Amides-buliding-blocks

Iridium-catalyzed C-H methylation and d₃-methylation of benzoic acids with application to late-stage functionalizations was written by Weis, Erik;Hayes, Martin A.;Johansson, Magnus J.;Martin-Matute, Belen. And the article was included in iScience in 2021.Electric Literature of C18H17NO5 This article mentions the following:

An iridium-catalyzed carboxylate-directed ortho C-H methylation and d₃-methylation of benzoic acids was reported. The method used com. available reagents and precatalyst and requires no inert atm. or exclusion of moisture. Substrates bearing electron-rich and electron-poor groups were successfully methylated, including compounds with competing directing/coordinating groups. The method was also applied to the LSF of several marketed drugs, forming analogs with increased metabolic stability compared with the parent drug. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Electric Literature of C18H17NO5).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C18H17NO5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Antiallergic Properties of Biflavonoids Isolated from the Flowers of Mesua ferrea Linn. was written by Manse, Yoshiaki;Sakamoto, Yusuke;Miyachi, Taiki;Nire, Mitsuyo;Hashimoto, Yoshinori;Chaipech, Saowanee;Pongpiriyadacha, Yutana;Morikawa, Toshio. And the article was included in Separations in 2022.Recommanded Product: 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid This article mentions the following:

The methanolic extract from the flowers of Mesua ferrea Linn. (Calophyllaceae) showed significant hyaluronidase inhibitory activity. Following a bioassay-guided separation of the extract, two biflavonoids, viz., mesuaferrone-A (1) and mesuaferrone-B (2), were isolated, along with ten flavonoids (3-12), two xanthones (13 and 14), three triterpenes (15-17), a phenylpropanoid (18), and five aromatics (19-24). Among the isolates, 1 and 2 (IC₅₀ = 51.1μM and 54.7μM, resp.) exhibited hyaluronidase inhibitory activity equivalent to that of the com. available antiallergic agents disodium cromoglycate (64.8μM) and ketotifen fumarate (76.5μM). These biflavonoids (1 and 2) are 8-8″ linked dimers that are composed of naringenin (1a) or apigenin (3), with their corresponding monomers lacking inhibitory activity (IC₅₀ > 300μM). In addition, 1 and 2 (IC₅₀ = 49.4μM and 49.2μM, resp.) inhibited the release of β-hexosaminidase, which is a marker of antigen-IgE-mediated degranulation, in rat basophilic leukemia (RBL-2H3) cells. These inhibitory activities were more potent than those of the antiallergic agents tranilast and ketotifen fumarate (IC₅₀ = 282μM and 158μM, resp.), as well as one of the corresponding monomers (1a; IC₅₀ > 100μM). Nonetheless, these effects were weaker than those of the other monomer (3; IC₅₀ = 6.1μM). In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Recommanded Product: 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some reactions of substituted 2-bromopyridines was written by Berrie, A. H.;Newbold, G. T.;Spring, F. S.. And the article was included in Journal of the Chemical Society in 1952.Recommanded Product: 3-Aminopicolinamide This article mentions the following:

2-Hydroxy-3-nitropyridine (I) (14 g.), added to 50 g. PBr₃ and 16 g. Br, heated 5 hrs. at 100°, cooled, treated dropwise with 100 cc. MeOH and then with 300 cc. H₂O, and extracted with boiling C₆H₆ and the residue from the C₆H₆ extracted with petr. ether (b. 60-80°), gives 10 g. 2-bromo-3-nitropyridine (II), m. 125°; the 5-Cl derivative of I yields 59% of the 5-Cl derivative (III) of II, m. 75°; the 5-Br derivative of I gives 80% of 2,5-dibromo-3-nitropyridine (IV), m. 93°. II (1 g.) and 10 cc. conductivity HCl in 10 cc. AcOH, refluxed 3 hrs., give 0.5 g. 2-hydroxy-3-nitropyridine (V), pale yellow, m. 224°; III yields 54% of the 5-Cl derivative (VI) of V, yellow, m. 235°; IV, HCl, and AcOH give 64% of the 5-Br derivative (VII) of V, pale yellow, m. 242°; 10 g. 2-amino-5-bromo-3-nitropyridine (VIII) in 25 cc. H₂SO₄ (d. 1.84) at 0°, treated with 6 g. NaNO₂ in 15 cc. H₂O, kept 30 min. at 0°, and diluted with 150 cc. H₂O, gives 6.05 g. VII. V (0.7 g.), 2 g. PCl₅, and 1.5 cc. POCl₃, heated 2 hrs. at 100°, give 0.2 g. 2-chloro-3-nitropyridine (IX), m. 101°; VI gives 52% 2,5-dichloro-3-nitropyridine (X), m. 43°; X results in 1.3 g. yield from 2-amino-5-chloro-3-nitropyridine. VII, PCl₅, and POCl₃ give 45% 5-bromo-2-chloro-3-nitropyridine (XI), m. 68° (51% from VIII). II (0.75 g.) and 0.7 g. CuCN, gradually heated to 150°, the pressure reduced to 1 mm., and the heat source removed after 15 sec., give 0.3 g. 3-nitropicolinonitrile (XII), m. 78°; III yields the 5-Cl derivative (XIII) of XII, m. 98°. IV gives 66% of the 5-Br derivative (XIV) of XII, m. 102°. 3-Amino-2-bromopyridine yields 32% 3-aminopicolinonitrile (XIVA), m. 149°; 5-Cl derivative (XIVB), m. 175°, 25%. XII (100 mg.) and 0.2 cc. H₂SO₄ (d. 1.84), heated 2 hrs. at 100°, give 50 mg. 3-nitropicolinamide (XV), m. 211°; XIII yields 55% of the 5-Cl derivative of XV, m. 230° and XIV gives-56% of the 5-Br derivative (XVA), m. 232-3° (decompn). II (1.45 g.), 2 g. Fe filings, and 12 cc. AcOH, heated 2 hrs. at 100°, diluted with 15 cc. H₂O, basified with 30% NaOH, and the cooled product extracted with CHCl₃, give 0.8 g. 3-amino-2-bromopyridine (XVI), m. 79°; 1.1 g. III yields 0.1 g. of the 2-Cl analog (XVII) of XVI, m. 79-80°; 1 g. XVI in 10 cc. HCl (d. 1.19), refluxed 3 hrs., gives 0.5 g. XVII. XV (20 mg.), 20 mg. Fe filings, and 0.12 cc. AcOH, heated 2 hrs. at 100°, give 10 mg. 3-aminopicolinamide (XVIII), m. 175-7°, sublimes at 100°/10^-1 mm.; 120 mg. XIVA and 0.24 g. concentrated H₂SO₄, heated 2 hrs. at 100°, give 10 mg. XVIII. XIII, reduced in AcOH with Fe, gives 67% of the 5-Cl derivative (XIX) of XVIII, m. 168°; XIVB yields 11% XIX; 5-Br derivative of XVIII, m. 168°, 72 and 18% yield, resp. XI gives 81% 3-amino-2-bromo-5-chloropyridine (XX), m. 142°, absorption maximum at 2520 and 3140 A. (ε 11,500 and 5700); IV gives 84% 3-amino-2,5-dibromopyridine (XXI), m. 153°; 2,5-di-Cl analog, m. 129°; it results in 87% on reduction of X and in 0.2-g. yield on refluxing 2 hrs. 0.5 g. 3-amino-5-bromo-2-chloropyridine (XXII) in 10 cc. concentrated HCl. Reduction of XI with Fe in AcOH gives 85% XXII, m. 131°, absorption maximum at 2510 and 3140 A. (ε 7200 and 4700); 1 part XXI and 20 parts concentrated HCl, refluxed 2 hrs., give 35% XXII; 2.82 g. IV, 7 g. Sn, and 30 cc. HCl, refluxed until solution results, give 0.2 g. XXII. 2-Amino-5-bromo-3-nitropyridine, reduced with Sn and HCl, gives 21% 2,3-diamino-5-bromo-4(6)-chloropyridine, m. 164° (quinoxaline derivative from phenanthraquinone, C₁₉H₉N₃ClBr, m. 270-2°). XXII (0.3 g.) in 10 cc. concentrated HCl, treated at 0° with 0.55 g. NaNO₂ in 1.5 cc. H₂O and then with 1.1 g. Cu, shaken 1 hr., almost neutralized with 30% NaOH, and the precipitate extracted with Me₂CO and the residue from the Me₂CO extracted with petr. ether, gives 100 mg. 5-bromo-2,3-dichloropyridine, m. 30-1°. XXI (1.26 g.) with NaNO₂ in concentrated H₂SO₄ gives 0.6 g. 2,5-dibromo-3-hydroxypyridine, m. 195-7°. XVA (12.1 g.) and KOBr give 7 g. 2-amino-5-bromo-3-nitropyridine, yellow, m. 205°. In the experiment, the researchers used many compounds, for example, 3-Aminopicolinamide (cas: 50608-99-6Recommanded Product: 3-Aminopicolinamide).

3-Aminopicolinamide (cas: 50608-99-6) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 3-Aminopicolinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A Series of Weakley-type Polyoxomolybdates: Synthesis, Characterization, and Magnetic Properties by a Combined Experimental and Theoretical Approach was written by She, Shan;Gao, Chen;Chen, Kun;Bayaguud, Aruuhan;Huang, Yichao;Wang, Bing-Wu;Gao, Song;Wei, Yongge. And the article was included in Inorganic Chemistry in 2018.Product Details of 2387-23-7 This article mentions the following:

Using the DCC as the dehydrating agent, a series of Weakley-type polyoxomolybdates [Bu₄N]₃{Ln[Mo₅O₁₃(OMe)₄(NO)]₂} (Ln = Tb, Dy, Ho, Er) were synthesized in one-pot reaction and structurally characterized by elemental, IR, UV-visible anal. and single-crystal x-ray diffraction. Furthermore, the static and dynamic measurements were used to investigate their magnetic performances. Typically, slow relaxation of magnetization was observed for Dy analog with an energy barrier for the reversal of the magnetization of 50 K, which is the highest barrier height observed on the polyoxomolybdates-based SMMs. For a deep understanding of the appearance of the SMM behavior on Weakley-type polyoxomolybdates series, ab initio calculation on {Dy[Mo₅O₁₃(OMe)₄(NO)]₂}^3- has been conducted. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Product Details of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Product Details of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and biological evaluation of a series of substituted 4,5-diphenylpyridine-2,6(1H,5H)-diones was written by Andrews, Peter R.;Brinkworth, Ross I.;Partridge, Ashton C.;Reiss, James A.. And the article was included in Australian Journal of Chemistry in 1988.Reference of 10268-06-1 This article mentions the following:

Esters R¹CCCO₂Et (R¹ = Ph, anisyl, ClC₆H₄) reacted with R²CH₂CONH₂ (R² = Ph, ClC₆H₄) and Na to give pyridinediones I. I (R¹ = 4-ClC₆H₄, R² = Ph) and I (R¹ = 2-ClC₆H₄, R² = 4-ClC₆H₄) showed some antipsychotic activity. Phosphoranes R¹COC(CO₂Et):PPh₃ were heated to give the resp. arylpropiolate esters. In the experiment, the researchers used many compounds, for example, 2-(2-Chlorophenyl)acetamide (cas: 10268-06-1Reference of 10268-06-1).

2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Reference of 10268-06-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of novel of Mn(II), Co(II), and Cu(II) Schiff base complexes and their high catalytic effect on bleaching performance with H₂O₂ was written by Tuna, Murat;Ugur, Tugba. And the article was included in Journal of Molecular Structure in 2022.Synthetic Route of C10H16N2O4 This article mentions the following:

Oxidation catalysts are used in a wide range of industrial processes. For instance, stain bleaching in detergents, bleaching of raw cotton and wood pulp, and drying of alkyd-based paint can be given as examples of oxidation catalysts. In this study, Me 2-(((3-hydroxynaphthalene -2-yl) methylene) amino) benzoate synthesized as the structure of a new Schiff base ligand by carrying out over 2-hydroxy-1-naphthaldehyde and Me 2-aminobenzoate. By the reactions of the synthesized Schiff base ligand and Cu(II), Mn(II), and Co(II) acetate salts, their ML₂ type complexes were obtained. The structural characterizations of obtained metal ion-Schiff base complexes were performed using FT-IR, ¹H-NMR, ¹³C-NMR, UV-Vis, MALDI-TOF, elemental anal. and m.p. methods. The bleaching performances of the prepared Schiff base complexes were examined by the degradation of morin as a hydrophilic dye that characterizes the wine stains. The bleaching processes of Schiff base complexes in the presence of catalyst and H₂O₂ in an aqueous solution buffered with Na₂CO₃/ NaHCO₃ at pH: 10.5 were investigated using the online spectrophotometric method. It was found that the prepared catalysts exhibited better bleaching performance at 25°C than that of tetraacetylethylenediamine (TAED) as a bleach activator com. used in powder detergent formulations. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Synthetic Route of C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Synthetic Route of C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

One-Pot Assembly and Synthetic Applications of Geminal Acyl/Alkoxy Tetrasubstituted Allenes was written by Bergstrom, Benjamin D.;Toth-Williams, Garrett;Lo, Anna;Toman, Jeffrey W.;Fettinger, James. C.;Shaw, Jared T.. And the article was included in Journal of Organic Chemistry in 2022.Recommanded Product: 226260-01-1 This article mentions the following:

Polysubstituted allenes are useful synthetic intermediates in many applications, offering structural complexity, modularity, and their axial chirality in further transformations. While acyl and alkoxy-substituted allenes are known, there are currently few examples of allenes containing both functionalities and no reports of geminally substituted acyl/alkoxy allenes being isolated and characterized. Herein, authors report the synthesis of tetrasubstituted allenes featuring a novel geminal acyl/alkoxy substitution. These unique “push-pull” allenes are bench-stable and exhibit interesting reactivity in several applications. In the experiment, the researchers used many compounds, for example, 3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1Recommanded Product: 226260-01-1).

3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)Nâ€?is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cmâˆ?. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: 226260-01-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Simple and Practical Conversion of Benzoic Acids to Phenols at Room Temperature was written by Xiong, Wenzhang;Shi, Qiu;Liu, Wenbo H.. And the article was included in Journal of the American Chemical Society in 2022.Product Details of 1146-43-6 This article mentions the following:

Herein, an efficient and practical approach to prepare phenols from benzoic acids via simple organic reagents at room temperature was reported. This approach was compatible with various functional groups and heterocycles and can be easily scaled up. To demonstrate its synthetic utility, bioactive mols. and unsym. hexaarylbenzenes was prepared by leveraging this transformation as strategic steps. Mechanistic investigations suggest that the key migration step involve a free carbocation instead of a radical intermediate. Considering the abundance of benzoic acids and the utility of phenols, it was anticipated that this method will find broad applications in organic synthesis. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Product Details of 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Product Details of 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex was written by Sutherell, Charlotte L.;Tallant, Cynthia;Monteiro, Octovia P.;Yapp, Clarence;Fuchs, Julian E.;Fedorov, Oleg;Siejka, Paulina;Muller, Suzanne;Knapp, Stefan;Brenton, James D.;Brennan, Paul E.;Ley, Steven V.. And the article was included in Journal of Medicinal Chemistry in 2016.Recommanded Product: 54166-95-9 This article mentions the following:

Bromodomain containing proteins PB1, SMARCA4, and SMARCA2 are important components of SWI/SNF chromatin remodeling complexes. We identified bromodomain inhibitors that target these proteins and display unusual binding modes involving water displacement from the KAc binding site. The best compound (I) binds the fifth bromodomain of PB1 with a K_D of 124 nM, SMARCA2B and SMARCA4 with K_D values of 262 and 417 nM, resp., and displays excellent selectivity over bromodomains other than PB1, SMARCA2, and SMARCA4. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Recommanded Product: 54166-95-9).

6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: 54166-95-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors α/δ dual agonists was written by Shen, Lan;Zhang, Yan;Wang, Aihua;Sieber-McMaster, Ellen;Chen, Xiaoli;Pelton, Patricia;Xu, June Z.;Yang, Maria;Zhu, Peifang;Zhou, Lubing;Reuman, Michael;Hu, Zhiyong;Russell, Ronald;Gibbs, Alan C.;Ross, Hamish;Demarest, Keith;Murray, William V.;Kuo, Gee-Hong. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Electric Literature of C7H5Cl2NO This article mentions the following:

Replacement of the methyl-thiazole moiety of GW501516 (a PPARδ selective agonist) with [1,2,4]thiadiazole gave compound 21 (I) which unexpectedly displayed submicromolar potency as a partial agonist at PPARα in addition to the high potency at PPARδ. A structure-activity relationships study of 21 resulted in the identification of 40 as a potent and selective PPARα/δ dual agonist. Compound 40 and its close analogs represent a new series of PPARα/δ dual agonists. The high potency, high selectivity, significant gene induction, excellent PK profiles, low P 450 inhibition or induction, and good in vivo efficacy in four animal models support 40 being selected as a pre-clin. study candidate, and may render 40 as a valuable pharmacol. tool in elucidating the complex roles of PPARα/δ dual agonists, and the potential usage for the treatment of metabolic syndrome. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Electric Literature of C7H5Cl2NO).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)Nâ€?is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cmâˆ?. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Electric Literature of C7H5Cl2NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics