Amides-buliding-blocks

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 621-38-5, name is 3-Bromoacetanilide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 621-38-5

Example 4; Example 3 is repeated under the same conditions except that 2% millimolar of (PdAllylCl)2 is used instead of Pd(OAc)2. The reaction is always conducted at 90C. The same product of example 3 is obtained with 84% molar yield.

The synthetic route of 621-38-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F.I.S. Fabbrica Italiana Sintetici S.p.A.; EP2433931; (2012); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

2623-33-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2623-33-8 as follows.

General procedure: A 10 mL Schlenk tube equipped with a magnetic stirrer was charged with [Rh Cp* Cl2]2 (5 mol%), AgSbF6 (20 mol%), Cu(OAc)2 (1equiv), Ag2CO3(1equiv),and substituted acetanilideas 1 (0.2 mmol). The tube wasevacuated and backfilled with argon for three times. Then allyl carbonate (0.4 mmol) in dioxane (1 mL) was added. After addition of all substrates, the reactionmixture was stirred and heated at 110Cfor 24h. Then reaction was cooled to room temperature. Solvent and volatile reagents were removed by rotary evaporation and theresidue was purified by flash column chromatography on silica gel to give the target product

According to the analysis of related databases, 4-Acetamidophenyl acetate, the application of this compound in the production field has become more and more popular.

Reference:
Article; Gong, Tian-Jun; Cheng, Wan-Min; Su, Wei; Xiao, Bin; Fu, Yao; Tetrahedron Letters; vol. 55; 11; (2014); p. 1859 – 1862;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

7341-96-0, A common compound: 7341-96-0, name is Propiolamide, belongs to amides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Example 6; Synthesis of compound (I): 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxyamide (Rufinamide) A 500 ml round-bottom flask is loaded with 2,6-difluorobenzyl azide (100 g, 0.59 mole) dissolved in methanol (300 ml), then propiolamide (49 g, 0.71 mole) obtained according to Example 5 is added under stirring to obtain a solution. Afterwards, CuSO4 pentahydrate (1.46 g, 5.9 mmoles) and ascorbic acid (5.19 g, 29.6 mmoles) are added in succession. The reaction mixture spontaneously reaches 40C and is kept under stirring for 4 hours at the same temperature. The formed solid is then filtered off, washed with methanol and water, and dried in an oven at 50C, thereby affording 133 g of a solid crude in 89% yield. The solid is suspended in water (300 ml), the suspension is treated with 33% aqueous ammonia (50 ml) and left under stirring for 3 hours, then the resulting white solid is filtered and dried in an oven. 130 g of a crystalline solid are obtained in 87% yield. 1H NMR (400 MHz, DMSO-d6), delta ppm: 8.56 (s, 1 H), 7.87 (bs, 1H), 7.60-7.43 (m, 2H), 7.20 (m, 2H), 5.72 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Propiolamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Dipharma Francis S.r.l.; EP2230234; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

640-61-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 640-61-9, name is N,4-Dimethylbenzenesulfonamide, A new synthetic method of this compound is introduced below.

To a solution of bromoethynylbenzene (1.4 g, 8.0 mmol) in 24 mL of anhydrous toluene in a reaction vial were added methyl phenylcarbamate (1.5 g, 9.6 mmol), K3PO4 (3.4 g, 16 mmol), copper sulfate-pentahydrate (400 mg, 16 mmol), and 1,10-phenanthroline (577 mg, 3.2 mmol). The reaction mixtures was capped under an argon atmosphere, and heated in an oil bath at 80 ?C for 15 h. The progress of the reaction was monitored using TLC analysis. Upon completion, the reaction mixture was allowed to cool to room temperature, and diluted with 15 mL of ethyl acetate. The mixture was filtered through a pad of celite, and the filtrate was concentrated in vacuo. The crude residue was purified by column chromatography with eluent of Hexane/ ethyl acetate = 19/1 to give 1.6 g of 1 in 80 % yield as a yellow oil. 1H NMR (400 MHz, CDCl3) delta 7.55 (dd, J = 1.2, 8.6 Hz, 2H), 7.45-7.40 (m, 4H), 7.33-7.28 (m, 4H), 3.92 (s, 3H). 13C NMR. (100 MHz, CDCl3) delta 154.9, 139.7, 131.5, 129.1, 128.4, 128.0, 127.2, 124.8, 123.0, 83.0, 70.3, 54.5.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Sato, Akihiro H.; Ohashi, Kazuhiro; Iwasawa, Tetsuo; Tetrahedron Letters; vol. 54; 10; (2013); p. 1309 – 1311;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

These common heterocyclic compound, 144-80-9, name is N-((4-Aminophenyl)sulfonyl)acetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 144-80-9

General procedure: To a stirred solution of sulphonamide (2 mmol),chloroacetylchloride (2 mL) and try ethylamine (0.1 mL)in dry dimethylformamide at 0-5 oC, aminochalcone 1d-1f (2 mmol) was added and stirred at room temperature for3-4 hours by a magnetic stirrer. The stirred reaction mixturewas then refluxed for 8-9 hours. The reaction was monitoredby TLC. After the completion of the reaction, the reactionmixture on hot was poured to crushed ice afforded precipitatesof chalcone-sulphonamide hybrids 3a-6f. Precipitatesthen washed with cold aqueous sodium carbonate and thecrude product was recrystallized in acetone.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 144-80-9.

Reference:
Article; Khanusiya, Mahammadali; Gadhawala, Zakirhusen; Journal of the Korean Chemical Society; vol. 63; 2; (2019); p. 85 – 93;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

239074-29-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 239074-29-4, name is tert-Butyl (trans-4-(hydroxymethyl)cyclohexyl)carbamate, A new synthetic method of this compound is introduced below.

b) ((1r,4r)-4-(Tert-Butoxycarbonylamino)cyclohexyl)methyl 4-methylbenzene-sulfonate A solution of 4-methylbenzene-1-sulfonyl chloride (2.28 g, 11.96 mmol) in dichloromethane was added to a solution of tert-butyl (1r,4r)-4-(hydroxymethyl) cyclohexylcarbamate (Preparation 14a, 2.11 g, 9.2 mmol) and triethylamine (1.59 mL, 11.4 mmol) in dichloromethane (50 mL) and the resulting mixture was stirred overnight at ambient temperature. The mixture was washed with 1M aqueous sodium hydroxide solution and the organic layer was dried (MgSO4), evaporated and the residue was purified by flash chromatography (diethyl ether/hexanes) to give the title compound (2.91 g, 83%) as a white solid. LRMS (m/z): 382 (M-H)+. 1H NMR delta (300 MHz, CDCl3): 0.90-1.12 (m, 4H), 1.43 (s, 3H), 1.78 (dd, 2H), 1.99 (d, 2H), 3.34 (m, 1H), 3.46 (t, 1H), 3.81 (d, 2H), 4.37 (m, 1H), 7.34 (d, 2H), 7.77 (d, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Almirall, S.A.; EP2527344; (2012); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1882-71-9, name is 2-Amino-5-methoxybenzamide, A new synthetic method of this compound is introduced below., 1882-71-9

General procedure: To a cold (0?5 ¡ãC) stirred suspension of aminobenzamides 15a?f and 20a,b (0.016 mol) in pyridine (13 mL), 0.016 mol of the appropriate phenoxyacetyl chloride 16a?e was added over 30 min. After addition was complete, the solution was stirred for24 h and then poured onto crushed ice. The precipitate was removed by filtration, washed with water, and crystallized from the indicated solvent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Raffa, Demetrio; Maggio, Benedetta; Plescia, Fabiana; Cascioferro, Stella; Raimondi, Maria Valeria; Cancemi, Gabriella; D’Anneo, Antonella; Lauricella, Marianna; Cusimano, Maria Grazia; Bai, Ruoli; Hamel, Ernest; Daidone, Giuseppe; Bioorganic and Medicinal Chemistry; vol. 23; 19; (2015); p. 6305 – 6316;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

17193-28-1, These common heterocyclic compound, 17193-28-1, name is 1-Amino-1-cyclopentanecarboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 1 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-one-monohydrochloride 20 g (0.156 mol) of 1-aminocyclopentane-1-carboxamide and 31 g (0.19 mol) of trimethyl orthovalerate are refluxed at 70-80 C. inner temperature for 1 hour. The condenser is then changed to a “No hold up” condenser, while heating and stirring are continued to distille off volatile components. The reaction is completed in vacuo. The residue is dissolved in 150 ml of acetone the pH is adjusted to 1-2, after cooling the resulting suspension the product is filtered off. 31 g of the title compound is obtained, yield 86.4%. IR: 3600-2200: vibr, NH; 1779: gammac=o; 1642 gammac, 1517: deltaNH (IRFT Perkin Elmer)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 17193-28-1.

Reference:
Patent; Sanofi-Synthelabo; US6162923; (2000); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4093-31-6 as follows. 4093-31-6

Stage B Preparation of 4-amino-5-chloro-2-methoxybenzoic acid Methyl 4-acetamido-5-chloro-2-methoxybenzoate is dissolved in ethanol and aqueous potassium hydroxide added. The solution is refluxed for a short time, cooled and concentrated hydrochloric acid added. The resulting precipitate is filtered off, washed with water and dried to give the title compound as a white solid.

According to the analysis of related databases, 4093-31-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Palmer, Richard Michael John; Meyers, Nicholas Leslie; Knight, John; US2005/49416; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

16982-21-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 16982-21-1 as follows.

To a boiling solution of ethyl thiooxamate (13,3 g ,10Og, 100 mmol) in ethanol (100 mL) was added l-bromo-3-methylbutan-2-one (17,6 g ,g, 106 mmol) dropwise during 15 minutes. The solution was refluxed for one hour. The solution was added to 250 mL of ice-cold water and basified with concentrated ammonia solution. This mixture was extracted twice with AcOEtethyl acetate. The organic phase was washed with brine, dried (Na2SO4) and evaporated under reduced pressure. The crude product was purified by column chromatography with dichloromethane to dichloromethane with 2% MeOH methanol to give 13,1 g (65%) of the target product: 1H-NMR-CDCl3: 7,20 (s, IH), 4,49 (m, 2H), 3,25 (m, IH), 1,42 (t, 3H), 1,35 (d, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 16982-21-1, and friends who are interested can also refer to it.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; MEDIVIR AB; WO2007/14921; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics