Amides-buliding-blocks

Related Products of 354-38-1,Some common heterocyclic compound, 354-38-1, name is 2,2,2-Trifluoroacetamide, molecular formula is C2H2F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The enynones (2) (0.50 mmol), trifluoroacetamide (1) (100 mg, 0.88 mmol), RuCl2(bpy)3 (9.6 mg, 0.015 mmol, 0.030 equiv), Na2CO3 (53 mg, 0.50 mmol, 1.0 equiv), and 1,2-dichloromethane (5.0 mL) were added to a reaction tube equipped with a stir bar. The tube was then exposed to blue LEDs irradiation at room temperature in air with stirring for 8 h. After the reaction was completed, the reaction mixture was extracted with 1,2-dichloromethane (30 mL),and washed with water (30 mL). The organic phase was dried with MgSO4 and evaporated in vacuo after filtration. The resulting residue was purified by column chromatography on silica gel to give the desired products 3.

The synthetic route of 354-38-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Taotao; Wu, Wei; Weng, Zhiqiang; Tetrahedron; vol. 75; 51; (2019);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26723-60-4, name is 3-Chloro-6,11-dihydro-5,5-dioxo-11-hydroxy-6-methyldibenzo[c,f][1,2]thiazepine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C14H12ClNO3S

Example 2 S^I-Dichloro-betajH-dihydro-e-methyl-deltajdelta-dioxodibenzoICjfUI^JthiazepineA suspension of compound of Formula III (58.0 g) in dichloromethane (600 ml) is cooled to 0-10 0C, HCI gas is bubbled through the above suspension for 2-4 hour at 0-10 0C. Upon completion of starting material, filter the precipitate and dry the solids obtained until constant weight to provide the title compound in 90-95% yield.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 26723-60-4.

Reference:
Patent; BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.; RANGISETTY, Jagadeesh, Babu; PULLAGURLA, Manik, Reddy; BHUDETI, Rajesh; WO2010/70667; (2010); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 1120-16-7, name is Dodecanamide, molecular formula is C12H25NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C12H25NO

A flask was charged with N-(7-chloro-7,8-dihydro-1,8- naphthyridin-2yl)dodecanamide (6) (15.6 g, 42.8mmol), dodecanamide (10.3 g, 51.3mmol), Pd(OAc)2 (593 mg, 2.6 mmol), Xantphos (3.3 g, 5.8mmol), K2CO3 (5.9 g, 42.8mmol), and dry dioxane (250 mL). Oven-dried molecular sieves (4) were added and the mixture was stirred overnight at room temperature under Ar. Subsequently, the mixture was heated to 80 C and stirred overnight under Ar. After cooling to room temperature, the mixture was filtered and the residue was rinsed with CHCl3. Recrystallization in ethanol and purification by flash chromatography (80% CHCl3/20% EtOAc) yielded the product as a white solid (16.5 g, 73%). 1HNMR (400 MHz, CDCl3): 8.42 (d, 2H, J = 8.8 Hz, Ar), 8.14 (d, 2H, J = 8.8 Hz, Ar), 8.12 (bs, 2H, NH), 2.47 (t, 4H, J = 7.6 Hz, O=C-CH2), 1.56 (m, 4H, J = 8.0, 7.6 Hz, O=C-CH2-CH2), 1.26 (m, 32H, alkyl-CH2), 0.88 (t, 6H, alkyl-CH3). 13CNMR (100 MHz, CDCl3): 172.2, 153.74, 138.98, 113.34, 110.01, 76.75, 38.13, 31.90, 29.60, 29.44, 29.33, 29.15, 25.29, 22.68, 14.12. MALDI-ToF MS: calculated for C32H52N4O2 524.78, observed m/z 525.43 [M + H+], 1087.79 [dimer + K+]. Elemental analysis: calculated for C32H52N4O2: C, 73.24; H, 9.99; N, 10.68; O, 6.10%. Found: C, 73.35; H, 9.59; N, 10.26%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1120-16-7, its application will become more common.

Reference:
Article; Teunissen, Abraham J.P.; Van Der Haas, Roy J.C.; Vekemans, Jef A.J.M.; Palmans, Anja R.A.; Meijer; Bulletin of the Chemical Society of Japan; vol. 89; 3; (2016); p. 308 – 314;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 109903-35-7, A common heterocyclic compound, 109903-35-7, name is 4-Amino-N-methylbenzenemethanesulfonamide, molecular formula is C8H12N2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N-Methyl-[4-(4-phenylamino-quinazolin-2-ylamino)-phenyl]-methanesulfonamide hydrochloride A solution of 2-chloro-4-phenylamino-quinazoline (0.92 g) (prepared as described in Example 1a and N-methyl-(4-aminophenyl)-methanesulfonamide (0.80 g) in 10 ml of isopentylalcohol is stirred under nitrogen at 170 C. for 15 min in a sealed vessel. The warm reaction mixture is diluted with 10 ml ethanol and the hydrochloride salt, which is crystallizing on cooling, is filtered off to yield N-methyl-[4-(4-phenylamino-quinazolin-2-ylamino)-phenyl]-methanesulfonamide hydrochloride as light yellow crystals melting at 259-263 C.; Rf (A2) 0.11, FAB-MS: (M+H)+ =420. Analytical data: C22 H21 N5 O2 S+HCl.

The synthetic route of 109903-35-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Synaptic Pharmaceutical Corporation; US5968819; (1999); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 83948-54-3, name is tert-Butyl (5-bromopentyl)carbamate, A new synthetic method of this compound is introduced below., category: amides-buliding-blocks

Compound 5-1 (0.95 g, 4.29 mmol) was dissolved in N, N-dimethylformamide,Join in sequence5- (tert-butoxycarbonylamino) bromopentane(1.7 g, 6.43 mmol)And potassium carbonate (1.78 g, 12.9 mmol) were reacted at 90 C for 6 hours,The solvent was evaporated under reduced pressure, and ethyl acetate (40 ml) and water (30 ml) were added. After extraction, the organic layer was dried over anhydrous sodium sulfate and filtered. The solvent was evaporated under reduced pressure and subjected to column chromatography to give compound 5-2 (1.6 g, Yield 89%).

The synthetic route of 83948-54-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Guangzhou Bio-pharmaceutical And Health Institute; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; China Pharmaceutical University; Jiang Sheng; Tu Zhengchao; Zhu Jidong; Yao Hequan; Yao Yiwu; Tan Xiaochu; Gu Shoulai; Qiu Yatao; (30 pag.)CN106928192; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 4141-08-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4141-08-6, name is 2-Amino-N-methylbenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A 25 mL Schlenk-type tube equipped with a magnetic stir bar was charged with o-substituted aniline 1a-1f. The reaction tube was evacuated and back-filled with O2. Under oxygen atmospheres, ethers or alcohols 2a-2n and DMSO were added at room temperature, then the reaction mixture was stirred at 120 C for 12 h. The reaction was monitored by TLC. After completion of the reaction, the resulting solution was cooled to room temperature, and neutralized with saturated NaHCO3 aqueous solution. The product was extracted with EtOAc or CHCl3, dried over anhydrous Na2SO4 and concentrated in vacuum. The crude product was purified by flash column chromatography on silica gel to give N-heterocyclic compounds 3.

The synthetic route of 2-Amino-N-methylbenzamide has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Xiuling; Qi, Hongxue; Wu, Shaofeng; Liu, Leng; Wen, Jianhui; Li, Wanxi; Guo, Fang; Bian, Yongjun; Li, Jun; Heterocycles; vol. 94; 1; (2017); p. 86 – 94;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 108468-00-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 108468-00-4 as follows.

100 mg (0.109 mmol) of compound 3d was dissolved in 4 ml of DMF and cooled to -15 C. After addition of 36 tl (0.327 mmol) of NMM and 15 tl (0.109 mmol) CKIBE, the solution was stirred for 15 mm, followed by addition of 40mg (0.169 mmol) ofBoc-p-diaminoxylene and 12 tl (0.109 mmol) of NMM. The mixture was stirred for one hour at 0 C. and overnight at RT. The solvent was removed in vacuo, the residue was mixed with 1 ml 90% TFA and stirred for 2 h at RT. After removing the solvent in vacuo, the residue was dissolved in 8 ml of 30% B and purified by prep. HPLC (start at 10% B). Fractions containing the product were combined, the solvent was removed in vacuo and the residue dissolved in 80% t-butanol/water and lyophilized.jOllO] Yield: 39

According to the analysis of related databases, 108468-00-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PHILIPPS-UNIVERSITAeT MARBURG; Steinmetzer, Torsten; Saupe, Sebastian; US2014/213781; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 830-43-3, name is 4-(Trifluoromethyl)benzenesulfonamide, molecular formula is C7H6F3NO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H6F3NO2S

Accurate weighing of the quinoline nitrogen oxides (44.3 mg, 0 . 25mmol), 4 – trifluoromethylbenzene sulfonamide (55.0 mg, 0 . 25mmol), double (trifluoroacetic acyloxy) iodobenzene (107.2 mg, 0 . 25mmol), 4 – N – morpholine – phenyl diphenyl phosphine (100.9 mg, 0 . 75mmol), and in turn to 25 ml of the bottle in the Schlenk, adding refined over-dimethyl sulfoxide (3.0 ml), is 120 C in oil bath reaction 30h. After the reaction, the solvent is removed under reduced pressure, the use of petroleum ether/ethyl acetate as eluant, separating by silica gel column, 4 – Trifluoromethyl – N – (quinolin – 2 – yl) benzenesulfonamide of yield is 67%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 830-43-3, its application will become more common.

Reference:
Patent; Dalian University of Technology; Yu Xiaoqiang; Bao Ming; Feng Xiujuan; Zhang Yue; Guo Mingju; (19 pag.)CN104447536; (2017); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 154748-63-7, A common heterocyclic compound, 154748-63-7, name is tert-Butyl (3-hydroxycyclobutyl)carbamate, molecular formula is C9H17NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of tert-butyl (1S,3R)-3-hydroxycyclopentylcarbamate (0.50g, 2.5mmol),4-(trifluoromethyl)phenol (0.49g, 3mmol) and triphenylphosphine (0.98g, 3.75mmol) in anhydrous THF (8mL) was dropwise added DIAD (0.98mL, 4.68mmol) in anhydrous THF (7mL). The reaction solution was stirred at room temperature overnight. The resulting solution was concentrated in vacuo, and the residue was subjected to flash column chromatography on silica gel (eluting with EtOAc-heptane by a gradient of EtOAc from 4% to 32%) to deliver title compound as colorless crystals (0.63g, 73%)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Aktas, Bertal H.; Bohm, Andrew; Chorev, Michael; Du, Ronghui; Halperin, Jose; Reis Monteiro dos Santos, Guilherme Rodrigo; Yefidoff-Freedman, Revital; Zhang, Qingwen; European Journal of Medicinal Chemistry; vol. 187; (2020);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 144072-29-7 as follows. HPLC of Formula: C12H17NO3

To a solution of 31 (8.2 g, 36.7 mmol) in DCM (150 mL) were added TEA (11.1 g, 110 mmol) and MsCl (6.3 g, 55.1 mmol) at 0 C. The mixture was stirred at rt for 3 h, and quenched with water (80 mL), the aqueous layer was extracted with DCM (100 mL × 2), dried over Na2SO4, and concentrated under vacuum to yield crude 32 (7.5 g, 68%) as a yellow oil. This product was used in the following reaction without further purification

According to the analysis of related databases, 144072-29-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Fujimoto, Jun; Hirayama, Takaharu; Hirata, Yasuhiro; Hikichi, Yukiko; Murai, Saomi; Hasegawa, Maki; Hasegawa, Yuka; Yonemori, Kazuko; Hata, Akito; Aoyama, Kazunobu; Cary, Douglas R.; Bioorganic and Medicinal Chemistry; vol. 25; 12; (2017); p. 3018 – 3033;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics