Category: amides-buliding-blocks

Expanding Pd-Catalyzed C-N Bond-Forming Processes: The First Amidation of Aryl Sulfonates, Aqueous Amination, and Complementarity with Cu-Catalyzed Reactions. [Erratum to document cited in CA139:117168] was written by Huang, Xiaohua;Anderson, Kevin W.;Zim, Danilo;Jiang, Lei;Klapars, Artis;Buchwald, Stephen L.. And the article was included in Journal of the American Chemical Society in 2003.Computed Properties of C11H15NO2 This article mentions the following:

An important reference pertinent to the Pd-catalyzed amination in water was omitted on page 6655. The work by Boche and co-workers (Wullner, G.; Jansch, H.; Kannenberg, S.; Schubert, F.; Boche, G. Chem. Commun. 1998, 1509-1510) describes one example of aryl amination in water and several examples of aryl amination in aqueous solvent mixtures using NaOH as base. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Computed Properties of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Computed Properties of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quantitative structure activity relationship of the aromatic carboxylic acid derivatives was written by Xue, Feiqun;Wang, Hanqing;Zhao, Rongcai. And the article was included in Zhongguo Shouyi Xuebao in 1996.Synthetic Route of C11H15NO2 This article mentions the following:

The repellency and QSAR of forty aromatic carboxylic acid derivatives were analyzed using Hansch’s method in the study. The results indicated that the repellency of a series of the compounds is significantly correlated with the boiling coefficient The size of substituent of the compounds should not be larger than benzene, the most appropriate value of the partition coefficient (logP) is about 3.50. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Synthetic Route of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Synthetic Route of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Antidiabetic and hypolipidemic potentials of extract of Picris Babylonica in streptozotocin-induced diabetic model in rats was written by Al-Mouslem, Abdulaziz K.. And the article was included in Biomedical and Pharmacology Journal in 2022.Related Products of 10238-21-8 This article mentions the following:

To investigate the hypoglycemic and hypolipidemic potentials of Picris babylonica extract in streptozotocin (STZ) induced diabetes in rats. Animals were injected with 40mg/kg of STZ to induce diabetes, a common diabetic model. Development of the disease were assessed by measuring blood glucose level 3 days prior systemic administration of STZ and following STZ injection. Animals received 200mg/kg and 400mg/kg of Picris babylonica extract and 0.6mg/kg of glibenclamide, standard, by oral rout for 14 consecutive days. Administration of the Picris babylonica extract significantly decreased serum blood glucose, total cholesterol, triglycerides, and low-d. lipoprotein-cholesterol. In addition, high d. lipoproteincholesterol level significantly enhanced as compared to standard Picris babylonica extract demonstrated beneficial effects in lowering blood glucose and improving lipid profile, therefore, Picris babylonica extract could be developed as hypoglycemic and hypolipidemic therapy. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Related Products of 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Related Products of 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Comparative effectiveness of cardiovascular, renal and safety outcomes of second-line antidiabetic drugs use in people with type 2 diabetes: A systematic review and network meta-analysis of randomised controlled trials was written by Sim, Ruth;Chong, Chun Wie;Loganadan, Navin K.;Fong, Alan Y. Y.;Navaravong, Leenhapong;Hussein, Zanariah;Khunti, Kamlesh;Lee, Shaun Wen Huey. And the article was included in Diabetic Medicine in 2022.Formula: C23H28ClN3O5S This article mentions the following:

To compare the cardiovascular, renal and safety outcomes of second-line glucose-lowering agents used in the management of people with type 2 diabetes. MEDLINE, EMBASE and CENTRAL were searched from inception to 13 July 2021 for randomised controlled trials comparing second-line glucose lowering therapies with placebo, standard care or one another. Primary outcomes included cardiovascular and renal outcomes. Secondary outcomes were non-cardiovascular adverse events. Risk ratios (RRs) and corresponding confidence intervals (CI) or credible intervals (CrI) were reported within pairwise and network meta-anal. The quality of evidence was evaluated using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) criteria. Number needed to treat (NNT) and number needed (NNH) to harm were calculated at 5 years using incidence rates and RRs. PROSPERO (CRD42020168322). We included 38 trials from seven classes of glucose-lowering therapies. Both sodium-glucose co-transporter-2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP1RA) showed moderate to high certainty in reducing risk of 3-point major adverse cardiovascular events, 3P-MACE (network estimates: SGLT2i [RR 0.90; 95% CrI 0.84-0.96; NNT, 59], GLP1RA [RR 0.88; 95% CrI 0.83-0.93; NNT, 50]), cardiovascular death, all-cause mortality, renal composite outcome and macroalbuminuria. SGLT2i also showed high certainty in reducing risk of hospitalization for heart failure (hHF), ESRD, acute kidney injury, doubling in serum creatinine and decline in eGFR. GLP1RA were associated with lower risk of stroke (high certainty) while glitazone use was associated with an increased risk of hHF (very low certainty). The risk of developing ESRD was lower with the use of sulfonylureas (low certainty). For adverse events, sulfonylureas and insulin were associated with increased hypoglycemic events (very low to low certainty), while GLP1RA increased the risk of gastrointestinal side effects leading to treatment discontinuation (low certainty). DPP-4i increased risk of acute pancreatitis (low certainty). SGLT2i were associated with increased risk of genital infection, volume depletion (high certainty), amputation and ketoacidosis (moderate certainty). Risk of fracture was increased with the use of glitazones (moderate certainty). SGLT2i and GLP1RA were associated with lower risk for different cardiorenal end points, when used as an adjunct to metformin in people with type 2 diabetes. Addnl., SGLT2i demonstrated benefits in reducing risk for surrogate end points in kidney disease progression. Safety outcomes differ among the available pharmacotherapies. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Formula: C23H28ClN3O5S).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Formula: C23H28ClN3O5S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Structural studies of organoboron compounds. XXXIV. 4-(N-Methoxymethylimino)-2,2-diphenyl-1,3-dioxa-2-borata-1,2,3,4-tetrahydronaphthalene and 4-diethylimino-2,2-diphenyl-1,3-dioxa-2-borata-1,2,3,4-tetrahydronaphthalene was written by Kliegel, Wolfgang;Tajerbashi, Mahmood;Rettig, Steven J.;Trotter, James. And the article was included in Canadian Journal of Chemistry in 1989.Formula: C11H15NO2 This article mentions the following:

Cyclocondensation of 2-HOC₆H₄CONRR¹ (R = Me, R¹ = OMe; R = R¹ = Et) with Ph₂BOBPh₂ in EtOH gave 88 and 86% title compounds I, resp. The crystal structures of both I were reported. In both structures the N,N-dialkylsalicylamidate ligands coordinate the Ph₂B moieties via the phenolate O and amide O atoms, forming 6-membered O-B-O chelate rings. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Formula: C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Formula: C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Phosphates and thiophosphates with a heterocyclic substituent. 9. Aza analogs. I. Aza analogs of phthalimide, benzotriazole, and 1,2,3,-benzotriazin-4(3H)-one derivatives was written by Ruefenacht, Kurt. And the article was included in Helvetica Chimica Acta in 1975.Application In Synthesis of 3-Aminopicolinamide This article mentions the following:

Thiophosphates RCH2SP(S)(OR1)2 (I, R = 2,3-pyridinedicarboximido, 3,4-pyridinedicarboximido, 2,3-pyrazinedicarboximido, 1-triazolo[4,5-b]pyridyl, 4-oxopyrido[2,3-e]-1,2,3-triazin-3-yl) were prepared by methylolating RH, chlorinating RCH2OH, and treating RCH2Cl with NH4SP(S)(OMe)2 or KSP(S)(OEt)2. I were approx. equal in toxicity and pesticidal activity to their known analogs. In the experiment, the researchers used many compounds, for example, 3-Aminopicolinamide (cas: 50608-99-6Application In Synthesis of 3-Aminopicolinamide).

3-Aminopicolinamide (cas: 50608-99-6) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Application In Synthesis of 3-Aminopicolinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The ortho effect in pyridines. Part XI. Substituent effects on basicity of 2- and 4-substituted 3-aminopyridines was written by Rasala, D.. And the article was included in Bulletin de la Societe Chimique de France in 1992.Safety of 3-Aminopicolinamide This article mentions the following:

The substituent effects on the pK_a values corresponding to the first protonation site of thirty 2- and 4-substituted 3-aminopyridines have been studied. The relative localized and delocalized effects are apparently sensitive to the variation of substituent position in the pyridine ring. An interaction of the 2-substituent with the protonation center has mainly inductive character, whereas, the pK_a values of 4-substituted 3-aminopyridines are highly affected by through-resonance. The steric effect was insignificant. In the experiment, the researchers used many compounds, for example, 3-Aminopicolinamide (cas: 50608-99-6Safety of 3-Aminopicolinamide).

3-Aminopicolinamide (cas: 50608-99-6) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Safety of 3-Aminopicolinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Low-temperature activated bleaching processes and mechanism of cotton fabric was written by Wang, Kuo;Liu, Kai;Yan, Ke-lu. And the article was included in Yinran in 2017.Computed Properties of C10H16N2O4 This article mentions the following:

Low-temperature activators TAED and JML-2 are adopted for cotton bleaching, and the hydroxyl radical (OH·) in TAED/H₂O₂ and JML-2/H₂O₂ systems is detected with a novel fluorescent probe benzenepentacarboxylic acid (BA). The results show that the optimum activated bleaching condition is: 30% H₂O₅ g/L, NaOH 2 g/L, TAED or JML-2 3g/L, bleaching at 70°C for 60 rain. OH · yield in TAED/H₂O₂ system is significantly higher than that in H₂O₂ system. The whiteness of cotton fabric is obviously decreased when the OH · is scavenged in TAED/H₂O₂ system. It proves that OH · plays a significant role in TAED/H₂O₂ system for low-temperature bleaching. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Computed Properties of C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Computed Properties of C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fe^III-Catalyzed Synthesis of Primary Amides from Aldehydes was written by Gowda, Ravikumar R.;Chakraborty, Debashis. And the article was included in European Journal of Organic Chemistry in 2011.Category: amides-buliding-blocks This article mentions the following:

A direct synthetic route for the transformation of aldehydes into primary amides in the presence of catalytic amounts of FeCl₃ in water is described. Hydroxylamine hydrochloride acts as the nitrogen source in this transformation, and reaction kinetics are investigated. The application of the methodol. to D-ribofuranose derivatives is demonstrated. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Category: amides-buliding-blocks).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A Catalytic Route to Pyrrole Derivatives via Copper-catalyzed Multicomponent Reaction was written by Samzadeh-Kermani, Alireza;Ghasemi, Samira. And the article was included in Journal of Heterocyclic Chemistry in 2019.Computed Properties of C13H24N2O This article mentions the following:

In the presence of CuI, Bu₄P⁺·AcO^–, and DBU in MeCN, terminal alkynes R¹CCH (R¹ = Ph, 3-MeC₆H₄, 3-MeOC₆H₄, 2-furyl, 2-thienyl, Bu, PhCH₂CH₂, Me₃Si), carbodiimides R²N:C:NR³ (R² = R³ = cyclohexyl, i-Pr, Ph; R² = Ph, 4-MeC₆H₄, 4-ClC₆H₄, R³ = cyclohexyl; R² = Ph, R³ = Bu), and malononitrile underwent regioselective three-component coupling and cyclization reactions to yield (alkylidene)iminopyrrolinecarbonitriles I (R¹ = Ph, 3-MeC₆H₄, 3-MeOC₆H₄, 2-furyl, 2-thienyl, Bu, PhCH₂CH₂, Me₃Si; R² = R³ = cyclohexyl, i-Pr, Ph; R² = Ph, 4-MeC₆H₄, 4-ClC₆H₄, R³ = cyclohexyl; R² = Ph, R³ = Bu). In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Computed Properties of C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Computed Properties of C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics