Tag: 100-200

Effect of heating, plasticizing, and filling on spherulite size distribution, and physical and mechanical properties of crystallizable polymers was written by Pelishenko, S. S.;Solomko, V. P.. And the article was included in Vysokomolekulyarnye Soedineniya, Seriya A in 1971.Formula: C9H13NO2S This article mentions the following:

Plasticization of crystallizing polyformaldehyde (I) (of mol. weight 60,000) with small amounts of Ph2NH and castor oil and of polycaprolactam (II) (of mol. weight 28,000) with N-isopropylbenzenesulfonamide and filling with kaolin and Aerosil led to improved physicomech. properties and spherulite size distribution. Addition of large amounts of plasticizers had the opposite effect. The flexural strength and impact strength of I increased following heat treatment at 160°. The spherulite size of I and II increased as the heat treatment temperature was raised from 140 to 160°. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Formula: C9H13NO2S).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Formula: C9H13NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Practical synthesis of C1 deuterated aldehydes enabled by NHC catalysis was written by Geng, Huihui;Chen, Xiaobei;Gui, Jingjing;Zhang, Yueteng;Shen, Zuyuan;Qian, Pengfei;Chen, Junwei;Zhang, Shilei;Wang, Wei. And the article was included in Nature Catalysis in 2019.Product Details of 13255-50-0 This article mentions the following:

N-heterocyclic carbenes promoted a reversible hydrogen-deuterium exchange reaction with simple aldehydes, which led to a practical approach to synthetically valuable C1 deuterated aldehydes RC(O)D [R = Ph, Bn, CH=CHPh, etc.]. The reactivity of the well-established N-heterocyclic carbene-catalyzed formation of Breslow intermediates from aldehydes was reengineered to overcome the overwhelmingly kinetically favorable benzoin condensation reaction and achieve the critical reversibility to drive the formation of desired deuterated products when an excess of D₂O was employed. Notably, this operationally simple and cost-effective protocol served as a general and truly practical approach to all types of 1-D-aldehydes including aryl, alkyl and alkenyl aldehydes and enabled chemoselective late-stage deuterium incorporation into complex, native therapeutic agents and natural products with uniformly high levels (>95%) of deuterium incorporation for a total of 104 tested substrates. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Product Details of 13255-50-0).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Product Details of 13255-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Auto-Tandem Catalysis with Ruthenium: From o-Aminobenzamides and Allylic Alcohols to Quinazolinones via Redox Isomerization/Acceptorless Dehydrogenation was written by Zhang, Weikang;Meng, Chong;Liu, Yan;Tang, Yawen;Li, Feng. And the article was included in Advanced Synthesis & Catalysis in 2018.Category: amides-buliding-blocks This article mentions the following:

A strategy for the synthesis of quinazolinones I [R = H, 7-Me, 6,8-di-Cl, etc.; R¹ = Et, i-Pr, n-Bu, etc.; R² = H, n-Bu, Bn] was proposed via Ru-catalyzed redox isomerization/acceptorless dehydrogenation of o-aminobenzamides with allylic alcs. and was obtained in moderate to high yields. This strategy was attractive due to high atom efficiency, minimal consumption of chems. and energy. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Category: amides-buliding-blocks).

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of 2-Benzylphenyl Ketones by Aryne Insertion into Unactivated C-C Bonds was written by Rao, Bin;Tang, Jinghua;Zeng, Xiaoming. And the article was included in Organic Letters in 2016.Application In Synthesis of 3-Fluoro-N-methoxy-N-methylbenzamide This article mentions the following:

A transition-metal-free procedure to access functionalized 2-benzylphenyl ketones is described by direct insertion of arynes into benzylic C-C bonds. This reaction was promoted by cesium fluoride at room temperature, allowing the products to form in high selectivity and achieve good functional group tolerance. In the experiment, the researchers used many compounds, for example, 3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1Application In Synthesis of 3-Fluoro-N-methoxy-N-methylbenzamide).

3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Application In Synthesis of 3-Fluoro-N-methoxy-N-methylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Direct Hydroxylation and Amination of Arenes via Deprotonative Cupration was written by Tezuka, Noriyuki;Shimojo, Kohei;Hirano, Keiichi;Komagawa, Shinsuke;Yoshida, Kengo;Wang, Chao;Miyamoto, Kazunori;Saito, Tatsuo;Takita, Ryo;Uchiyama, Masanobu. And the article was included in Journal of the American Chemical Society in 2016.Computed Properties of C11H15NO2 This article mentions the following:

Deprotonative directed ortho cupration of aromatic/heteroaromatic C-H bond and subsequent oxidation with t-BuOOH furnished functionalized phenols in high yields with high regio- and chemoselectivity. DFT calculations revealed that this hydroxylation reaction proceeds via a copper (I → III → I) redox mechanism. Application of this reaction to aromatic C-H amination using BnONH₂ efficiently afforded the corresponding primary anilines. These reactions show broad scope and good functional group compatibility. Catalytic versions of these transformations are also demonstrated. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Computed Properties of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Computed Properties of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

KB₃H₈: an environment-friendly reagent for the selective reduction of aldehydes and ketones to alcohols was written by Li, Xinying;Mi, Tongge;Guo, Wenjing;Ruan, Zhongrui;Guo, Yu;Ma, Yan-Na;Chen, Xuenian. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.HPLC of Formula: 13255-50-0 This article mentions the following:

Selective reduction of aldehydes and ketones to their corresponding alcs. with KB₃H₈, an air- and moisture-stable, nontoxic, and easy-to-handle reagent, in water and THF has been explored under an air atm. for the first time. Control experiments illustrated the good selectivity of KB₃H₈ over NaBH₄ for the reduction of 4-acetylbenzaldehyde and aromatic keto esters. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0HPLC of Formula: 13255-50-0).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.HPLC of Formula: 13255-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Conformation and stereodynamics of ortho-hydroxy and ring-unsubstituted N,N-dialkylbenzamides was written by Jennings, W. Brian;Randall, David;Saket, Barahman Movassagh. And the article was included in Journal of the Chemical Society, Chemical Communications in 1982.Computed Properties of C11H15NO2 This article mentions the following:

Low temperature NMR spectral study of o-RC₆H₄CONR¹₂ (R = OH, R¹ = CHMe₂, Et, CH₂Ph; R = H, NR¹₂ = 3,5-dimethylpiperidino) showed these compounds to have a noncoplanar conformation with barriers of 7-9 kcal/mol to rotation about the aryl-CO bond. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Computed Properties of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Predictably Selective (sp³)C-O Bond Formation through Copper Catalyzed Dehydrogenative Coupling: Facile Synthesis of Dihydro-oxazinone Derivatives was written by Modak, Atanu;Dutta, Uttam;Kancherla, Rajesh;Maity, Soham;Bhadra, Mohitosh;Mobin, Shaikh M.;Maiti, Debabrata. And the article was included in Organic Letters in 2014.COA of Formula: C11H15NO2 This article mentions the following:

An intramol. dehydrogenative (sp³)C-O bond formation in salicylamides can be initiated by an active Cu/O₂ species to generate pharmaceutically relevant dihydrooxazinones. E.g., in presence of CuCl₂ and pyridine in m-xylene at 130 °C, dehydrogenative coupling of salicylamide derivative (I) gave 90% 2H-benz[e][1,3]oxazin-4(3H)-one derivative (II). Exptl. findings suggest that stereoelectronic parameters in both coupling partners are controlling factors for site selectivity in bond formation. Mechanistic investigations including isotope labeling and kinetic studies helped us to propose a catalytic cycle. The method provides a convenient synthesis of an investigational new medicine CX-614, which has potential in finding treatment for Parkinson’s and Alzheimer’s diseases. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2COA of Formula: C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.COA of Formula: C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Aza-Knoevenagel-type condensation of secondary amides: direct access to N-monosubstituted β,β-difunctionalized enamines was written by Huang, Pei-Qiang;Ou, Wei;Ye, Jian-Liang. And the article was included in Organic Chemistry Frontiers in 2015.Reference of 13255-50-0 This article mentions the following:

An efficient approach to N-monosubstituted β,β-difunctionalized enamines, a class of versatile building blocks for the synthesis of bioactive compounds, was reported. The method was based on the triflic anhydride-mediated direct aza-Knoevenagel-type condensation of secondary amides with active methylene compounds The reaction showed good chemoselectivity and functional group tolerance. A number of title compounds were synthesized in good to excellent yields in one pot from readily available starting materials. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Reference of 13255-50-0).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Reference of 13255-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Potentiation of the cytotoxic action of mafosfamide by N-isopropyl-p-formylbenzamide, a metabolite of procarbazine was written by Maki, Patricia A.;Sladek, Norman E.. And the article was included in Cancer Research in 1991.Recommanded Product: 13255-50-0 This article mentions the following:

Several mouse aldehyde dehydrogenases catalyze the detoxification of aldophosphamide, the pivotal metabolite of the prodrugs cyclophosphamide, mafosfamide, and other oxazaphosphorines. N-Isopropyl-p-formylbenzamide, a major metabolite of procarbazine, was found to be an excellent substrate (K_m = 0.84 μM) for at least one of these enzymes, namely mouse aldehyde dehydrogenase-2. The K_m for mouse aldehyde dehydrogenase-2-catalyzed detoxification of aldophosphamide is 16 μM. Thus, competition between N-isopropyl-p-formylbenzamide and aldophosphamide for the catalytic site on the enzyme should strongly favor the former, and the rate at which aldophosphamide is detoxified should be markedly retarded. Mouse L1210/OAP and P388/CLA leukemia cells are relatively insensitive to the oxazaphosphorines because they contain large amounts of mouse aldehyde dehydrogenase-2. As predicted, N-isopropyl-p-formylbenzamide markedly potentiated the cytotoxic action of mafosfamide against these cells. Mouse L1210/0 and P388/0 lack the enzyme. Again, as expected, N-isopropyl-p-formylbenzamide essentially did not potentiate the cytotoxic action of mafosfamide against these cells. Certain mouse and human hematopoietic progenitor cells also contain an aldehyde dehydrogenase that catalyzes the detoxification of aldophosphamide, but the specific identity of this enzyme remains to be established. N-Isopropyl-p-formylbenzamide potentiated the cytotoxic action of mafosfamide against these cells as well. Clin., procarbazine and the oxazaphosphorines are used to treat certain neoplastic diseases. Frequently, they are used in combination. These findings demonstrate the potential for both desirable and undesirable drug interactions when these agents are used concurrently. Similar drug interactions can be expected when other substrates for, or inhibitors of, the relevant aldehyde dehydrogenases, e.g., chloramphenicol, chloral hydrate, and methyltetrazolethiol-containing cephalosporins, are co-administered with the oxazaphosphorines. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Recommanded Product: 13255-50-0).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Recommanded Product: 13255-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics