Category: amides-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 456-64-4, name is 1,1,1-Trifluoro-N-phenylmethanesulfonamide, This compound has unique chemical properties. The synthetic route is as follows., category: amides-buliding-blocks

6-Oxo-6,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid methyl ester described in Preparation Example T-8 (9mg, 43mumol), N-phenyltrifluoromethanesulfonimide (23mg, 65mumol) and dimethyl-pyridin-4-yl-amine (catalytic amount) were dissolved in dichloromethane (0.5mL), and the solution was stirred for 18.5 hours at room temperature. Water was added to the reaction solution, which was then extracted with ethyl acetate, the organic layer was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated in vacuo, the residue was purified by NH silica gel column chromatography (hexane : ethyl acetate = 3 : 1), and the title compound (10mg, 29mumol, 68%) was obtained as a white solid. 1H-NMR Spectrum (CDCl3) delta(ppm) : 4.03 (3H, s), 7.43 (1H, d, J=5.9Hz), 7.73 (1H, d, J=5.9Hz), 8.87 (1H, s).

According to the analysis of related databases, 456-64-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eisai Co., Ltd.; EP1669348; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 28797-48-0, name is 11-(2-Chloroacetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one, This compound has unique chemical properties. The synthetic route is as follows., Safety of 11-(2-Chloroacetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

EXAMPLE 7 5,11-Dihydro-11-[[[2-(1-ethyl-2-pyrrolidinyl)ethyl]amino]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Prepared analogously to Example 1 from 11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-(2-aminoethyl)-1-ethylpyrrolidine. Yield: 9.5% of theory, Mp.: 109-111 C. (ethyl acetate/cyclohexane 2/1 v/v).

According to the analysis of related databases, 28797-48-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Mihm; Gerhard; Eberlein; Wolfgang; Engel; Wolfhard; Trummlitz; Gunter; Mayer; Norbert; de Jonge; Adrian; Doods; Henri; US5002943; (1991); A;,
Amide – Wikipedia,
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Synthetic Route of 758-96-3, The chemical industry reduces the impact on the environment during synthesis 758-96-3, name is N,N-Dimethylpropionamide, I believe this compound will play a more active role in future production and life.

General procedure: tert-Butyl acetate (0.14 mL; 1.0 mmol) was added to a solution of LDA (1.0 mmol) in 3 mL of dry THF at -78 C under argon atmosphere with stirring. After the solution was stirred for 10 min, a solution of vinyl sulfoxide 8 (71 mg; 0.2 mmol) in THF (1 mL) was added. The reaction mixture was stirred for 15 min and then reaction was quenched by adding saturated aq. NH4Cl. The whole mixture was extracted with CHCl3. The product was purified by silica gel column chromatography to afford adduct 9 (94 mg; 99%) as colorless oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N,N-Dimethylpropionamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Satoh, Tsuyoshi; Awata, Yu; Kato, Yuichi; Ogata, Shingo; Ishigaki, Masashi; Sugiyama, Shimpei; Saitoh, Hideki; Tetrahedron; vol. 67; 6; (2011); p. 1102 – 1113;,
Amide – Wikipedia,
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Some common heterocyclic compound, 67074-78-6, name is 3,4-Dihydropyrido[2,3-b]pyrazin-2(1H)-one, molecular formula is C7H7N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 67074-78-6

A mixture of 3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one (0.477 g), 4-methoxy-2-(4-(trifluoromethoxy)phenoxy)butanoic acid (0.883 g), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.690 g), 1-hydroxybenzotriazole monohydrate (0.551 g) and N,N-dimethylformamide (15 mL) was stirred at room temperature for 2 hr. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (1.09 g). 1H NMR (300 MHz, DMSO-d6) delta 1.75-2.04 (2H, m), 3.03 (3H, s), 3.23-3.46 (2H, m), 4.25 (1H, d, J = 16.6 Hz), 4.63 (1H, d, J = 16.6 Hz), 6.15 (1H, dd, J = 7.5, 4.1 Hz), 6.94-7.08 (2H, m), 7.28 (3H, dt, J = 8.3, 2.1 Hz), 7.42 (1H, dd, J = 7.9, 1.9 Hz), 8.07 (1H, dd, J = 4.7, 1.7 Hz), 10.89 (1H, brs).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 67074-78-6, its application will become more common.

Reference:
Patent; Takeda Pharmaceutical Company Limited; NAKAMURA, Shinji; MIKAMI, Satoshi; KAWASAKI, Masanori; NOMURA, Izumi; ASHIZAWA, Tomoko; TANIGUCHI, Takahiko; EP2873669; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 7223-30-5, The chemical industry reduces the impact on the environment during synthesis 7223-30-5, name is 3-Phenylpropiolamide, I believe this compound will play a more active role in future production and life.

General procedure: A degassed solution of 3-phenylpropiolamide (5.0 mmol) and N,N-dimethylethane-1,2-diamine (5.0mmol) in DMF (6.0 mL) was added through canula to a degassed solution of thevinyl iodide (1.0 mmol), Cs2CO3 (5.0 mmol) and CuI (2.0mmol) in DMF (25.0 mL) at 23 C. After stirring for the indicated time, thereaction was quenched with water and extracted with EtOAc (x3). The combined organic layers were washedwith brine, dried over Na2SO4 and filtered. The solventwas concentrated under reduced pressure, and the residue was purified byflash chromatography as indicated.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Phenylpropiolamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Garcia-Rodriguez, Jose; Mendiratta, Saurabh; White, Michael A.; Xie, Xiao-Song; De Brabander, Jef K.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 20; (2015); p. 4393 – 4398;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 2564-07-0, The chemical industry reduces the impact on the environment during synthesis 2564-07-0, name is 2-Chloro-N-(2,3-dimethylphenyl)acetamide, I believe this compound will play a more active role in future production and life.

The procedure described in Example 8 was followed, substituting the product from Example 17A for N-chloroacetyl-3-nitroaniline, to provide the title compound (32% yield as a white solid. mp 124-126 C.; 1H NMR (300 MHz, DMSO-d6) ? 2.12 (s, 3H), 2.26 (s, 3H), 2.72 (m, 4H), 3.21 (s, 2H), 3.69 (m, 4H), 6.94 (dd, 1H, J=7.8, 4.8 Hz), 6.99 (br d, 1H, J=7.4 Hz), 7.07 (dd, 1H, J=7.4, 7.4 Hz), 7.45 (br d, 1H, J=7.8 Hz), 8.08 (dd, 1H, J=7.8, 2.0 Hz), 8.42 (dd, 1H, 4.8, 2.1 Hz), 9.42 (br s, 1H); MS (DCI/NH3) m/e 350 (M+H)+; Anal. calcd for C20H23N50.0.10H2O: C, 68.39; H, 6.66; N, 19.94. Found: C, 68.74; H, 6.58; N, 19.56.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-N-(2,3-dimethylphenyl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Stewart, Andrew O.; Kolasa, Teodozyj; US2003/232836; (2003); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 640-61-9,Some common heterocyclic compound, 640-61-9, name is N,4-Dimethylbenzenesulfonamide, molecular formula is C8H11NO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Prepared according to the general procedures. 1) Tube reactorwith 4 static mixers, a 6 mL reactor volume and a residencetime of 3 min, 1.5 M NaOCl (aq) at 1 mL/min and 1 MN-benzylmethylamine in EtOAc at 1 mL/min. 2) CSTR with a reactor volume of 50 mL, and residence time of 25 min. 1.1 MNaOCl (aq) at 1 mL/min and 1 M N-benzylmethylamine intoluene at 1 mL/min were used. The product was isolated foreach reactor volume by separation of the organic phase for eachreactor volume of solution and removal of the solvent by rotaryevaporation to give a white solid (1 reactor volume gives666 mg, 3.0 mmol, quantitative yield). NMR data matches thatreported in the literature [37]. 1H NMR (CDCl3, 500 MHz) deltappm 7.82 (d, J = 8.4 Hz, 2H, CHAr), 7.42 (d, J = 8.4 Hz, 2H,CHAr), 3.09 (s, 3H, NCH3), 2.48 (s, 3H, Ar-CH3); 13C NMR(CDCl3, 125 MHz) delta ppm 145.75 (CAr), 129.80 (2CHAr),129.78 (2 CHAr), 128.28 (CAr), 45.51 (NCH3), 21.70 (ArCH3).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N,4-Dimethylbenzenesulfonamide, its application will become more common.

Reference:
Article; Blacker, A. John; Jolley, Katherine E.; Beilstein Journal of Organic Chemistry; vol. 11; (2015); p. 2408 – 2417;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1259224-00-4, name is tert-Butyl (1-(4-aminophenyl)cyclobutyl)carbamate, A new synthetic method of this compound is introduced below., Formula: C15H22N2O2

To the solution of 4,6-dichloro-5-iodopyrimidine (5.50 g, 20.00 mmol) (prepared according to the ref of Organic Letters; English; 11; 8; 2009; 1837 – 1840; ) in dioxane (100 mL) was slowly added the solution of tert-butyl l-(4-aminophenyl)cyclobutylcarbamate (5.2 g, 20.00 mmol) in dioxane (20 mL) and Et3N(5 ml). The reaction mixture was stirred at 80C for overnight, lc-ms indicated 4,6-dichloro-5-iodopyrimidine was completed consumed. After removed the excess solvents under the reduced pressure to get a residue, which was dissolved in Ethyl acetate (250 mL) and washed water and brine. The combined organic layer was dried over Na2S04 and then filtered, the filtrate was concentrated to give the crude product, which was further purified by flash chromatography to afford tert-butyl l-(4-(6-chloro-5-iodopyrimidin-4- ylamino)phenyl)cyclobutylcarbamate. (5.00 g 50% yield).LC/MS: (ESI+): 501 [M+l], 523 [M+Na].

The synthetic route of 1259224-00-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; SKELTON, Nicholas; GRADL, Stefan; BLAKE, James F.; GRAHAM, James M.; GUNAWARDANA, Indrani W.; HENTEMANN, Martin; MARLOW, Allison L.; TANG, Tony P.; WO2013/78254; (2013); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 389890-43-1, name is tert-Butyl (cis-3-hydroxycyclobutyl)carbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 389890-43-1, HPLC of Formula: C9H17NO3

In a round-bottomed flask charged with tert-butyl(cis-3-hydroxycyclobutyl)carbamate (1.11 g, 5.93 mmol) and triethylamine (2.474 ml, 17.79 mmol) was added CH2Cl2 (12 ml). methanesulfonyl chloride (0.505 ml, 6.52 mmol) was added dropwise via syringe at -20 C. over 5 min. The reaction mixture was stirred at room temperature for 30 min, then diluted with water (15 mL) and extracted with CH2Cl2(2*). The organic extract was washed with saturated NH4Cl and dried over MgSO4. It was filtered and concentrated in vacuo to give cis-3-((tert-butoxycarbonyl)amino)cyclobutyl methanesulfonate (1.64 g, 6.1 mmol, 100% yield) as a off-white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl (cis-3-hydroxycyclobutyl)carbamate, and friends who are interested can also refer to it.

Reference:
Patent; AMGEN INC.; Allen, Jennifer R.; Amegadzie, Albert; Andrews, Kristin L.; Brown, James; Chen, Jian J.; Chen, Ning; Harrington, Essa Hu; Liu, Qingyian; Nguyen, Thomas T.; Pickrell, Alexander J.; Qian, Wenyuan; Rumfelt, Shannon; Rzasa, Robert M.; Yuan, Chester Chenguang; Zhong, Wenge; US2013/225552; (2013); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 85006-25-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 85006-25-3, name is tert-Butyl (tert-butoxycarbonyl)oxycarbamate, This compound has unique chemical properties. The synthetic route is as follows.

A solution of tert-butyl-N-(tert-butoxycarbonyloxy) carbamate (224 mg, 0.96 mmol) in DMF (2 [MNo.) ] was reacted with sodium hydride (38 mg, 0.96 mmol) at [0 C] and stirred for 20 mins at room temperature. The reaction mixture was treated by dropwise addition of benzyl [N- [4- (BROMOMETHYL)-2-FLUOROPHENYL]] carbamate compound 52 (250 mg, 0.74 mmol) and stirred for 1 hour. After concentrating, residual mixture was purified by column chromatography on Silica gel with EtOAc/hexanes (1: 5) solvent mixture as an eluant to give 355 mg of yellow oil of tert-butyl [N-[(TERT-BUTOXYVARBONYL) OXY]-N-{4-] [[(BENZYLOXY) CARBONYLAMINO]-3-FLUOROBENZYL} CARBAMATE] compound 53 (yield: [98%).] 1H-NMR [(CDC13)] 8 : 8.06 (bt, 1 H), 7.35-7. 45 (m, 5 H, Ph), 7.05-7. 12 (m, 2 H), 6.89 (bs, 1 H, NH), 5.22 (s, 2 H, [OCH2PH),] 4.68 (s, 2 H, CH2NO), 1.48 (s, 9 H, C [(CH3)] 3), 1.47 (s, 9 H, [ C (CH3) 3)]

The chemical industry reduces the impact on the environment during synthesis tert-Butyl (tert-butoxycarbonyl)oxycarbamate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Digital Biotech Co., Ltd.; WO2004/35533; (2004); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics