Tag: 100-200

Oxidation of substituted benzyl amines using a phenoxo-bridged dimeric nickel(II) complex: synthesis, crystal structure and catalytic activity was written by Kumar, Robin;Kumar, Ravinder;Mahiya, Kuldeep;Mathur, Pavan. And the article was included in Transition Metal Chemistry (Dordrecht, Netherlands) in 2015.HPLC of Formula: 2670-38-4 This article mentions the following:

A benzimidazole-based Schiff base ligand and its dinuclear complex [Ni₂(L)₂(NO₃)₂] where HL = [2-(2-(1H-benzo[d]imidazol-2-yl)ethylimino)methyl]phenol were synthesized. An x-ray crystallog. study showed that both the metal centers in the complex adopt a distorted octahedral geometry. Variable-temperature magnetic studies suggest that the Ni(II) centers are antiferromagnetically coupled. Cyclic voltammetry confirms that the dinickel complex retains its identity in the presence of tert-Bu hydroperoxide in the solution state. The complex was used as a catalyst for the homogeneous oxidation of substituted benzyl amines in the presence of tert-Bu hydroperoxide. The yields of these reactions depend upon the nature of the substituent in the aromatic ring. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4HPLC of Formula: 2670-38-4).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.HPLC of Formula: 2670-38-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Green Catalyst- and Additive-Free Three-Component Deamination Cyclization Synthesis of 3-Substituted-4- oxo-2-quinazolinonyl Sulfides was written by Zheng, Lvyin;Xie, Zhen;Cai, Liuhuan;Liu, Gongping;Mei, Weijie;Zou, Xiaoying;Zhuo, Xiaoya;Fan, Xiaolin;Guo, Wei. And the article was included in ChemistrySelect in 2021.Product Details of 119023-25-5 This article mentions the following:

An efficient three-component deamination annulation of 2-aminobenzamides 2-NH₂-RC₆H₄C(O)NH₂ (R = H, 3-Me, 4-F, 5-Cl, etc.), isothiocyanates R¹NCS (R¹ = Ph, Bn, Me, etc.) and alkyl bromides R²R³CHBr (R² = ethoxycarbonyl, benzyloxycarbonyl, Ph, etc.; R³ = H, Et, Pr, Bu, phenyl) for the synthesis of valuable 3-substituted-4-oxo-2-quinazolinonyl sulfides I (R⁴ = H, 6-Me, 7-Cl, 8-Br, etc.) is reported. The reaction proceeds in the absence of any external catalysts and additives. The facile process has the advantages of broad substrate scopes, mild reaction conditions and environmental friendliness, which might provide the synthetic applications for 3-substituted-4-oxo-2-quinazolinonyl sulfides I as potential anti-cancer agents in medicinal chem. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Product Details of 119023-25-5).

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Product Details of 119023-25-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Transition-Metal-Free Synthesis of C3-Arylated Benzofurans from Benzothiophenes and Phenols was written by Yang, Kevin;Pulis, Alexander P.;Perry, Gregory J. P.;Procter, David J.. And the article was included in Organic Letters in 2018.Application In Synthesis of N,N-Diethylsalicylamide This article mentions the following:

A transition-metal-free synthesis of benzofurans from benzothiophenes and phenols that exploits the unique reactivity of sulfoxides, is reported. Through a sequence involving an interrupted Pummerer reaction and [3,3] sigmatropic rearrangement, phenols can be combined with readily accessible yet synthetically unexplored benzothiophene S-oxides to provide C3-arylated benzofuran products. The products from this approach can undergo subsequent functionalization to gain access to a range of important benzofuran derivatives In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Application In Synthesis of N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Application In Synthesis of N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A chiroptical nanoprobe for highly selective recognition of histidine enantiomers in aqueous media was written by Liu, Keyuan;Du, Ganhong;Ye, Long;Jiang, Liming. And the article was included in Sensors and Actuators, B: Chemical in 2019.COA of Formula: C11H15NO2 This article mentions the following:

Histidine is one of the essential amino acids in the human body, and the variation of its concentration in vivo has shown it to align with some liver and kidney diseases. In this work, a series of novel poly(2-oxazoline) derivatives bearing chiral pyrrolidine-triazole moieties in the side chain were designed and synthesized to serve as chem. sensors for histidine. The results demonstrated that the homopolymer HPOx2 is capable of selectively binding optically active histidine through nitrogen/Cu²⁺ coordination to form complexes exhibiting induced CD (ICD) signals with signs related to the absolute configuration of the guest compound Interestingly, the micelle-type nanoparticles assembled from the corresponding amphiphilic copolymer (CPOx2) gave a much stronger CD response, with an intensity five times that of its small mol.- or homopolymer counterparts. The proposed method, based on the chiroptical probe, allows for enantioselective detection of histidine in aqueous media, showing potential application in the field of biomedical assay and chiral drug synthesis. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2COA of Formula: C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.COA of Formula: C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

One-pot transition-metal-free synthesis of Weinreb amides directly from carboxylic acids was written by Niu, Teng;Wang, Ke-Hu;Huang, Danfeng;Xu, Changming;Su, Yingpeng;Hu, Yulai;Fu, Ying. And the article was included in Synthesis in 2014.Recommanded Product: 106675-70-1 This article mentions the following:

Weinreb amides were prepared directly from carboxylic acids, N,O-dimethylhydroxylamine, and phosphorus trichloride in one pot at 60° in toluene in high yields, thus avoiding the separation of the moisture and air sensitive intermediate P[NMe(OMe)]₃ in advance. Sterically hindered carboxylic acids also give the corresponding Weinreb amides in excellent yields. Various functional groups are tolerated on the carboxylic acid. The method, which is a simple process and gives high yields, is suitable for large-scale production In the experiment, the researchers used many compounds, for example, N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1Recommanded Product: 106675-70-1).

N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 106675-70-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Toxicity and analgetic activity of some congeners of salicylamide was written by Way, E. Leong;Takemori, Akira E.;Smith, Glenn E. Jr.;Anderson, Hamilton H.;Brodie, Donald C.. And the article was included in Journal of Pharmacology and Experimental Therapeutics in 1953.Application of 19311-91-2 This article mentions the following:

Eighty-one congeners of salicylamide (I), with small substituted groups in various positions on the benzene ring or on the phenolic O and amino N, were evaluated in rats as to toxicity and ability to elevate the pain-response threshold to pressure stimulus. Most of the compounds appear to be central nervous system depressants and some possess marked hypnotic properties. The relation between structure and activity is discussed. 2-Allyloxybenzamide was about 3 times as potent as I. N,N-Dimethyl-3-phenyl-salicylamide, 3-phenylsalicylamide, and N-(2-hydroxy-ethyl)-3-phenylsalicylamide were less toxic and more potent than I. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Application of 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application of 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita was written by Chen, Xiulei;Zhou, Zhen;Li, Zhong;Xu, Xiaoyong. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2020.Application In Synthesis of 6-Chloro-2-aminobenzamide This article mentions the following:

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol I (R = H, 5-OMe, 7-F, 8-NO₂, etc.) was synthesized. The bioassay results showed that compounds I (R = 7-OMe, 6-NO₂, 7-Cl (A)) exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L^-1 in vivo. Compound (A) showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L^-1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Application In Synthesis of 6-Chloro-2-aminobenzamide).

6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Application In Synthesis of 6-Chloro-2-aminobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ortho- and Para-Selective Ruthenium-Catalyzed C(sp²)-H Oxygenations of Phenol Derivatives was written by Liu, Weiping;Ackermann, Lutz. And the article was included in Organic Letters in 2013.Name: N,N-Diethylsalicylamide This article mentions the following:

Versatile ruthenium catalysts allowed for efficient direct oxygenations of aryl carbamates under remarkably mild reaction conditions to provide o-hydroxy products, e.g., I. In addition to chelation-assisted C-H activation, the optimized ruthenium catalyst proved amenable to para-selective hydroxylations of anisoles without Lewis basic directing groups. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Name: N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Name: N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors was written by Si, Dongjuan;Luo, Huijuan;Zhang, Xiaomeng;Yang, Kundi;Wen, Hongmei;Li, Wei;Liu, Jian. And the article was included in Bioorganic Chemistry in 2021.Application In Synthesis of 2-(2-Chlorophenyl)acetamide This article mentions the following:

Inhibition of the interactions of the tumor suppressor protein p53 with its neg. regulators MDM2 in vitro and in vivo, representing a valuable therapeutic strategy for cancer treatment. The natural product chalcone exhibited moderate inhibitory activity against MDM2, thus based on the binding mode between chalcone and MDM2, a hit unsaturated pyrrolidone scaffold was obtained through virtual screening. Several unsaturated pyrrolidone derivatives were synthesized and biol. evaluated. As a result, because the three critical hydrophobic pockets of MDM2 were occupied by the substituted-Ph linked at the pyrrolidone fragment, compound I demonstrated good binding affinity with the MDM2. Addnl., compound I also showed excellent antitumor activity and selectivity, and no cytotoxicity against normal cells in vitro. The further antitumor mechanism studies were indicated that compound I could successfully induce the activation of p53 and corresponding downstream p21 proteins, thus successfully causing HCT116 cell cycle arrest in the G1/M phase and apoptosis. Thus, the novel unsaturated pyrrolidone p53-MDM2 inhibitors could be developed as novel antitumor agents. In the experiment, the researchers used many compounds, for example, 2-(2-Chlorophenyl)acetamide (cas: 10268-06-1Application In Synthesis of 2-(2-Chlorophenyl)acetamide).

2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Application In Synthesis of 2-(2-Chlorophenyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Correlation between chemical structure and rodent repellency of benzoic acid derivatives was written by Fearn, James E.;DeWitt, James B.. And the article was included in Journal of Agricultural and Food Chemistry in 1965.Computed Properties of C7H5Cl2NO This article mentions the following:

Sixty-five benzoic acid derivatives were either prepared or obtained from com. concerns, tested for rat repellency, and their indexes of repellency computed. The data from these tests were considered anal. for any correlation between chem. structure and rat repellency. The results suggest a qual. relation which is useful in deciding probability of repellency in other compounds In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Computed Properties of C7H5Cl2NO).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Computed Properties of C7H5Cl2NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics