiation, which was assessed using Oil red O or Alizarin red S staining, resp. RT-PCR, qRT-PCR, and Western blotting were used to determine gene and protein expression of calcium channels and adipocyte-specific markers. Treatment with the calcium ionophore ionomycin simulated the inhibitory effect of FIR irradiation on adipogenic differentiation but had no effect on osteogenic differentiation, indicating the involvement of intracellular Ca2+ in adipogenic differentiation. Inhibition of pan-TRP channels using ruthenium red reversed the FIR irradiation-induced inhibition of adipogenic differentiation. Among the TRP channels tested, inhibition of the TRPV2 channel by tranilast or siRNA against TRPV2 attenuated the inhibitory effect of FIR irradiation on adipogenic differentiation, accompanied by a decrease in intracellular Ca2+ levels. By contrast, activation of the TRPV2 channel by probenecid simulated FIR irradiation-induced inhibition of adipogenic differentiation. Expectedly, the stimulatory effect of FIR irradiation on osteogenic differentiation was independent of the TRPV2 channel. Our data demonstrate that the TRPV2 channel is a sensor/receptor for the inhibited adipogenic differentiation of TMSCs associated with FIR irradiation In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Recommanded Product: 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Direct transformation of amides: a one-pot reductive Ugi-type three-component reaction of secondary amides was written by Zheng, Jian-Feng;Qian, Xiang-Yang;Huang, Pei-Qiang. And the article was included in Organic Chemistry Frontiers in 2015.Recommanded Product: 13255-50-0 This article mentions the following:

An efficient reductive Ugi-type reaction has been established. The method employs common secondary amides as starting materials. The reaction exhibited a broad substrate scope, good chemoselectivity and functional group tolerance and provides rapid access to a variety of functionalized α-acetamidoamides. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Recommanded Product: 13255-50-0).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 13255-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Exploiting a “Beast” in Carbenoid Chemistry: Development of a Straightforward Direct Nucleophilic Fluoromethylation Strategy was written by Parisi, Giovanna;Colella, Marco;Monticelli, Serena;Romanazzi, Giuseppe;Holzer, Wolfgang;Langer, Thierry;Degennaro, Leonardo;Pace, Vittorio;Luisi, Renzo. And the article was included in Journal of the American Chemical Society in 2017.Formula: C9H10FNO2 This article mentions the following:

The first direct and straightforward nucleophilic fluoromethylation of organic compounds is reported. The tactic employs a “fleeting” lithium fluorocarbenoid (LiCH₂F) generated from com. available fluoroiodomethane. Precise reaction conditions were developed for the generation and synthetic exploitation of such a labile species. The versatility of the strategy is showcased in ca. 50 examples involving a plethora of electrophiles. Highly valuable chems. such as fluoroalcs., fluoroamines, and fluoromethylated oxygenated heterocycles could be prepared in very good yields through a single synthetic operation. The scalability of the reaction and its application to complex mol. architectures (e.g., steroids) are documented. PhSOCH₂F. In the experiment, the researchers used many compounds, for example, 3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1Formula: C9H10FNO2).

3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Formula: C9H10FNO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tyre additive chemicals, tyre road wear particles and high production polymers in surface water at 5 urban centres in Queensland, Australia was written by Rauert, Cassandra;Vardy, Suzanne;Daniell, Benjamin;Charlton, Nathan;Thomas, Kevin V.. And the article was included in Science of the Total Environment in 2022.Synthetic Route of C13H24N2O This article mentions the following:

Plastics pollution is a global issue impacting every part of our environment. Tire road wear particle (TRWP) plastics pollution is thought to be one of the largest pollution sources in urban environments. These plastics are also of concern due to the presence of additive chems., incorporated during manufacture, that can be released into the surrounding environment. This study aimed to provide information on concentrations of a range of anthropogenic plastics related pollutants in the Australian environment through a scoping study of surface water in 5 key urban centers around Queensland, Australia. Samples were analyzed for a suite of 15 common tyre additive chems., TRWPs and 6 common high production polymers, and included the new transformation product of concern 6PPD-quinone which has recent reports of causing mass mortality events in certain aquatic species. The additives were ubiquitously detected (2.9-1440 ng/L) with 6PPD-quinone concentrations lower than in previous studies (<0.05-24 ng/L) and TRWPs detected at 18 of the 21 sites (<MDL to between 690 and 1990μg/L). Of the high production polymers, polyethylene and polypropylene were detected at the highest concentrations (16-1750 and <0.7-37μg/L resp.) with profiles highly variable between sites. A traffic related additive profile was determined at 7 sites, which all had nearby traffic related sources. Concentrations of additive chems. were significantly correlated with average daily traffic volumes (p = 0.006), although concentrations of TRWPs were not correlated. Generally, concentrations were in line with or lower than concentrations in other geog. regions, although it is noted samples were collected during the dry season and further sampling during the tropical wet season would be of interest. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Synthetic Route of C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Synthetic Route of C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some examples of the Schmidt rearrangement was written by Edwards, W. G. H.;Petrow, V.. And the article was included in Journal of the Chemical Society in 1948.Safety of 6-Chloro-2-aminobenzamide This article mentions the following:

The Schmidt rearrangement is carried out in 10 volumes concentrated H₂SO₄ at 0° by adding dropwise 1.1 equivalents NaN₃ in a min. quantity of H₂O and allowing the mixture to stand overnight. Isatin (I) gives ο-H₂NC₆H₄CONH₂ (II); the 5-NO₂ derivative of II results in 42% yield; the 6-Cl derivative of I gives 80% of the 4-Cl derivative of II; the 4-Cl derivative of I gives 40% 6,2-Cl(H₂N)C₆H₃CO₂H. Isatin-7-carboxylic acid fails to react, as do oxindole and its N-HO and 5-NO₂ derivatives 1-Acetylindoxyl gives a dark amorphous solid which could not be purified. Benzisoxazolone & and coumaranone are recovered unchanged. Acenaphthenone gives a tarry product that could not be purified. Acenaphthenequinone gives naphthalic anhydride. 3-Acetylacenaphthene gives a mixture of 3-aminoacenaphthenesulfonic acid and the Ac derivative; the latter forms an S-benzylisothiuronium salt, m. 226° (decomposition, corrected); in H₃PO₄, unchanged ketone was recovered. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Safety of 6-Chloro-2-aminobenzamide).

6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Safety of 6-Chloro-2-aminobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rearrangement of aldoximes to amides in water under air atmosphere catalyzed by water-soluble iridium complex [Cp*Ir(H₂O)₃][OTf]₂ was written by Sun, Chunlou;Qu, Panpan;Li, Feng. And the article was included in Catalysis Science & Technology in 2014.Recommanded Product: 3,4-Dichlorobenzamide This article mentions the following:

In the presence of the water-soluble iridium complex [Cp*Ir(H₂O)₃][OTf]₂, a variety of aldoximes, including aromatic, aliphatic, conjugated unsaturated and non-conjugated unsaturated, were converted into their corresponding amides in water with good to excellent yields. Further, the one-pot synthesis of amides from aldehydes, hydroxylamine hydrochloride and sodium carbonate via a tandem condensation-rearrangement reaction in water was also accomplished. Compared with the reported organometallic catalysts for the rearrangement of aldoximes to amides in water, the present catalyst exhibited some advantages such as being phosphorus ligand-free, having low catalyst loading, and operational convenience under air atm. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Recommanded Product: 3,4-Dichlorobenzamide).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: 3,4-Dichlorobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics