Amides-buliding-blocks

Reference of 147291-66-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 147291-66-5, name is tert-Butyl 3-aminobenzylcarbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of3 g (13.5 mmol) (3-amino-benzyl)-carbamic acid tert-butyl ester (WO 9740028 Al) and 1.81 ml (13.5 mmol) benzoyl isothiocyanate in 60 ml THF was stirred at room temperature for 1 h and afterwards evaporated under reduced pressure. 80 ml MeOH and 5.6 g (40.5 mmol) potassium carbonate in 80 ml water were added and the mixture was stirred at room temperature for 16 h. The mixture was concentrated under reduced pressure and extracted with ethyl acetate. The organic layers were washed with saturated NaHCO3 solution and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica eluding with a gradient of hexane/ethyl acetate to yield after evaporation of the product fractions 3.56 g (94%) of the title compound as yellow amorphous solid. 1-H-NMR (300 MHz, DMSO d6) ?=1.39 (s, 9H, Boc), 4.10 (d, J=6.0 Hz, 2H, CH2), 6.9-7.4 (m, 7H, Ar+NHBoc+NH2), 9.69 ppm (s, 1H, NH). MS (m/e): 282.0 (MH+, 100%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 3-aminobenzylcarbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Neidhart, Werner; Nettekoven, Matthias Heinrich; Pflieger, Philippe; US2005/38089; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 40724-47-8, name is 4-Bromomethylbenzenesulfonamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 4-Bromomethylbenzenesulfonamide

[0174] In a microwave tube was placed ethyl 2-(3 -([1,1? -biphenyll -3-yl)-4-(4,4 ,5 ,5- tetramethyl- 1,3 ,2-dioxaborolan-2-yl)- 1 H-pyrazol- 1 -yl)thiazole-4-carboxylate (91 mg, 0.1 mmol), 4-(bromomethyl)benzenesulfonamide (25.01 mg, 0.100 mmol), and Pd(Ph3P)4 (11.56 mg, 10.00 tmol). The tube was sealed and air was removed and re-filled with N2 (2-3 times). A mixture of toluene (0.75 ml, ratio: 2.500)/EtOH (0.3 ml, ratio: 1.000) was added, and then 2N Na2CO3(aq) (0.3 mL, 0.6 mmol, 6 equiv) was added. The mixture was stirred at 80 ¡ãC (pre-heated) for 2 h. The organic layer was separated, and the aqueous layer was extracted with EtOAc (2 mL x 3). The combined organic layer was dried (Na2504) and filtered. After removal of the solvent, the product was purified by silica gel chromatography using 30-60percent EtOAc/hexane as the eluent to give ethyl 2-(3-([1,1?-biphenyll-3-yl)-4-(4-sulfamoylbenzyl)- 1H-pyrazol-1-yl)thiazole-4-carboxylate 20 (35 mg, 0.064 mmol, 64.3percent yield) as a white solid. Some of the reduction product (ca. 30 mg) from either the reaction and/or from a previous step was collected and subjected to hydrolysis to give 22 (see Example 31, Scheme7A).

The synthetic route of 40724-47-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; VANDERBILT UNIVERSITY; MALONEY, David J.; JADHAV, Ajit; BANTUKALLU, Ganesha Rai; BRIMACOMBE, Kyle Ryan; MOTT, Bryan T.; YANG, Shyh Ming; URBAN, Daniel Jason; HU, Xin; SIMEONOV, Anton; KOUZNETSOVA, Jennifer L.; WATERSON, Alex Gregory; SULIKOWSKI, Gary Allen; KIM, Kwangho; CHRISTOV, Plamen; JANA, Somnath; (387 pag.)WO2016/109559; (2016); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 79-16-3, A common heterocyclic compound, 79-16-3, name is N-methylacetamide, molecular formula is C3H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A Schlenk tube was charged with amide (1.2 mmol), aryl iodides (1 mmol), CuI (0.1 mmol), N,N-dimethylglycine (0.2 mmol), and potassium phosphate (2 mmol). The tube was evacuated and backfilled with argon at room temperature. DMF (0.5 mL) was added under argon via syringe. The Schlenk tube was immersed in a preheated oil bath and the reaction mixture was stirred for the specified time at the indicated temperature. The cooled mixture was partitioned between water and ethyl acetate. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by column chromatography on silica gel (eluting with 1:8 to 1:2 ethylacetate/petroleum ether) to give the the desired N-aryl amides.

The synthetic route of 79-16-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jiang, Liqin; Molecules; vol. 19; 9; (2014); p. 13448 – 13460;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 21744-84-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21744-84-3, name is 4-Methyl-2H-1,4-Benzoxazin-3-one belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of (2-chloro-5-methoxy-phenyl)-acetic acid (1 g) in tetrahydrofuran (20 ml) were added N,N-dimethylformamide (2 drops) and oxalylchloride (1.03 g). The mixture was stirred overnight at room temperature. The solvent was evaporated; toluene was added and again evaporated. The residue was dried under high vacuum to give the crude acid chloride. To a cooled solution (ice bath) of 4-methyl-2H-1,4-benzoxazin-3(4H)-one (830 mg) in 1,2-dichloroethane (5 ml) was added AlCl3 (1.99 g). The mixture was stirred for 10 min and a solution of the acid chloride in 1,2-dichloroethane (5 ml) was added dropwise. The mixture was stirred at 0 C. for 4.5 h. The mixture was poured into ice water and hydrochloric acid and extracted with dichloromethane. The organic phase was dried (MgSO4), filtered and concentrated. The product was purified by chromatography (SiO2, cyclohexane/EtOAc 1_0=>0:1) to give the title compound (1.6 g) as an off-white solid. MS (m/e)=346.1 [M+H-].

The synthetic route of 4-Methyl-2H-1,4-Benzoxazin-3-one has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius; US2010/249124; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

402-46-0, name is 4-Fluorobenzenesulfonamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C6H6FNO2S

To a solution of 4-fluorobenzenesulfonamide (1 .02 g, 5.71 mmol) in H20 (10 mL) was added piperazine (2.46 g, 28.55 mmol). The reaction mixture was stirred at 100 00 overnight. The mixture was cooled to room temperature and filtered. The filtration cake was washed with H20 (20 mL), toluene(30 mL) and ether (30 mL) to give 26.1 (401 mg, 29% yield). MS (ESI) m/z = 242.0 [M¡ÂH]. 1H NMR (400 M, DMSO-c), oe 7.60 (d, J = 8.8 Hz, 2H), 7.05 (m, 2H), 7.00 (d, J = 8.8 Hz, 2H), 3.17 (m, 4H), 2.80 (m, 4H), 2.33 (m, 1H).

The synthetic route of 402-46-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNITY BIOTECHNOLOGY, INC.; BACKES, Bradley; W. VON GELDERN, Thomas; CHEN, Bing; (121 pag.)WO2017/101851; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 194920-62-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 194920-62-2 name is tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of 7 (10.8 g, 30.3 mrnol, 1.0 equiv) in DCM (400 mL) was treated at 4 C with triethylamine (5.29 mL, 37.9 minol, 1.3 equiv), followed by allyl chloroformate (3.56 mL, 33.4 rnmol, 1.1 equiv) . After 15 mm, the reaction was allowed to warm to room temperature and was stirred for 2 h. Then, the reaction mixturewas washed with water (3 x 250 mL), dried over MgSO4, filtered and concentrated under reduced pressure. The product waspurified by flash chromatography (200 g SiC2 ethylacetate/hexanes 1:1, then ethyl acetate) to give 8 (11.0 g, 90%)as a colorless oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate, and friends who are interested can also refer to it.

Reference:
Patent; ETH ZURICH; CARREIRA, Erick, Moran; SCHAFROTH, Michael, Andreas; SOBOTZKI, Nadine; WOLLSCHEID, Bernd; (67 pag.)WO2017/81069; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 6228-73-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6228-73-5, name is Cyclopropanecarboxamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a microwave tube was added7-chloro-2-(2,6-dichlorophenyl)thieno[2,3-c]pyridine(150 mg, 0.48 mmol),cyclopropanecarboxamide(81 mg, 0.95 mmol), Pd2(dba)3(22 mg, 0.024 mmol), XantPhos (28 mg, 0.048 mmol), Cs2CO3(311 mg, 0.95 mmol) and dioxane (4 mL).The mixture was degassed with N2for 10 min. The resulting mixture was irradiated in a microwave reactor at 150 C for 1.5 h and then cooled to room temperature. The mixture was filtered throughCeliteand the filtrate was concentrated. The residue was purified by silica gel column chromatography eluting with a 0-60% gradient ofEtOAcin dichloromethane to afford a solid. The solid was triturated with diethyl ether and collected by filtration to afford the title compound (110 mg, 64% yield). H NMR (300 MHz, CDCl3):delta 8.96 (1H,brs), 8.21 – 8.17 (1H, m), 7.55 (1H, d,J= 5.5 Hz), 7.45 – 7.41 (2H, m), 7.35-7.24 (2H, m), 1.24 – 1.15 (3H, m), 0.99 – 0.91 (2H, m); LCMS (ESI) m/z: 363.2 [M+H]+.HRMS m/z [M+H]+calcd.forC17H12Cl2N2OS 363.0125, found 363.0118.

The synthetic route of Cyclopropanecarboxamide has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liang, Jun; Van Abbema, Anne; Balazs, Mercedesz; Barrett, Kathy; Berezhkovsky, Leo; Blair, Wade S.; Chang, Christine; Delarosa, Donnie; DeVoss, Jason; Driscoll, Jim; Eigenbrot, Charles; Goodacre, Simon; Ghilardi, Nico; MacLeod, Calum; Johnson, Adam; Bir Kohli, Pawan; Lai, Yingjie; Lin, Zhonghua; Mantik, Priscilla; Menghrajani, Kapil; Nguyen, Hieu; Peng, Ivan; Sambrone, Amy; Shia, Steven; Smith, Jan; Sohn, Sue; Tsui, Vickie; Ultsch, Mark; Williams, Karen; Wu, Lawren C.; Yang, Wenqian; Zhang, Birong; Magnuson, Steven; Bioorganic and Medicinal Chemistry Letters; vol. 27; 18; (2017); p. 4370 – 4376;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 75175-77-8

General procedure: N,N-Dimethylenaminones 1 (1.0 mmol), amines 2 (0.5mmol), PEG-400 (5 mL), oxone (1.2 eq) and trifluoroacetic acid (TFA) (0.2 mL) were charged into a 25 mL round-bottom flask, and the mixture was stirred at 120 oC for 20 min until the N,N-dimethyl enaminones1 were completely consumed. The mixture was cooled to room temperature,neutralized with a saturated solution of Na2CO3 to pH 8-9, and then EtOAc (30 mL ¡Á 2) were added. The organic phase was washed with water (20 mL), dried over Na2SO4, concentrated and purified by flash column chromatography to afford 1,4-DHPs 3 in a 50-72% yield.

According to the analysis of related databases, 75175-77-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yu, Fu-Chao; Zhou, Bei; Xu, Hui; Chang, Kwen-Jen; Shen, Yuehai; Tetrahedron Letters; vol. 56; 6; (2015); p. 837 – 841;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 148017-28-1, name is tert-Butyl sulfamoylcarbamate, This compound has unique chemical properties. The synthetic route is as follows., category: amides-buliding-blocks

Step b: fert-Butyl (aminosulf onyl) f r(3aR,4R<6R,6aR)-6-(6-chloro-9H-purin-9-yl)- 2,2-dimethyltetrahydrofuror3,4-rfiri31dioxol-4-yl1memyl)carbamate; [0237] (2R/3R,4S,5R)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (6.352g, 0.01944mol), N-Boc-sulfamide (5.717g, 0.02913mol) and triphenylphosphine (6.119g, 0.02333mol) were dissolved in ethyl acetate (20OmL) under nitrogen and diisopropyl azodicarboxylate (5.742mL, 0.02916mol) was added dropwise. The solution was stirred for 2h, and then concentrated in vacuo. The residue was purified by flash chromatography (Hex/EtOAc 25% to 65%) to afford 5.46Og of product as a white solid and 1.4Og of product with triphenylphosphine oxide impurity. This second batch was purified by flash chromatography (Hex/EtOAc 20% to 60%). The product was obtained as a white solid (6.16Og, 63%).[0238] LCMS: R.t. 1.66 min ES+ 505 (formic acid). Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 148017-28-1. Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2006/84281; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 774-67-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 774-67-4, name is 4-Amino-N-isopropylbenzamide, This compound has unique chemical properties. The synthetic route is as follows.

(14) methyl 3-(Z)-[1-{4-[isopropyl-carbamoyl]-phenylamino}-1-phenyl-methylidene]-2-indolinone-6-carboxylate Prepared from 1-acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone and 4-amino-N-isopropyl-benzamide. Yield: 0.18 g (46% of theoretical), Melting point: 273-274 C.

The chemical industry reduces the impact on the environment during synthesis 4-Amino-N-isopropylbenzamide. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Roth, Gerald Juergen; Heckel, Armin; Lehmann-Lintz, Thorsten; Kley, Joerg; Hilberg, Frank; Van Meel, Jacobus; US2003/92756; (2003); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics