Pais, M. A. et al. published their research in Neftekhimiya in 1975 | CAS: 5339-69-5

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.HPLC of Formula: 5339-69-5

Activity coefficients of sulfurous compounds in different extractants was written by Pais, M. A.;Bondarenko, M. F.;Abramovich, Z. I.;Kruglov, E. A.. And the article was included in Neftekhimiya in 1975.HPLC of Formula: 5339-69-5 This article mentions the following:

The activity coefficients of sulfur compounds such as cyclo- and dialkyl sulfides (I), mercaptans (II), and alkylthiophenes (III) in 10 extractants were determined by gas-liquid chromatog. The relative separation selectivities of the S compounds and hydrocarbons were calculated The separation selectivities decreased in the following order: III �alkylbenzenes (IV) �I > normal-paraffins > II. The activity coefficients of cyclic S compounds such as thiophane (V) and III varied with temperature increase in a manner similar to that shown by the corresponding IV in the same extractants. Thus, the activity coefficients of IV, V, and III increased in sulfolane [126-33-0] and tricresyl phosphate [1330-78-5] with increasing temperature In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5HPLC of Formula: 5339-69-5).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.HPLC of Formula: 5339-69-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Samejima, Masayoshi et al. published their research in Yakugaku Zasshi in 1960 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Synthetic Route of C11H15NO2

Solubilizing agents. V. Pyridinecarboxamides was written by Samejima, Masayoshi. And the article was included in Yakugaku Zasshi in 1960.Synthetic Route of C11H15NO2 This article mentions the following:

2-HO2CC5H4N.HCl (120 g.) in 313 g. MeOH and 150 g. concentrated H2SO4 refluxed 5 hrs., the MeOH removed, the residue neutralized with Na2CO3, and the product extracted with C6H6 gave 117 g. 2-MeO2CC5H4N, b11 109-11°. Li (20.9 g.) in 1200 ml. Et2O treated dropwise with 58 ml. PhBr, 139.7 g. 2-MeC5H4N added dropwise, the mixture refluxed 30 min., the product poured onto 1000 g. solid CO2, the Et2O removed, the residue in 1200 ml. EtOH at 0° saturated with dry HCl gas, the EtOH removed, the residue in 750 ml. CHCl3, 338 g. K2CO3, and 188 g. H2O heated, and the CHCl3 layer distilled gave 83.1 g. 2-EtO2CCH2C5H4N, b6 109-12°. 3-HO2CC5H4N (61.8 g.) and 47.1 g. PhOH heated at 110-20°, the mixture treated dropwise with 76.7 g. POCl3, heated at 130-40° until evolution of HCl gas ceased, the product poured into ice H2O, neutralized with Na2CO3, and extracted with C6H6 gave 67.5 g. 3-PhO2CC5H4N, m. 71-2° (EtOH-petr. ether). The above esters and 4-MeO2CC5H4N treated with NH4OH or amines and the products distilled gave x-RHNOCC5H4N (I) (x, R, % yield, and b.p./mm. or m.p. given): 2, H, 90, 105-6°; 2, Me, 77, 118-20°/4; 2, Et, 90, 128-9°/4; 2, Bu, 86, 122-3°/2; 2, HOC2H4, 69, 190-1°/4; 3, Me, 71, 104-5°; 3, Et, 89, 146-7°/3; 3, Bu, 85, 173-4°/3.5; 3, HOC2H4, 71, 90-1° 4, H, 86, 133-4°; 4, Me, 73, 113-14°; 4, Et, 69, 65-6°; 4, Bu, 84, 155-6°/1; 4, HOC2H4, 70, 133-4°. 2-RNHOCH2CC5H4N (II) (R, % yield, b.p./mm. or m.p. given): H, 77, 118-20°; Me, 78, 137°/1; Et, 67, 61-2°; HOC2H4, 67, 94-5°. 3-PhO2CC5H4N (10 g.) and 5 g. PhNH2 (or 2-H2NC5H4N) fused 3 hrs. at 200-10°, the PhOH removed in vacuo, and the product extracted with Et2O gave 3-RNHOCC5H4N (III) (R, % yield, and m.p. given): Ph, 67, 122-3°; 2-pyridyl, 79, 139-41°. Solubilization effects of I, II, and III were studied by use of adrenochrome monosemicarbazone (IV), o-HOC6H4CONH2 (V), p-MeC6H4NH2 (VI), and caffeine (VII). There was practically no difference by the position in isomers of I. II showed increased solubilization activity, the effect being better in lower homologs with Me and Et groups. III was found to give a far stronger effect, while introduction of two alkyls into the N in the acid amide group resulted in increased solubility in the case of V and VI, but 30-40% decrease in the case of IV and VII. II showed a lowering of solubilization activity by 10-40% compared to 3-H2NOCC5H4N. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Synthetic Route of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Synthetic Route of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Parker, Kathlyn A. et al. published their research in Journal of Organic Chemistry in 1987 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Name: N,N-Diethylsalicylamide

Directed hydroxylation of aromatics was written by Parker, Kathlyn A.;Koziski, Kathleen A.. And the article was included in Journal of Organic Chemistry in 1987.Name: N,N-Diethylsalicylamide This article mentions the following:

Regiospecific hydroxylation of an aromatic ring was accomplished by directed lithiation followed by oxygenation. Thus, EtCHMeLi was added to benzamide I (R = H) and Me2NCH2CH2NMe2 in THF. Then O was bubbled through the mixture to give 52% I (R = OH). In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Name: N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Name: N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Iannotti, Fabio Arturo et al. published their research in British Journal of Pharmacology in 2019 | CAS: 53902-12-8

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid

Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice was written by Iannotti, Fabio Arturo;Pagano, Ester;Moriello, Aniello Schiano;Alvino, Filomena Grazia;Sorrentino, Nicolina Cristina;D’Orsi, Luca;Gazzerro, Elisabetta;Capasso, Raffaele;De Leonibus, Elvira;De Petrocellis, Luciano;Di Marzo, Vincenzo. And the article was included in British Journal of Pharmacology in 2019.Recommanded Product: 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid This article mentions the following:

We explored the possibility of using non-euphoric compounds present in Cannabis sativa, cannabidiol (CBD), cannabidivarin (CBDV) and tetrahydrocannabidivarin (THCV), to reduce inflammation, restore functional autophagy and pos. enhance muscle function in vivo. Exptl. Approach : Using quant. PCR, western blots and [Ca2+]i measurements, we explored the effects of CBD and CBDV on the differentiation of both murine and human skeletal muscle cells as well as their potential interaction with TRP channels. After treatment, locomotor tests and biochem. analyses were used to evaluate their effects on inflammation and autophagy. Key Results : CBD and CBDV promoted the differentiation of murine C2C12 myoblast cells into myotubes by increasing [Ca2+]i mostly via TRPV1 activation, an effect that undergoes rapid desensitization. In primary satellite cells and myoblasts isolated from healthy and/or DMD donors, not only CBD and CBDV but also THCV promoted myotube formation, in this case, mostly via TRPA1 activation. In mdx mice, CBD (60 mg·kg-1) and CBDV (60 mg·kg-1) prevented the loss of locomotor activity, reduced inflammation and restored autophagy. Conclusion and Implications : We provide new insights into plant cannabinoid interactions with TRP channels in skeletal muscle, highlighting a potential opportunity for novel co-adjuvant therapies to prevent muscle degeneration in DMD patients. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Recommanded Product: 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kato, Motoyasu et al. published their research in Drug Design, Development and Therapy in 2020 | CAS: 53902-12-8

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Quality Control of 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid

Tranilast inhibits pulmonary fibrosis by suppressing TGFβ/SMAD2 pathway was written by Kato, Motoyasu;Takahashi, Fumiyuki;Sato, Tadashi;Mitsuishi, Yoichiro;Tajima, Ken;Ihara, Hiroaki;Nurwidya, Fariz;Baskoro, Hario;Murakami, Akiko;Kobayashi, Isao;Hidayat, Moulid;Shimada, Naoko;Sasaki, Shinichi;Mineki, Reiko;Fujimura, Tsutomu;Kumasaka, Toshio;Niwa, Shin-ichiro;Takahashi, Kazuhisa. And the article was included in Drug Design, Development and Therapy in 2020.Quality Control of 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid This article mentions the following:

Purpose: Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of extracellular matrix (ECM) protein in the lungs. Transforming growth factor (TGF) β- induced ECM protein synthesis contributes to the development of IPF. Tranilast, an antiallergy drug, suppresses TGFβ expression and inhibits interstitial renal fibrosis in animal models. However, the beneficial effects of tranilast or its mechanism as a therapy for pulmonary fibrosis have not been clarified. Methods: We investigated the in vitro effect of tranilast on ECM production and TGFβ/SMAD2 pathway in TGFβ2-stimulated A549 human alveolar epithelial cells, using quant. polymerase chain reaction, Western blotting, and immunofluorescence. In vitro observations were validated in the lungs of a murine pulmonary fibrosis model, which we developed by i.v. injection of bleomycin. Results: Treatment with tranilast suppressed the expression of ECM proteins, such as fibronectin and type IV collagen, and attenuated SMAD2 phosphorylation in TGFβ2-stimulated A549 cells. In addition, based on a wound healing assay in these cells, tranilast significantly inhibited cell motility, with foci formation that comprised of ECM proteins. Histol. analyses revealed that the administration of tranilast significantly attenuated lung fibrosis in mice. Furthermore, tranilast treatment significantly reduced levels of TGFβ, collagen, fibronectin, and phosphorylated SMAD2 in pulmonary fibrotic tissues in mice. Conclusion: These findings suggest that tranilast inhibits pulmonary fibrosis by suppressing TGFβ/SMAD2-mediated ECM protein production, presenting tranilast as a promising and novel anti-fibrotic agent for the treatment of IPF. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Quality Control of 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Quality Control of 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Perumal, Nithiyaa et al. published their research in Biomedicine & Pharmacotherapy in 2022 | CAS: 10238-21-8

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Synthetic Route of C23H28ClN3O5S

Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination was written by Perumal, Nithiyaa;Nallappan, Meenakshii;Shohaimi, Shamarina;Kassim, Nur Kartinee;Tee, Thiam Tsui;Cheah, Yew Hoong. And the article was included in Biomedicine & Pharmacotherapy in 2022.Synthetic Route of C23H28ClN3O5S This article mentions the following:

Type 2 Diabetes Mellitus accounts for 90% of most diabetes cases. Many com. drugs used to treat this disease come with adverse side effects and eventually fail to restore glucose homeostasis. Therefore, an effective, economical and safe antidiabetic remedy from dietary source is considered. Taraxacum officinale (L.) Weber ex F. H.Wigg and Momordica charantia L. were chosen since both are used for centuries as traditional medicine to treat various ailments and diseases. In this study, the antidiabetic properties of a polyherbal combination of T. officinale and M. charantia ethanol extracts are evaluated. The bioactive solvent extracts of the samples selected from in vitro antidiabetic assays; α-amylase, α-glucosidase, and dipeptidyl peptidase-4 (DPP-4) inhibition, and glucose-uptake in L6 muscle cells were combined (1:1) to form the polyherbal combination. The antidiabetic efficacy of polyherbal combination was evaluated employing the above stated in vitro antidiabetic assays and in vivo oral glucose tolerance test and streptozotocin-nicotinamide (STZ-NA) induced diabetic rat model. A quadrupole time-of-flight liquid chromatog.-mass spectrometry (Q-TOF LCMS) anal. was done to identify active compounds The polyherbal combination exerted improved antidiabetic properties; increased DPP-4, α-amylase, and α-glucosidase inhibition. The polyherbal combination tested in vivo on diabetic rats showed optimum blood glucose-lowering activity comparable to that of Glibenclamide and Metformin. This study confirms the polyherbal combination of T. officinale and M. charantia to be rich in various bioactive compounds, which exhibited antidiabetic properties. Therefore, this polyherbal combination has the potential to be further developed as complex phytotherapeutic remedy for the treatment of Type 2 Diabetes Mellitus. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Synthetic Route of C23H28ClN3O5S).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Synthetic Route of C23H28ClN3O5S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reverdin, Frederic et al. published their research in Arch. sci. phys. nat. gen. in 1907 | CAS: 1146-43-6

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C13H13NO3S

The Nitration of Some Derivatives of p-Aminophenol, (Continued) was written by Reverdin, Frederic;Dinner, Fritz. And the article was included in Arch. sci. phys. nat. gen. in 1907.Electric Literature of C13H13NO3S This article mentions the following:

The nitration of acetyl and benzoyl derivatives of the hydroxy- and amino- groups of sulphotoluene were studied. 1-o-Acetyl-4-N-toluenesulphoneamino phenol, m. 138-139°, by acetylation of N-toluenesulphoneaminophenol (J. pr. Chem., [2] 51, 438), easily saponifiable, with HNO3, sp. gr. 1.52, at 0° to 10°, yielded dinitrotoluenesulphoneaminophenol, C7H7SO2NH(1)C6H2(NO2)2(2,6)(OH)(4), m. 157-158°, the structure following from the fact that heating with concentrate H2SO4 gave dinitroammophenol, m. 231°, C6H2(OH)(NO2)2NH2(1)(3)(5)(4). Nitration preceded saponification, since the free phenol could not be nitrated. Nitration with HNO3 and H2SO4 in acetic anhydride caused decomposition and formation of nitroaminophenols. 1-o-Benzoyl-4-N-toluenesulphoneaminophenol, m. 170°, on nitration yielded a tetranitro derivative, m. 189-190°, probably C6H2(1)OC7H4ONO2(3,5)(NO2)7(4)NHSO2CH3C2H3NO2, with HNO3 and H2SO4, nitroaminophenols were formed. 1-o-toluene-p-sulphone-4-acetylaminophenol, m. 146° (Ber., 34, 237), on nitration yielded a mononitro-, m. 146°, or a dinitroderivative, m. 134°, for the latter acetic anhydride must be present, the structures of which were proved by saponification. With stronger acids, saponification took place at the same time as nitration. 1-o-Toluenesulphone-4-N-benzoylaminophenol, m. 218°, gave a trinitroderivative, m. 145-150°, 1 nitro group in the ring, 2 in the side chains, together with small quantities of mono- and dinitroderivatives. The colors of the various nitroaminophenols with soda served to identify them. Some conclusions with regard to the directive influence in the nitration of the groups present in the ring are given, the groups on the amino appearing to exert the greatest influence. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Electric Literature of C13H13NO3S).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C13H13NO3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Chao-Jie et al. published their research in European Journal of Medicinal Chemistry in 2021 | CAS: 119023-25-5

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Application of 119023-25-5

Discovery of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one derivatives as potential anticancer agents by inhibiting cell proliferation and inducing apoptosis in hepatocellular carcinoma cells was written by Wang, Chao-Jie;Guo, Xinxin;Zhai, Rui-Qin;Sun, Changning;Xiao, Guokai;Chen, Jin;Wei, Mei-Yan;Shao, Chang-Lun;Gu, Yuchao. And the article was included in European Journal of Medicinal Chemistry in 2021.Application of 119023-25-5 This article mentions the following:

Hepatocellular carcinoma (HCC) is the most common form of liver cancer and the fourth leading cause of cancer-related death worldwide. First-line drugs such as sorafenib provide only a modest benefit to HCC patients. In this study, the gram-scale synthesis of 2-benzoylquinazolin-4(3H)-one skeleton was achieved successfully via the I2/DMSO catalytic system. A series of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one derivatives was synthesized and evaluated for their cytotoxic activities against four cancer cell lines, HepG2, Bel-7402, A549, and U251. Among these compounds, I was the most effective one with IC50 values of 1.22μM and 1.71μM against HepG2 and Bel-7402 cells, resp. Mechanistic studies showed that I inhibited hepatocellular carcinoma cell proliferation via arresting cell cycle. Addnl., I induced HepG2 cells apoptosis by inducing reactive oxygen species production and elevating the expression of apoptosis-related proteins. More importantly, I displayed significant in vivo anticancer effects in the HepG2 xenograft models. This suggests that I is a promising lead compound with the potential to be developed as a chemotherapy agent for hepatocellular carcinoma. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Application of 119023-25-5).

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Application of 119023-25-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ghinato, Simone et al. published their research in Chemistry – A European Journal in 2022 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: 19311-91-2

Chemo- and Regioselective Anionic Fries Rearrangement Promoted by Lithium Amides under Aerobic Conditions in Sustainable Reaction Media was written by Ghinato, Simone;De Nardi, Federica;Bolzoni, Paola;Antenucci, Achille;Blangetti, Marco;Prandi, Cristina. And the article was included in Chemistry – A European Journal in 2022.Recommanded Product: 19311-91-2 This article mentions the following:

A straightforward and efficient protocol to promote the metalation/anionic Fries rearrangements of O-aryl carbamates, using for the first time a lithium amide as metalating agent under aerobic/ambient-friendly reaction conditions, was reported. This approach enabled the sustainable preparation of salicylamide derivatives such as I [R = Et, i-Pr; R1 = H, 5-MeO, 3-Ph, etc.] with high levels of chemoselectivity within ultrafast reaction times, working at room temperature in the presence of air/moisture, and using environmentally responsible cyclopentyl Me ether as a solvent. Furthermore, the regioselective manipulation of O-2-tolyl carbamates had been accomplished using interchangeably alkyllithiums or lithium amides, with an unexpected beneficial contribution from the employment of biorenewable protic eutectic mixtures as non-innocent reaction media. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Recommanded Product: 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Suzuki, Hirotsugu et al. published their research in Organic & Biomolecular Chemistry in 2020 | CAS: 116332-61-7

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C10H10F3NO2

Dealkoxylation of N-alkoxyamides without an external reductant driven by Pd/Al cooperative catalysis was written by Suzuki, Hirotsugu;Shiomi, Takahiro;Yoneoka, Kenji;Matsuda, Takanori. And the article was included in Organic & Biomolecular Chemistry in 2020.Computed Properties of C10H10F3NO2 This article mentions the following:

Lewis acid-assisted palladium-catalyzed dealkoxylation of N-alkoxyamides has been developed. This reaction proceeded smoothly with a range of N-alkoxyamides in the absence of an external reductant, thereby establishing a convenient and reductant-free protocol. In addition, a gram-scale reaction could be achieved. Preliminary mechanistic investigations indicated that β-hydrogen elimination from a palladium alkoxide intermediate generated an intramol. hydride source. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Computed Properties of C10H10F3NO2).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C10H10F3NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics