Amides-buliding-blocks

Reference of 72505-21-6, These common heterocyclic compound, 72505-21-6, name is 4-(Trifluoromethyl)thiobenzamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate Example P; EMI70.1Ethyl 4- (1-methylethyl)-2- [4- (trifluoromethyl) phenyl]-1, 3-thiazole-5-carboxylate(XI-5a) Ethyl isobutyrylacetate(XI-3a) (3.006 g, 19.0mmol) was dissolved in chloroform (20 mL). Sulfuryl chloride (1.70 mL, 21.2mmol) was added and the solution was stirred at RT for 18 hours, then was concentrated. The residue was dissolved in ethanol (50 mL).4- (Trifluoromethyl) benzenethioamide (4.234 g, 20.6mmol) was added and the solution was heated to reflux for 24 hours. The mixture was cooled to RT and filtered. The solid was washed with cold ethanol and dried to provide the title product (2.68 g, 32%) as a pale yellowsolid.’H NMR (400 MHz,CDCI3)6 8.09 (d, J= 8.1 Hz, 2H), 7.69 (d, J= 8.1 Hz, 2H), 4.35 (q, J= 7.1 Hz, 2H), 3.99 (qu, J= 6.8 Hz,1H), 1.39 (t, J= 7.1 Hz,3H), 1.35 (d, J= 6.8 Hz, 6H).

Statistics shows that 4-(Trifluoromethyl)thiobenzamide is playing an increasingly important role. we look forward to future research findings about 72505-21-6.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/51890; (2005); A1;,
Amide – Wikipedia,
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Related Products of 6292-59-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a stirred solution of glucal (1 equiv.) and N-nucleophile (1.1 equiv.) inanhydrous 1,2-dichloroethanne (2 mL/mmol) under an atmosphere of argon was added Zn(OTf)2 (10 molpercent) at 40?C. The reaction mixture was stirred untilthe complete consumption of the starting material (glycal). The solvent wasfiltered and concentrated in vacuo, and the crude residue was redissolved indichloromethane and loaded on a silica gel column. The product was purified by silica gel column chromatography using hexane/EtOAc as the eluent to affordthe 2,3-unsaturated N-glycosides. All of the products were confirmed by1H NMR, 13C NMR, and MS/HRMS spectroscopy and compared with that of literature data; characterization data of new products are outlined in the experimentalsection

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(tert-Butyl)benzenesulfonamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Reddy, Thurpu Raghavender; Battina, Suresh Kumar; Kashyap, Sudhir; Journal of Carbohydrate Chemistry; vol. 34; 3; (2015); p. 133 – 144;,
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Related Products of 53844-02-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53844-02-3, name is Benzyl (2-bromoethyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of 1 (15.0mmol) in CH3CN (60mL) were added K2CO3 (3.10g, 22.5mmol) and N-Cbz-2-bromoethylamine (3.87g, 15.0mmol) under stirring. It was then kept at 80C, and monitored by TLC (Hexane/EtOAc=2/1, v/v). Next, K2CO3 was removed by filtration. The filtrate was concentrated to give a light brown oil. The oil was dissolved in ethyl acetate (150mL) and the solution was washed with water (2¡Á50mL). The organic phase was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude product. The residue was concentrated and purified by silica gel column chromatography (Hexane/EtOAc=4/1, v/v) to give a white solid

The synthetic route of Benzyl (2-bromoethyl)carbamate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ao, Chunyan; Men, Jian; Wang, Yang; Shao, Tao; Huang, Yuanyuan; Huo, Junji; Gao, Guowei; Tetrahedron Asymmetry; vol. 27; 13; (2016); p. 589 – 595;,
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These common heterocyclic compound, 138-41-0, name is Carzenide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Carzenide

Compound 3-7 (300 mg, 1.33 mmol), p-sulfonamide benzoic acid (294 mg, 1.46 mmol, 1.1 eq.), HOBt (539 mg, 3.99 mmol, 3 eq.) and EDCI (765 mg, 3.99 mmol, 3 eq.) in 50 mL Single mouth bottle,DMF and TEA (0.74 mL, 5.32 mmol, 4 eq.) were added.Stir at room temperature overnight. TLC tracking monitoring. Rotate the DMF,Add EA and water for extraction, wash with saturated brine, dry, spin dry, and pass through column (DCM:acetone = 3:1). A white solid of 450 mg was obtained in a yield of 83%.

The synthetic route of Carzenide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangzhou Hengnuokang Pharmaceutical Technology Co., Ltd.; Zhang Jiancun; Lin Cai; Zou Qingan; (45 pag.)CN108456208; (2018); A;,
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Application of 3984-14-3, These common heterocyclic compound, 3984-14-3, name is N,N-Dimethylsulfamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 5 (+/-)8-cyclohexyl-N-[(dimethylamino)sulfonyl]-1,1a,2,12b-tetrahydro-1a-(4-morpholinylcarbonyl)-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide. A 2M solution of oxalyl chloride (0.093 mL, 0.186 mmol) in CH2Cl2 was added dropwise to a solution of (+/-)-8-cyclohexyl-1,1a,2,12b-tetrahydro-1a-(4-morpholinylcarbonyl)-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid (45 mg, 0.093 mmol) in CH2Cl2 (10 mL), containing one drop of DMF. The reaction mixture was stirred at rt. for 2 hr., after which it was concentrated and dried under high vacuum. The residue was subsequently dissolved in THF (10 mL) and a solution of N,N-dimethylsulfonamide, (23 mg, 0.186 mmol) and DIPEA (0.049 mL, 0.279 mmol)) in THF (2 mL) was added. This was followed by the addition of DMAP (10 mg), after which the reaction was stirred at rt. for 10 min., and then at 50 C. overnight. It was then cooled, and the mixture concentrated under reduced pressure. The resultant residue was purified by preparative reverse phase HPLC to afford the product as a yellow solid, (5.0 mg, 9% yield). MS m/z 591(MH+), Retention time: 3.525 min; 1H NMR (300 MHz, CD3OD) delta ppm. Compound was observed to exist as inter-converting rotamers, as evidenced from the compound’s NMR spectrum.

The synthetic route of 3984-14-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/60565; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 154350-29-5, These common heterocyclic compound, 154350-29-5, name is Cyclopropanesulfonamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To an iced slurry of cyclopropanesulfonamide (1.21 g, 9.99 mmol), Triethylamine (2.95 mL, 20.97 mmol), and 4-Dimethylaminopyridine (0.061 g, 0.499 mmol) in CH2Cl2 (50 mL) was added solution of Di-tert-butyl dicarbonate (2.423 mL, 10.99 mmol) in DCM (10 mL) dropwise. The formed solution was stirred at room temperature overnight, Removed the solvent in vacuo. The residual oil was taken up in EtOAc and washed with 1M HCl and brine. Dried over MgSO4, filtered, and concentrated. The residue was purified by Biotage column, eluted with gradient 5percent50percent acetone-hexane to yield the desired produce tert-butyl cyclopropylsulfonylcarbamate (2.17 g, 9.61 mmol, 96percent yield) as a viscous oil, which solidified upon standing on bench. 1H NMR (400 MHz, CDCl3) ppm 1.11-1.13 (m, 2H) 1.37-1.39 9m, 2H) 1.53 (s, 9H), 2.89-2.92 (m, 1H) 7.00-7.05 (b, NH).

The synthetic route of 154350-29-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bristol-Myers Squibb Company; US2010/150866; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 811442-84-9, name is tert-Butyl (14-amino-3,6,9,12-tetraoxatetradecyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows., name: tert-Butyl (14-amino-3,6,9,12-tetraoxatetradecyl)carbamate

200 mg (0.594 mmol) of tert-butyl (14-amino-3,6,9,12-tetraoxatetradec-1-yl)carbamate, 111 mg (0.713 mmol) of (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid and 410 mul (2.4 mmol) of N,N-diisopropylethylamine were dissolved in 6 ml of dimethylformamide, and 339 mg (0.892 mmol) of HATU were added. The reaction mixture was stirred at RT for 1 h and purified directly by preparative RP-HPLC (column: Reprosil 250¡Á30; 10mu, flow rate: 50 ml/min, MeCN/water, 0.1% TFA). The solvents were evaporated under reduced pressure and the residue was dried under high vacuum. This gave 130 mg (43% of theory) of tert-butyl [17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]carbamate. LC-MS (Method 1): Rt=0.71 min; MS (ESIpos): m/z=474 (M+H)+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 811442-84-9.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; MARX, Leo; JOHANNES, Sarah Anna Liesa; STELTE-LUDWIG, Beatrix; DIETZ, Lisa; TERJUNG, Carsten; MAHLERT, Christoph; GREVEN, Simone; SOMMER, Anette; BERNDT, Sandra; (481 pag.)US2019/77752; (2019); A1;,
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Some common heterocyclic compound, 207405-68-3, name is tert-Butyl endo-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate, molecular formula is C12H22N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C12H22N2O2

step 2-A mixture of 68b (2 mmol) and 80 (2 mmol) in n-BuOH was heated in a sealed tube at 160 C. for 6 h. When no starting material was detected by TLC, the reaction was cooled to RT and concentrated in vacuo. The crude product 82a was used in the next step without further purification

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 207405-68-3, its application will become more common.

Reference:
Patent; Roche Palo Alto LLC; US2008/146595; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13304-62-6, name is N-Benzylacrylamide, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 13304-62-6

A mixture of 11-iodo-7,12-dihydropyrido[2?,3?:2,3]azepino[4,5-b]indol-6(5H)-one (11 b, 200mg, 0.530mmol), N-benzylacrylamide (95mg, 0.59mmol), triethylamine (101mg, 1.00mmol, 0.14mL), and Pd(OAc)2 (7mg, 0.03mmol) in DMF (3 mL) was heated for 40 min to 100 C in a sealed microwave reaction vial by means of a mono mode microwave device (100 W, 150 PSI, CEM Discover, CEM GmbH, Kamp-Lintfort, Germany). After cooling to room temperature the mixture was filtered through a charcoal frit. Upon addition of ethyl acetate (220 mL) to the filtrate a precipitate formed, which was filtered off and was washed on the frit with n-hexane (320 mL). In the combined washing layers more precipitate formed, which was also filtered off. The combined precipitates were crystallized from ethanol to yield a brown solid (49.0 mg, 22.7%); dec. starting at 226 C; IR (KBr): 3423 (NH), 2918 (CH aliphat.), 1655 (C=O), 1441, 1350 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 11.95 (s, 1H), 10.38 (s, 1H), 8.64 (t, 1H, 3JH,H = 6.0 Hz), 8.44 (dd, 1H, 3JH,H = 4.7 Hz, 4JH,H = 1.7 Hz), 8.36 (dd, 1H, 3JH,H = 7.9Hz, 4JH,H = 1.8 Hz), 8.23 (d, 1H, 3JH,H = 15.5 Hz), 7.95 (s, 1H), 7.75 (dd, 1H, 3JH,H= 7.8 Hz, 4JH,H = 0.9 Hz), 7.59 – 7.45 (m, 1H), 7.44 – 7.30 (m, 4H), 7.32 – 7.20 (m, 1H), 7.22 – 7.09 (m, 1H), 6.86 (d, 1H, 3JH,H = 15.6 Hz), 4.46 (d, 2H, 3JH,H = 5.9Hz), 3.63 (s, 2H); 13C NMR (100.6 MHz, DMSO-d6): delta = 171.4, 165.2, 162.3, 147.7, 139.4, 136.6, 131.2, 127.4, 117.6, 108.4 (quat C); 147.6, 136.3, 134.5, 128.3 (2C), 127.4 (2C), 126.8, 122.1, 119.5, 119.5, 119.3, 119.0 (tert C); 42.3, 35.7 (sec C); C25H20N4O2 (408.45); MS (EI): m/z = 408 ([M]+, 95), 301 (52), 274 ([C17H12N3O]+, 21), 259 (100); HRMS (EI): m/z ([M]+) calcd. 408.15808, found 408.15883; HPLC: 96.8% at 254 nm, 97.1% at 280 nm, tN = 6.4 min, tM = 1.09 min (ACN/H2O; 40:60), max = 269, 338 nm.

According to the analysis of related databases, 13304-62-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Maiwald, Franziska; Benitez, Diego; Charquero, Diego; Dar, Mahin Abad; Erdmann, Hanna; Preu, Lutz; Koch, Oliver; Hoelscher, Christoph; Loaec, Nadege; Meijer, Laurent; Comini, Marcelo A.; Kunick, Conrad; European Journal of Medicinal Chemistry; vol. 83; (2014); p. 274 – 283;,
Amide – Wikipedia,
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Electric Literature of 640-61-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 640-61-9, name is N,4-Dimethylbenzenesulfonamide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a resealable Schlenk tube was added Fe3O4SiO2-P-AuOTf (66 mg, 0.025 mmol). The reaction tubewas evacuated and back-filled with argon and this evacuation/back-fillprocedure was repeated one additional time. Alkynylcyclopropane(0.5 mmol), sulfonamide (0.6 mmol) and DCE (5 mL) were then addedunder a stream of argon. The reaction tube was quickly sealed and thecontents were stirred while heating in an oil bath at 100 C for 24 h. After thereaction mixture was cooled to room temperature, the supported goldcatalyst was magnetically separated and the reaction mixture wasconcentrated under vacuum and then purified by flash chromatography(petroleum ether/ethyl acetate = 7:1) to afford the corresponding product.The recovered gold catalyst was washed with DCE (2 2 mL), air-dried andused directly for the next run.

The chemical industry reduces the impact on the environment during synthesis N,4-Dimethylbenzenesulfonamide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Yi, Feiyan; Huang, Bin; Nie, Quan; Cai, Mingzhong; Tetrahedron Letters; vol. 57; 39; (2016); p. 4405 – 4410;,
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