Amides-buliding-blocks

The chemical industry reduces the impact on the environment during synthesis 118753-70-1, name is tert-Butyl bis(2-chloroethyl)carbamate, I believe this compound will play a more active role in future production and life. 118753-70-1

To a solution of tert-butyl bis(2-chloroethyl)carbamate (5.08 g) and 2-(3,4-dichlorophenyl)acetonitrile (3.00 g) in anhydrous DMF (50 mL), 60percent (w/w) sodium hydride in oil (1.935 g) was added at 0¡ãC, and the mixture was stirred overnight at 70¡ãC in a nitrogen atmosphere. The reaction mixture was diluted with a saturated aqueous solution of ammonium chloride, followed by extraction with ethyl acetate. The extract was washed with water and saturated brine, dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (ethyl acetate/hexane) to obtain the title compound (3.41 g). MS, found: 254.9.

The chemical industry reduces the impact on the environment during synthesis 118753-70-1. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Takeda Pharmaceutical Company Limited; IMAMURA Keisuke; TOMITA Naoki; ITO Yoshiteru; ONO Koji; MAEZAKI Hironobu; NII Noriyuki; (123 pag.)EP3118200; (2017); A1;,
Amide – Wikipedia,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1120-16-7 name is Dodecanamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 1120-16-7

General procedure: For the synthesis of amide carboxylic acid (1-2 mM) wasdissolved in toluene (10 ml) then solution of borane tetrahydrofuran(THF) (1 M) was added at 0 oC. After additionof borane THF complex reaction mixture is kept at roomtemperature for 1 h. DAA was added to the reaction mixtureand reaction mixture refluxed for 5-10 h. Then reactionmixture was cooled to room temperature and acidifies with1M HCl, and extracted with ethyl acetate. Wash with water2-3 times. Organic phase was dried over anhydrous Na2SO4and concentrate under reduced pressure. Purification ofproduct was accomplished by column chromatographyusing silica gel (hexane: ethyl acetate). (+)-N-(dodecanoyl)-dehydroabietylamine (2) Rf: 0.627(hexane/ethylacetate, 9:1) State: gummy, Yield:93.15%, [alpha]D26: -18.42 (C=0.0403, CHCl3), HRMS-ESI:calcd for C32H54NO (M+H)+ 468.4205, found 468.4179,IR (cm-1): 3303 (N-H stretching), 2923 (C-H), 2856(C-H),1647 (C=O), 1548 (N-H bending), 1460 (CH2 bending),1375 (CH3 bending), 719 (CH2 long chain band). UV: lambdamax241, 254, 276. 1HNMR (400MHz, CDCl3) delta ppm: 0.86(3H, t, J = 6.0 Hz, H-12?), 0.98 (3H, s, H-19), 1.23 (24H, Brs, H-16, and 17, 3?-11?), 1.95 (1H, t, J = 5.6 Hz, H-5), 2.32(4H, t, J = 7.6 Hz, H-1, and 2?), 2.86 (2H, m, H-3), 2.98(1H, m, H-15), 3.17 (1H, dd, J = 6.4 and 13.6 Hz, H-18a),3.28 (1H, dd, J = 6.4 and 13.6 Hz, H-18b), 7.28 (1H, d, J =8.0 Hz, H-12), 7.39 (1H, d, J = 8.0 Hz, H-11), 7.83 (1H, s,H-14). 13CNMR (100MHz, CDCl3) delta ppm: 14.1 (C-12?),18.5 (C-2), 18.7 (C-19), 18.9 (C-6), 22.6 (C-11?), 24.7 (C-16 and 17), 25.2 (C-20), 29.5-29.3 (C-3?-9?), 31.8 (C-10?),33.5 (C-15), 33.7 (C-2?), 35.7 (C-3), 37.3 (C-4), 37.4 (C-10), 38.3 (C-1), 44.5 (C-5), 49.7 (C-18), 123.6 (C-12),124.9 (C-11), 132.6 (C-14), 134.7 (C-8), 145.6 (C-13),147.1 (C-9), 173.5 (C-1?).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Dodecanamide, and friends who are interested can also refer to it.

Reference:
Article; Mustufa, Muhammad Ayaz; Aslam, Afshan; Ozen, Cigdem; Ali Hashmi, Imran; Naqvi, Naim ul Hasan; Ozturk, Mehmet; Ali, Firdous Imran; Medicinal Chemistry Research; vol. 26; 7; (2017); p. 1367 – 1376;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

127-77-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127-77-5, name is 4-Amino-N-phenylbenzenesulfonamide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 4-chloro-2-(chlorocarbonyl)phenyl benzoate (1 mmol, 1.4 equiv) in DCM (0.2 M), amine (0.7 mmol, 1 equiv) and triethylamine (0.6 mL, 1.2 mmol, 1.7 equiv) were added at 0 C. The mixture was stirred at room temperature (16 h) and extracted with DCM. The organic layer was washed with water and brine, dried (MgSO4), and the solvent was removed under vacuum. The residue was purified by flash column chromatography. (0025) Potassium carbonate (18 mg, 0.13 mmol, 1.2 equiv) was added to a solution of crude product from the previous step (0.11 mmol, 1.0 equiv) in 1:1 MeOH:1,4-dioxane (0.1 M). The reaction mixture was stirred at room temperature (2 h) and acidified with 1 N HCl, followed by extraction with EtOAc and DCM. The organic layer was washed with water and brine, dried (MgSO4), and the solvent was removed under vacuum. The residue was purified by column chromatography (1:19 MeOH:CHCl3), and recrystallized from Et2O/Hex.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Lee, Ill-Young; Gruber, Todd D.; Samuels, Amanda; Yun, Minhan; Nam, Bora; Kang, Minseo; Crowley, Kathryn; Winterroth, Benjamin; Boshoff, Helena I.; Barry III, Clifton E.; Bioorganic and Medicinal Chemistry; vol. 21; 1; (2013); p. 114 – 126;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

127828-22-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127828-22-2, name is tert-Butyl (2-(2-aminoethoxy)ethyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows.

6.3g of compd 42 and 2.Og of 2-bromohypoxanthine were dispersed in 55ml monomethoxyethanol and 17.5ml water. The reaction mixture was stirred at reflux for 16h, and the solvent was removed under reduced pressure. Then the concentrate was stirred in 20ml MC and 10ml water for 30 min, and the resulting precipitate was collected by filtration to obtain 2.1g of compd 43 as a pale yellow solid. 1H NMR (500MHz; DMSOd6) delta 12.43 (br s, IH), 10.45 (br s, IH), 7.89 (s, 0.2H), 7.61 (s, 0.8H), 6.77 (m, IH), 6.34 (s, 0.8H), 6.12 (s, 0.2H), 3.52 (t, 2H), 3.41 (m, 4H), 3.09 (q, 2H), 1.36 (s, 9H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; CTI BIO; WO2009/113828; (2009); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A common heterocyclic compound, 17193-28-1, name is 1-Amino-1-cyclopentanecarboxamide, molecular formula is C6H12N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 17193-28-1.

To a solution of 1-aminocyclopentane-l-carboxamide (1.15 g, 8.97 mmol) and DCM (32 mL) was added acetic anhydride (1.191 g, 11.66 mmol). The reaction mixture was stirred at RT for 18 hours. Reaction was concentrated and used without further purification in the next step. Intermediate 110a (1.53 g, 8.99 mmol, 100 % yield). LC-MS (Method A2) RT = 0.43 min, MS (ESI) m/z: 171.1 (M+H)+. 1H NMR (400 MHz, CDCl3) delta 7.09 – 6.89 (m, 1H), 5.72 (br s, 1H), 5.38 – 5.19 (m, 1H), 2.40 – 2.30 (m, 2H), 2.07 – 1.98 (m, 5H), 1.86 – 1.75 (m, 4H)

The synthetic route of 1-Amino-1-cyclopentanecarboxamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITE DE MONTREAL; BRISTOL-MYERS SQUIBB COMPANY; PRIESTLEY, Eldon, Scott; REZNIK, Samuel, Kaye; RUEDIGER, Edward, H.; GILLARD, James, R.; HALPERN, Oz, Scott; JIANG, Wen; RICHTER, Jeremy; RUEL, Rejean; TRIPATHY, Sasmita; YANG, Wu; ZHANG, Xiaojun; (642 pag.)WO2018/5591; (2018); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

711007-44-2, Name is 2,3-Diaminobenzamide, 711007-44-2, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

To a solution of 2,3-diamino-benzamide (302 mg, 2 mmol) in ether (12 mL) and DCM(9mL), methyl 2,2,2-trichloroacetimidate (0.44 mL, 2.5 mmol) and TFA (1.0 mL, 12.8 mmol)were added. The reaction mixture was stirred at room temperature for 6 h. After evaporation, andchromatography (DCM/methanol=70:1) gave the title compound 5 as a white solid (340 mg,61.3%).

Statistics shows that 2,3-Diaminobenzamide is playing an increasingly important role. we look forward to future research findings about 711007-44-2.

Reference:
Article; Zhou, Jie; Ji, Ming; Zhu, Zhixiang; Cao, Ran; Chen, Xiaoguang; Xu, Bailing; European Journal of Medicinal Chemistry; vol. 132; (2017); p. 26 – 41;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A common heterocyclic compound, 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide, molecular formula is C10H15NO2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 6292-59-7.

A mixture of 4-teritary butyl benzene sulfonamide (15.2 grams) having 0.11percent of 4-isopropyl benzene sulfonamide, potassium carbonate (19.77 grams), tetrabutylammonium bromide (0.7 grams) in toluene (750 ml) was heated to 45-50¡ãC and stirred for 30 minutes.4,6-dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine (25 grams) was added the above mixture and heated to reflux temperature then stirred for 12 hours. The reaction mixture was cooled and then quenched with water. The reaction mixture was filtered and washed the solid with water. Acetonitrile (300 ml) was added to wet solid and heated to reflux temperature then stirred for 2 hours. Water (50 ml) was added to the above wet solid and acidified with hydrochloric acid. The solid was filtered, washed with water and dried to get the title compound.Yield: 80 grams; Purity by HPLC: 98.97 percent; isopropyl derivative: 0.11percent

The synthetic route of 4-(tert-Butyl)benzenesulfonamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; VENKAT REDDY, Ghojala; WO2011/21216; (2011); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The chemical industry reduces the impact on the environment during synthesis 811442-84-9, name is tert-Butyl (14-amino-3,6,9,12-tetraoxatetradecyl)carbamate, I believe this compound will play a more active role in future production and life. 811442-84-9

200 mg (0.594 mmol) of tert-butyl (14-amino-3,6,9,12-tetraoxatetradec-1-yl)carbamate, 111 mg (0.713 mmol) of (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid and 410 mul (2.4 mmol) of N,N-diisopropylethylamine were dissolved in 6 ml of dimethylformamide, and 339 mg (0.892 mmol) of HATU were added. The reaction mixture was stirred at RT for 1 h and purified directly by preparative RP-HPLC (column: Reprosil 250*30; 10mu, flow rate: 50 ml/min, MeCN/water/0.1% TFA). The solvents were evaporated under reduced pressure and the residue was dried under high vacuum. This gave 130 mg (43% of theory) of tert-butyl [17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]carbamate. LC-MS (Method 1): Rt=0.71 min; MS (ESIpos): m/z=474 (M+H)+.

The chemical industry reduces the impact on the environment during synthesis 811442-84-9. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Bayer Pharma Aktiengesellschaft; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; CANCHO GRANDE, Yolanda; MARX, Leo; STELTE-LUDWIG, Beatrix; TERJUNG, Carsten; MAHLERT, Christoph; GREVEN, Simone; SOMMER, Anette; BERNDT, Sandra; (684 pag.)US2018/169256; (2018); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

563-83-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 563-83-7, name is Isobutyramide, A new synthetic method of this compound is introduced below.

A solution of 2-methylpropanamide (6.53 g, 75.0 mmol) and 2,4-bis(4- methoxyphenyl)-1 ,3-dithia-2,4-diphosphetane-2,4-disulfide (15.17 g, 37.51 mmol) in THF (100 mL) was heated to reflux for 4 h. The reaction mixture was then cooled to room temperature and poured into saturated aqueous NaHCO3 (200 mL). The mixture was extracted with ether (4 x 100 mL). The organic fractions were combined, dried over Na2SO , filtered, andconcentrated. Purification by flash column chromatography (20%EtOAc:hexanes) afforded the title compound. 4.77 g (62% yield) 1H-NMR (400 MHz, CDCI3) delta 7.63 (brs, 1 H), 6.90 (brs, 1 H), 2.88 (m, 1 H), and 1 .27 (d, 6H, J = 6.8 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; GLAXOSMITHKLINE LLC; ADAMS, Jerry, Leroy; FAITG, Thomas; KASPAREC, Jiri; PENG, Xin; RALPH, Jeffrey; RHEAULT, Tara Renae; WATERSON, Alex Gregory; WO2011/59610; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

3119-02-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3119-02-6, name is 4-Cyanobenzenesulphonamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 4-cyano benzenesulfonamide (3.8 g, 20.88 mmol, Intermediate 42 or commercial source: Combi-Blocks) in Lambda/,/V-dimethylformamide (50 mL), sodium azide (13.57 g, 208.73 mmol) and ammonium chloride (1 1.17 g, 208.78 mmol) were added at 27 C. The reaction mixture was heated to 120 C and was stirred at the same temperature for 5 h. Upon completion, the reaction mixture was cooled to 27 C, quenched with 1 N HCI (150 mL) and extracted with ethyl acetate (3×100 mL). The organic layer was dried over anhydrous Na2S04, filtered and the filtrate was concentrated under reduced pressure. The residue was stirred with dichloromethane (10 mL) at 27 C for 30 min and filtered. The solid was dried under vacuum to afford 4-(2H-tetrazol-5- yl)benzenesulfonamide (3.2 g, 68%) as an off-white solid.1H NMR (400 MHz, DMSO-c/6) delta 8.23 (d, J = 8.5 Hz, 2H), 8.04 (d, J = 8.5 Hz, 2H), 7.53 (s, 2H). MS m/z [M-H]”=224.03.

The synthetic route of 4-Cyanobenzenesulphonamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ALEMPARTE-GALLARDO, Carlos; ENCINAS, Lourdes; ESQUIVIAS PROVENCIO, Jorge; (206 pag.)WO2019/34729; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics