Amides-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 579474-47-8, name is tert-Butyl 2-amino-4-fluorophenylcarbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 579474-47-8, Product Details of 579474-47-8

Step 4. A mixture of tert-butyl 2-amino-4-fluorophenylcarbamate (2.70 g, 11.95 mmol), 4,6-dichloro-2-(methylsulfonyl)pyrimidine (2.71 g, 11.95 mmol) and DMSO (15 mmol) was stirred at ambient temperature overnight. The mixture was partitioned betweenethyl acetate and water. The organic phase was washed twice with water, then brine, dried over Mg504, then filtered and the remaining liquid evaporated. The residual tert-butyl 2-(6-chloro-2-(methylsulfonyl)pyrimidin-4-ylamino)-4-fluorophenylcarbamate was used directly in the next step.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; PTC THERAPEUTICS, INC.; DU, Wu; BAIAZITOV, Ramil; LEE, Chang-sun; MOON, Young-Choon; PAGET, Steven, D.; REN, Hongyu; SYDORENKO, Nadiya; WILDE, Richard, Gerald; WO2015/30847; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 316146-27-7, These common heterocyclic compound, 316146-27-7, name is N-(4-Bromophenyl)-3-phenylpropanamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

b) Preparation of intermediate 5; The reaction was carried out twice. POCl3 (1.225 mol) was added dropwise at 10¡ãC to DMF (0.525 mol). Then intermediate 4 (0.175 mol) was added at room temperature. The mixture was stirred overnight at 80¡ãC, poured out on ice and extracted with CH2Cl2. The organic layer was dried (MgSO4), filtered, and the solvent was evaporated. The product was used without further purification. Yield: 77.62 g of intermediate 5 (67 percent).

The synthetic route of 316146-27-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/14885; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 758-96-3 as follows. Computed Properties of C5H11NO

Weigh benzothiazole (0.5mmol, 67mg), K2S2O8 (2mmol, 0.54g) and Eosin Y (0.01mmol, 6.5mg) in a 25mL Schlenk reaction tube, and then add N, N-dimethylpropionamide (38mmol, 3.8g), placed under a 20W LED white light to react, stirred the reaction at room temperature, followed by TLC to monitor the progress of the reaction, the reaction was completed after 24 hours, the reaction solution was concentrated to remove the solvent, and the concentrated solution was separated by column chromatography (eluent Petroleum ether / ethyl acetate) in a volume ratio of 5: 1) to give a yellow oil, the derivative Ik. The yield was 66%.

According to the analysis of related databases, 758-96-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhejiang University of Technology; Weng Jianquan; Xu Wenxiu; Dai Xiaoqiang; Liu Xinghai; (11 pag.)CN110432282; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 513-74-6, These common heterocyclic compound, 513-74-6, name is Ammonium carbamodithioate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Following literature procedures,1 ammonia gas was bubbled into carbon disulfide 1 (16.7g, 0.22 mol) in THF (100 ml) keeping the temperature below 45 ¡ãC. After 1 hr, the reaction was stopped by allowing the temperature to decrease to rt. The excess ammonia gas was removed by streaming N2 for 30 min or by rotary evaporation under vacuum. The precipitate was collected by filtration to afford white solid ammonium dithiocarbamate 2 (23.1 g, 96percent). Methyl iodide (17.8 g, 0.125 mol) was added to a solution of 2 (5.5 g, 0.05 mol) in acetone (100 ml) at rt and the mixture was stirred for 24 hr. The solid was collected by filtration, washed with chilled acetone (20 ml) and dried under vacuum to provide white solid S,S?-dimethyliminodithiocarbonate hydroiodide ammonium iodide 3 (18.9 g, 96percent). 3 (7.9 g, 0.02 mol) was treated with sat. aq. NaHCO3 solution (100 ml x 2) and the organic products extracted with dichloromethane (50 ml). The organic layer was dried over Na2SO4 and concentrated in vacuo to a clear, colorless liquid 4 (2.3 g, 95percent). 1H NMR (400 MHz, CDCl3) delta 8.88 (s, 1H), 2.42 (s, 6H). 13C NMR (101 MHz, CDCl3) delta 172.10, 14.50. HRMS (ESI+) m/z calcd for C3H8N+ 122.0098, found 122.0096.

Statistics shows that Ammonium carbamodithioate is playing an increasingly important role. we look forward to future research findings about 513-74-6.

Reference:
Article; Pollock, Julie A.; Kim, Sung Hoon; Katzenellenbogen, John A.; Tetrahedron Letters; vol. 56; 44; (2015); p. 6097 – 6099;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 2603-10-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2603-10-3 as follows.

In a fixed bed reactor, 20 g of a supported heteropoly solid acid catalyst having a phosphomolybdic acid content of 1% added, the dimethyl carbonate was continuously added to a fixed bed reactor with a pump, and the temperature was raised to 80 C. Respectively, the preheating mass concentration of 5% phenylcarbamic acid methyl ester-dimethyl carbonate solution and concentration 10% formaldehyde solution to 80 C and simultaneously with a pump in a fixed bed reactor, Adjust the flow rate of phenylcarbamic acid methyl ester-dimethyl carbonate solution 0.4 ml/min, formaldehyde solution flow rate of 0.1 ml/min, Under normal pressure conditions for continuous condensation reaction, reaction material timing sampling analysis,MDC conversion rate of 99. 1%,The selectivity was 81.6%.Distillation crystallization gave dimethyl 4,4′-diphenylmethane dicarbamate.

According to the analysis of related databases, 2603-10-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; China Petroleum & Chemical Corporation; Research Institute of Nanjing Chemical Industry Group; He, yu miao; Jin, Hanjiang; Wu, Qijian; Jin, Yu Cun; Liu, Zhuo; Chen, Yongping; (5 pag.)CN106565545; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3118-68-1, name is 3-Cyanobenzenesulfonamide, A new synthetic method of this compound is introduced below., category: amides-buliding-blocks

Production Example 27 N-hydroxy-3-sulfamoylbenzene carboximidamide A mixture of 3-cyanobenzenesulfonamide (5.00 g), 50% hydroxylamine aqueous solution (1.84 mL) and ethanol (27 mL) was heated to reflux for 6 hours. Thereafter, the reaction solution was concentrated under a reduced pressure, so as to obtain the title compound (5.80 g) in the form of a colorless amorphous substance. 1H NMR (600 MHz, DMSO-d6) delta ppm 5.92 (s, 2H) 7.36 (s, 2H) 7.57 (t, J=7.79 Hz, 1H) 7.72-7.93 (m, 2H) 8.09-8.21 (m, 1H) 9.80 (s, 1H); MS (ESI neg.) m/z: 214 [M-H]-

The synthetic route of 3118-68-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; Nakamura, Toshio; Sakagami, Kazunari; Konishi, Kazuhide; Yamamoto, Kanako; Masuda, Seiji; Matsuda, Yohei; Okada, Kumiko; Shibata, Tsuyoshi; Ohta, Hiroshi; Yasuhara, Akito; Kawamoto, Hiroshi; Amada, Hideaki; Urabe, Hiroki; Nishikawa, Rie; Kashiwa ASHIWA, Shuhei; US2013/137865; (2013); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 144-80-9, name is N-((4-Aminophenyl)sulfonyl)acetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 144-80-9

2 mmol compound 1a or 1b and 0.194 g (2 mmol) potassiumthiocyanate in about 25 mL acetone were refluxed for 30 min. Theresulting solid (KCl) was removed by filtration. Then to this solutioncorresponding sulfonamides (2 mmol) in about 10 mL acetone wasadded dropwise, the mixture was stirred under reflux for 2 h. The resulting solution was evaporated under reduced pressure. Then,the residue was treated with the water to give crude product as awhite solid. The resulting crude product was stirred with diethyletherat room temperature for 1 h and then filtered. After theseexperimental procedures, the white colored substance was obtainedas pure.

The synthetic route of 144-80-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Koca, ?rfan; Yi?itcan, Serhat; Guemue?, Mehmet; Goekce, Halil; Sert, Yusuf; Journal of Molecular Structure; vol. 1204; (2020);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 138-41-0,Some common heterocyclic compound, 138-41-0, name is Carzenide, molecular formula is C7H7NO4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of 4-(aminosulfonyl)benzoic acid (500 mg, 2.5 mmol) in MeOH (2 ml) at O0C is added thionylchloride (0.2 ml, 7.4 mmol). The reaction mixture is stirred at rt overnight. When TLC confirms the total consumption of the starting acid, the solvent and excess thionyl chloride are removed under reduced pressure to afford 400 mg (75 %) of the title compound, which was used in the next step without any further purification. LC/MS: (ES+):215.9, (ES-):214.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Carzenide, its application will become more common.

Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2007/23186; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 24310-36-9, name is 1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one, A new synthetic method of this compound is introduced below., Quality Control of 1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

A solution of Br2 (558 mg, 3.48 mmol) in DCM (10 mL) was added dropwise to compound from Example 1 step 1 (1.00 g, 3.17 mmol), NBS (57 mg, 0.32 mmol), Et3N (352 mg, 3.48 mmol) in DCM (50 mL) at rt. The mixture was stirred at 50oC for 5 hrs and then quenched with water, extracted with DCM. The organic layer was washed with NaHCO3 (aq), concentrated and purified by silica gel column chromatography to give the desired compound (1.2 g, 96%) as brown solid. ESI MS m/z = 394.15 [M+1].

The synthetic route of 24310-36-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; YU, Jianming; SHOOK, Brian, C.; BLAISDELL, Thomas, P.; KIM, In, Jong; PANARESE, Joseph; MCGRATH, Kevin; NEGRETTI-ENMANUELLI, Solymar; OR, Yat, Sun; (301 pag.)WO2017/123884; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 1118-92-9, The chemical industry reduces the impact on the environment during synthesis 1118-92-9, name is N,N-Dimethyloctanamide, I believe this compound will play a more active role in future production and life.

Example 2; 1-octanol was produced from N,N-dimethyloctanamide according to the following equation.[0084] [Chem. 13] [0085] 0.01 mmol of the complex 1 produced in Example 1 was placed in a 50 mL-autoclave equipped with a stirrer, and the autoclave was purged with nitrogen. 300 microliters of methanol, 1 mmol of N,N-dimethyloctanamide, and 500 microliters of methanol solution of 2.0 M sodium methoxide were added to the autoclave, and the autoclave was purged with hydrogen. The resulting mixture was stirred under hydrogen atmosphere (5 MPa) and 100 degrees C for 16 hours to obtain a reaction solution. The reaction solution was analyzed by gas chromatography, and as a result, it was confirmed that the GC area percentage of the amide as a raw material was 2% and the GC area percentage of 1-octanol was 92%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N,N-Dimethyloctanamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAKASAGO INTERNATIONAL CORPORATION; OGATA, Osamu; KURIYAMA, Wataru; MATSUMOTO, Takaji; WO2012/39098; (2012); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics