Amides-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 955406-36-7, name is Benzyl (3-hydroxycyclohexyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Benzyl (3-hydroxycyclohexyl)carbamate

Solid TBSCI (2.66 g, 17.6 mmol) was added to a stirring mixture of benzyl (3-hydroxycyclohexyl)carbamate (4.0 g, 16 mmol) and imidazole (1.63 g, 24 mmol) inDMF (16 mL). After 3 h the mixture was partitioned with 2 M HCI (100 mL) and Et20(100 mL). The layers were separated and the aqueous phase was extracted with Et20(2 x 50 mL). The combined organic extracts were concentrated and purified by flashchromatography to afford the desired cis diastereomer 53 (2.99 g, 73% based on 7:3 dr in starting material). H (400 mHz, CDCI3) 0.06 (6H, s), 0.89 (9h, s), 1.28-1.51 (4H, m), 1.60-1.71 (2H, m), 1.75-1.85 (1H, m), 1.86-1.93 (1H, m), 3.70-3.80 (1H, m), 3.83- 3.92 (1 H, m), 5.08 (2H, distorted ABq), 5.70 (1 H, br s), 7.27-7.37 (5H, m); (150mHz, CDCI3)-5.0, -4.8, 18.0, 25.8, 31.4, 34.0, 39.4 br, 47.4, 66.2, 68.9, 127.8, 127.85,155.5, 128.4, 136.9; m/z (ES+) 364.3 [M+H HRMS (ES+) exact mass calculated forC20H34NO3Si [M+H], 364.2308; found 364.2301. The stereochemistry was confirmedby conversion of a sample to the known cis-benzyl (3-hydroxycyclohexyl)carbamate byTBAF deprotection: H (400 MHz, CDCI3) 1.10-1.39 (4H, m), 1.67-1.89 (3H, m), 2.20-2.29 (1H, m), 3.53-3.89 (1H, m), 3.69-3.81 (1H, m), 5.09 (3H, brs), 7.27-7.40 (5H,m).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 955406-36-7.

Reference:
Patent; UNIVERSITY COLLEGE CORK; KATHOLIEKE UNIVERSITEIT LEUVEN; DEHAEN, Wim; BALZARINI, Jan; MAGUIRE, Anita; KEANE, Sarah Jane; FORD, Alan; MAGUIRE, Nuala; MULLINS, Nicholas, D.; WO2014/79903; (2014); A1;,
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Electric Literature of 37045-73-1,Some common heterocyclic compound, 37045-73-1, name is 3-(Methylsulfonamido)aniline, molecular formula is C7H10N2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The solution of cyanuryl chloride (1 mmol, 1 equiv.) in THF (20 ml) was stirred,cooled to -10 C, and aniline (1 mmol, 1 equiv.) in THF (6 ml) and DIEA (3.6 mmol, 1.2equiv.) was added dropwise. The mixture was stirred at this temperature for 0.5-2 h. Uponcompletion, monitored by TLC, another aniline (1 mmol, 1 equiv.) was added. The mixturewas stirred under room temperature for 2-12 h. After the solvent was removed under reducedpressure the resulting solid was collected by filtration, dried and crystallised or purified bysilica gel column chromatography to get the desired product as a white solid.

The synthetic route of 37045-73-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Dao, Pascal; Jarray, Rafika; Le Coq, Johanne; Lietha, Daniel; Loukaci, Ali; Lepelletier, Yves; Hadj-Slimane, Reda; Garbay, Christiane; Raynaud, Francoise; Chen, Huixiong; Bioorganic and Medicinal Chemistry Letters; vol. 23; 16; (2013); p. 4552 – 4556;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 563-83-7, name is Isobutyramide, A new synthetic method of this compound is introduced below., name: Isobutyramide

Step A: 2-Methylpropanethioamide; H*C^NH2 CH*A solution of 2-methylpropanamide (6.53 g, 75.0 mmol) and 2,4-bis(4- methoxyphenyl)-1 ,3-dithia-2,4-diphosphetane-2,4-disulfide (15.17 g, 37.51 mmol) in THF (100 ml_) was heated to reflux for 4 h. The reaction mixture was then cooled to rt and poured into saturated aqueous NaHCO3 (200 ml_). The mixture was extracted with ether (4 x 100 ml_). The organic fractions were combined, dried over Na2SO4, filtered, and concentrated. Purification by flash column chromatography (20% EtOAc: hexanes) afforded 4.77 g (62%) of the title compound of Step A. 1H-NMR (400 MHz, CDCI3) delta 7.63 (brs, 1 H), 6.90 (brs, 1 H), 2.88 (m, 1 H), and 1.27 (d, 6H, J = 6.8 Hz).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/76140; (2009); A1;,
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Synthetic Route of 5511-18-2, The chemical industry reduces the impact on the environment during synthesis 5511-18-2, name is Adamantane-1-carboxamide, I believe this compound will play a more active role in future production and life.

A solution of adamantanecarboxamide (1 mmol) in THF (4 mL) was treated with LiAIH4 (4 mmol) at 0 C and stirred under a N2 atmosphere whilst warming to room temperature. After 2 h, the reaction was heated at reflux for 16 h and then cooled on ice. Chilled H20 (150 pL) was added dropwise, with vigorous stirring, and then followed by aqueous sodium hydroxide (15% wiv, 150 pL) and additional water (0.5 mL). The solution was left stirring at room temperature until effervescence had ceased and the grey powder had turned white (30 min). The solution was dried (MgS04) and then filtered. The precipitate was washed with additional dichloromethane (2 x 4 mL). The filtrates in each case were combined. Purification was carried out as follows

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Adamantane-1-carboxamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE UNIVERSITY OF SYDNEY; KASSIOU, Michael; FIGTREE, Gemma; O’BRIEN-BROWN, James; WILKINSON, Shane; HANSEN, Thomas; (64 pag.)WO2020/37350; (2020); A1;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5004-88-6 as follows. Computed Properties of C9H12N2O3

General procedure: A mixture of 2-chlorobenzoic acid (1b) (0.61 g, 3.92 mmol) and thionyl chloride (1 mL) was heated for 2 h. The excess of thionyl chloride was recovered under reduced pressure and the residue so obtained was dissolved in dry dioxane (1 mL). The solution was then dropwise added to mixture of 2-amino-4,5-dimethoxybenzamide (2) (0.7 g, 3.57 mmol) and TEA (1.2 mL, 8.92 mmol) in dry dioxane (2 mL) at 10 C. The reaction mixture was stirred at rt for another 1 h and quenched into cold water (50 mL). The precipitate formed was filtered, washed with water and dried to obtain compound 3b (0.85 g, 71%).

According to the analysis of related databases, 5004-88-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yadav, Mange R.; Grande, Fedora; Chouhan, Bishram S.; Naik, Prashant P.; Giridhar, Rajani; Garofalo, Antonio; Neamati, Nouri; European Journal of Medicinal Chemistry; vol. 48; (2012); p. 231 – 243;,
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Synthetic Route of 71026-66-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 71026-66-9, name is tert-Butyl (4-aminophenyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The aldehyde (294 mg, 1.68 mmol, 1 eq. ) was added to a solution of aniline (350 mg, 1.68 mmol, 1 eq. ) and MGS04 (420 mg, 3.36 mmol, 2 eq. ) in 10 mL of toluene. The reaction mixture was stirred at 25 C for 12h, and the solvents were evaporated to give the imine (85%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (4-aminophenyl)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CAREX S.A.; WO2004/72046; (2004); A2;,
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Electric Literature of 57957-24-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57957-24-1, name is N-(1-Phenylvinyl)acetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

; (Examples 10 to 22); In a 50-mL autoclave, 6 mg (1.0¡Á10-2 mmol) of the [rhodium(I)((1S,1S’,2R,2R’)-1,1′-do-tert-butyl-[2,2′]-diphosphetane)(norbornadiene)]hexafluorophosphate synthesized in Example 8 and used as a catalyst and 1 mmol of the dehydroamino acid derivative (or enamide derivative) shown in Table 1 were charged. Then, the system was evacuated and purged with hydrogen four times. The autoclave was returned to normal pressure, and a cock was opened to rapidly add 4 mL of degassed dehydrated methanol from the cock using a syringe and then closed. The reactor was cooled with dry ice/ethanol, and then the reaction system was again evacuated and purged with hydrogen four times. After the hydrogen pressure was set to a predetermined value, the refrigerant was removed, and the reaction system was stirred with a magnetic stirrer until hydrogen consumption was stopped. After the completion of reaction, the reaction solution was passed through silica gel column chromatography (developing solvent: ethyl acetate) to remove the catalyst, and then the residue was concentrated with an evaporator to obtain a reduced product. In any reaction, the yield was about 100%. The optical purity (ee) of each product was analyzed with chiral HPLC or chiral GC. The results are shown in Table 1. These results were obtained at a ratio of substrate : catalyst = 100 : 1. [Table 1]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(1-Phenylvinyl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Amide – Wikipedia,
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Electric Literature of 115643-59-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 115643-59-9, name is 2-Amino-6-fluorobenzamide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Compound 14 was prepared according tothe procedure previously reported.38 A solution of sodiumnitrite (4.14 g, 60 mmol) in 0.5 N HCl (240 mL) was stirred at0 C for 20 min. Anthranilamide 13 (30 mmol) dissolved inN,N-dimethylformamide (DMF, 15 mL) was then addeddropwise to the solution described above for 40 min. Afterthe mixture had been stirred for an additional 1 h at 0 C, 30%aqueous ammonia was added slowly to adjust the pH to 10.0.The reaction mixture was allowed to stir for 15 min and thenreacidified to pH 2.0. After the mixture had been stirred for 30min, the precipitated product was filtered off with suction,washed with water (200 mL), and dried to afford compound 14in yields of 75-83%.

The chemical industry reduces the impact on the environment during synthesis 2-Amino-6-fluorobenzamide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Zhou, Yuan; Feng, Jiangtao; He, Hongwu; Hou, Leifeng; Jiang, Wen; Xie, Dan; Feng, Lingling; Cai, Meng; Peng, Hao; Biochemistry; vol. 56; 49; (2017); p. 6491 – 6502;,
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Synthetic Route of 99733-18-3,Some common heterocyclic compound, 99733-18-3, name is tert-Butyl (7-aminoheptyl)carbamate, molecular formula is C12H26N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: tert-butyl(3-aminopropyl)carbamate (3a,508 mg, 2.93 mmol)was added toa stirred solutionof4-aminobenzoic acid (2a, 200 mg, 1.46 mmol), EDCI (421mg, 2.20 mmol), HOBt(237 mg, 1.76 mmol), DIEA (502 muL, 2.92 mmol) in DMF (10 mL), stirred overnight at RT. After monitored by TLC to observe completion of reaction, the mixture was diluted with water (20 mL), and then the water phase was extracted with ethylacetate (20 mL¡Á2). The combined organic phase was washed with water (20 mL¡Á3)for three times and dried with anhydrous Na2SO4. The crude product was purified bysilica gel column chromatography to afford intermediates 5aa in 81% yield as whitesolid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl (7-aminoheptyl)carbamate, its application will become more common.

Reference:
Article; Wang, Xin; Yu, Chenhua; Wang, Cheng; Ma, Yakun; Wang, Tianqi; Li, Yao; Huang, Zhi; Zhou, Manqian; Sun, Peiqing; Zheng, Jianyu; Yang, Shengyong; Fan, Yan; Xiang, Rong; European Journal of Medicinal Chemistry; vol. 181; (2019);,
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Reference of 6973-09-7, A common heterocyclic compound, 6973-09-7, name is 5-Amino-2-methylbenzenesulfonamide, molecular formula is C7H10N2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example No.B.1.1 : ter*-Butyl-cis-4-((6-(4-methyl-3-sulf amoylphenylamino)- l/ -p r azolo [3,4- i/|pyrimidin-l-yl)methyl)cyclohexylcarbamate; A solution of ~er~-butyl-cw-4-((6-chloro-l//-pyrazolo[3,4-i/]pyrimidin-l- yl)methyl)cyclohexylcarbamate (1.66 g, 4.53 mmol, prepared using A from Preparation No.2 and ter^butyl-czs-(4-hydroxymethyl)cyclohexylcarbamate [AMRI]), 5-amino-2- methylbenzenesulfonamide (1.10 g, 5.89 mmol, Waterstone), and sodium teri-butoxide (1.306 g, 13.59 mmol) in 1,4-dioxane (15 mL) was stirred at ambient temperature for about 30 min. In a separate 10 mL nitrogen purged vial charged with Pd2(dibenzylideneacetone)3 (0.415 g, 0.453 mmol) and 2-di-~er~-butylphosphino-2′,4′,6′-triisopropylbiphenyl (0.789 g, 1.86 mmol) was added 1,4-dioxane (2 mL) followed by heating to about 80 ¡ãC for about 2 min. The mixture was subsequently cooled to ambient temperature. The catalyst solution was added to the reaction mixture at ambient temperature and the reaction mixture was heated to about 80 ¡ãC for about 16 h. The reaction mixture was cooled to ambient temperature then water (100 mL) and EtOAc (50 mL) were added and the organic layer was separated. The aqueous layer was further extracted with EtOAc (2 x 50 mL) and the combined organic extracts were dried over anhydrous MgSOt, filtered through a silica gel pad, and concentrated under reduced pressure. The crude residue was purified by silica gel chromatography eluting with 50percent EtOAc in heptane to provide tert-butyl-cis-4-((6- (4-methyl-3-sulfamoylphenylamino)-lH-pyrazolo[3,4-d]pyrimidin-l- yljmethyljcyclohexylcarbamate (0.58 g, 25percento) as a light yellow solid. LC/MS (Table 2, Method a) R, = 1.38 min; MS m/z: 516 (M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ABBOTT LABORATORIES; WOLLER, Kevin R.; CURTIN, Michael L.; FRANK, Kristine E.; JOSEPHSOHN, Nathan S.; LI, Biqin C.; WISHART, Neil; WO2011/156698; (2011); A2;,
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